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An Integrated Scheduling Algorithm for the Same Equipment Process Sequencing Based on the Root-Subtree Vertical and Horizontal Pre-Scheduling

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Computer Modeling in Engineering & Sciences 2023年第1期134卷 179-200页

作者： Zhiqiang Xie Haikun Teng anak agung ayu putri ardyanti Xu Yu Harbin University of Science and Technology Harbin150000China Qingdao University of Science and Technology Qingdao266061China

Given the existing integrated scheduling algorithms,all processes are ordered and scheduled overall,and these algorithms ignore the influence of the vertical and horizontal characteristics of the product process tree on the product scheduling *** paper presents an integrated scheduling algorithm for the same equipment process sequencing based on the Root-Subtree horizontal and vertical pre-scheduling to solve the above ***,the tree decomposition method is used to extract the root node to split the process tree into several Root-Subtrees,and the Root-Subtree priority is set from large to small through the optimal completion time of vertical and horizontal *** Root-Subtree processes on the same equipment are sorted into the stack according to the equipment process pre-start time,and the stack-top processes are combined with the schedulable process set to schedule and dispatch the *** start processing time of each process is determined according to the dynamic start processing time strategy of the equipment process,to complete the fusion operation of the Root-Subtree processes under the constraints of the vertical process tree and the horizontal ***,the root node is retrieved to form a substantial scheduling scheme,which realizes scheduling optimization by mining the vertical and horizontal characteristics of the process *** by examples shows that,compared with the traditional integrated scheduling algorithms that sort the scheduling processes as an overall,the integrated scheduling algorithmin this paper is *** proposed algorithmenhances the process scheduling compactness,reduces the length of the idle time of the processing equipment,and optimizes the production scheduling target,which is of universal significance to solve the integrated scheduling problem.

关键词： Horizontal and vertical pre-scheduling the priority of the Root-Subtree the equipment process pre-start time the dynamic start time strategy of the equipment process

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Preventive effect of Peperomia pellucida(L.) Kunth herbs on ovariectomyinduced osteoporotic rats

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Journal of Chinese Pharmaceutical Sciences 2016年第7期25卷 546-551页

作者： Cynthia Astiti putri I Gusti agung ayu Kartika I Ketut Adnyana Department of Clinical Pharmacology and Toxicology School of Pharmacy Bandung Institute of Technology

Osteoporosis is a metabolic skeletal disorder leading to bone fracture which adversely impacts the quality of life. In the present, we aimed to investigate the effect of Peperomia pellucida(L.) Kunth herb juice and ethanolic extract on ovariectomy(OVX)-induced osteoporotic rat model. Osteoporosis was induced by OVX with a double dorsolateral approach on female Wistar rats. Female Wistar rats undergoing sham surgeries(sham-control group) served as controls. The ovariectomized rats were divided into six groups based on administered treatments,(i) CMC Na 0.3%(OVX-control group),(ii) standard drug(ethynil estradiol 4.5 μg/kg),(iii) P. pellucida juice at dose of 50 mg/kg, and(iv) 100 mg/kg,(v) P. pellucida ethanolic extract at dose of 50 mg/kg, and(vi) 100 mg/kg. Treatments were started 1 week after the surgeries and lasted for 6 weeks. Rats treated with 100 mg/kg P. pellucida ethanol extract had significantly decreased serum ALP level and reduced excretion of urine calcium compared with the OVX-control group(P<0.05). These levels were not significantly altered when compared with the sham-control group(P<0.05). Furthermore, 100 mg/kg ethanolic extract-treated group showed improvement on three-dimensional image of the trabecular bone compared with the OVX-control group. Trabecular cavity formation in 100 mg/kg ethanolic extract-treated group was minimal. Ethanolic extract of Peperomia pellucida(L.) Kunth herbs at a dose of 100 mg/kg had preventive effect on OVX-induced osteoporotic rats.

关键词： Osteoporosis Ovariectomy Peperomia pellucida(L.)Kunth

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Application of organic fertilizer for improving soybean production under acidic stress

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Oil Crop Science 2024年第1期9卷 46-52页

作者： putri Gita Lestari ayu Oshin Yap Sinaga David Septian Sumanto Marpaung Winati Nurhayu Indah Oktaviani Department of Biology Institut Teknologi SumateraJl.Terusan RyacuduWay HuwiKec.Jati AgungLampung SelatanLampung35365Indonesia Department of Biosystems Engineering Institut Teknologi SumateraJl.Terusan RyacuduWay HuwiKec.Jati AgungLampung SelatanLampung35365Indonesia

The presence of acidic soil in rural areas poses difficulties for agricultural *** factor regulating soil pH is the overuse of inorganic *** increased use of fertilizers in soybean production not only raises sustainability concerns but also contributes to soil ***,the use of organic fertilizer could offer a solution for addressing both issues related to soil acidity and *** purpose of this study was to investigate the manipulation of soil pH using organic fertilizer for soybean production under acidic *** planting medium,consisting of a mixture of topsoil,rice husk charcoal,and organic fertilizer(in a ratio of 2:1:1),was supplemented with 0.5 g of NPK fertilizer as a basal treatment in each planting *** regulate the soil acidity to pH 4,we added FeSO_(4) and allowed the mixture to incubate for 30 *** results demonstrate that the application of three types of organic fertilizers chicken manure(P1),oil palm empty bunch fertilizer(P2),and vermicompost(P3)positively impacts the growth of three soybean *** findings indicate that the application of P2 organic fertilizer can increase vegetative growth almost 50%in soybeans on acidic soil,including plant height,leaf count,and root ***,applying P3 organic fertilizer can boost reproductive growth responses in soybeans on acidic soil,such as pod number(from around 0-4 unit to 42-51 unit),grain number(from around 0-5 unit to 88-90 unit),and grain weight(from around 0-0.37 g to 12-25 g).Organic fertilizer has the potential to regulate soil pH,promoting higher yields of soybeans under acidic stress.

关键词： Organic fertilizer Acidic stress Soybean Agriculture production

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Combinational effects of hexane insoluble fraction of Ficus septica *** doxorubicin chemotherapy on T47D breast cancer cells

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Asian Pacific Journal of Tropical Biomedicine 2013年第4期3卷 297-302页

作者： agung Endro Nugroho Adam Hermawan Dyaningtyas Dewi Pamungkas putri Anindya Novika Edy Meiyanto Cancer Chemoprevention Research Center Faculty of PharmacyGadjah Mada UniversityJogjakarta 55281Indonesia Department of Pharmacology and Clinical Pharmacy Faculty of PharmacyGadjah Mada UniversityJogjakarta 55281Indonesia Department of Pharmaceutical Chemistry Faculty of PharmacyGadjah Mada UniversityJogjakarta 55281Indonesia

Objective:To evaluate the effects of n-hexane insoluble fraction(HIF)of Ficus septica leaves in combination with doxorubicin on cytotoxicity,cell cycle and apoptosis induction of breast cancer T47D cell ***:The in vitro drugs-stimulated cytotoxic effects were determined using MTT *** of cell cycle distribution was performed using flowcytometer and the data was analyzed using ModFit LT 3.0 *** assay was earned out by double staining method using ethydium bromide-acridin *** expression of cleaved-poly(ADP-ribose)polymerase(PARP)on T47D cell lines was identified using ***:The combination exhibited higher inhibitory effect on cell growth than the single treatment of doxorubicin in T47D *** addition,combination of doxorubicin and HIF increased the incidence of cells undergoing *** could improve doxorubicin cytotoxic effect by changing the accumulation of cell cycle phase from G_2/M to G_1 *** combination also exhibited upregulation of cleaved-PARP in T47D ***:Based on this results,HIF is potential to be developed as co-chemotherapeutic agent for breast cancer by inducing apoptosis and cell cycle ***,the molecular mechanism need to be explored further.

关键词： Ficus septica Burm.F.,Cancer T47D cells Cytotoxic

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棱果榕乙酸乙酯萃取物和阿霉素化疗对人类乳腺癌细胞T47D的协同效应（英文）

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中西医结合学报 2012年第10期10卷 1162-1170页

作者： agung E.Nugroho Adam Hermawan Dyaningtyas D.P.putri Edy Meiyanto Lukman Hakim Cancer Chemoprevention Research Center Faculty of PharmacyUniversitas Gadjah MadaJogjakarta 55281Indonesia Department of Pharmacology and Clinical Pharmacy Faculty of PharmacyUniversitas Gadjah MadaJogjakarta 55281Indonesia Department of Pharmaceutical Chemistry Faculty of PharmacyUniversitas Gadjah MadaJogjakarta 55281Indonesia

目的:以往研究已证实,棱果榕树叶的乙醇提取物及其乙酸乙酯萃取物(ethyl acetate soluble fraction,EASF)对人类乳腺癌细胞T47D有很强的细胞毒效应。本研究将进一步明确棱果榕树叶乙醇提取物的EASF联合阿霉素对人类乳腺癌T47D细胞系在... 详细信息

目的:以往研究已证实,棱果榕树叶的乙醇提取物及其乙酸乙酯萃取物(ethyl acetate soluble fraction,EASF)对人类乳腺癌细胞T47D有很强的细胞毒效应。本研究将进一步明确棱果榕树叶乙醇提取物的EASF联合阿霉素对人类乳腺癌T47D细胞系在细胞毒性、细胞周期阻滞以及诱导细胞凋亡方面的协同效应。方法:使用溴化噻唑蓝四氮唑比色法分析T47D细胞毒性效应,流式细胞仪进行细胞周期分析,ModFitLT3.0程序进行数据处理;采用溴化乙锭/吖啶橙双染色法检测细胞凋亡;免疫组织化学法识别T47D细胞系的聚ADP-核苷酸聚合酶(poly ADP-ribose polymerase,PARP)的表达。结果:EASF(0.875～7μg/mL)与阿霉素(2～8nmol/L)联合使用比单纯使用阿霉素能更有效地抑制T47D细胞生长。此外,二者联合使用能够增加细胞凋亡的发生率。研究发现,EASF能通过改变细胞从G2/M期至G1期而增强阿霉素的细胞毒效应。并且,二者的结合比单独使用能刺激T47D细胞中裂解性PARP的表达。结论:EASF可以通过诱导细胞凋亡和细胞周期停滞加强T47D细胞中的阿霉素活性。

关键词：榕属植物提取物乳腺肿瘤细胞系,肿瘤药物疗法,联合细胞凋亡

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Effect of probiotic Lactobacillus plantarum Dad-13 powder consumption on the gut microbiota and intestinal health of overweight adults

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World Journal of Gastroenterology 2021年第38期27卷 107-128页

作者： Endang Sutriswati Rahayu Mariyatun Mariyatun Nancy Eka putri Manurung Pratama Nur Hasan Phatthanaphong Therdtatha Riko Mishima Husnita Komalasari Nurul Ain Mahfuzah Fathyah Hanum Pamungkaningtyas Wahyu Krisna Yoga Dina Aulia Nurfiana Stefanie Yolanda Liwan Mohammad Juffrie agung Endro Nugroho Tyas Utami Department of Food and Agricultural Technology Faculty of Agricultural TechnologyUniversitas Gadjah MadaYogyakarta 55281Indonesia Center for Food and Nutrition Studies Universitas Gadjah MadaYogyakarta 55281Indonesia Department of Bioscience and Biotechnology Faculty of AgricultureKyushu University774 MotookaNishi-kuFukuokaJapan Department of Public Health Faculty of MedicinePublic Health and NurseryUniversitas Gadjah MadaYogyakarta 55281Indonesia Department of Pharmacology and Clinical Pharmacy Faculty of PharmacyUniversitas Gadjah MadaYogyakarta 55281Indonesia

BACKGROUND Shifting on lifestyle,diet,and physical activity contributed on increasing number of obese people around the *** factors influence the development of *** research suggested that gut microbiota(GM)plays an important role in nutrient absorption and energy regulation of individuals,thus affecting their nutritional *** of Indonesia Basic Health Research showed that the prevalence of obesity in every province tended to *** the root cause of obesity is excessive calorie intake compared with expenditure,the differences in gut microbial ecology between healthy and obese humans may affect energy *** affect body weight,especially *** that are consumed while alive and able to colonize in the intestine are expected to increase the population of good bacteria,especially Bifidobacteria and Lactobacilli,and suppress pathogens such as Enterobacteriaceae and *** strain of *** Dad-13 has been demonstrated to survive and colonize in the gastrointestinal tract of healthy Indonesian adults who consume fermented milk containing *** *** consumption of probiotic *** Dad-13 powder decreased *** and *** coliform bacteria in school-aged children in *** is a dominant bacterium in the average Indonesian’s *** this reason,this bacterium is probably a more suitable probiotic for *** To determine the effect of the consumption of indigenous probiotic Lactobacillus plantarum Dad-13 powder in overweight adults in Yogyakarta(Indonesia).METHODS Sixty overweight volunteers with a body mass index(BMI)equal to or greater than 25 consume indigenous probiotic powder *** Dad-13(2×109 CFU/gram/sachet)for 90 *** study was a randomized,double-blind,placebocontrolled *** volunteers filled in a diary on a daily basis,which consisted of questions on study product intake(only during ingestion period),other food intake,number of bowe

关键词： Obesity Body mass index Lipid profile Gut microbiota Short chain fatty acid Probiotic Lactobacillus plantarum Dad-13

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