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Cancer Biology & Medicine 2017年第1期14卷 74-82页

作者： Suman Morampudi Neha Das Arun Gowda anand patil Phamax Analytic Resources Pvt.Ltd. Bengaluru 560095India

Objective: Lung cancer is one of the leading cancers and major causes of cancer mortality worldwide. The economic burden associated with the high mortality of lung cancer is high, which accounts for nearly $180 billion on a global scale in 2008. This paper aims to understand the economic burden of lung cancer in terms of disability adjusted life years(DALY) in Australia, the Philippines, and ***: The years of life lost(YLL) and years lost due to disability(YLD) were calculated using the formula developed by Murray and Lopez in 1996 as part of a comprehensive assessment of mortality and disability for diseases, injuries and risk factors in 1990 and projected to 2020. The same formula is represented in the Global Burden of Disease template provided by the World Health Organization. Appropriate assumptions were made when data were unavailable and projections were performed using regression analysis to obtain data for ***: The total DALYs due to lung cancer in Australia, the Philippines, and Singapore were 91,695, 38,584, and 12,435,respectively, and the corresponding DALY rates per a population of 1,000 were 4.0, 0.4, and 2.2, respectively, with a discount rate of 3%. When researchers calculated DALYs without the discount rate, the burden of disease increased substantially; the DALYs were 117,438 in Australia, 50,977 in the Philippines, and 16,379 in Singapore. Overall, YLL or premature death accounted for more than 95% of DALYs in these ***: Strategies for prevention, early diagnosis, and prompt treatment must be devised for diseases where the major burden is due to mortality.

关键词： Lung cancer DALY YLD YLL burden of disease DALY rate discount rate

Comparison of skeletal, dental and soft tissue changes in young adults with Class II malocclusion, treated either by camouflage, fixed functional appliance or orthognathic surgery—A prospective study on Indian subjects

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Open Journal of Stomatology 2012年第4期2卷 373-382页

作者： Anjana Shetty anand patil Sanjay Ganeshkar Department of Orthodontics and Dentofacial Orthopaedics AECS Maaruthi Dental College Banglore India Department of Orthodontics and Dentofacial Orthopaedics SDM College of Dental Sciences Dharwad India

Introduction: Borderline Class II malocclusion due to deficient mandible can be treated either by orthodontic camouflage, fixed functional appliances or by orthodontics followed by surgical mandibular advancement. Methodology: A prospective study was designed on young adults with Class II malocclusion on account of a deficient mandible. A total of 45 subjects were divided into three groups of 15 individuals each. The patients were treated either by camouflage, fixed functional appliances or by orthognathic surgery. Pre and post treatment cephalograms were used to assess the skeletal, dental and soft tissue changes. Pre and post treatment profile photographs were assessed on a Visual Analogue Scale (VAS) by orthodontists, oral surgeons and laypersons. Results: Each group achieved a reduction in facial convexity, but the results obtained from the surgical group were more pronounced than the camouflage and the fixed functional group. Conclusion: The reduction in convexity in the camouflage group was by retracting the upper anteriors, which increases the nasolabial angle. In the fixed functional appliance a combination of skeletal and dentoalveolar changes can be observed. However the most appropriate reduction in profile convexity can be obtained by combined orthodontic and surgical treatment of malocclusion.

关键词： Class II Malocclulsion Camouflage Fixed Function Appliance Orthognathic Surgery

Big Data Analytics Using Swarm-Based Long Short-Term Memory for Temperature Forecasting

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Computers, Materials & Continua 2022年第5期71卷 2347-2361页

作者： Malini M.patil P.M.Rekha Arun Solanki anand Nayyar Basit Qureshi JSS Academy of Technical Education Bengaluru560060India Gautam Buddha University Greater Noida201312India Graduate School Duy Tan UniversityDa Nang550000Vietnam Faculty of Information Technology Duy Tan UniversityDa Nang550000Vietnam College of Computer&Info Sc Prince Sultan UniversitySaudi Arabia

In the past few decades,climatic changes led by environmental pollution,the emittance of greenhouse gases,and the emergence of brown energy utilization have led to global *** warming increases the Earth’s temperature,thereby causing severe effects on human and environmental conditions and threatening the livelihoods of millions of *** warming issues are the increase in global temperatures that lead to heat strokes and high-temperature-related diseases during the summer,causing the untimely death of thousands of *** forecast weather conditions,researchers have utilized machine learning algorithms,such as autoregressive integrated moving average,ensemble learning,and long short-term memory *** techniques have been widely used for the prediction of *** this paper,we present a swarm-based approach called Cauchy particle swarm optimization(CPSO)to find the hyperparameters of the long shortterm memory(LSTM)*** hyperparameters were determined by minimizing the LSTM validationmean square error *** optimized hyperparameters of the LSTM were used to forecast the temperature of Chennai *** proposed CPSO-LSTM model was tested on the openly available 25-year Chennai temperature *** experimental evaluation on MATLABR2020a analyzed the root mean square error rate and mean absolute error to evaluate the forecasted *** proposed CPSO-LSTM outperforms the traditional LSTM algorithm by reducing its computational time to 25 min under 200 epochs and 150 hidden neurons during *** proposed hyperparameter-based LSTM can predict the temperature accurately by having a root mean square error(RMSE)value of 0.250 compared with the traditional LSTM of 0.35 RMSE.

关键词： Climatic change big data temperature forecasting swarm intelligence deep learning

Determinants of plant species richness along elevational gradients:insights with climate, energy and water–energy dynamics

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Ecological Processes 2024年第04期 364-383页

作者： Abhishek Kumar Meenu patil Pardeep Kumar anand Narain Singh Soil Ecosystem and Restoration Ecology Lab Department of BotanyPanjab University

Background Understanding the patterns and processes of species distributions has long remained a central focus of biogeographical and ecological research. While the evidence for elevational patterns in species richness is widespread, our understanding of underlying causes and mechanisms remains limited. Therefore, this study aimed to entangle the influence of environmental variables on plant species richness along elevational gradients in the Western *** We compiled elevational distribution for about 1150 vascular plants using the published literature and available database. The species richness was estimated in 100-m elevational bands using the range interpolation method. We used the generalised linear model and structural equation modelling(SEM) framework to identify the direct and indirect effects of climatic factors on species *** Our results indicated that primary environmental correlates of species richness varied with elevational gradients. Climatic variables combined with energy and water availability were more important than the topographic heterogeneity. Further, the direct and interaction effects of climatic variables were more substantial than their indirect effects. The indirect effects of climate are more strongly mediated by water–energy dynamics than the energy *** Overall, our findings emphasise the importance of considering direct effects and interactions among environmental variables while studying the underlying mechanisms governing elevational biodiversity gradients. Species richness appeared to be shaped by climatic tolerances rather than habitat heterogeneity at regional scales. This information can have implications for biodiversity dynamics under environmental change.

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Nonmetric Traits in Permanent Teeth as Clues to Ethnicity in Vidarbha Subpopulation to Aid Forensic Profiling:Pilot Study

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Journal of Forensic Science and Medicine 2024年第1期10卷 11-19页

作者： Vaishali Amarlal Sadhwani Nilima Prakash GLPradeep Rekha patil Shubhechha anand Khivsara Sabiha Mokashi Khan MGV’S KBH Dental College NashikMaharashtraIndia Oral Cancer Screening and Awareness in Cancer Screening Vertical Indian Cancer SocietyMumbaiMaharashtraIndia

Introduction:Nonmetric dental traits have a crucial role in ethnic classification of populations that help in forensic racial *** studies have demonstrated the differences in the expression and frequency of dental traits between various ethnic groups for ancestry determination in the context of forensic dental *** present study is an attempt to assess the frequency and variation in nonmetric traits for establishing ethnicity in the Vidarbha ***:The aim of the study was to assess the frequency and variation of nonmetric traits in permanent teeth for establishing ethnicity in the Vidarbha *** and Methods:Participants of the Vidarbha subpopulation were selected by random sampling ***,premolars,and incisors were evaluated for frequency of nonmetric traits,and variations were graded according to Dentoanthropological System of State University of Arizona *** statistics,Chi-square test,and Student’s t-test were used for analysis of ***:The most common occlusal morphology in mandibular first and second molar was 5 cusp and 4 cusp,respectively,with the“+”groove *** 3 and cusp 4 were observed frequently in the maxillary *** lingual cusp was most commonly seen in mandibular premolars show while incisors showed faint ***:Our study concludes that nonmetric traits were present and showed variation in permanent maxillary and mandibular teeth among the Vidarbha *** 5 and Cusp 4 in first and second mandibular molars,respectively,groove pattern“+”and grade 1 protostylid were the most frequent grades observed in permanent mandibular *** lingual cusp was most commonly seen in mandibular premolars and faint shoveling was a notable feature in incisors of this population.

关键词： Cusp number ethnicity forensic anthropology molar protostylid

Pharmacokinetics/Pharmacodynamics study of Fixtral SB as compared to supra bioavailable itraconazole and conventional itraconazole

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World Journal of Pharmacology 2023年第1期12卷 1-11页

作者： Syed Mujtaba Hussain Naqvi Monil Yogesh Neena Gala Snehal Muchhala anand Arumugam Dhananjay Panigrahi Dipak patil Rahul Rathod Amey Mane Medical Affairs Dr Reddy’s LaboratoriesHyderabad 500016India Global Clinical Management Dr Reddy’s LaboratoriesHyderabad 500016India Formulation Development Dr Reddy’s LaboratoriesHyderabad 500016India

BACKGROUND Itraconazole is a broad-spectrum triazole antifungal inhibiting fungal growth by inhibiting ergosterol synthesis and exhibits a nonlinear pharmacokinetic *** absorption pattern with wide fluctuations in blood levels causes inconsistent and unpredictable clinical behaviour of this drug despite its low minimum inhibitory concentration(MIC)as compared to other antifungal *** To compare the oral bioavailability and bioequivalence of Fixtral SB(supra bioavailable itraconazole)with reference product R2(supra bioavailable 2×50 mg itraconazole).METHODS The study population consisted of 54 healthy volunteers,aged between 18-45 years and randomized to receive a single oral dose of either test[T;Fixtral SB(supra bioavailable itraconazole)100 mg]or reference product(R1;Sporanox 100 mg×2 capsules and R2;Lozanoc capsules 50 mg×2 capsules).Blood samples were taken pre-dose and post-dose up to 96 *** study evaluated bioequivalence by comparing the oral bioavailability of the test product with reference product *** pharmacodynamic characteristics of the drug were evaluated by comparing the test product with reference product ***(PK)-PD comparative analysis[area under the concentration-time curve(AUC)/minimum inhibitory concentration(MIC)>25]was performed for conventional itraconazole 100 mg and supra bioavailable itraconazole 50 *** events(AEs)assessments were performed in each study period and post-study *** Statistical analysis of primary PK variables revealed bioequivalence,with confidence intervals being completely inside the acceptance criteria of 80%-125%.The peak concentration levels of itraconazole were achieved at 10 h(T)and 8.5 h(R2),*** parameter assessment showed that AUC/MIC for R1 are comparable to Fixtral SB 100mg for MIC levels up to 16mcg/mL(P>0.05 and observed P=0.3196).Six AEs were observed that were mild to moderate in severity and *** severe AE was reported.

关键词： Supra-Bioavailable itraconazole Conventional itraconazole Oral bioavailability Pharmacodynamics Efficacy Adverse events

Exploring the potential of Lactobacillus and Saccharomyces for biofunctionalities and the release of bioactive peptides from whey protein fermentate

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Food Bioscience 2022年第4期48卷 320-338页

作者： Chopada Kevalkumar Dineshbhai Bethsheba Basaiawmoit Amar A.Sakure Ruchika Maurya Mahendra Bishnoi Kanthi Kiran Kondepudi G.B.patil Maunil Mankad Zhenbin Liu Subrota Hati Dept.of Dairy Microbiology Anand Agricultural UniversityAnand388110GujaratIndia Dept.of Rural Development and Agricultural Production North-Eastern Hill UniversityTura CampusTura794002MeghalayaIndia Dept.of Agriculture Biotechnology Anand Agricultural UniversityAnand388110GujaratIndia Regional Center for Biotechnology FaridabadHaryana121001India Healthy Gut Research Group Food&Nutritional Biotechnology DivisionNational Agri-Food Biotechnology InstituteKnowledge CitySector 81SAS NagarPunjab140306India Dept.of Tissue Culture Anand Agricultural UniversityAnand388110GujaratIndia School of Food and Biological Engineering Shaanxi University of Science and Technology18Xi’an710021China

Whey protein concentrate-80(WPC-80)fermented with ***(KGL4)(37℃)and ***(WBS2A)(25℃)was tested for ACE-inhibitory and antioxidant activities over different periods(12,24,36 and 48 h).Proteolytic activity(OPA method)was used to optimize the growth conditions(inoculation rate,*** 1.5%,2.0%,and 2.5%and incubation time,i.e.12,24,36,and 48 h)for peptide *** indicated that the highest amount of peptides was obtained at 7.24 mg/mL for KGL4(37℃,48 h)and 8.59 mg/mL for WBS2A(25℃,48 h).The whey protein fermentate inhibited the LPS-induced NO production,while enhanced production concentrations of TNF-α,IL-6,and IL-1β.Subsequently,SDS-PAGE,as well as Two-Dimensional(2D)gel electrophoresis methods,were applied for protein purification using water-soluble extracts(WSEs)of WPC-80 fermented by a combination of *** and *** SDS-PAGE,protein bands were observed in the range of 10-55 kDa,whereas on the 2D page,protein spots were in the range of 10-70 *** the 2D spots were analyzed using RPLC/*** of 3 kDa and 10 kDa permeates were used in RP-HPLC to identify distinct peptide *** data from LC/MS was also characterized by utilizing ProteinPilot ***,different functional groups were also analyzed using FTIR *** research aims to isolate and characterize novel ACE-inhibitory and antioxidative peptides from fermented WPC-80 produced by Lactobacillus fermentum and ***.

关键词： ACE-Inhibitory Antioxidative activity Anti-inflammatory SDS FTIR RP-HPLC L.fermentum S.cerevisiae Whey protein fermentate

A comparative study of fermented buffalo and camel milk with anti-inflammatory, ACE-inhibitory and anti-diabetic properties and release of bio active peptides with molecular interactions: In vitro, in silico and molecular study

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Food Bioscience 2023年第2期52卷 687-721页

作者： Ruchita Khakhariya Amar A.Sakure Ruchika Maurya Mahendra Bishnoi Kanthi Kiran Kondepudi Srichandan Padhi Amit Kumar Rai Zhenbin Liu G.B.patil Maunil Mankad Subrota Hati Dept.of Dairy Microbiology SMC College of Dairy ScienceKamdhenu UniversityAnand388110GujaratIndia Dept.of Agriculture Biotechnology Anand Agricultural UniversityAnand388110GujaratIndia Regional Center for Biotechnology FaridabadHaryana121001India Healthy Gut Research Group Food&Nutritional Biotechnology DivisionNational Agri-Food Biotechnology InstituteKnowledge CitySector 81SAS NagarPunjab140306India Institute of Bioresources and Sustainable Development Regional CentreTadong737102SikkimIndia School of Food and Biological Engineering Shaanxi University of Science and TechnologyXi’an710021China Dept.of Tissue Culture Anand Agricultural UniversityAnand388110GujaratIndia

The aim of this study is to compare ACE inhibitory,anti-diabetic and Anti-inflammatory activity of buffalo and camel milk using Lacticaseibacillus paracasei(M11)in combination with yeast Saccharomyces cerevisiae(WBS2A)and to release peptides with antihypertensive and anti-diabetic *** buffalo and camel milk were considered for the evaluation of Angiotensin-converting enzyme(ACE)inhibitory and anti-diabetic activities at specific time intervals(12,24,36 and 48 h)at 37℃.For the growth condition optimization,proteolytic activity was evaluated with specific inoculation rates(1.5%,2.0%,and 2.5%)and at specific incubation periods(12,24,36,and 48 h).The highest peptides were produced at 2.5%inoculation rate and at 48 h of incubation in both buffalo and camel milk at 37℃.Further,camel and buffalo milk fermented with M11+WBS2A significantly lower the overproduction of TNF-α,IL-6,IL-1βand Nitric oxide(NO),that was induced by lipopolysaccharide(LPS)stimulation in RAW 267.4 *** protein purification,2D gel electrophoresis and SDS-PAGE were *** and buffalo milk that had not been fermented displayed protein bands between 10 and 100 kDa and 10 and 75 kDa respectively,whereas all the fermented samples showed bands between 10 and 75 *** SDS-PAGE,in permeates,there were no apparent protein *** fermented buffalo and camel milk were electrophoresed in 2D gel,a total of 26 and 25 protein spots were *** 2D gel electrophoresis,protein spots had sizes between 10 and 37 *** RP-HPLC,water-soluble extracts(WSEs)of ultra-filtered fractions were used to distinguish different fractions of a *** software was used to characterize the LC/MS *** transform-infrared spectroscopy(FTIR)was used to evaluate various functional groups of fermented *** molecular docking study,the peptide sequences identified from the fermented buffalo milk(FBM)and camel milk(FCM)were examined for their binding affinity against the binding sites of

关键词： ACE inhibitory Anti-diabetic activity Buffalo milk Camel milk SDS FTIR RP-HPLC LC/MS Molecular docking