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Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

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Precision Clinical medicine 2024年第1期7卷 1-13页

作者： J.Sebastian Garcia-medina Karolina Sienkiewicz S.anand Narayanan Eliah G.Overbey Kirill Grigorev Krista A.Ryon marissa Burke Jacqueline Proszynski Braden Tierney Caleb m.Schmidt Nuria mencia-Trinchant Remi Klotz Veronica Ortiz Jonathan Foox Christopher Chin Deena Najjar Irina matei Irenaeus Chan Carlos Cruchaga Ashley Kleinman JangKeun Kim Alexander Lucaci Conor Loy Omary mzava Iwijn De Vlaminck Anvita Singaraju Lynn E.Taylor Julian C.Schmidt michael A.Schmidt Kelly Blease Juan moreno Andrew Boddicker Junhua Zhao Bryan Lajoie Andrew Altomare Semyon Kruglyak Shawn Levy min Yu Duane C.Hassane Susan m.Bailey Kelly Bolton Jaime mateus Christopher E.mason Department of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of Stem Cell Biology and Regenerative medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space Exploration Technologies Corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Human Performance Group BoulderCO 80302USA Children's Cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA meyer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Department of Systems Engineering Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Department of Environmental and Radiological Health Sciences Colorado State UniversityFort CollinsCO 80523USA Cell and molecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St Louis Oncology Division St.LouisMO 63100USA meinig School of Biomedical Engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative PCR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(CHIP)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of CHIP in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low Earth orbit(LEO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

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Ulam-Hyers stability and analytical approach for m-dimensional Caputo space-time variable fractional order advection-dispersion equation

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International Journal of modeling, Simulation, and Scientific Computing 2022年第1期13卷 131-174页

作者： Pratibha Verma manoj Kumar anand Shukla Department of mathematics motilal Nehru National Institute of Technology Allahabad Prayagraj–211004 Uttar PradeshIndia†Department of Mathematics Wollega UniversityNekemteEthiopia

This article introduces the computational analytical approach to solve the m-dimensional space-time variable Caputo fractional order advection–dispersion equation with the Dirichlet boundary using the two-step Adomian decomposition method and obtain the exact solution in just one ***,with the help of fixed point theory,we study the existence and uniqueness conditions for the positive solution and prove some new ***,obtain the Ulam–Hyers stabilities for the proposed *** gen-eralized examples are considered to show the method’s applicability and compared with other existing numerical *** present method performs exceptionally well in terms of efficiency and ***,we solved both examples using the two most well-known numerical methods and compared them with the TSADm solution.

关键词： Fixed point theorems space-time variable Caputo’s fractional operators advection-dispersion equation Ulam-Hyers stability two-step Adomian decomposition method

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Thirty-day readmission in patients with heart failure with preserved ejection fraction:Insights from the nationwide readmission database

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World Journal of Cardiology 2022年第9期14卷 473-482页

作者： Anil Kumar Jha Chandra P Ojha anand m Krishnan Timir K Paul Internal medicine Lowell General HospitalLowellMA 01852United States Department of medicine Texas Tech University Health Sciences CenterEl PasoTX 79905United States Department of Cardiovascular Disease Larner College of Medicine at the University of VermontBurlingtonVT 05405United States Department of Clinical Education University of Tennessee Health Sciences Center at NashvilleNashvilleTN 37025United States

BACKGROUND There are rising numbers of patients who have heart failure with preserved ejection fraction(HFpEF).Poorly understood pathophysiology of heart failure with preserved and reduced ejection fraction and due to a sparsity of studies,the management of HFpEF is *** To determine the hospital readmission rate within 30 d of acute or acute on chronic heart failure with preserved ejection fraction and its effect on mortality and burden on health care in the United *** We performed a retrospective study using the Agency for Health-care Research and Quality Health-care Cost and Utilization Project,Nationwide Readmissions Database for the year *** collected data on hospital readmissions of 60514 adults hospitalized for acute or acute on chronic *** primary outcome was the rate of all-cause readmission within 30 d of *** outcomes were cause of readmission,mortality rate in readmitted and index patients,length of stay,total hospitalization costs and *** risk factors for readmission were identified using Cox regression *** The thirty day readmission rate was 21%.Approximately 9.17%of readmissions were in the setting of acute on chronic diastolic heart *** chronic kidney disease with heart failure(1245;9.7%)was the most common readmission *** patients had higher in-hospital mortality(7.9%vs 2.9%,P=0.000).Our study showed that medicaid insurance,higher Charlson co-morbidity score,patient admitted to a teaching hospital and longer hospital stay were significant variables associated with higher readmission *** readmission rate was found in residents of small metropolitan or micropolitan areas,older age,female gender,and private insurance or no insurance were associated with lower risk of *** We found that patients hospitalized for acute or acute on chronic HFpEF,the thirty day readmission rate was 21%.Readmission cases had a higher mortal

关键词： Heart failure with preserved ejection fraction Diastolic heart failure Readmission National readmission database Health care resource utilization

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Topological feature engineering for machine learning based halide perovskite materials design

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npj Computational materials 2022年第1期8卷 1943-1950页

作者： D.Vijay anand Qiang Xu JunJie Wee Kelin Xia Tze Chien Sum Division of mathematical Sciences School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore637371Singapore Division of Physics&Applied Physics School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore637371Singapore

Accelerated materials development with machine learning(mL)assisted screening and high throughput experimentation for new photovoltaic materials holds the key to addressing our grand energy ***-driven mL is envisaged as a decisive enabler for new perovskite materials ***,its full potential can be severely curtailed by poorly represented molecular descriptors(or fingerprints).Optimal descriptors are essential for establishing effective mathematical representations of quantitative structure-property *** we reveal that our persistent functions(PFs)based learning models offer significant accuracy advantages over traditional descriptor based models in organic-inorganic halide perovskite(OIHP)materials design and have similar performance as deep learning *** multiscale simplicial complex approach not only provides a more precise representation for OIHP structures and underlying interactions,but also has better transferability to mL *** results demonstrate that advanced geometrical and topological invariants are highly efficient feature engineering approaches that can markedly improve the performance of learning models for molecular data ***,new structure-property relationships can be established between our invariants and *** anticipate that our molecular representations and featurization models will transcend the limitations of conventional approaches and lead to breakthroughs in perovskite materials design and discovery.

关键词： perovskite halide invariants

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Intelligent Deep Learning Enabled Human Activity Recognition for Improved medical Services

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Computer Systems Science & Engineering 2023年第2期44卷 961-977页

作者： E.Dhiravidachelvi m.Suresh Kumar L.D.Vijay anand D.Pritima Seifedine Kadry Byeong-Gwon Kang Yunyoung Nam Department of Electronics and Communication Engineering Mohamed Sathak A.J.College of EngineeringChennai603103India Department of Information Technology Sri Sairam Engineering CollegeChennai602109India Department of Robotics Engineering Karunya Institute of Technology and SciencesCoimbatore641114India Department of mechatronics Engineering Sri Krishna College of Engineering and TechnologyCoimbatore641008India Deparmtent of Applied Data Science Noroff University CollegeKristiansandNorway Department of Information and Communication Engineering Soonchunhyang UniversityAsanKorea Department of Computer Science and Engineering Soonchunhyang UniversityAsanKorea

Human Activity Recognition(HAR)has been made simple in recent years,thanks to recent advancements made in Artiﬁcial Intelligence(AI)*** techniques are applied in several areas like security,surveillance,healthcare,human-robot interaction,and *** wearable sensor-based HAR system includes in-built sensors,human activities can be categorized based on sensor ***,it can also be employed in other applications such as gait diagnosis,observation of children/adult’s cognitive nature,stroke-patient hospital direction,Epilepsy and Parkinson’s disease examination,***-developed Artiﬁcial Intelligence(AI)techniques,especially Deep Learning(DL)models can be deployed to accomplish effective outcomes on HAR *** this motivation,the current research paper focuses on designing Intelligent Hyperparameter Tuned Deep Learning-based HAR(IHPTDL-HAR)technique in healthcare *** proposed IHPTDL-HAR technique aims at recogniz-ing the human actions in healthcare environment and helps the patients in mana-ging their healthcare *** addition,the presented model makes use of Hierarchical Clustering(HC)-based outlier detection technique to remove the ***-HAR technique incorporates DL-based Deep Belief Network(DBN)model to recognize the activities of ***,Harris Hawks Opti-mization(HHO)algorithm is used for hyperparameter tuning of DBN ***,a comprehensive experimental analysis was conducted upon benchmark dataset and the results were examined under different *** experimental results demonstrate that the proposed IHPTDL-HAR technique is a superior per-former compared to other recent techniques under different measures.

关键词： Artiﬁcial intelligence human activity recognition deep learning deep belief network hyperparameter tuning healthcare

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Exploration of IoT Nodes Communication Using LoRaWAN in Forest Environment

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Computers, materials & Continua 2022年第6期71卷 6239-6256页

作者： Anshul Sharma Divneet Singh Kapoor anand Nayyar Basit Qureshi Kiran Jot Singh Khushal Thakur Embedded Systems&Robotics Research Group Chandigarh UniversityMohali140413PunjabIndia Graduate School Duy Tan UniversityDa Nang550000Vietnam Faculty of Information Technology Duy Tan UniversityDa Nang550000Vietnam Department of Computer Science Prince Sultan UniversityRiyadh11586Saudi Arabia

The simultaneous advances in the Internet of Things(IoT),Artificial intelligence(AI)and Robotics is going to revolutionize our world in the near *** recent years,LoRa(Long Range)wireless powered by LoRaWAN(LoRa Wide Area Network)protocol has attracted the attention of researchers for numerous applications in the IoT *** is a low power,unlicensed Industrial,Scientific,and medical(ISm)bandequipped wireless technology that utilizes a wide area network protocol,i.e.,LoRaWAN,to incorporate itself into the network *** this paper,we have evaluated the LoRaWAN communication protocol for the implementation of the IoT(Internet of Things)nodes’communication in a forest *** outdoor performance of LoRa wireless in LoRaWAN,i.e.,the physical layer,has been evaluated in the forest area of Kashirampur Uttarakhand,***,the present paper aims towards analyzing the performance level of the LoRaWAN technology by observing the changes in Signal to Noise Ratio(SNR),Packet Reception Ratio(PRR)and Received Signal Strength Indicator(RSSI),with respect to the distance between IoT *** article focuses on estimating network lifetime for a specific set of LoRa configuration parameters,hardware selection and power *** the experimental results,it has been observed that transmissions can propagate to a distance of 300 m in the forest environment,while consuming approx.63%less energy for spreading factor 7 at 2 dBm,without incurring significant packet loss with PRR greater than 80%.

关键词： LoRa LoRaWAN IoT communication protocol wireless sensor networks packet reception ratio

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A Convergent Understanding of Charged Defects

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Accounts of materials Research 2022年第7期3卷 685-696页

作者： Shashwat anand michael Y.Toriyama Chris Wolverton Sossina m.Haile G.Jeffrey Snyder Department of materials Science and Engineering Northwestern UniversityEvanstonIllinois 60208United States materials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCalifornia 94720United States

CONSPECTUS:Historically,defects in semiconductors and ionic conductors have been studied using very different *** the solid-state ionics community,nonstoichiometry and defect thermochemistry are often probed directly through *** dependency of defect concentrations on chemical conditions(typically oxygen pressure)are modeled using a physical chemistry framework and compactly represented by the well-known Brouwer diagrams.

关键词： defect chemistry ionic

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Clinical and biochemical predictors of intensive care unit admission among patients with diabetic ketoacidosis

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World Journal of Diabetes 2023年第3期14卷 271-278页

作者： Adeel Ahmad Khan Fateen Ata Phool Iqbal mohammed Bashir anand Kartha Department of Endocrinology Hamad Medical CorporationDoha 00000Qatar Department of medicine Metropolitan Hospital CenterNew YorkNY 10595United States Department of medicine Hamad Medical CorporationDoha 00000Qatar

BACKGROUND Diabetic ketoacidosis(DKA)contributes to 94%of diabetes-related hospital admissions,and its incidence is *** to the complexity of its management and the need for rigorous monitoring,many DKA patients are managed in the intensive care unit(ICU).However,studies comparing DKA patients managed in ICU to non-ICU settings show an increase in healthcare costs without significantly affecting patient *** is,therefore,essential to identify suitable candidates for ICU care in DKA *** To evaluate factors that predict the requirement for ICU care in DKA *** This retrospective study included consecutive patients with index DKA episodes who presented to the emergency department of four general hospitals of Hamad medical Corporation,Doha,Qatar,between January 2015 and march *** adult patients(>14 years)fulfilling the American Diabetes Association criteria for DKA diagnosis were *** We included 922 patients with DKA in the final analysis,of which 229(25%)were managed in the *** to non-ICU patients,patients admitted to ICU were older[mean(SD)age of 40.4±13.7 years vs 34.5±14.6 years;Pmass index[median(IQR)of 24.6(21.5-28.4)kg/m2 vs 23.7(20.3-27.9)kg/m2;Pm(61.6%)and were predominantly males(69%vs 31%;Pmedian(IQR)of 15.1(10.2-21.2)×103/uL vs 11.2(7.9-15.7)×103/uL,Pmedian(IQR)of 6.5(4.6-10.3)mmol/L vs 5.6(4.0-8.0)mmol/L;Pmedian(IQR)of 99(75-144)mmol/L vs 82(63-144)mmol/L;Pmedian(IQR)of 27(9-83)mg/L vs 14(5-33)mg/L;Pmedian(IQR)of 24.0(19.2-29.0)mEq/L vs 22(17-27)mEq/L;Pmean(SD)of 7.10±0.15 vs 7.20±0.13;Pmean(SD)of 9.2±4.1 mmol/L vs 11.6±4.3 mmol/L;Pmission than those not requiring ICU management of DKA(Pmedian(IQR)of

关键词： Diabetic ketoacidosis Type 1 diabetes mellitus Type 2 diabetes mellitus Intensive care unit Critical care outcomes Length of stay

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Synthesis of metallic Nanoparticles Based on Green Chemistry and Their medical Biochemical Applications:Synthesis of metallic Nanoparticles

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Journal of Renewable materials 2023年第6期11卷 2575-2591页

作者： Kakudji Kisimba anand Krishnan mbuso Faya Kahumba Byanga Kabange Kasumbwe Kaliyapillai Vijayakumar Ram Prasad Department of Pharmaceutical Sciences University of Kwazulu-NatalPrivate Bag X54001DurbanSouth Africa Department of Chemical Pathology School of PathologyFaculty of Health SciencesUniversity of the Free StateBloemfonteinSouth Africa Faculty of Pharmaceutical Sciences University of LubumbashiLubumbashiDemocratic Republic of Congo Department of Biotechnology and Food Sciences Durban University of TechnologyDurbanSouth Africa Department of Chemistry M.Kumarasamy College of EngineeringKarurTamilnaduIndia Department of Botany Mahatma Gandhi Central UniversityMotihariBiharIndia

Nanoparticles have distinct properties that make them potentially valuable in a variety of *** a result,emerging approaches for the manufacture of nanoparticles are gaining a lot of scientific *** biological pathway of nanoparticle synthesis has been suggested as an effective,affordable,and environmentally safe *** of nanoparticles through physical and chemical processes uses unsafe materials,expensive equipment and adversely affects the *** a result,in order to support the increased utilization of nanoparticles across many sectors,nanotechnology research activities have shifted toward environmentally safe and cost-effective techniques that outperform chemical and/or biological *** use of organisms to produce metal nanoparticles is among the most frequently discussed *** appear to be the best candidates among these organisms for large-scale nanoparticle *** plants have been employed as reducing agents and NP stabilizers to minimize the toxicity of NPs in both the environment and the human ***,the presence of certain functional components in plant extracts may be extremely useful and effective for the human ***,for example,which may have antioxidant properties,might intercept free radicals before they interact with other biomolecules and cause considerable *** current article analyzes the most recent developments and improvements in the green synthesis of metal nanoparticles by different plants and the use of these nanoparticles for various biomedical applications and hopes to provide insights into this exciting research frontier.

关键词： Biosynthesis nanoparticles antimicrobial anticancer antioxidant medicinal plants

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Determining the relationship between chemical composition and size, shape and effective density of airborne fine particles through concurrent use of inertial and optical based measurements

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Particuology 2016年第5期14卷 93-101页

作者： anand Kumar Tarun Gupta Environmental Engineering and management Program Indian Institute of Technology Kanpur Kanpur 208016 India Institute of Atmospheric and Climate Science Swiss Federal Institute of Technology Zurich Zurich 8092 Switzerland Department of Civil Engineering Indian Institute of Technology Kanpur Kanpur 208016 India

This study presents the development of a medium flow, multiple slit based Pm2.5 （particle aerodynamic diameter 〈2.5 μm） inertial impactor. Its performance was compared with that of a light scattering based optical particle sizer in a field study and in controlled lab based experiments using polydisperse dolomite powder as test aerosol. The impactor＇s optimum nozzle configuration had a cutoff size of 2.51 μm （aero- dynamic diameter） at an operating flow rate of 215 L/rain with a pressure drop of 0.35 kPa across the impactor stage. Because the apparent particle density of an ambient aerosol depends on the physical properties and the chemical composition of the particles, the Pm2.5 mass concentration was measured with an optical particle sizer and an inertial impactor over a weekday and a weekend day in a field study during which the effective particle shape factor and density were in tandem modified in order to com- pare the results from the two sampling techniques. The correlation of the two instrument results tended towards 1：1 with increasing values of shape factor （irregular shaped） and effective particle density. This observation was supported through chemical investigations of the collected mass, which showed a higher percentage contribution from elements which are mostly of crustal nature （namely, Ca, Fe, and mg）.

关键词： lmpactor Pm2.5 Optical particle counter Effective particle density Shape factor

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