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Laparoscopic management of remnant gall bladder with stones: Lessons from a tertiary care centre's experience

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第1期7卷 27-33页

作者： Gilbert Samuel Jebakumar Jeevanandham Muthiah Loganathan Jayapal R.Santhosh Kumar Siddhesh Tasgaonkar K.S.Santhosh anand J.K.A.Jameel Sudeepta Kumar Swain K.J.Raghunath Prasanna Kumar Reddy Tirupporur Govindaswamy Balachandar Department of Surgical Gastroenterology Apollo HospitalsChennai 600006India Department of General Surgery Apollo HospitalsChennai 600006India Department of Minimal Access Surgery Apollo HospitalsChennai 600006India

Objective:Laparoscopic cholecystectomy is currently the gold standard for treating symptomatic gallstone *** its success,approximately 10%of patients may experience persistent biliary symptoms,leading to the post-cholecystectomy syndrome.A remnant gallbladder with cystic duct or bile duct stones is one of the causes of this *** objective of this study was to shed light on the clinical manifestations,evaluation,therapeutic strategies,and outcomes associated with laparoscopic management of symptomatic remnant ***:This was a retrospective study,conducted over a five-year period(January 2017 to December 2022)at Apollo Hospitals in South *** patients who underwent laparoscopic completion cholecystectomy for a remnant gall bladder were *** following data were collected:patient demographics,symptoms,preoperative investigations,intraoperative details and post operative ***:In total,36 patients were included and *** majority of patients were male(25,69.4%),with a mean age of 50.7±12.1 *** most common presentation was pain in the upper abdomen or right upper quadrant region(24,66.7%).The laparoscopic approach was attempted in all patients,with a success rate of 94.4%.Two patients required conversion to open *** fistula to the colon was observed in one *** was observed in 7 patients(19.4%),and stone clearance was successfully achieved using endoscopic retrograde cholangiopancreatography in all patients ***:Incomplete gall bladder removal either intentionally or unintentionally leaves a remnant gall bladder that is at risk for stone formation and *** who have this clinical entity with symptoms require a redo or complete cholecystectomy,a complex procedure associated with certain *** study highlights the feasibility and safety of laparoscopic completion cholecystectomy for the management of remnant gallbladder

关键词： Remnant gall bladder Stump cholecystitis Subtotal cholecystectomy Laparoscopic completion cholecystectomy

Alternative models of cancer stem cells: The stemness phenotype model, 10 years later

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World Journal of Stem Cells 2021年第7期13卷 934-943页

作者： Vivek Kaushik Yogesh kulkarni Kumar Felix Neelam Azad anand Krishnan V Iyer Juan Sebastian Yakisich School of Pharmacy Department of Pharmaceutical SciencesHampton UniversityHamptonVA 23668United States

The classical cancer stem cell(CSCs)theory proposed the existence of a rare but constant subpopulation of *** this model cancer cells are organized hierarchically and are responsible for tumor resistance and tumor ***,eliminating CSCs will eventually lead to cure of *** simplistic model has been challenged by experimental *** 2010 we proposed a novel and controversial alternative model of CSC biology(the Stemness Phenotype Model,SPM).The SPM proposed a non-hierarchical model of cancer biology in which there is no specific subpopulation of CSCs in ***,cancer cells are highly plastic in term of stemness and CSCs and non-CSCs can interconvert into each other depending on the *** model predicts the existence of cancer cells ranging from a pure CSC phenotype to pure non-CSC phenotype and that survival of a single cell can originate a new *** the past 10 years,a plethora of experimental evidence in a variety of cancer types has shown that cancer cells are indeed extremely plastic and able to interconvert into cells with different stemness *** this review we will(1)briefly describe the cumulative evidence from our laboratory and others supporting the SPM;(2)the implications of the SPM in translational oncology;and(3)discuss potential strategies to develop more effective therapeutic regimens for cancer treatment.

关键词： Cancer Stem cells Stemness Plasticity Chemotherapy Interconversion

Seismic bearing capacity of strip footing on partially saturated soil using modal response analysis

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Earthquake Engineering and Engineering Vibration 2022年第3期21卷 641-662页

作者： Abhijit anand Rajib Sarkar Department of Civil Engineering IIT(ISM)DhanbadDhanbad 826004India

The present study proposes a novel and simplified methodology to assess the seismic bearing capacity(SBC) of a shallow strip footing by incorporating strength non-linearity arising due to partial saturation of a soil matrix. Furthermore, developed methodology incorporates the modal response analysis of soil layers to assess SBC. A constant matric suction distribution profile has been considered throughout the depth of the soil. The Van Genuchten equation and corresponding fitting parameters have been considered to quantify matric suction in the analysis. SBC has been obtained for three different geomaterials;viz. sand, fly ash and clay, based on their predominant grain size and diverse soil water characteristics curve(SWCC) attributes. Variation of SBC with different modes of vibration and damping ratio are reported for ranges of matric suction pertinent to the geomaterials considered in the study. The relative significance of matric suction on SBC has been reported for suction values within the transition zone of each geomaterial. It is observed that the SBC of sand is drastically reduced, with matric suction reaching beyond the residual suction value. The SBC of fly ash remains constant beyond the residual suction value, whereas the SBC of clay shows an increasing trend toward the practical range of matric suction values.

关键词： seismic bearing capacity modal analysis matric suction

Settling and spreading behaviour of particle clusters in quiescent liquids in confined vessels

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Particuology 2023年第12期83卷 91-100页

作者： Sayan Pal Amol A.kulkarni Chemical Engineering&Process Development Division CSIR-National Chemical LaboratoryPune411008India Academy of Scientific and Innovative Research(AcSIR) Ghaziabad 201002India University College London Torrington PlaceLondonWC1E 7JEUK

Here we report experiments on particle cluster settling at high Reynolds number in quiescent liquid contained in a *** particles were observed to spread at the vessel bottom surface in a near-circular annular shape after settling irrespective of the shape of the vessel cross-section and particle shape,size,and *** of different parameters such as mass,type and aspect ratio of the particles,height,and viscosity of liquid was investigated on spreading *** of the hemispherical bottom cap of the cluster that bounces upon hitting the vessel bottom surface was found to be responsible for the final circular annular shape of the settled *** leakage from the cluster was seen in the form of a *** the liquid having viscosity beyond 100 cP,cluster breakage was observed that resulted in hindered settling and asymmetric shapes of finally settled *** observations are useful to understand the overall area over which settling and spreading of such clusters can be observed.

关键词： Particle cluster Temporal evolution Settling Spreading

Corrigendum to'Cancer chemotherapy and beyond:Current status,drug candidates,associated risks and progress in targeted therapeutics'[Genes&Diseases 10(2023)1367-1401]

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Genes & Diseases 2024年第4期11卷 426-427页

作者： Uttpal anand Abhijit Dey Arvind K.Singh Chandel Rupa Sanyal Amarnath Mishra Devendra Kumar Pandey Valentina De Falco Arun Upadhyay Ramesh Kandimalla Anupama Chaudhary Jaspreet Kaur Dhanjal Saikat Dewanjee Jayalakshmi Vallamkondu Jose M.Perez de la Lastra Department of Life Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel Department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Center for Disease Biology and Integrative Medicine Faculty of MedicineThe University of TokyoTokyo 113-0033Japan Department of Botany Bhairab Ganguly College(affliated to West Bengal State University)KolkataWest Bengal 700056India Faculty of Science and Technology Amity Institute of Forensic SciencesAmity University Uttar PradeshNoida 201313India Department of Biotechnology School of Bioengineering and BiosciencesLovely Professional UniversityPhagwaraPunjab 144411India Institute of Endocrinology and Experimental Oncology(IEOS) National Research Council(CNR)Department of Molecular Medicine and Medical Biotechnology(DMMBM)University of Naples FedericoⅡNaples 80131Italy Department of Biochemistry School of Life SciencesCentral University of RajasthanBandar SindariKishangarhAjmerRajasthan 305817India CSiR-indian Institute of Chemical Technology HyderabadTelangana 500007India Department of Biochemistry Kakatiya Medical CollegeWarangalTelangana 506007India Orinin-BioSystems LE-52Lotus Road 4CHD CityKarnalHaryana 132001India Department of Computational Biology Indraprastha Institute of Information Technology Delhi(ⅢT-D)Okhla Industrial EstatePhaseⅢNew Delhi 110020India Advanced Pharmacognosy Research Laboratory Department of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India Department of Physics National Institute of Technology-WarangalWarangalTelangana 506004India Biotechnology of Macromolecules Research Group Instituto de Productos Naturales y AgrobiologiaIPNA-CSICSan Cristobal de La Laguna 38206TenerifeSpain

In the published article,there was an error in the affiliation information about the first author Uttpal anand[a].Instead of"Department of Life Sciences,Ben-Gurion University of the Negev,Beer-Sheva 84105,Israel",it should be"CytoGene Research&Development LLP,K-51,UPSIDA Industrial Area,Kursi Road(Lucknow),***,225001,Uttar Pradesh,India".The authors would like to apologize for any inconvenience caused and state that this does not change the scientific conclusions of thearticle inanyway.

关键词： Cancer Cor targeted

Determining Potential Passive Islanding Detection Indicators for Single-point Single Inverter,Single-point Multi-inverter and Multi-point Multi-inverter Scenarios

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CSEE Journal of Power and Energy Systems 2022年第3期8卷 696-709页

作者： Nitin Kumar kulkarni Mohan Khedkar Department of Electrical Engineering Visvesvaraya National Institute of TechnologyNagpurIndia

Distributed Generation(DG)sources,predominantly renewable energy-based,such as solar photovoltaic and wind energy sources,have significantly penetrated into power system *** high penetration of DG sources may lead to the formation of unintentional islands,which is hazardous to both the equipment and personnel,if *** this paper,46 passive parameters are considered to find out which candidate(s)are promising for detecting sustained unintentional islands and avoid false DG *** 46 parameters are derived from point of common coupling(PCC)voltage,DG output current,frequency,power factor angle,active and reactive *** these parameters are tested on standard IEEE 13 and 34 bus distribution networks,integrated with inverter-interfaced DGs at different locations for different penetration levels in the MATLAB/SIMULINK *** parameters are tested for different islanding events(comprising of various local loads,such as conventional parallel RLC resonant load,R,RC,and RL loads)and for different non-islanding *** parameters are then ranked accordingly by a suitable averaging approach based performance ranking *** this analysis,the best candidates are obtained for detecting inverter DG islands at single-point(or single PCC)locations and multi-point(or multiple PCCs)*** best passive candidates are obtained for different island scenarios from which a set of promising islanding detection indicators are proposed.

关键词： Averaging approach inverter DG point of common coupling(PCC) passive parameters test system

Torus actions, fixed-point formulas, elliptic genera and positive curvature

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Frontiers of Mathematics in China 2016年第5期11卷 1151-1187页

作者： anand DESSAI Institute of Mathematics Beijing Jiaotong University Beijing 100044 China

We study fixed points of smooth torus actions on closed manifolds using fixed point formulas and equivariant elliptic genera. We also give applications to positively curved Riemannian manifolds with symmetry.

关键词： Torus actions fixed point formulas equivariant indices elliptic genera rigidity and vanishing

Determining the relationship between chemical composition and size, shape and effective density of airborne fine particles through concurrent use of inertial and optical based measurements

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Particuology 2016年第5期14卷 93-101页

作者： anand Kumar Tarun Gupta Environmental Engineering and Management Program Indian Institute of Technology Kanpur Kanpur 208016 India Institute of Atmospheric and Climate Science Swiss Federal Institute of Technology Zurich Zurich 8092 Switzerland Department of Civil Engineering Indian Institute of Technology Kanpur Kanpur 208016 India

This study presents the development of a medium flow, multiple slit based PM2.5 （particle aerodynamic diameter 〈2.5 μm） inertial impactor. Its performance was compared with that of a light scattering based optical particle sizer in a field study and in controlled lab based experiments using polydisperse dolomite powder as test aerosol. The impactor＇s optimum nozzle configuration had a cutoff size of 2.51 μm （aero- dynamic diameter） at an operating flow rate of 215 L/rain with a pressure drop of 0.35 kPa across the impactor stage. Because the apparent particle density of an ambient aerosol depends on the physical properties and the chemical composition of the particles, the PM2.5 mass concentration was measured with an optical particle sizer and an inertial impactor over a weekday and a weekend day in a field study during which the effective particle shape factor and density were in tandem modified in order to com- pare the results from the two sampling techniques. The correlation of the two instrument results tended towards 1：1 with increasing values of shape factor （irregular shaped） and effective particle density. This observation was supported through chemical investigations of the collected mass, which showed a higher percentage contribution from elements which are mostly of crustal nature （namely, Ca, Fe, and Mg）.

关键词： lmpactor PM2.5 Optical particle counter Effective particle density Shape factor

Julia sets of permutable Holomorphic maps Dedicated to Professor Sheng GONG on the occasion of his 75th birthday

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Science China Mathematics 2006年第11期49卷 1715-1721页

作者： SINGH anand P Department of Mathematics University of Jammu Jammu-180006India

Let f and g be two permutable transcendental holomorphic maps in the *** shall discuss the dynamical properties of f, g and f o g and prove, among other things, that if either f has no wandering domains or f is of bou... 详细信息

关键词： Julia set, Fatou set, permutable maps.