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Advances in oral mesenchymal stem cell-derived extracellular vesicles in health and disease

Genes & Diseases 2024年第1期11卷 346-357页

作者： Huanyu Luo anahid.ahmad. birjand. Feilong Ren Tianmeng Sun Paul T.Sharpe Hongchen Sun Zhengwen An Department of Oral Biology Jilin Provincial Key Laboratory of Tooth Development and Bone RemodelingSchool and Hospital of StomatologyJilin UniversityChangchunJilin 130021China Faculty of Dentistry Oral&Craniofacial SciencesCentre for Craniofacial and Regenerative BiologyKing's College LondonLondonSE19RTUK Department of Oral Pathology Jilin Provincial Key Laboratory of Tooth Development and Bone RemodelingSchool and Hospital of StomatologyJilin UniversityChangchunJilin 130021China

Extracellular vesicles(EVs)are nano-size vesicles secreted naturally by all cells into the extracellular space and have been recognized as important cell-cell mediators in multicel-lular *** contain nucleic acids,proteins,lipids,and other cellular components,regulating many basic biological processes and playing an important role in regenerative med-icine and *** can be traced to their cells of origin and exhibit a similar ***,EVs demonstrate low immunogenicity,good biocompatibility,and fewer side ef-fects,compared to their parent *** stem cells(MsCs)are one of the most important resource cells for EVs,with a great capacity for self-renewal and multipotent differ-entiation,and play an essential role in stem cell *** mechanism of MsC therapy was thought to be attributed to the differentiation of MsCs after targeted migration,as previously ***,emerging evidence shows the previously unknown role of MsC-derived para-crine factors in stem cell *** EVs derived from oral tissue MSCs(OMSC-EVs),show more advantages than those of all other MsCs in tissue repair and regeneration,due to their lower invasiveness and easier accessibility for sample ***,we systematically review the biogenesis and biological characteristics of OMSC-EVs,as well as the role of OMsC-EVs in intercellular ***,we discuss the potential therapeutic roles of OMSC-EVs in oral and systemic *** highlight the current challenges and future directions of OMSC-EVs to focus more attention on clinical *** aim to provide valuable insights for the explorative clinical application of OMSC-EVs.

关键词： Disease Extracellular vesicles Oral tissue MSC Therapeutic application Tissue regeneration

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Quality assessment of OpenStreetMap data using trajectory mining

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Geo-Spatial Information Science 2016年第1期19卷 56-68页

作者： anahid Basiri Mike Jackson Pouria Amirian Amir Pourabdollah Monika Sester Adam Winstanley Terry Moore Lijuan Zhang The Nottingham Geospatial Institute The University of NottinghamNottinghamUK Ordnance Survey SouthamptonUK The School of Computer Science The University of NottinghamNottinghamUK Institute of Cartography and Geoinformatics(IKG) Leibniz UniversitätHannoverGermany e Department of Computer Science Maynooth UniversityMaynoothIreland Faculty of Civil and Environmental Engineering The Technion-Israel Institute of TechnologyHaifaIsrael

OpenStreetMap(OSM)data are widely used but their reliability is still *** contributors to OSM have not been trained in geography or surveying and consequently their contributions,including geometry and attribute data inserts,deletions,and updates,can be inaccurate,incomplete,inconsistent,or *** are some mechanisms and applications dedicated to discovering bugs and errors in OSM *** systems can remove errors through user-checks and applying predefined rules but they need an extra control process to check the real-world validity of suspected errors and *** paper focuses on finding bugs and errors based on patterns and rules extracted from the tracking data of *** underlying idea is that certain characteristics of user trajectories are directly linked to the type of *** such rules,some sets of potential bugs and errors can be identified and stored for further investigations.

关键词： Spatial data quality OpenStreetMap(OSM) trajectory data mining

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