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Design multifunctional Mg–Zr coatings regulating Mg alloy bioabsorption

Journal of Magnesium and Alloys 2024年第4期12卷 1461-1478页

作者： Zohra Benzarti Sandesh Itani JoséDavid Castro Sandra Carvalho ana Sofia ramos University of Coimbra CEMMPREARISEDepartment of Mechanical EngineeringRua Luís Reis Santos3030-788CoimbraPortugal Laboratory of Multifunctional Materials and Applications(LaMMA) Department of PhysicsFaculty of Sciences of SfaxUniversity of SfaxSoukra Road km 3.5B.P.1171Sfax3000Tunisia

Magnesium(Mg)alloys are widely used for temporary bone implants due to their favorable biodegradability,cytocompatibility,hemocompatibility,and close mechanical properties to ***,rapid degradation and inadequate strength limit their *** overcome this,the direct current magnetron sputtering technique is employed for surface coating in Mg-based alloys using various zirconium(Zr)*** approach presents a promising strategy for simultaneously improving corrosion resistance,maintaining biocompatibility,and enhancing strength without compromising *** leveraging Mg’s inherent biodegradability,it has the potential to minimize the need for secondary surgeries,thereby reducing costs and *** paper is a systematic study aimed at understanding the corrosion mechanisms of Mg–Zr coatings,denoted Mg-xZr(x=0–5 at.%).Zr-doped coatings exhibited columnar growth leading to denser and refined structures with increasing Zr *** analysis confirmed the presence of the Mg(00.2)basal plane,shifting towards higher angles(1.15°)with 5 at.%Zr doping due to lattice parameter changes(i.e.,decrease and increase of“c”and“a”lattice parameters,respectively).Mg–Zr coatings exhibited“liquidphilic”behavior,while Young’s modulus retained a steady value around 80 GPa across all ***,the hardness has significantly improved across all samples’coating,reaching the highest value of(2.2±0.3)GPa for 5 at.%*** testing in simulated body fluid(SBF)at 37℃ revealed a significant enhancement in corrosion resistance for Mg–Zr coatings containing 1.0–3.4 at.%*** with the 5 at.%Zr coating which exhibited a corrosion rate of 32 mm/year,these coatings displayed lower corrosion rates,ranging from 1 to 12 mm/*** synergistic enhancement in mechanical properties and corrosion resistance,achieved with 2.0–3.4 at.%Zr,suggests potential ability for reducing stress shielding and controlled degradation performance,and consequentl

关键词： Mg-Zr coatings Magnetron sputtering Nanoindentation Corrosion resistance Bone implants

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Histological Assessment of Bone Regeneration in the Maxilla with Homologous Bone Graft:A Feasible Option for Maxillary Bone Reconstruction

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Journal of Renewable Materials 2024年第1期12卷 131-148页

作者： Sergio Henrique Gonçalves Motta ana Paula ramos Soares Juliana Campos Hasse Fernandes Gustavo Vicentis Oliveira Fernandes Graduate Center of Faculdade Redentor CLIVORio de JaneiroBrazil Periodontics and Oral Medicine Department University of Michigan School of DentistryAnn ArborMI48109USA Centre for Interdisciplinary Research in Health(CIIS) Universidade Católica PortuguesaViseu3504-505Portugal

Bone biomaterials have been increasingly used to reconstruct maxillary atrophic ***,the aim of this study was to evaluate bone reconstruction in the maxilla using a homologous cortico-cancellous FFB(lyophilized)graft and verify its *** individuals were included from 2014 to *** first surgery was performed to install homologous bone blocks in the *** period of the second intervention varied between 5 months and 15 days to 11 months(≈7.93 months).The biopsies were taken from the central region of the matured graft during the surgery for implant *** patients presented clinical and radiographic conditions for the installation of dental *** was a 100%of survival *** histological assessment showed that the homologous block bone graft was an osteoconductive biomaterial,with connective tissue present,and newly formed bone juxtaposed on its *** were bone trabeculae with osteocytes and active osteoblasts with connective tissue in the mineralization process;the remodeling process can be found through the reverse lines.A limited focus of necrosis with fibrosis was detected,with small resorption and areas of inflammatory infiltrate,but without clinical *** homologous block bone graft can be considered a feasible option to substitute the autogenous bone graft(gold standard),with predictable clinical and favorable histological *** patients had a shorter surgical period,low morbidity,and an unlimited amount of biomaterial available at an accessible cost.

关键词： Regeneration bone graft histology homologous allogenous autogenous

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A geomechanics classification for the rating of railroad subgrade performance

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Railway Engineering Science 2022年第3期30卷 323-359页

作者： Antonio Gomes Correia ana ramos Department of Civil Engineering ISISEUniversity of MinhoGuimara˜esPortugal

The type of subgrade of a railroad foundation is vital to the overall performance of the track *** the train speed and tonnage increase,as well as environmental changes,the evaluation and influence of subgrade are even more paramount in the railroad track structure performance.A geomechanics classification for subgrade is proposed coupling the stiffness(resilient modulus)and permanent deformation behaviour evaluated by means of repeated triaxial loading *** classification covers from fine-to coarse-grained soils,grouped by UIC and *** this achievement,we first summarize the main models for estimating resilient modulus and permanent deformation,including the evaluation of their robustness and their sensitivity to mechanical and environmental *** is followed by the procedure required to arrive at the geomechanical classification and rating,as well as a discussion of the influence of environmental *** work is the first attempt to obtain a new geomechanical classification that can be a useful tool in the evaluation and modelling of the foundation of railway structures.

关键词： Subgrade Resilient modulus Permanent deformation Geomechanical classification

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Influence of train speed and its mitigation measures in the short-and long-term performance of a ballastless transition zone

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铁道工程科学:英文版 2023年第4期31卷 309-324页

作者： ana ramos Rui Calçada António Gomes Correia Department of Civil Engineering Faculty of EngineeringUniversity of PortoCONSTRUCT-LESEPortoPortugal Department of Civil Engineering University of MinhoISISEGuimarãesPortugal

The ballastless track is nowadays the most popular railway system due to the required low number of maintenance opera-tions and costs,despite the high *** gradual change from ballasted to ballastless tracks has been occurring in Asia,but also in Europe,increasing the number of transition *** transition zones are a special area of the railway networks where there is an accelerated process of track degradation,which is a major concern of the railway infrastructure ***,the accurate prediction of the short-and long-term performance of ballastless tracks in transition zones is an important topic in the current paradigm of building/rehabilitating high-speed *** work purposes the development of an advanced 3D model to study the global performance of a ballastless track in an embankment-tunnel transition zone considering the influence of the train speed(220,360,500,and 600 km/h).Moreover,a mitigation measure is also adopted to reduce the stress and displacements levels of the track in the transition.A resilient mat placed in the tunnel and embank-ment aims to soften the *** behaviour of the track with the resilient mat is evaluated considering the influence of the train speed,with special attention regarding the critical *** used methodology is a novel and hybrid approach that allows including short-term and long-term performance,through the development of a powerful 3D model combined with the implementation of a calibrated empirical permanent deformation model.

关键词： Ballastless track Train speed Numerical modelling Transition zone Critical speed

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REVISITING THE SIMILAR PROCESS TO ENGINEER THE CONTEMPORARY SYSTEMS

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Journal of Systems Science and Systems Engineering 2010年第3期19卷 321-350页

作者： ana Luísa ramos José Vasconcelos FERREIRA Jaume BARCELó GOVCOPP-Department of Economics Management and Industrial EngineeringUniversity of Aveiro Department of Statistics and Operations Research Technical University of Catalonia

This paper addresses the present-day context of Systems Engineering, revisiting and setting up an updated framework for the SIMILAR process in order to use it to engineer the contemporary systems. The contemporary world is crowded of large interdisciplinary complex systems made of other systems, personnel, hardware, software, information, processes, and facilities. An integrated holistic approach is crucial to develop these systems and take proper account of their multifaceted nature and numerous interrelationships. As the system＇s complexity and extent grow, the number of parties involved （stakeholders and shareholders） usually also raises, bringing to the interaction a considerable amount of points of view, skills, responsibilities, and interests. The Systems Engineering approach aims to tackle the complex and interdisciplinary whole of those socio-technical systems, providing the means to enable their successful realization. Its exploitation in our modern world is assuming an increasing relevance noticeable by emergent standards, academic papers, international conferences, and post-graduate programmes in the field. This work aims to provide ＂the picture＂ of modern Systems Engineering, and to update the context of the SIMILAR process model in order to use this renewed framework to engineer the challenging contemporary systems. The emerging trends in the field are also pointed-out with particular reference to the Model-Based Systems Engineering approach.

关键词： SIMILAR process systems engineering standards MBSE

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Colorectal cancer screening:A review of current knowledge and progress in research

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1119-1133页

作者： Sara ramos Lopes Claudio Martins Inês Costa Santos Madalena Teixeira Élia Gamito ana Luisa Alves Department of Gastroenterology Centro Hospitalar de SetúbalSetúbal 2910-446Portugal

Colorectal cancer(CRC)is one of the most prevalent malignancies worldwide,being the third most commonly diagnosed malignancy and the second leading cause of cancer-related deaths *** the progress in screening,early diagnosis,and treatment,approximately 20%-25%of CRC patients still present with metastatic disease at the time of their initial ***,the burden of disease is still expected to increase,especially in individuals younger than 50 years old,among whom early-onset CRC incidence has been *** and early detection are pivotal to improve CRC-related *** is well established that CRC screening not only reduces incidence,but also decreases deaths from *** screening strategies have proven effective in decreasing both CRC incidence and mortality,though variations in efficacy have been reported across the ***,uncertainties persist regarding the optimal screening method,age intervals and ***,adherence to CRC screening remains globally *** recent years,emerging technologies,notably artificial intelligence,and non-invasive biomarkers,have been developed to overcome these ***,controversy exists over the actual impact of some of the new discoveries on CRC-related outcomes and how to effectively integrate them into daily *** this review,we aim to cover the current evidence surrounding CRC *** will further critically assess novel approaches under investigation,in an effort to differentiate promising inno-vations from mere novelties.

关键词： Colorectal cancer Screening Review Oncology Artificial intelligence

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金融素养和网络能力对中小企业财务绩效的影响：市场导向的调节作用

金融素养和网络能力对中小企业财务绩效的影响：市场导向的调节作...

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作者： Araujo ramos ana Maria 浙江工商大学

学位级别：硕士

Small and Medium Enterprises（SMEs）play a fundamental role in enhancing a country economic development and job *** need to maintain a good financial performance in order to survive and grow in today’s changing business *** the fact that SMEs are managed by on individual（manager/owner）,this study examines the impact of financial literacy and networking competency possessed by SMEs managers on their firms’ financial performance with emphasis on the potential moderating role of market orientation in Chinese and Peruvian *** an initial stage,exploratory interviews were conducted with some SMEs’ managers about their perception and importance of financial literacy,networking competency,and market orientation in enhancing financial *** questionnaires were used to collect data from owners/managers of SMEs and data analyzed using structural equation *** finding showed a significant positive impact financial literacy and networking competency on SMEs financial performance in China and *** Chinese context,market orientation was found to strengthen the impact of financial literacy and networking competency on SMEs financial performance,whereas in Peruvian context,market orientation was found to strengthen the relationship between networking competency and financial performance of SMEs *** by the research findings,a set of recommendations to policy makers and managers of SMEs are withdrawn as well as identifying future areas of research.

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Enhancement of the benthic communities around an isolated island in the Antarctic Ocean

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Acta Oceanologica Sinica 2013年第6期32卷 47-55页

作者： José I Saiz Nuria anadón Javier Cristobo Oscar García-Alvarez Gerardo García-Castrillo Eduardo López Cruz Palacín Jesús S Troncoso ana ramos Department of Zoology and Animal Cell Biology University of the Basque CountryBilbao 48080 Spain Department of Organisms and Systems Biology (Zoology) Rodrigo Uría s/n University of OviedoOviedo 33071 Spain Spanish Institute of Oceanography Gijón Oceanographic Centre Príncipe de Asturias 70bisGijón 33212 Spain Department of Zoology and Physical Anthropology University of Santiago de CompostelaSouth Campus Santiago de Compostela 15706 Spain Cantabrian Maritime Museum San Martín de Bajamar s/nSantander 39004 Spain Department of Biology Faculty of Sciences Autonomous University of MadridMadrid 28049 Spain Department of Animal Biology University of BarcelonaAvinguda Diagonal 645 Barcelona 08028 Spain Department of Ecology and Animal Biology Marine Sciences Faculty University of VigoVigo 36310 Spain Spanish Institute of Oceanography Subida a Radio Faro 50-52Vigo 36390 Spain

Insular marine biotas are often richer in faunal diversity than those from the open sea in the same geo- graphical region. The existence of particular island effects were tested under polar conditions by compar- ing infaunal benthic assemblages on Peter I Island with those of similar latitudes in the open ocean at the Bellingshausen Sea and also from the coast of the Antarctic Peninsula. Sampling was carried out aboard the R/V Hesperides during the expedition named BENTART-2003 from 24 January to 3 March 2003. Benthic samples were collected at 18 stations ranging from 90 to 2 044 m depth, using an USNEL-type box corer （BC） dredge. Representatives of 32 higher taxa of invertebrates were found. Univariate and multivariate analyses revealed various patterns in the data. First, significant differences in polychaete abundance were detected between the stations located in the open sea and the remaining sites （island plus mainland sites）. Bivalve abundances were also distinct between island and mainland sampling sites. Sediment columns taken from the island seafloor exhibited the highest rate of bioturbation by the infauna. These findings confirm the model that islands develop distinct assemblages characterized by the enhancement of the benthic commu- nities even in cold waters. Several abiotic factors were measured simultaneously at the seafloor and along the water column to investigate faunal distribution patterns. Significant correlations were found between the benthic assemblages and a combination of two environmental variables：＂island effect＂（measured as a categorical variable） and the redox state of sediments. Richer and more complex benthic assemblages were found in Peter I Island＇s sea bottom, whereas the more depauperate bottoms remained in the open sea.

关键词： Antarctica Bellingshausen Sea benthos Peter I Island PRIMER

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VAMP2 is implicated in the secretion of antibodies by human plasma cells and can be replaced by other synaptobrevins

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Cellular & Molecular Immunology 2018年第4期15卷 353-366页

作者： Laura Gómez-Jaramillo Raquel Romero-García Gema Jiménez-Gómez Lisa Riegle ana Belén ramos-Amaya JoséAntonio Brieva Marie Kelly-Worden Antonio Campos-Caro Unidad de Investigación Hospital Universitario Puerta del MarCádizSpain Department of Biology Ball State UniversityMuncieINUSA

The production and secretion of antibodies by human plasma cells(PCs)are two essential processes of humoral *** secretion process relies on a group of proteins known as soluble N-ethylmaleimide-sensitive factor attachment protein receptors(SNAREs),which are located in the plasma membrane(t-SNAREs)and in the antibody-carrying vesicle membrane(v-SNARE),and mediate the fusion of both *** have previously shown that SNAP23 and STX4 are the t-SNAREs responsible for antibody ***,using human PCs and antibody-secreting cell lines,we studied and characterized the expression and subcellular distribution of vesicle associated membrane protein(VAMP)isoforms,demonstrating that all isoforms(with the exception of VAMP1)are expressed by the referenced ***,the functional role in antibody secretion of each expressed VAMP isoform was tested using *** results show that VAMP2 may be the v-SNARE involved in vesicular antibody *** further support this conclusion,we used tetanus toxin light chain to cleave VAMP2,conducted experiments to verify co-localization of VAMP2 in antibody-carrying vesicles,and demonstrated the coimmunoprecipitation of VAMP2 with STX4 and SNAP23 and the in situ interaction of VAMP2 with *** together,these findings implicate VAMP2 as the main VAMP isoform functionally involved in antibody secretion.

关键词： exocytosis human immunoglobulin plasma cells VAMP proteins

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Surgical Technique Used for Portal Vein Thrombosis when Thrombectomy Is Not Possible During Liver Transplantation

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Surgical Science 2011年第5期2卷 248-251页

作者： José Roberto Alves Ilka de Fátima Santana Ferreira Boin anaísa Portes ramos Catherine Puliti Hermida Reigada Nelson Caserta Adilson Roberto Cardoso Cristina Arrivabene Caruy Elaine Cristina Ataíde Jazon Romilson Souza Almeida 不详

Portal vein thrombosis (PVT) was for a long time considered a barrier to liver transplantation. The aim of this study is to demonstrate the surgical technical options for portal vein reconstruction during liver transplantation in patients with PVT in which thrombectomy was not possible. Between September 1991 and March 2009, 420 liver transplanted patients were retrospectively analyzed, identifying 29 cases with PVT (6.9%). Preoperative diagnosis, preoperative risk factors, surgical technique options to treat various forms (grades) of PVT, postoperative recurrence and actuarial survival rates were studied. In three cases of PVT grade II and in one case PVT grade III the thrombectomy was insufficient, requiring some surgical technique options (13.79%). In two cases placement of iliac vein graft was performed, in one an anastomosis of the portal vein with collateral splenorenal vein and in the other with left gastric varicose. The actuarial survival rate for patients without PVT and patients with PVT and effective thrombectomy was 73.8% while those with PVT who needed some type of surgical option was 75%. Our results suggest that actuarial survival rates were similar among patients with PVT or PVT with effective thrombectomy when compared with PVT that required some surgical options.

关键词： Liver Transplantation Portal Vein Thrombosis Surgical Technique

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