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A Comparative Study of Managing a Project Using Traditional Management Techniques and a Critical Chain Project Management Methodology in Aircraft Maintenance Field

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Journal of Transportation Technologies 2022年第4期12卷 544-558页

作者： Devinder Kumar Yadav anand kulkarni Hui Yao University of Nottingham Ningbo China Ningbo China Department of Management National University of Singapore Queenstown Singapore Ningbo DEKO Information Technology Company Limited Ningbo China

Aircraft on ground or down-time for its maintenance is a clear loss in revenue for an airline operation. With never ending competition and growing operating costs of aircraft, airlines continuously need to explore opportunities to reduce the aircraft down-time in order to remain sustainable. Due to round the clock operation feature of scheduled airlines, aircraft maintenance operations are generally carried out using traditional management methodologies instead of considering it as a project. Though aircraft heavy maintenance checks consist of several major tasks that can last from few weeks to a year, the maintenance organisations do not adopt modern project management methodologies. Therefore, this paper models a heavy maintenance check of an Airbus aircraft as a typical project and adopts contemporary project management methodology to explore the possibility of reducing the downtime. To this end, a case study has been done at an aircraft maintenance company to analyse the potential of this project management method in aircraft maintenance industry.

关键词： Aviation Airline Aircraft Engineering Management Maintenance Operations Planning Project

Management of hepatitis B and C in special population

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World Journal of Gastroenterology 2021年第40期27卷 6861-6873页

作者： anand V kulkarni Nageshwar Reddy Duvvuru Department of Hepatology Asian Institute of GastroenterologyHyderabad 500032TelanganaIndia Department of Gastroenterology Asian Institute of GastroenterologyHyderabad 500032TelanaganaIndia

Chronic viral hepatitis is one of the leading causes of cirrhosis *** hepatitis B is more common in the Asia-Pacific region due to the larger population and lower screening *** C predominates in the west due to injection drug *** discovery of(oral)direct-acting antiviral agents(DAAs)has changed the landscape of chronic hepatitis C(CHC)***(t)ide analogs(NUCs)have also changed the approach to the treatment of chronic hepatitis B(CHB).Oral NUCs and DAAs have excellent efficacy and patient acceptance as well as a lower risk of ***,certain populations have no robust data and safety and efficacy of such oral drugs is still *** this review,we provide an overview of the management of CHB and CHC in special populations,such as those with chronic kidney disease,pregnant women,healthcare workers,and those undergoing chemo-or immunosuppressive therapy.

关键词： Chronic kidney disease Pregnancy Hepatitis B Hepatitis C Health care professionals Tenofovir

Drugs for Non-alcoholic Steatohepatitis (NASH): Quest for the Holy Grail

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Journal of Clinical and Translational Hepatology 2021年第1期9卷 40-50页

作者： Mithun Sharma Madhumita Premkumar anand V kulkarni Pramod Kumar D Nageshwar Reddy Nagaraja Padaki Rao Department of Hepatology Asian Institute of GastroenterologyHyderabadIndia Department of Hepatology PGIMERChandigarhIndia Department of Gastroenterology Asian Institute of GastroenterologyHyderabadIndia

Nonalcoholic fatty liver disease (NAFLD) is a global epidemic that is likely to become the most common cause of chronic liver disease in the next decade, worldwide. Though numerous drugs have been evaluated in clinical trials, most of them have returned inconclusive results and shown poorly-tolerated adverse effects. None of the drugs have been approved by the Food and Drug Administration for treating biopsy-proven non-alcoholic steatohepatitis (NASH). Vitamin E and pioglitazone have been extensively used in treatment of biopsy-proven nondiabetic NASH patients. Although some amelioration of inflammation has been seen, these drugs did not improve the fibrosis component of NASH. Therefore, dietary modification and weight reduction have remained the cornerstone of treatment of NASH;moreover, they have shown to improve histological activity as well as fibrosis. The search for an ideal drug or ‘Holy Grail’ within this landscape of possible agents continues, as weight reduction is achieved only in less than 10% of patients. In this current review, we summarize the drugs for NASH which are under investigation, and we provide a critical analysis of their up-to-date results and outcomes.

关键词： Fatty liver NAFLD NASH Obeticholic acid Saroglitazar

Nonselective beta‐blockers reduce mortality in patients with acute‐on‐chronic liver failure

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Portal Hypertension & Cirrhosis 2022年第1期1卷 15-22页

作者： anand V.kulkarni Madhumita Premkumar Karan Kumar Juned A.Khan Baqar A.Gora Sowmya Tirumalle Sameer Shaik Mithun Sharma Rajesh Gupta Nageshwar D.Reddy Padaki N.Rao Department of Hepatology AIG HospitalsHyderabadIndia Department of Hepatology PGIMERChandigarhIndia Department of Hepatology Mahatma Gandhi HospitalsJaipurIndia Department of Hepatology Hopewell HospitalLucknowIndia

Aim:Nonselective beta‐blockers(NSBBs)can reduce the incidence of complications in patients with cirrhosis and prolong *** safety and efficacy of NSBBs in real‐world settings in patients with acute‐on‐chronic liver failure(ACLF)identified by the Asian Pacific Association for the Study of Liver criteria are *** study aimed to assess the safety and efficacy of NSBBs in patients with Asian Pacific Association for the Study of Liver(APASL)‐defined ACLF Methods:In this retrospective,multicenter study,patients with ACLF with complete 30 days follow‐up from January 2019 to December 2021 were *** primary objective was to compare 30‐day mortality among standard of care(SOC)and NSBB(+SOC)*** secondary objectives were to compare the incidence of infection,variceal bleed,and recompensation among both the ***:A total of 346 patients were *** 26%(n=89)of them received NSBBs,while 74%(n=257)received only *** Kaplan-Meier analysis,the incidence of mortality was 21%(95%confidence interval[CI]:16.20-26.50)in SOC group compared to only 8%(95%CI:3.22-15.53)in NSBB group at Day 30(p=0.005).Similarly,mortality in SOC group was 63%(95%CI:56.81-69.00)compared to 46%(95%CI:35.44-57.00)in NSBB group at 1 year(p=0.001).NSBB therapy could not reduce the incidence of infections or variceal ***‐seven percent of patients in the SOC group and 73%of patients in the NSBB group(p<0.001)*** was prescribed in 77.5%and propranolol in 22.5%of ***:NSBBs reduce mortality without any effect on infection or variceal bleed in patients with ***,only one in four ACLF patients are suitable for NSBB therapy.

关键词： ACLF infection portal hypertension variceal bleed

Favipiravir-induced Liver Injury in Patients with Coronavirus Disease 2019

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Journal of Clinical and Translational Hepatology 2021年第2期9卷 276-278页

作者： Pramod Kumar anand kulkarni Mithun Sharma Padaki Nagaraja Rao Duvvuru Nageshwar Reddy Department of Hepatology and Liver Transplantation Asian Institute of Gastroenterology HospitalsHyderabadIndia Department of Gastroenterology Asian Institute of Gastroenterology HospitalsHyderabadIndia

Favipiravir,an antiviral,was given restricted emergency use approval to treat coronavirus disease 2019(COVID-19)in many *** the clinical efficacy of favipiravir in COVID-19 remains uncertain,the approval was based on findings from in vitro studies and a clinical trial.1 Limited data from studies of the Ebola virus and influenza disease showed a favorable safety profile.2 Herein,we provide the first report of drug-induced liver injury(DILI)due to favipiravir in patients treated for COVID-19.

关键词： clinical approval Liver

Nonlinear system dynamics of calcium and nitric oxide due to cell memory and superdiffusion in neurons

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Communications in Theoretical Physics 2024年第5期76卷 16-32页

作者： anand Pawar Kamal Raj Pardasani Department of Mathematics Bioinformatics and Computer ApplicationsMaulana Azad National Institute of TechnologyBhopal-462003Madhya PradeshIndia

The integer-order interdependent calcium([Ca^(2+)])and nitric oxide(NO)systems are unable to shed light on the influences of the superdiffusion and memory in triggering Brownian motion(BM)in ***,a mathematical model is constructed for the fractional-order nonlinear spatiotemporal systems of[Ca^(2+)]and NO incorporating reaction-diffusion equations in *** two-way feedback process between[Ca^(2+)]and NO systems through calcium feedback on NO production and NO feedback on calcium through cyclic guanosine monophosphate(cGMP)with plasmalemmal[Ca^(2+)]-ATPase(PMCA)was incorporated in the *** Crank–Nicholson scheme(CNS)with Grunwald approximation along spatial derivatives and L1 scheme along temporal derivatives with Gauss–Seidel(GS)iterations were *** numerical outcomes were analyzed to get insights into superdiffusion,buffer,and memory exhibiting BM of[Ca^(2+)]and NO *** conditions,events and mechanisms leading to dysfunctions in calcium and NO systems and causing different diseases like Parkinson’s were explored in neurons.

关键词： [Ca^(2+)]and nitric oxide signaling reaction-diffusion equations fractional-order systems Grunwald approximation Gauss-Seidel iterations

基于队列智能方法的分数阶PI~λD~μ控制器设计（英文）

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Frontiers of Information Technology & Electronic Engineering 2018年第3期19卷 437-445页

作者： Pritesh SHAH Sudhir AGASHE anand J.kulkarni Symbiosis Institute of Technology Symbiosis International University Department of Instrumentation and Control Engineering College of EngineeringPune Odette School of Business University of Windsor

近年来,队列智能方法逐步演变为一种基于人工智能的优化方法。本文首次采用队列智能方法对分数阶PID控制器的参数进行优化。验证了队列智能方法在分数阶PID控制器设计中的性能,并与其他方法如粒子群优化方法、遗传算法和改进的电磁算法... 详细信息

近年来,队列智能方法逐步演变为一种基于人工智能的优化方法。本文首次采用队列智能方法对分数阶PID控制器的参数进行优化。验证了队列智能方法在分数阶PID控制器设计中的性能,并与其他方法如粒子群优化方法、遗传算法和改进的电磁算法等的性能进行比较。结果表明,与其它3种算法相比,队列智能方法在代价函数、计算时间和函数评估方面表现出更好性能。此外,队列智能方法对应的标准差表明,提出的方法在解决控制问题时具有鲁棒性。

关键词：队列智能分数阶微积分分数阶PID控制器调节

Numerical Analysis of Phase Change and Container Materials for Thermal Energy Storage in the Storage Tank of Solar Water Heating System

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Journal of Thermal Science 2024年第2期33卷 408-421页

作者： SINGH Shailendra anand Abhishek SHUKLA Amritanshu SHARMA Atul Non-Conventional Energy Laboratory Rajiv Gandhi Institute of Petroleum TechnologyJais Amethi229304India

This study evaluates the effectiveness of phase change materials(PCMs) inside a storage tank of warm water for solar water heating(SWH) system through the theoretical simulation based on the experimental model of *** et *** model is explained by five fundamental equations for the calculation of various parameters like the effectiveness of PCMs,the mass of hot water,total heat content,and duration of *** study simulated eleven PCMs to analyze their effectiveness like Sodium hydrogen phosphate dodecahydrate(SHPD),OM 37,N-Eicosane(NE),Lauric acid(LA),Paraffin wax(PW),OM 48,Paraffin wax C_(20-33)(PW-C20-33),Sodium acetate trihydrate(SAT),Palmitic acid(PA),Myristic acid(MA),and Stearic acid(SA).Among all PCMs,the SHPD has found the highest value of effectiveness factor of ***,it is the most recommended PCM for the storage tank of the SWH *** study also includes the melt fraction analysis of all enumerated PCMs corresponding to container materials of stainless steel,glass,aluminum mixed,tin,aluminum,and *** melt fraction analysis is performed by making a coding program in the FORTRAN programming *** the analysis,copper container material is found to have high melting rate for all PCMs so it is superior to other container materials.

关键词： theoretical model solar water heating system phase change material effectiveness factor melt fraction

PML nuclear bodies:new players in familial amyotrophic lateral sclerosis-frontotemporal dementia?

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Neural Regeneration Research 2024年第9期19卷 1875-1876页

作者： anand Goswami Serena Carra Institute of Neuropathology RWTH Aachen University HospitalAachenGermany Department of Neurology Eleanor and Lou Gehrig ALS CenterColumbia UniversityNew YorkNYUSA Department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly

Amyotrophi c lateral s c lerosis(ALS)and frontotemporal dementia(FTD)are two closely related disorders with overlapping clinical,genetic,and neuropathological features,forming a continuous disease spectrum(Ling et al.,2013).The major pathological hallmark of ALS and FTD are the depletion from the nucleus of the RNA-binding proteins TAR DNA‐binding protein 43(TDP-43)and FUsed in Sarcoma(FUS)and their abnormal accumulation in ubiquitin-positive cytoplasmic inclusions(Ling et al.,2013).

关键词： clinical familial