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Ethanol exposed maturing rat cerebellar granule cells show impaired energy metabolism and increased cell death after oxygen-glucose deprivation

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Neural Regeneration Research 2019年第3期14卷 485-490页

作者： ana Spataru Diana Le Duc Leon zagrean ana-maria zagrean Division of Physiology and Neuroscience Carol Davila University of Medicine and Pharmacy King's College Hospital London UK Institute of Human Genetics University of Leipzig Hospitals and Clinics Leipzig GermanyDepartment of Evolutionary Genetics Max Planck Institute for Evolutionary Anthropology

Alcohol, a widely abused drug, has deleterious effects on the immature nervous system. This study investigates the effect of chronic in vitro ethanol exposure on the metabolism of immature rat cerebellar granular cells(CGCs) and on their response to oxygen-glucose deprivation(OGD). Primary CGC cultures were exposed to ethanol(100 mM in culture medium) or to control ethanol-free medium starting day one in vitro(DIV1). At DIV8, the expression of ATP synthase gene ATP5 g3 was quantified using real-time PCR, then cultures were exposed to 3 hours of OGD or normoxic conditions. Subsequently, cellular metabolism was assessed by a resazurin assay and by ATP level measurement. ATP5 g3 expression was reduced by 12-fold(P = 0.03) and resazurin metabolism and ATP level were decreased to 74.4 ± 4.6% and 55.5 ± 6.9%, respectively after chronic ethanol treatment compared to control values(P < 0.01). Additionally, after OGD exposure of ethanol-treated cultures, resazurin metabolism and ATP level were decreased to 12.7 ± 1.0% and 9.0 ± 2.0% from control values(P < 0.01). These results suggest that chronic ethanol exposure reduces the cellular ATP level, possibly through a gene expression down-regulation mechanism, and increases the vulnerability to oxygen-glucose deprivation. Thus, interventions which improve metabolic function and sustain ATP-levels could attenuate ethanol-induced neuronal dysfunction and should be addressed in future studies.

关键词： cell culture chronic ethanol exposure oxygen-glucose deprivation cerebellar granule cells toxicity gene expression cellular ATP cellular metabolism metabolic impairment cell death

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Treatment of spinal cord injury with biomaterials and stem cell therapy in non-human primates and humans

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Neural Regeneration Research 2025年第2期20卷 343-353页

作者： ana Milena Silva Olaya Fernanda Martins Almeida ana maria Blanco Martinez Suelen Adriani Marques PhD Program in Pathological anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Biomedical Science Institute Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological anatomy(PPGAP/UFRJ) Department of Neurobiology/Institute of BiologyCampus do GragoatáNiteróiRio de JaneiroBrazil

Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical ***,in the search for more effective treatments than those already applied for years,which are not entirely efficient,researches have been able to demonstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord *** of these strategies has been developed and meticulously evaluated in several animal models with the aim of analyzing the potential of interventions for neuronal repair and,consequently,boosting functional *** the majority of experimental research has been conducted in rodents,there is increasing recognition of the importance,and need,of evaluating the safety and efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in *** article is a literature review from databases(PubMed,Science Direct,Elsevier,Scielo,Redalyc,Cochrane,and NCBI)from 10 years ago to date,using keywords(spinal cord injury,cell therapy,non-human primates,humans,and bioengineering in spinal cord injury).From 110 retrieved articles,after two selection rounds based on inclusion and exclusion criteria,21 articles were ***,this review arises from the need to recognize the experimental therapeutic advances applied in non-human primates and even humans,aimed at deepening these strategies and identifying the advantages and influence of the results on extrapolation for clinical applicability in humans.

关键词： bioengineering biomaterials cell therapy humans non-human primates spinal cord injury stem cell therapy

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Oxygen-evolving SnO_(2)-based Ceramic Anodes in Aluminium Electrolysis

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Chemical Research in Chinese Universities 2014年第5期30卷 800-805页

作者： POPESCU ana-maria Ilie Murgulescu Institute of Physical Chemistry of the Romanian Academy 060021-Bucharest Romania

This study deals with SnO2-based ceramic anodes doped with Sb203 and CuO, aiming at contributing new data regarding their electrochemical behavior in cryolite melts. The performances of the anodes were evaluated by anodic polarization, cyclic voltammetry, and current efficiency and corrosion measurements. The investigation proves that the anodic process of SnO2-based inert anodes occurs at a low overvoltage and the oxygen discharge takes place in one step with an exchange of two electrons. The current efficiency and corrosion were proved to be dependent on the electrolysis parameters and composition of electrolysis bath. For a long term electrolysis, the dissolution of the anode in the cryolite-alumina melt produced small aluminium contamination（ca. 0.2%, mass fraction）.

关键词： Inert anode Aluminium electrolysis Polarization Voltammetry

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Perspective on automated in vivo drug screening using the chodl mutant zebrafish line

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Neural Regeneration Research 2022年第11期17卷 2437-2438页

作者： ana-maria Oprisoreanu Center for Regenerative Therapies Dresden(CRTD) TU Dresden

Since the early 2000s, the popularity of zebrafish in in vivo drug screening has shown a substantial *** zebrafish has become an important screening tool covering a wide range of tissue-specific pathologies and diseas... 详细信息

关键词： fish vivo screening

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Synthetic gauge fields for ultracold atoms

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National Science Review 2016年第2期3卷 166-167页

作者： ana maria Rey JILA NIST and Department of PhysicsUniversity of Colorado

Ultracold gases are remarkably versatile and controllable systems with untapped potential to emulate a variety of quantum phenomena[1].Atoms are,however,electrically neutral and therefore it is highly desirable to make them behave as charged *** capability has recently been demonstrated in a series of recent experiments[2-4].Although many challenges remain ahead,

关键词： Synthetic gauge fields for ultracold atoms

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Insights on Chemical and Natech Risk Management in Japan and South Korea:A Review of Current Practices

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International Journal of Disaster Risk Science 2022年第3期13卷 359-371页

作者： Hyejeong Park ana maria Cruz Disaster Prevention Research Institute Kyoto UniversityKyoto611-0011Japan

A growing number of natural hazard-triggered technological accidents(Natech)has been reported by several researchers,and this trend is expected to continue due to climate *** a result,some governments have initiated direct efforts to manage Natech risks,particularly in the United States and ***,two surveys conducted by the Organisation for Economic Co-operation and Development(OECD)in 2009 and 2017 found that there was a lack of proper risk management and risk governance for Natech among OECD member states,including Japan and South *** study aimed to identify relevant regulations and practical considerations for chemical and Natech risk management from government perspectives in Japan and South *** article provides a review of the current state of risk management,emergency response,and risk communication on chemical and Natech risk management in the two countries,and concludes with a discussion of some of the issues that require improvement of the current chemical risk *** practices for chemical risk management in Japan and South Korea point to the possibility of improvements in dealing with the Natech *** practical lessons will be valuable for improving the capacity for dealing with challenges in chemical and Natech risk management.

关键词： Chemical accidents Government perspectives Japan Natech Risk governance Risk management South Korea

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Structure and heat capacity of the NaCeF_4 compound

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Journal of Rare Earths 2013年第9期31卷 911-915页

作者： Virgil Constantin ana-maria Popescu "Ilie Murgulescu" Institute of Physical Chemistry of the Romanian Academy Splaiul Independentei 202 st.060021BucharestRomania

This work continued our general research program on obtaining metallic cerium by electrodeposition from NaCeF4 dis-solved in different molten fluorides. The structure of NaCeF4 （cubic or hexagonal depending on the way of preparation） was estab-lished by DTA analysis, IR spectra and X-ray diffraction. The heat capacity （Cp） of NaCeF4 was measured by differential scanning calorimetry in the temperature range of 300-1093 K using the“step-method”. The Cp was fitted by an equation with a satisfactory re-sult. Heat capacity was compared with that calculated from the Neumann-Kopp rule （NKR） and the deviations observed were consis-tent with the stability of the NaCeF4 compound.

关键词： cerium compounds structure heat capacity NaCeF4 rare earths

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Current Efficiency, Corrosion and Structural Changes in SnO2-Sb2O3-CuO Inert Anodes for Aluminium Electrolysis

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Chinese Journal of Chemical Physics 2014年第3期27卷 368-372页

作者： ana-maria Popescu Virgil Constantin Ilie Mur&ulescu Institute of Physical Chemistry of the Romanian Academy Splaiul Independentei 202060021 Bucharest Romania

A systematic study was conducted on current efficiency （CE）, corrosion and structural changes in SnO2-based inert anodes （made of 96wt%SnO2＋2wt%Sb2O3＋2wt%CuO） on a laboratory Hall-Heroult aluminium cell. The influence of operating parameters and electrolyte composition on the CE and corrosion process were evaluated. The CE was found to be more than 90% and catastrophic corrosion took place at low percent of Al2O3, high percent of LiF, low cryolite ratio and high current densities. From all the structural changes that took place in the SnO2-based inert anodes, we assumed that the most important contribution was due to the migration of CuO towards the outer limits of the constituent grains of SnO2 based ceramic. The complex process occurred during the formation of various phases and their sintering ability both directly depended on Cu/Sb molar ratio.

关键词： Inert anode Aluminium electrowinning Current efficiency

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Synthesis, Characterization and Thermophysical Properties of Three Neoteric Solvents-Ionic Liquids Based on Choline Chloride

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Chemical Research in Chinese Universities 2014年第1期30卷 119-124页

作者： POPESCU ana-maria CONSTANTIN Virgil Laboratory of Molten Salts llie Murgulescu Institute of Physical Chemistry of the Romanian Academy Bucharest 006021 Romania

The authors prepared,characterized and preliminary studied the properties of some neoteric solvents-ionic liquids based on choline chloride,i.e.,three ionic liquids based on the eutectics of choline chloride（2-hydroxyN,N,N-trimethylethanaminium chloride） with,respectively,urea,malonic acid and citric *** obtained mixtures were clear and colorless ionic liquids at room *** thermophysical properties,namely,density,viscosity,and electrical conductivity of these mixtures were investigated as a function of temperature within a range of 298-353 *** for the temperature dependence of the measured properties were generated and discussed in terms of Arrhenius *** the electrochemical windows of the eutectic liquids were determined.

关键词： Neoteric solvent Ionic liquid Choline chloride Malonic acid Citric acid Density Viscosity Conductivity

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Electrochemical studies on cerium(Ⅲ) in molten fluoride mixtures

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Journal of Rare Earths 2010年第3期28卷 428-434页

作者： VIRGIL CONSTANTIN ana-maria POPESCU MIRCEA OLTEANU Romanian Academy Institute of Physical Chemistry "Ilie Murgulescu"Department of Molten Salts Splaiul Independentei 202Bucharest-Romania

This study aims to determine the principal electrochemical characteristics of the electrodeposition of cerium metal from molten fluoride *** cathodic process of Ce3+ ions in LiF-NaF and LiF-NaF-CaF2 molten salts was studied using electrochemical techniques as steady state and cyclic voltammetry *** decomposition potential(Ed) and the overvoltage(η) were determined for NaCeF4 using current-potential curves under galvanostatic *** Ed was found to be 2.025 V in LiF-NaF and 2.045 V in...

关键词： cerium molten salts lanthanides NaCeF4 electrolysis cyclic voltammetry

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