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Outcomes of long-acting injectable antipsychotics use in pregnancy:A literature review

World Journal of Psychiatry 2024年第4期14卷 582-599页

作者： ana v.pejčić Srdjan M Stefanović MilošN Milosavljević vladimir S Janjić Marko M Folić Nevena D Folić Jovana Z Milosavljević Department of Pharmacology and Toxicology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Pharmacy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Clinical Pharmacology University Clinical Center KragujevacKragujevac 34000Serbia Department of Psychiatry Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Clinic for Psychiatry University Clinical Center KragujevacKragujevac 34000Serbia Center for Pharmaceutical and Pharmacological Research Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Pediatrics Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Pediatric Clinic University Clinical Center KragujevacKragujevac 34000Serbia Department of anatomy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

BACKGROUND Women with a history of serious psychotic disorders are at increased risk of disease relapse during ***-acting injectable(LAi)antipsychotics have been widely used to improve adherence and prevent relapse in patients with various severe psychotic disorders,but there is a lack of high-quality data from previous research on the safety of LAi antipsychotics during *** To summarize relevant data on maternal,pregnancy,neonatal,and developmental outcomes from published cases of LAi antipsychotic use in *** A literature search was performed through November 11,2023,using three online databases:PubMed/MEDLiNE,Scopus,and Web of *** reports or case series that reported information about the outcomes of pregnancy in women who used LAi antipsychotics at any point in pregnancy,with available full texts,were *** statistics,narrative summation,and tabulation of the extracted data were *** A total of 19 publications satisfied the inclusion criteria:3 case series,15 case reports,and 1 conference *** reported the outcomes of LAi antipsychotic use in 74 women and 77 *** use of secondgeneration LAi antipsychotics was reported in the majority(n=47;61.0%)of ***-generation LAi antipsychotics were administered during 30 pregnancies(39.0%).Most of the women(approximately 64%)had either satisfactory control of symptoms or no information about relapse,while approximately 12%of them had developed gestational diabetes mellitus.A minority of cases reported adverse outcomes such as stillbirth,spontaneous abortion,preterm birth,low birth weight,congenital anomalies,and neurological manifestations in ***,there were no reports of negative long-term developmental *** Currently available data seem reassuring,but further well-designed studies are required to properly evaluate the risks and benefits of LAi antipsychotic use during pregnancy.

关键词： Antipsychotic agents Long-acting injectable Pregnancy Outcome Review

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Anomalies in the short-range local environment and atomic diffusion in single crystalline equiatomic CrMnFeCoNi highentropy alloy

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Nano Research 2024年第6期17卷 5336-5348页

作者： Alevtina Smekhova Daniel Gaertner Alexei Kuzmin ana Guilherme Buzanich Goetz Schuck ivo Zizak Gerhard Wilde Kirill v.Yusenko Sergiy Divinski Helmholtz-Zentrum Berlin für Materialien und Energie(HZB) D-12489 BerlinGermany institute of Materials Physics University of MünsterD-48149 MünsterGermany institute of Solid State Physics University of LatviaLV-1063 RigaLatvia Bundesanstalt für Materialforschung und–prüfung(BAM) D-12489 BerlinGermany

Multi-edge extended X-ray absorption fine structure(EXAFS)spectroscopy combined with reverse Monte Carlo(RMC)simulations was used to probe the details of element-specific local coordinations and component-dependent structure relaxations in single crystalline equiatomic CrMnFeCoNi high-entropy alloy as a function of the annealing *** representative states,namely a high-temperature state,created by annealing at 1373 K,and a low-temperature state,produced by long-term annealing at 993 K,were compared in *** features identified in atomic configurations of particular principal components indicate variations in the local environment distortions connected to different degrees of compositional disorder at the chosen representative *** detected changes provide new atomistic insights and correlate with the existence of kinks previously observed in the Arrhenius dependencies of component diffusion rates in the CrMnFeCoNi high-entropy alloy.

关键词： high-entropy alloys diffusion short-range order extended X-ray absorption fine structure(EXAFS) reverse Monte Carlo

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Thermal properties and high-temperature ablation of high-entropy (Ti_(0.25)v_(0.25)Zr_(0.25)Hf_(0.25))B_(2) coating on graphite substrate

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Journal of Advanced Ceramics 2024年第8期13卷 1268-1281页

作者： ana C.Feltrin Daniel Hedman Farid Akhtar Division of Materials Science Lulea University of TechnologyLulea 97187Sweden Center for Multidimensional Carbon Materials(CMCM) Institute for Basic Science(IBS)Ulsan 44919Republic of Korea

An entropy-stabilized multicomponent ultrahigh-temperature ceramic(UHTC)coating,(Ti_(0.25)v_(0.25)Zr_(0.25)Hf_(0.25))B_(2),on a graphite substrate was in-situ sintered by spark plasma sintering(SPs)from constituent transition metal diboride ***(Ti_(0.25)v_(0.25)Zr_(0.25)Hf_(0.25))B_(2) coating had a hardness of 31.2±2.1 GPa and resisted 36.9 GPa of stress before delamination,as observed at the *** temperature-dependent thermal properties of the multicomponent diboride(Ti_(0.25)v_(0.25)Zr_(0.25)Hf_(0.25))B_(2) were obtained by molecular dynamics(MD)simulations driven by a machine learning force field(MLFF)trained on density functional theory(DFT)*** thermal conductivity,density,heat capacity,and coefficient of thermal expansion obtained by the MD simulations were used in time-dependent thermal stress finite element model(FEM)*** low thermal conductivity(icomponent diboride coupled with its similar coefficient of thermal expansion to that of graphite indicated that stresses of less than 10 GPa were generated at the interface at high temperatures,and therefore,the coating was mechanically resistant to the thermal stress induced during *** experiments at 220℃ showed that the multicomponent diboride coating was resistant to thermal stresses with no visible cracking or *** ablation mechanisms were mechanical denudation and evaporation of B_(2)O_(5) and light v-Ti oxides,which caused a decrease in the mass and thickness of the coating and resulted in mass and linear ablation rates of-0.51 mg·s^(-1) and -1.38μm·s^(-1),respectively,after 60 *** findings demonstrated the thermal and mechanical stability of multicomponent entropy-stabilized diborides as coatings for carbon materials in engineering components under extreme environments.

关键词： entropy-stabilized diborides ultrahigh temperature ceramics molecular dynamics(MD)simulations density functional theory(DFT) ablation properties

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Synthesis and applications of lanthanoid complexes of pentadentate and hexadentate N_(5) and N_(6) macrocycles:A review

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Journal of Rare Earths 2024年第1期42卷 1-15,I0001页

作者： Julio Corredoira-vázquez Cristina González-Barreira Paula Oreiro-Martínez ana M.García-Deibe Jesús Sanmartín-Matalobos Matilde Fondo Departamento de Química inorganica Facultade de QuímicaUniversidade de Santiago de CompostelaCampus Vida15782Santiago de CompostelaSpain Phantom-g CICECO-Aveiro Institute of MaterialsDepartment of PhysicsUniversity of Aveiro3810-193AveiroPortugal institute of Materials(iMATUS) Universidade de Santiago de Compostela15782Santiago de CompostelaSpain

in this paper,the lanthanoid complexes of N_(5) and N_(6) macrocycle ligands,without pendant arms or additional heteroatoms,are *** review covers the period from 2015 to the current date,since in 2014 Schiff base macrocyclic ligands incorporating the pyridine moiety,and their complexes,were revised,and in 2015 the chemistry of pentaaza macrocycle ligands with rare earth metals was also *** and phthalocyanine ligands are not included in this review,which primarily focuses on complexes with Schiff bases and amines without pendant arms or any additional donor other than *** synthetic methods,structural characterization,based on single X-ray crystal data,and properties of the lanthanoid complexes,with special attention to magneto-structural correlations,are presented herein.

关键词： Lanthanoid N_(5),N_(6)macrocycle Coordination chemistry Chirality Biological activity Molecule magnet

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Effect of operational parameters on the performance of an anaerobic sequencing batch reactor(AnSBR)treating protein-rich wastewater

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Environmental Science and Ecotechnology 2024年第1期17卷 89-99页

作者： Zhe Deng Julian Muñoz Sierra ana Lucia Morgado Ferreira Daniel Cerqueda-Garcia Henri Spanjers Jules B.van Lier Delft University of Technology Faculty of Civil Engineering and GeosciencesStevinweg 12628 CNDelftthe Netherlands veolia Water Technologies Techno Center Netherlands B.v.-Biothane Tanthofdreef 212623 EWDelftthe Netherlands KWR Water Research institute Groningenhaven 7P.O.Box 10723430 BBNieuwegeinthe Netherlands institute of Ecology.A.C Cluster Cientifico y Tecnologico BioMimic®Carretera Antigua a Coatepec 351El Haya91073XalapaVeracruzMexico

Treating protein-rich wastewater using cost-effective and simple-structured single-stage reactors presents several *** this study,we applied an anaerobic sequencing batch reactor(AnSBR)to treat protein-rich wastewater from a *** focused on identifying the key factors influencing the removal of chemical oxygen demand(COD)and the settling performance of the *** AnSBR achieved a maximum total COD removal of 90%,a protein degradation efficiency exceeding 80%,and a COD to methane conversion efficiency of over 70%at organic loading rates of up to 6.2 g COD L^(-1)d^(-1).We found that the variations in both the organic loading rate within the reactor and the hydraulic retention time in the buffer tank had a significant effect on COD *** hydraulic retention time in the buffer tank and the reactor,which determined the ammonification efficiencies and the residual carbohydrate concentrations in the reactor liquid,affected the sludge ***,the genus Clostridium sensu stricto 1,known as protein-and lipids-degraders,was predominant in the *** analysis showed a significant correlation between the core microbiome and ammonification efficiency,highlighting the importance of protein degradation as the governing process in the *** results will provide valuable insights to optimise the design and operation of AnSBR for efficient treatment of protein-rich wastewater.

关键词： anaerobic digestion anaerobic sequencing batch reactor (AnSBR) Protein Microbial community Slaughterhouse wastewater

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impacts of Pi3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-Núñez María Fernanda González ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(Pi3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the Pi3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/Pi3K/AKT/connexin 43,and Notch/Pi3K/AKT *** targeting the inactivation of the Pi3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the Pi3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

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Laser processing effects on Ti−45Nb alloy surface,corrosive and biocompatible properties

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Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2533-2551页

作者： i.CviJOviĆ-ALAGiĆ S.LAKETiĆ M.MOMČiLOviĆ J.CiGANOviĆ Đ.vELJOviĆ J.BAJAT v.KOJiĆ M.RAKiN vinča institute of Nuclear Sciences-National institute of the Republic of Serbia University of BelgradeP.O.Box 52211001 BelgradeSerbia Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Oncology institute of vojvodina Faculty of MedicineUniversity of Novi SadPut Dr Goldmana 421204 Sremska KamenicaSerbia

The Ti−45Nb(wt.%)alloy properties were investigated in relation to its potential biomedical *** surface modification was utilized to improve its performance in biological *** a result of the laser treatment,(Ti,Nb)O scale was formed and various morphological features appeared on the alloy *** electrochemical behavior of Ti−45Nb alloy in simulated body conditions was evaluated and showed that the alloy was highly resistant to corrosion deterioration regardless of additional laser surface modification ***,the improved corrosion resistance after laser treatment was evident(the corrosion current density of the alloy before laser irradiation was 2.84×10^(−8)A/cm^(2),while that after laser treatment with 5 mJ was 0.65×10^(−8)A/cm^(2))and ascribed to the rapid formation of a complex and passivating bi-modal surface oxide *** cytotoxicity and effects of the Ti−45Nb alloy laser surface modification on the MRC-5 cell viability,morphology,and proliferation were also *** Ti−45Nb alloy showed no cytotoxic ***,cells showed improved viability and adherence to the alloy surface after the laser irradiation *** highest average cell viability of 115.37%was attained for the alloy laser-irradiated with 15 *** showed that the laser surface modification can be successfully utilized to significantly improve alloy performance in a biological environment.

关键词： Ti−45Nb alloy laser surface scanning electrochemical properties biocompatibility cell morphology

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Study of the Conversion of Postconsumer Polystyrene on CeO₂/HZSM-5 Type Materials

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Journal of Materials Science and Chemical Engineering 2024年第4期12卷 29-41页

作者： Mirna Oliveira Sant’ana Anne Michelle Garrido Pedrosa Marcelo José Barros de Souza Graduate Program in Chemical Engineering at UFS Federal University of Sergipe (UFS) S&#227o Crist&#243v&#227o Brazil Department of Chemistry Federal University of Sergipe S&#227o Crist&#243v&#227o Brazil

The catalytic conversion of polystyrene (PS) was studied in the presence of the materials type HZSM-5, CeO2, 10% CeO2/HZSM-5 and 20% CeO2/HZSM-5, which were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and nitrogen adsorption at 77K. The catalytic tests were performed via thermogravimetric analysis (TG) at heating rates of 5, 10 and 20˚C min−1 in a temperature range from 30˚C to 900˚C. For the tests, a ratio of 30% by mass of each catalytic material mixed with PS was used and the activation energy of the degradation process was determined by the vyazovkin method. The obtained results showed that the addition of the catalyst to the PS in general reduced its degradation temperature. The 10% CeO2/HZSM-5 catalyst showed greater efficiency, as it resulted in lower activation energy for PS degradation. Thus, the combination of CeO2 with HZSM-5 resulted in materials with potential for application in the catalytic degradation of polystyrene and the results indicate that the production of a composite material can be a good strategy to generate an increase in catalytic activity and a decrease in energy process activation.

关键词： HZSM-5 Zeolite Cerium Oxide Polystyrene Pyrolysis

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vanadium mineralization at Los Chihuidos sediment-hosted Cu-v deposit,Neuquén Basin,Argentina:An approach to vanadium ore forming processes

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Geoscience Frontiers 2024年第1期15卷 225-246页

作者： ana L.Rainoldi Daniel Beaufort Marta B.Franchini Adolfo Giusiano Sabine Petit Patricia Patrier M.Josefina Pons Dpto.de Geología Universidad Nacional del Sur(UNS)8000 Bahía BlancaArgentina Consejo Nacional de investigaciones Científicas y Técnicas Centro Patagónico de Estudios MetalogenéticosArgentina Universitéde Poitiers IC2MPCNRS-UMR 7285HydrasaF-86022 Poitiers CedexFrance Universidad Nacional del Comahue Facultad de IngenieríaDepartamento de Geología y Petróleo8300 NeuquénArgentina Consultant Geologist 8300 NeuquénArgentina Universidad Nacional de Río Negro Instituto de Investigación en Paleobiología y GeologíaRío NegroArgentina

vanadium mineralization at Los Chihuidos deposit of the Neuquén Basin is linked to the development of a redox front system related to the inflow of hydrocarbons into the red sandstone of the Huincul *** of hydrocarbons with oxidized red beds and connate water generated redox reactions where hematite was dissolved due to iron reduction resulting in the discoloration of the red *** the contact between oxidized red sandstone and reduced white sandstone,precipitation of specific mineral phases resulted in the v ore with minor amounts of *** the implementation of the redox interface,abundant v-montmorillonite and v-hematite precipitated at the more oxidizing conditions and Cu-v-corrensite-type at the more reducing conditions of the redox *** the redox front advanced with fluids constantly migrating into the reservoir,more reducing conditions were stablished,promoting chloritization and minor illitization with v-Cu incorporation and continuous upgrading of the *** ore mineralogy consists of clay minerals including v-bearing montmorillonite,Cu-v-corrensite-type,v-di-trioctahedral chlorite and Cu-tri-trioctahedral chlorite with minor v-illite-smectite mixed-layer minerals and associated secondary *** over illitization was favored due to high amounts of Fe and Mg in detrital clasts and in connate fluids and by low K availability related to low amounts of detrital *** spatial transition of v and/or Cu bearing clay minerals observed through the mineralized redox front at Los Chihuidos deposit(kaolinite→smectite→illite/smectite→corrensite-type→di-trioctahedral-chlorite→tri-trioctahedral-chlorite)and the related variation of v-Cu concentrations in bulk rock are indicative of increasing pH and decreasing Eh of resident solutions from red to white sandstones during the hypogene mineralization *** influx of Cu-rich oxidized basinal brines precipitated main copper ore with Cu-sulfides in the white sandst

关键词： Clay minerals v-chlorite Redox front Bleaching Hydrocarbons

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in silico prospective analysis of the medicinal plants activity on the CagA oncoprotein from Helicobacter pylori

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World Journal of Clinical Oncology 2024年第5期15卷 653-663页

作者： Rafaela viana vieira Gabrielle Caroline Peiter Fabrício Freire de Melo ana Carla Zarpelon-Schutz Kádima Nayara Teixeira Universidade Federal do Paraná Campus ToledoToledo 85919-899Brazil Universidade Tecnológica Federal do Paraná Campus ToledoParaná85902-490Brazil Universidade Federal da Bahia Instituto Multidisciplinar em Saúde-Campus Anísio TeixeiraVitória da Conquista 45029-094Brazil Universidade Federal do Paraná-Setor Palotina Programa de Pós-graduação em BiotecnologiaPalotina 85950-000Brazil

BACKGROUND Colonization with Helicobacter pylori(***)has a strong correlation with gastric cancer,and the virulence factor CagA is implicated in *** have been conducted using medicinal plants with the aim of eliminating the pathogen;however,the possibility of blocking ***-induced cell differentiation to prevent the onset and/or progression of tumors has not been *** type of study is expensive and time-consuming,requiring in vitro and/or in vivo tests,which can be solved using ***,prospective computational analyses were conducted to assess the feasibility of interaction between phenolic compounds from medicinal plants and the CagA *** To perform a computational prospecting of the interactions between phenolic compounds from medicinal plants and the CagA oncoprotein of *** in this in silico study,the structures of the phenolic compounds(ligands)kaempferol,myricetin,quercetin,ponciretin(flavonoids),and chlorogenic acid(phenolic acid)were selected from the PubChem *** phenolic compounds were chosen based on previous studies that suggested medicinal plants as non-drug treatments to eliminate *** *** three-dimensional structure model of the CagA oncoprotein of ***(receptor)was obtained through molecular modeling using computational tools from the i-Tasser platform,employing the threading *** primary sequence of CagA was sourced from GenBank(BAK52797.1).A screening was conducted to identify binding sites in the structure of the CagA oncoprotein that could potentially interact with the ligands,utilizing the GRaSP online *** the ligands and receptor were prepared for molecular docking using AutoDock Tools 4(ADT)software,and the simulations were carried out using a combination of ADT and AutoDock vina v.1.2.0 *** sets of simulations were performed:One involving the central region of CagA with phenolic compounds,and another involvi

关键词： CagA oncoprotein Phenolic compounds Helicobacter pylori in silico analyses Medicinal plants Prospective analysis

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