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The Value of Whole Body18F-FDG PET/CT Imaging in Cytologically Proven metastatic Cervical Carcinoma of Unknown Primary (CCUP): a Retrospective Study

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The Value of Whole Body18F-FDG PET/CT Imaging in Cytological...

作者： anand Gungadin（阿南）华中科技大学

学位级别：硕士

Background Carcinoma of unknown primary （CUP） represents a heterogeneous group of metastaticmalignancies for which no primary tumor site can be identified after extensive routinediagnostic workup. Failure at this level has led to patients being referred for a whole body18F-FDG PET/CT scan in attempt to localize the primary site. Purpose The aim of this study was to assess the potential of1F-fluorodeoxyglucose （1FDG） wholebody positron emission tomography/computed tomography （PET/CT） imaging, in patientsreferred with metastatic cervical carcinomas of unknown primaries （CCUP）, in detectingthe primary tumor and concomitant metastases as well as to investigate the presence of anyprognostic factors to this heterogeneous group of tumors. materials and methods Eighty consecutive patients with cervical metastasis of CUP （CCUP） who had previouslyundergone PET/CT between January2010and September2012were retrospectivelyanalyzed. All patients had histologically proven cervical metastatic carcinomas and relevantdiagnostic workup prior to18F-FDG PET/CT failed to detect a primary tumor. All the patientsincluded have full follow-up material. The average time of follow-up was of16months,ranging from4to34months. The golden standard used was the final clinical diagnosis. Results Whole body18F-FDG PET/CT scan correctly detected the primary tumor in55%（44of80）of patients with histologically proven cervical CUP. The sensitivity, specificity, and accuracyof18F-FDG PET/CT scans were91.6%,90.6%, and91.25%, respectively. The lung andhead/neck area were the two most commonly detected primary tumor sites （36%each）. Thepositive predictive value was93.6%and negative predictive value was87.8%. Furthermore, in25%（20out of80） of patients,18F-FDG PET/CT detected extra-nodal distantmetastases （m stage） leading to a re-staging and possibly influencing subsequent treatmentplans. Cox hazard ratio regression analysis revealed a significant difference in overall survivalbetween pat

关键词：癌转移性恶性肿瘤异质群体 Cox风险比率回归临床诊断

machine Learning Chemical Guidelines for Engineering Electronic Structures in Half-Heusler Thermoelectric materials

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Research 2020年第1期2020卷 978-985页

作者： maxwell TDylla Alexander Dunn Shashwat anand Anubhav Jain G.Jeffrey Snyder Department of materials Science and Engineering Northwestern UniversityIL 60208USA Department of materials Science and Engineering UC BerkeleyCA 94720USA Lawrence Berkeley National Laboratory Energy Technologies AreaCA 94720USA

Half-Heusler materials are strong candidates for thermoelectric applications due to their high weighted mobilities and power factors,which is known to be correlated to valley degeneracy in the electronic band ***,there are over 50 known semiconducting half-Heusler phases,and it is not clear how the chemical composition affects the electronic *** all the n-type electronic structures have their conduction band minimum at either theΓ-or X-point,there is more diversity in the p-type electronic structures,and the valence band maximum can be at either theΓ-,L-,or ***,we use high throughput computation and machine learning to compare the valence bands of known half-Heusler compounds and discover new chemical guidelines for promoting the highly degenerate W-point to the valence band *** do this by constructing an“orbital phase diagram”to cluster the variety of electronic structures expressed by these phases into groups,based on the atomic orbitals that contribute most to their valence ***,with the aid of machine learning,we develop new chemical rules that predict the location of the valence band maximum in each of the *** rules can be used to engineer band structures with band convergence and high valley degeneracy.

关键词： structure valence bands

Resveratrol inhibits matrix metalloproteinases to attenuate neuronal damage in cerebral ischemia:a molecular docking study exploring possible neuroprotection

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Neural Regeneration Research 2015年第4期10卷 568-575页

作者： anand Kumar Pandey Pallab Bhattacharya Swet Chand Shukla Sudip Paul Ranjana Patnaik School of Biomedical Engineering Indian Institute of TechnologyBanaras Hindu University Department of Neurology Leonard M.Miller School of MedicineUniversity of Miami School of Biochemical Engineering Indian Institute of TechnologyBanaras Hindu University Department of Biomedical Engineering North Eastern Hill University (NEHU)

The main pathophysiology of cerebral ischemia is the structural alteration in the neurovascular unit, coinciding with neurovascular matrix degradation. Resveratrol has been reported to be one of the most potent chemopreventive agents that can inhibit cellular processes associated with ischemic stroke. matrix metalloproteinases （mmPs） has been considered as a potential drug target for the treatment of cerebral ischemia. To explore this, we tried to investigate the inter-action of resveratrol with mmPs through molecular docking studies. At 30 minutes before and 2 hours after cerebral ischemia/reperfusion induced by occlusion of the middle cerebral artery, 40 mg/kg resveratrol was intraperitoneally administered. After resveratrol administration, neu-rological function and brain edema were significantly alleviated, cerebral infarct volume was signiifcantly reduced, and nitrite and malondialdehyde levels in the cortical and striatal regions were signiifcantly decreased. The molecular docking study of resveratrol and mmPs revealed that resveratrol occupied the active site of mmP-2 and mmP-9. The binding energy of the complexes was –37.848672 kJ/mol and –36.6345 kJ/mol for mmP-2 and mmP-9, respectively. In case of mmP-2, Leu 164, Ala 165 and Thr 227 were engaged in H-Bonding with resveratrol and in case of mmP-9, H-bonding was found with Glu 402, Ala 417 and Arg 424 residues. These ifndings collectively reveal that resveratrol exhibits neuroprotective effects on cerebral ischemia through inhibiting mmP-2 and mmP-9 activity.

关键词： nerve regeneration neuroprotection resveratrol cerebral ischemia cerebral infarction matrix metalloproteinase molecular docking extracellular matrix neural regeneration

Acute fractures of the pediatric foot and ankle

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World Journal of Pediatrics 2015年第1期11卷 14-20页

作者： mansur Halai Bilal Jamal Paul Rea mobeen Qureshi anand Pillai Department of Trauma and Orthopedics University Hospitials of South ManchesterManchester M239LTUK

Background:Injuries around the foot and ankle are *** is a paucity of literature,outside that of specialist orthopedic journals,that focuses on this subject in the pediatric *** sources:In this review,we outline pediatric foot and ankle fractures in an anatomically oriented manner from the current *** aim is to aid the emergency department doctor to manage these challenging injuries more efectively in the acute ***:These injuries require a detailed history and examination to aid the ***,plain radiographs are suficient,but more complex injuries require the use of magnetic resonance *** is dependent on the proximity to skeletal maturity and the degree of displacement of *** have a marked ability to remodel after fractures and therefore mainstay treatment is immobilization by a cast or *** fxation,although uncommon in this population,may be necessary with adolescents,certain unstable injuries or in cases with displaced articular *** the setting of severe foot trauma,skin compromise and compartment syndrome of the foot must be ***:The integrity of the physis,articular surface and soft tissues are all equally important in treating these injuries.

关键词： ankle foot fractures

Non-alcoholic fatty liver disease may not be a severe disease at presentation among Asian Indians

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World Journal of Gastroenterology 2006年第21期12卷 3400-3405页

作者： Kaushal madan Yogesh Batra S Datta Gupta Bal Chander K D anand Rajan m S Tewatia S K Panda S K Acharya Department of Gastroenterology All India Institute of medical Sciences New DelhiIndia Department of Gastroenterology All India Institute of medical Sciences New DelhiIndia Department of PathologyAll India Institute of Medical SciencesNew DelhiIndia Department of Pathology All India Institute of medical Sciences New DelhiIndia

AIm： To evaluate the clinical and biochemical profile of patients with non alcoholic fatty liver disease （NAFLD） and to assess their histological severity at ***： Consecutive patients presenting to the liver clinic of All India Institute of medical Sciences （AIImS） with raised transaminases to at least 1.5 times upper limit of normal, and histologically confirmed non-alcoholic fatty liver disease were included. Patients who had significant alcohol intake or positive markers of other liver diseases or who were taking drugs known to produce fatty liver were excluded. The clinical, biochemical and histological profile of this group was studied. RESULTS： Fifty-one patients with NAFLD formed the study population. Their median age and BmI were 34（17-58） years and 26.7（21.3-32.5） kg/m^2 respectively and 46 （90.1%） were males. The majority of the patients had mild inflammation, either grade 1 [32 （63%）] or grade 2 [16 （31%）] and only 3 （6%） patients had severe （grade 3） inflammation. Twenty-three （45%）, 19 （37%）, 8（16%） and 1（2%） patient had stage 0, 1, 2 and 3 fibrosis respectively on index biopsy and none had cirrhosis. On univariate analysis, triglyceride levels more than 150 mg % （OR = 7.1; 95% CI： 1.6-31.5, P = 0.002） and AST ALT ratio 〉 1 （OR = 14.3; 95% CI： 1.4-678.5, P = 0.008） were associated with high grades of inflammation and none was associated with advanced fibrosis. On multivariate logistic regression analysis, hypertriglyceridemia 〉150 mg% was the only factor independently associated with presence of high grade of inflammation （OR = 1.6; 95% CI： 1.3-22.7, P =0.02）, while none was associated with advanced fibrosis. Triglyceride levels correlated positively with inflammatory grade （r = 0.412; P = 0.003）. CONCLUSION： NAFLD in North Indian patients is a disease of young over-weight males, most of whom are insulin resistant and they tend to have a mild histological disease at presentation.

关键词： Inflammation Fibrosis Triglycerides Non alcoholic steatohepatitis

Development of a validated UPLC-qTOF-mS/mS method for determination of bioactive constituent from Glycyrrhiza glabra

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Journal of Pharmaceutical Analysis 2013年第3期3卷 205-210页

作者： D.K.Gupta m.K.Verma R.anand R.K.Khajuria Natural Product Chemistry Division CSIR-Indian Institute of Integrative Medicine Analytical Chemistry Division CSIR-Indian Institute of Integrative Medicine

An ultra-performance liquid chromatography quadrupole time of flight mass spectrometry （UPLC-qTOF-mS/mS） method was developed and validated for the simultaneous determination of glycyrrhizin and glycyrrhetic acid. These analytes were separated on a reverse phase C18 column using a mobile phase of acetonitrile：2% acetic acid in water （75：25, v/v） with a flow rate of 200 μL/min. The qTOF-mS was operated under multiple reaction monitoring （mRm） mode using the electrospray ionization （ESI） technique with positive ion polarity. A comparison of three different extraction techniques i.e. accelerated solvent extraction （ASE）, extraction under ultrasonic waves （USW） and the classical extraction by percolation （CE） method was done and quantification of these extracts was also carried out by the proposed method.

关键词： Glycyrrhiza glabra Glycyrrhizin Glycyrrhetic acid Accelerated solventextraction Ultrasonication Ultra-performanceliquid chromatographyquadrupole time offlight mass spectrometer(UPLC-qTOF-mS/mS)

In vitro Safety Evaluation and Anticlastogenic Effect of Bacomind^(Tm) on Human Lymphocytes

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Biomedical and Environmental Sciences 2008年第1期21卷 7-23页

作者： DIPANWITA DUTTA DEB PREETI KAPOOR R. P. DIGHE R. PADmAJA m. S. anand P. D'SOUZA m. DEEPAK B. mURALI AmIT AGARWAL Natural Remedies Pvt. Ltd 19 K. M. Stone Hosur Road Plot No. 5B Veerasandra Indl. Area Bangalore 560100 India

Objective Bacomind^Tm （Bm） is a standardized extract of Bacopa monnieri, which belongs to the family Scrophulariaceae and is a creeping annual plant found throughout the Indian subcontinent. It has been used by Ayurvedic medicinal practitioners in India for almost 3000 years and is classified as a medharasayana, a substance which improves memory and intellect. With the widespread traditional use as well as scientific validation of Bacopa monnieri for nootropic activity, a bioactive-rich unique phytochemical composition-Bacomind^Tm was developed from B. monnieri for use as a cognition and memory enhancing agent. The present study aimed to investigate the in vitro toxicity of this formulation of Bacomind^Tm on human lymphocytes and to rule out its possible contribution to mutagenicity. methods In the present investigation the active ingredients present in Bm were identified and quantified by high performance liquid chromatography （HPLC） and high performance thin-layer chromatography （HPTLC）. Antioxidant and anticlastogenic properties of Bm were studied in vitro with and without metabolic activation. Doses of Bm were chosen on the basis of mitotic index （mI） and cytokinesis-block proliferation index （CBPI）. Clastogenicity assays were performed at 31.2 μg/mL, 62.5 μg/mL, and 125 μg/mL, while the Salmonella reverse mutation assay （Ames test） was performed at doses of 61.72, 185.18, 555.55, 1666.67, and 5000.00 μg/plate. Results HPLC and HPTLC analysis of Bm revealed the presence of bacoside A3. bacopaside Ⅰ, bacopaside Ⅱ, jujubogenin isomer of bacopasaponin C, bacosine, luteolin, apigenin, bacosine, and β-sitosterol D glucoside. Bm demonstrated significant antioxidant activity. The number of chromosomal aberrations and the frequency of micronuclei induced by Bm were not statistically significant up to a dose of 62.5 μg/mL. A subsequent dose of 125 μg/mL prior to metabolic activation induced mild clastogenicity, but it was found to be biologically insignificant as this ef

关键词： Bacomind^Tm Cytotoxicity Chromosomal aberration Ames test micronucleus, Clastogens Antioxidant High performance liquid chromatography High performance thin-layer chromatography (HPTLC)

Comparative Studies of Different Organs of Nyctanthes arbortristis in modulation of Cytokines in murine model of Arthritis

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Biomedical and Environmental Sciences 2007年第2期20卷 154-159页

作者： BRIJESH RATHORE BHOLANATH PAUL BHUSAN P CHAUDHURY ASHOK KUmAR SAXENA anand PRAKASH SAHU YOGENDRA KUmAR GUPTA Immunobiology Laboratory Central Pathology Laboratory Preventive Toxicology Laboratory Industrial Toxicology Research Centre M. G. MargLucknow 226001India

Objective To study the modulation effect of pro- and anti-inflammatory cytokines following long term use of water soluble ethanol extracts from different organs of Nyctanthes arbortristis （NAT） in mouse model of arthritis. methods Arthritis was induced in mice by two injections of Freund＇s complete adjuvant on days 0 and 12 in the sub-planter surface of the right hind paw. Results Injection of adjuvant resulted in a maximum primary edema of the footpad with erythema, and edema and distortion of joints of the right hind paw after 24-48 hours. Second injection of FCA led to the formation of secondary swellings persisting more than four weeks that spread onto the other hind limb but to a lesser extent. Histological analysis of the ankle on day 47 showed marked evidence of cartilage destruction in association with pannus formation and moderate bone resorption. Proinfiammatory cytokine levels in the inflamed joint homogenate were elevated on days 2, 14, and 47. Oral administration of leaf and fruit extracts in arthritic mice reduced joint homogenate levels of tumor necrosis factor-α, interleukin-1β, and interleukin-6 on days 2, 14, and 47 in comparison to untreated arthritic mice. Intedeukin-10 level was elevated in the inflamed joint on days 2, 14, and 47 in comparisons to untreated arthritic mice. Confusion Evidence of lesser inflammation of the footpad and joint and associated histological observation support the therapeutic benefit of leaf and fruit extracts from Nyctanthes arbortristis. This study helps in understanding the mechanism of anti-inflammatory action of Nyctanthes arbortristis in the light of pro- and anti-inflammatory cytokine balance.

关键词： Nyctanthes arbortristis Arthritis TNF-α IL- 1β IL-6 IL-10

machine learning models compared to existing criteria for noninvasive prediction of endoscopic retrograde cholangiopancreatography-confirmed choledocholithiasis

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Liver Research 2021年第4期5卷 224-231页

作者： Camellia Dalai John m Azizian Harry Trieu anand Rajan Formosa C Chen Tien Dong Simon W Beaven James H.Tabibian UCLA-Olive View Internal medicine Residency Program Department of MedicineOlive View-UCLA Medical CenterSylmarCAUSA Keck School of medicine University of Southern CaliforniaLos AngelesCAUSA Department of Surgery David Geffen School of Medicine at UCLALos AngelesCAUSA Vatche and Tamar manoukian Division of Digestive Diseases David Geffen School of Medicine at UCLALos AngelesCAUSA Division of Gastroenterology Department of MedicineOlive View-UCLA Medical CenterSylmarCAUSA

Background and aims:Noninvasive predictors of choledocholithiasis have generally exhibited marginal performance *** aimed to identify noninvasive independent predictors of endoscopic retrograde cholangiopancreatography(ERCP)-confirmed choledocholithiasis and accordingly developed predictive machine learning models(mLms).methods:Clinical data of consecutive patients undergoing first-ever ERCP for suspected chol-edocholithiasis from 2015 to 2019 were abstracted from a prospectively-maintained *** logistic regression was used to identify predictors of ERCP-confirmed *** were then trained to predict ERCP-confirmed choledocholithiasis using pre-ERCP ultrasound(US)imaging only as well as using all available noninvasive imaging(US,computed tomography,and/or magnetic reso-nance cholangiopancreatography).The diagnostic performance of American Society for Gastrointestinal Endoscopy(ASGE)“high-likelihood”criteria was compared to ***:We identified 270 patients(mean age 46 years,62.2%female,73.7%Hispanic/Latino,59%with noninvasive imaging positive for choledocholithiasis)with native papilla who underwent ERCP for suspected choledocholithiasis,of whom 230(85.2%)were found to have ERCP-confirmed *** regression identified choledocholithiasis on noninvasive imaging(odds ratio(OR)¼3.045,P¼0.004)and common bile duct(CBD)diameter on noninvasive imaging(OR¼1.157,P¼0.011)as predictors of ERCP-confirmed *** the various mLms trained,the random forest-based mLm performed best;sensitivity was 61.4%and 77.3%and specificity was 100%and 75.0%,using US-only and using all available imaging,*** high-likelihood criteria demonstrated sensitivity of 90.9%and specificity of 25.0%;using cut-points achieving this specificity,mLms achieved sensitivity up to 97.7%.Conclusions:mLms using age,sex,race/ethnicity,presence of diabetes,fever,body mass index(BmI),total bilirubin,maximum CBD di

关键词： machine learning models(mLms) Endoscopic retrograde cholangiopancreatography(ERCP) Noninvasive imaging Bile duct disorders Common bile duct stones Gallstones