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Nonmetric Traits in Permanent Teeth as Clues to Ethnicity in Vidarbha Subpopulation to Aid Forensic Profiling:Pilot Study

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Journal of Forensic Science and Medicine 2024年第1期10卷 11-19页

作者： Vaishali Amarlal Sadhwani Nilima prakash GLPradeep Rekha Patil Shubhechha anand Khivsara Sabiha Mokashi Khan MGV’S KBH Dental College NashikMaharashtraIndia Oral Cancer Screening and Awareness in Cancer Screening Vertical Indian Cancer SocietyMumbaiMaharashtraIndia

Introduction:Nonmetric dental traits have a crucial role in ethnic classification of populations that help in forensic racial *** studies have demonstrated the differences in the expression and frequency of dental traits between various ethnic groups for ancestry determination in the context of forensic dental *** present study is an attempt to assess the frequency and variation in nonmetric traits for establishing ethnicity in the Vidarbha ***:The aim of the study was to assess the frequency and variation of nonmetric traits in permanent teeth for establishing ethnicity in the Vidarbha *** and Methods:Participants of the Vidarbha subpopulation were selected by random sampling ***,premolars,and incisors were evaluated for frequency of nonmetric traits,and variations were graded according to Dentoanthropological System of State University of Arizona *** statistics,Chi-square test,and Student’s t-test were used for analysis of ***:The most common occlusal morphology in mandibular first and second molar was 5 cusp and 4 cusp,respectively,with the“+”groove *** 3 and cusp 4 were observed frequently in the maxillary *** lingual cusp was most commonly seen in mandibular premolars show while incisors showed faint ***:Our study concludes that nonmetric traits were present and showed variation in permanent maxillary and mandibular teeth among the Vidarbha *** 5 and Cusp 4 in first and second mandibular molars,respectively,groove pattern“+”and grade 1 protostylid were the most frequent grades observed in permanent mandibular *** lingual cusp was most commonly seen in mandibular premolars and faint shoveling was a notable feature in incisors of this population.

关键词： Cusp number ethnicity forensic anthropology molar protostylid

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Silica Induced Early Fibrogenic Reaction in Lung of Mice Ameliorated by Nyctanthes arbortristis Extract

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Biomedical and Environmental Sciences 2002年第3期15卷 215-222页

作者： BHOLA NATH PAUL anand prakash SIRISH KUMAR AJAY KYADAV UMANI ASHOK KSAXENA anand prakash SAHU KEWAL LAL KALYAN KDUTTA Immunobiology Laboratory Industrial Toxicology Research CentreM.G.MargLucknow 226001U.P.India Inhalation Toxicology Laboratory Industrial Toxicology Research CentreM.G.MargLucknow 226001U.P.India Preventive Toxicology Laboratory Industrial Toxicology Research CentreM.G.MargLucknow 226001U.P.India

Objective To investigate the pharmacological effect of Nyctanthes arbortristis (NAT) leaf extract in the prevention of lung injury induced by silica particles. Method Lung injury was induced in Swiss mice through inhalation exposure to silica particles (<5m) using a Flow Past Nose Only Inhalation Chamber at the rate of -10 mg/m3 respirable mass for 5 h. Lung bronchoalveolar lavage (BAL) fluid collected between 48 and 72 h was subjected to protein profiling by electrophoresis and cytokine evaluation by solid phase sandwich ELISA. Lung histopathology was performed to evaluate lung injury. Results Inhalation of silica increased the level of tumor necrosis factor-a (TNF-a), and of the 66 and 63 kDa peptides in the BAL fluid in comparison to sham-treated control. Pre-treatment of silica exposed mice with NAT leaf extract significantly prevented the accumulation of TNF-a in the BAL fluid, but the 66 and 63 kDa peptides remained unchanged. The extract was also effective in the prevention of silica-induced early fibrogenic reactions like congestion, edema and infiltration of nucleated cells in the interstitial alveolar spaces, and thickening of alveolar septa in mouse lung. Conclusion NAT leaf extract helps in bypassing silica induced initial lung injury in mice.

关键词： Nyctanthes arbortristis Lung-injury Silica Mice prevention

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Anterior resection for rectal carcinoma-risk factors for anastomotic leaks and strictures

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World Journal of Gastroenterology 2011年第11期17卷 1475-1479页

作者： Ashok Kumar Ram Daga Paari Vijayaragavan anand prakash Rajneesh Kumar Singh Anu Behari Vinay K Kapoor Rajan Saxena Department of Surgical Gastroenterology Sanjay Gandhi Post Graduate Institute of Medical Sciences Lucknow 226014India

AIM:To determine the incidence and factors responsible for anastomotic leaks and stricture following anterior resection(AR)and its subsequent ***:Retrospective analysis of data from 108 patients with rectal carcinoma who underwent AR or low anterior resection(LAR)to identify the various preoperative,operative,and post operative factors that might have influence on anastomotic leaks and ***:There were 68 males and 40 females with an average of 47 years(range 21-75 years).The median distance of the tumor from the anal verge was 8 cm(range 3-15 cm).Sixty(55.6%)patients underwent handsewn anastomosis and 48(44.4%)were *** median operating time was 3.5 h(range2.0-7.5 h).Sixteen(14.6%)patients had an anastomotic *** these,11 patients required reexploration and five were managed *** anastomotic leak rate was similar in patients with and without diverting stoma(8/60,13.4%with stoma and 8/48;16.7%without stoma).In 15(13.9%)patients,resection margins were positive for ***(17.6%)patients developed anastomotic strictures at a median duration of 8 mo(range 3-20 mo).Among these,15 patients were successfully managed with per-anal *** multivariate analysis,advance age(>60 years)was the only risk factor for anastomotic leak(P=0.004).On the other hand,anastomotic leak(P=0.00),mucin positive tumor(P =0.021),and lower rectal growth(P=0.011)were found as risk factors for the development of an anastomotic ***:Advance age is a risk factor for an anastomotic *** anastomotic leak,a mucin-secreting tumor,and lower rectal growth predispose patients to develop anastomotic strictures.

关键词：危险因素直肠癌切除术狭窄恶性肿瘤后续管理平均距离运行时间

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Comparative Studies of Different Organs of Nyctanthes arbortristis in Modulation of Cytokines in Murine Model of Arthritis

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Biomedical and Environmental Sciences 2007年第2期20卷 154-159页

作者： BRIJESH RATHORE BHOLANATH PAUL BHUSAN P CHAUDHURY ASHOK KUMAR SAXENA anand prakash SAHU YOGENDRA KUMAR GUPTA Immunobiology Laboratory Central Pathology Laboratory Preventive Toxicology Laboratory Industrial Toxicology Research Centre M. G. MargLucknow 226001India

Objective To study the modulation effect of pro- and anti-inflammatory cytokines following long term use of water soluble ethanol extracts from different organs of Nyctanthes arbortristis （NAT） in mouse model of arthritis. Methods Arthritis was induced in mice by two injections of Freund＇s complete adjuvant on days 0 and 12 in the sub-planter surface of the right hind paw. Results Injection of adjuvant resulted in a maximum primary edema of the footpad with erythema, and edema and distortion of joints of the right hind paw after 24-48 hours. Second injection of FCA led to the formation of secondary swellings persisting more than four weeks that spread onto the other hind limb but to a lesser extent. Histological analysis of the ankle on day 47 showed marked evidence of cartilage destruction in association with pannus formation and moderate bone resorption. Proinfiammatory cytokine levels in the inflamed joint homogenate were elevated on days 2, 14, and 47. Oral administration of leaf and fruit extracts in arthritic mice reduced joint homogenate levels of tumor necrosis factor-α, interleukin-1β, and interleukin-6 on days 2, 14, and 47 in comparison to untreated arthritic mice. Intedeukin-10 level was elevated in the inflamed joint on days 2, 14, and 47 in comparisons to untreated arthritic mice. Confusion Evidence of lesser inflammation of the footpad and joint and associated histological observation support the therapeutic benefit of leaf and fruit extracts from Nyctanthes arbortristis. This study helps in understanding the mechanism of anti-inflammatory action of Nyctanthes arbortristis in the light of pro- and anti-inflammatory cytokine balance.

关键词： Nyctanthes arbortristis Arthritis TNF-α IL- 1β IL-6 IL-10

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Effectiveness of m-health technology-enabled physical activity program on physical activity adoption and adherence in people with hypertension in India:A randomized controlled trial protocol

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Chronic Diseases and Translational Medicine 2024年第2期10卷 92-101页

作者： Vidhi Thakar Sureshkumar Kamalakannan V.prakash Ashok&Rita Patel Institute of Physiotherapy Charotar University of Science and TechnologyChangaAnandGujaratIndia Department of Social Work Education and Community-WellbeingNorthumbria UniversityNewcastle upon TyneUK

Background Exercise and medication have similar benefits in reducing blood pressure(BP);however,hypertension management initiatives primarily focus on *** is due to scarce research on the effectiveness of implementation strategies for optimal exercise adoption and *** were found to be effective in delivering hypertension care and increase exercise *** this,only a small number of research projects in India have used smartphones as a strategy for managing *** We hypothesized that smartphone application-based care would lead to higher exercise adherence among adults(30–79 years)with hypertension compared to those who receive usual *** will be a multicentric,randomized controlled,parallel-design,superiority clinical *** outcome assessor and data analyst will be blinded to group *** in the intervention group will receive mobile application-based care for 6 *** in the usual care group will receive a standard *** groups will receive the same number of *** The primary outcome is the difference in the proportion of people adherent to the recommended level of physical activity evaluated using an exercise adherence rating scale in the intervention group and the control *** adoption will be measured as the percentage of eligible participants in each study setting willing to initiate the exercise *** secondary outcome includes differences in systolic and diastolic BP and self-management(evaluated using the Hypertension Self-Care Profile).The trial outcome will be accompanied by a process *** This research will inform about the comparative effectiveness of conventional and m-health interventions for exercise adoption and adherence in people with hypertension in resource-constrained settings.

关键词： hypertension low-and middle-income countries m-health physical activity adherence

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通过液相混合制备具有优异耐疲劳性和耐磨性的胶料

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现代橡胶技术 2016年第4期42卷 41-46页

作者：李俊 anand prakash Michael Morris Russell Coverley

在聚合物中通过获得高质量的填充剂分散可以大大提高硫化胶的耐磨性能和耐疲劳性能。并用丁二烯橡胶的Transfinity胶料可提高硫化胶的磨耗性能,但拉伸强度和撕裂强度会受到影响;在实际应用中拉伸强度和撕裂强度也许很重要,而耐冲击磨耗... 详细信息

在聚合物中通过获得高质量的填充剂分散可以大大提高硫化胶的耐磨性能和耐疲劳性能。并用丁二烯橡胶的Transfinity胶料可提高硫化胶的磨耗性能,但拉伸强度和撕裂强度会受到影响;在实际应用中拉伸强度和撕裂强度也许很重要,而耐冲击磨耗性能是关键。本研究还提出了能清楚说明提高炭黑在聚合物中的分散性对硫化胶耐磨性影响的磨耗试验方法。

关键词：液相混合 Transfinity胶料填充剂分散耐疲劳性耐磨性

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安达曼海深水盆地天然气水合物聚集证据及利用井震数据估算其资源量

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海洋地质 2015年第4期31卷 15-29页

作者： anand prakash B. G. Samanta N. E Singh 康冬菊不详广州海洋地质调查局矿产所 510760

通过对安达曼海深水盆地2D、3D地震反射数据以及测井数据等资料的分析，识别与天然气水合物聚集有关的地球物理标志并估算其饱和度。地震数据分析揭示了该地区存在似海底反射（BSR），并展现了与气体水合物聚集有关的所有典型特征。研究... 详细信息

通过对安达曼海深水盆地2D、3D地震反射数据以及测井数据等资料的分析，识别与天然气水合物聚集有关的地球物理标志并估算其饱和度。地震数据分析揭示了该地区存在似海底反射（BSR），并展现了与气体水合物聚集有关的所有典型特征。研究区B的某些地震剖面上还发现了双BSR，表明该地区的压力．温度（P-T）条件在过去发生过巨大变化，这一温压条件变化可以通过该区域水合物稳定带厚度（200～650m）的变化体现。研究区B位于AlcockRise西部的积水填充区，其3D地震数据体经过叠前深度偏移处理。根据深度偏移数据体建立的速度模型可观察到BSR上下的速度（1950～1650m／s）存在反转。BSR之下的低速区（1450m／s）和高振幅表明了水合物层之下存在水合物分解形成的气体或游离气。利用AVO技术对研究区B的BSR进行分析，结果表明反射振幅随偏移距增大而增大，这一趋势与水合物聚集有关的BSR分析结果类似。研究区B的一口已钻油气勘探井的测井数据表明水合物是存在的，与此处根据地震数据的预测结果吻合，从而也证实这一技术在水合物检测中的有效性。根据钻探井的电阻率曲线和声波时差曲线得到的水合物层底界与叠前深度偏移地震剖面所解释的水合物底界是一致的。电阻率和声波时差曲线显示的水合物层深度区间为1865～1895m，厚度为30m，估算的水合物饱和度近30％。研究区B水合物所包含的气体总资源量估计为1．8×10^10m^3，与一个常规的大型天然气田的储量相当。

关键词：天然气水合物似海底反射水合物饱和度估计资源量评价安达曼海深水盆地

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Sarcopenia in Chronic Liver Disease:A Metabolic Perspective

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1213-1222页

作者： Ramesh Kumar Sabbu Surya prakash Rajeev Nayan Priyadarshi Utpal anand Department of Gastroenterology All India Institute of Medical SciencesPatnaIndia Department of Radiodiagnosis All India Institute of Medical SciencesPatnaIndia Department of Surgical Gastroenterology All India Institute of Medical SciencesPatnaIndia

Sarcopenia,a condition of low muscle mass,quality,and strength,is commonly found in patients with chronic liver disease(CLD)and is associated with adverse clinical out-comes including reduction in quality of life,increased mor-tality,and complications.A major contributor to sarcopenia in CLD is the imbalance in muscle protein turnover wherein changes in various metabolic factors such as hyperammone-mia,amino acid deprivation,hormonal imbalance,gut dys-biosis,insulin resistance,chronic inflammation,*** important *** particular,hyperammonemia is a key mediator of the liver-gut axis and is known to contribute to sarcopenia by various mechanisms including increased ex-pression of myostatin,increased phosphorylation of eukary-otic initiation factor 2a,cataplerosis ofα-ketoglutarate,mi-tochondrial dysfunction,increased reactive oxygen species that decrease protein synthesis and increased autophagy-mediated *** muscle is a major organ of insulin-induced glucose metabolism,and sarcopenia is closely linked to insulin resistance and metabolic *** with liver cirrhosis are in a hypermetabolic state that is associated with catabolism and depletion of amino acids,particularly branched-chain amino *** can have significant implications for nonalcoholic fatty liver disease,the most common form of CLD worldwide,because of the close link between metabolic syndrome and *** review discusses the potential metabolic derange-ment as a cause or effect of sarcopenia in CLD,as well as interorgan crosstalk,which that might help identifying a novel therapeutic strategies.

关键词： Sarcopenia Liver cirrhosis Chronic liver disease Metabolism Hy-perammonemia

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In vitro cytotoxicity and antimicrobial activity of Talaromyces flavus SP5 inhabited in the marine sediment of Southern Coast of India

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Chinese Journal of Natural Medicines 2016年第12期14卷 913-921页

作者： Bibin G.anand C.K.Navin Thomas S.prakash Department of Biotechnology Udaya School of Engineering Udaya Nagar Tamil Nadu india Cherraan's Institute of Health Sciences Tamil Nadu India Center for Biologically Inspired Systems Science Department of Biology Indian Institute of Technology Jodhpur Old Residency Road Jodhpur Rajasthan India

Marine sediment samples were collected from the coastal areas of Southern India, particularly in Kanyakumari District. Twenty-eight different fungal strains were isolated. The screening of fungi from marine sediment was done to isolate a potent fungus that can produce bioactive compounds for biomedical applications. Only three strains viz Trichoderma gamsii SP4, Talaromyces flavus SP5 and Aspergillus oryzae SP6 were screened for further studies. The intracellular bioactive compounds were extracted using solvent extraction method. The crude extracts were tested for its anti-microbial and anti-cancer properties and analytically characterized using Gas Chromatography Mass Spectrometry(GC-MS). All the three extracts were active, but the extract from T. flavus SP5 was found to be more active against various human pathogens, viz., Pseudomonas aeruginosa ATCC 27853(17.8 ± 0.1), Escherichia coli ATCC 52922(18.3 ± 0.3), and Candida tropicalis ATCC 750(17.7 ± 0.4). It also exhibited cytotoxic activity against HEp2 carcinoma cell line with the LC_(50) value of 25.7 μg·mL^(-1). The GC-MS data revealed the presence of effective bioactive compounds. These results revealed that the extract from isolated fungus T. flavus SP5 acted as a potent antimicrobial, antifungal, and anticancer agent, providing basic information on the potency of marine fungi towards biomedical applications; further investigation may lead to the development of novel anticancer drugs.

关键词： Marine sediment fungi Bioactive compounds Anti-microbial Anticancer agents

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Anticoagulation in simultaneous pancreas kidney transplantation - On what basis?

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World Journal of Transplantation 2020年第7期10卷 206-214页

作者： Jeevan prakash Gopal Frank JMF Dor Jeremy S Crane Paul E Herbert Vassilios E Papalois anand SR Muthusamy Imperial College Renal and Transplant Center Imperial College Healthcare NHS TrustHammersmith HospitalLondon W120HSUnited Kingdom Department of Surgery and Cancer Imperial CollegeLondon W120HSUnited Kingdom

BACKGROUND Despite technical refinements,early pancreas graft loss due to thrombosis continues to *** coagulation tests(CCT)do not detect hypercoagulability and hence the hypercoagulable state due to diabetes is left ***(TEG)is an in-vitro diagnostic test which is used in liver transplantation,and in various intensive care settings to guide *** is better than CCT because it is dynamic and provides a global hemostatic profile including *** To compare the outcomes between TEG and CCT(prothrombin time,activated partial thromboplastin time and international normalized ratio)directed anticoagulation in simultaneous pancreas and kidney(SPK)transplant *** A single center retrospective analysis comparing the outcomes between TEG and CCT-directed anticoagulation in SPK recipients,who were matched for donor age and graft type(donors after brainstem death and donors after circulatory death).Anticoagulation consisted of intravenous(IV)heparin titrated up to a maximum of 500 IU/h based on CCT in conjunction with various clinical parameters or directed by TEG *** loss due to thrombosis,anticoagulation related bleeding,radiological incidence of partial thrombi in the pancreas graft,thrombus resolution rate after anticoagulation dose escalation,length of the hospital stays and,1-year pancreas and kidney graft survival between the two groups were *** Seventeen patients who received TEG-directed anticoagulation were compared against 51 contemporaneous SPK recipients(ratio of 1:3)who were anticoagulated based on *** graft losses occurred in the TEG group,whereas 11 grafts(7 pancreases and 4 kidneys)were lost due to thrombosis in the CCT group(P=0.06,Fisher’s exact test).The overall incidence of anticoagulation related bleeding(hematoma/gastrointestinal bleeding/hematuria/nose bleeding/re-exploration for bleeding/post-operative blood transfusion)was 17.65%in the TEG group and 45

关键词： Anticoagulation Pancreas transplantation Thromboelastography Thrombosis Hypercoagulability

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