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Long chikungunya?An overview to immunopathology of persistent arthralgia

World Journal of Virology 2024年第2期13卷 48-57页

作者： Jayme Euclydes Picasky Silveira-Freitas Maria Luiza Campagnolo Mariana dos Santos Cortez Fabrício Freire de Melo ana Carla Zarpelon-Schutz Kádima Nayara Teixeira Campus Toledo Universidade Federal do ParanáToledoParaná85919-899Brazil Instituto Multidisciplinar em Saúde Universidade Federal da BahiaCampus Anísio TeixeiraVitória da ConquistaBahia 45029-094Brazil Programa de Pós-graduação em Biotecnologia PalotinaUniversidade Federal do Paraná-Setor PalotinaParaná85950-000Brazil Programa Multicêntrico de Pós-graduação em Bioquímica e Biologia Molecular PalotinaUniversidade Federal do Paraná-Setor PalotinaParaná85950-000Brazil

Chikungunya fever(CF)is caused by an arbovirus whose manifestations are extremely diverse,and it has evolved with significant severity in recent *** clinical signs triggered by the Chikungunya virus are similar to those of other ***,fever starts abruptly and reaches high levels,followed by severe polyarthralgia and myalgia,as well as an erythematous or petechial maculopapular rash,varying in severity and *** 40%to 60%of affected individuals report persistent arthralgia,which can last from months to *** symptoms of CF mainly represent the tissue tropism of the virus rather than the immunopathogenesis triggered by the host's immune *** main mechanisms associated with arthralgia have been linked to an increase in T helper type 17 cells and a consequent increase in receptor activator of nuclear factor kappa-Βligand and bone *** review suggests that persistent arthralgia results from the presence of viral antigens post-infection and the constant activation of signaling lymphocytic activation molecule family member 7 in synovial macrophages,leading to local infiltration of CD4+T cells,which sustains the inflammatory process in the joints through the secretion of pro-inflammatory *** term"long chikungunya"was used in this review to refer to persistent arthralgia since,due to its manifestation over long periods after the end of the viral infection,this clinical condition seems to be characterized more as a sequel than as a symptom,given that there is no active infection involved.

关键词： Chikungunya Immunopathology Inflammation process Persistent arthralgia Signaling lymphocytic activation molecule family member 7

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Adding vortexing to the Maki technique provides no benefit for the diagnosis of catheter colonization or catheter-related bacteremia

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World Journal of Critical Care Medicine 2024年第1期13卷 58-64页

作者： Leonardo Lorente Maria Lecuona Fernandez Adriana González-Mesa Judith Oliveras-Roura Cristina Rosado Pablo Cabrera Emma Casal Alejandro Jiménez María Luisa Mora ana Madueño Intensive Care Unit Hospital Universitario de CanariasLa Laguna 38320Spain Microbiology and Infection Control Service Hospital Universitario de CanariasLa Laguna 38320Spain Research Unit Hospital Universitario de CanariasLa Laguna 38320Spain

BACKGROUND A previous study compared vortexing and Maki techniques for the diagnosis of catheter-related bloodstream infection(CRBSI),and concluded that vortexing was not superior to Maki *** To determine whether the combined use of vortexing and Maki techniques provides profitability versus the Maki technique for the diagnosis of catheter tip colonization(CTC)and *** Observational and prospective study carried out in an Intensive Care *** with suspected catheter-related infection(CRI)and with one central venous catheter for at least 7 days were *** area under the curve(AUC)of the Maki technique,the vortexing technique and the combination of both techniques for the diagnosis of CTC and CRBSI were *** We included 136 episodes of suspected *** found 21 cases of CTC of which 10 were also CRBSI *** the 21 CTC episodes,18(85.7%)were diagnosed by Maki technique and vortexing technique,3(14.3%)only by the technique of Maki,and none only by technique of *** the 10 CRBSI episodes,9(90.0%)were diagnosed by the techniques of Maki and vortexing,1(10.0%)was diagnosed only by the technique of Maki,and none only by the technique of *** no found differences in the comparison of AUC between the technique of Maki and the combination of Maki and vortexing techniques for the diagnosis of CTC(P=0.99)and CRBSI(P=0.99).CONCLUSION The novel finding of our study was that the combined use of vortexing and Maki techniques did not provide profitability to the technique of Maki alone to CRBSI diagnosis of.

关键词： Vortexing Maki Bloodstream infection Colonization

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人工智能时代的机遇与挑战——第18届远程教育与在线学习研究会议综述

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世界教育信息 2024年第7期37卷 73-80页

作者：蒋亦璐牛阿娜国家开放大学终身教育研究院北京100039 天津开放大学社会教育学部天津300191

在第18届远程教育与在线学习研究会议上,来自24个国家和地区的600多位与会者就新兴技术的应用、教育理论和方法的创新、在线学习评估、国际化与跨国教育、学生的归属感和幸福感、在线协作学习等主题的120多项最新学术研究展开深入交流... 详细信息

在第18届远程教育与在线学习研究会议上,来自24个国家和地区的600多位与会者就新兴技术的应用、教育理论和方法的创新、在线学习评估、国际化与跨国教育、学生的归属感和幸福感、在线协作学习等主题的120多项最新学术研究展开深入交流。专家立足远程教育与在线学习方面的理论和实践创新,对如何应对人工智能时代的机遇和挑战形成一定共识:一是人工智能等新兴技术正在重塑教育形态,二是推进教学理论与方法创新以助力人机协作,三是创设包容友好的学习环境和改善学习体验,四是灵活的教育形式可以改善资源不足和质量不均。

关键词：远程教育在线学习教育模式变革教育技术应用个性化学习智能教育

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The Convex-Set Algebra and Intersection Theory on the Toric Riemann–Zariski Space

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Acta Mathematica Sinica,English Series 2022年第3期38卷 465-486页

作者： ana María BOTERO Institut Für Mathematik Universität RegensburgUniversitätsstr.3193053RegensbergGermany

In previous work of the author,a top intersection product of toric b-divisors on a smooth complete toric variety is *** is shown that a nef toric b-divisor corresponds to a convex set and that its top inetersection number equals the volume of this convex *** goal of this article is to extend this result and define an intersection product of sufficiently positive toric b-classes of arbitrary *** this,we extend the polytope algebra of McMullen to the so called convex-set algebra and we show that it embeds in the toric b-Chow *** this way,the convex-set algebra can be viewed as a ring for an intersection theory for sufficiently positive toric *** an application,we show that some Hodge type inequalities are satisfied for the convex set algebra.

关键词： Convex geometry intersection theory toric varieties b-Chow groups Riemann–Zariski spaces

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Severe asthma exacerbation:Changes in patient characteristics,management,and outcomes from 1997 to 2016 in 40 ICUs in the greater Paris area

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Journal of Intensive Medicine 2024年第2期4卷 209-215页

作者： Romy Younan Jean Loup Augy Bertrand Hermann Bertrand Guidet Philippe Aegerter Emmanuel Guerot ana Novara Caroline Hauw-Berlemont Amer Hamdan Clotilde Bailleul Francesca Santi Jean-Luc Diehl Nicolas Peron Nadia Aissaoui Intensive Care Unit AP-HPGeorges Pompidou European HospitalUniversitéde ParisParisFrance Intensive Care Unit AP-HPSaint Antoine HospitalUniversités de SorbonneUniversitéPierre et Marie CurieParisFrance INSERM U1136 ParisFrance Versailles Saint-Quentin-en-Yvelines University INSERM U1018Groupe Interrégional de Recherche Clinique et d'InnovationÎle-de-FranceFrance Respiratory Medicine Department AP-HPGeorges Pompidou European HospitalUniversitéde ParisParisFrance Innovative Therapies in Hemostasis INSERM UMR-S1140Universitéde ParisParisFrance Intensive Care Unit and Biosurgical Research Lab(Carpentier Foundation) AP-HPGeorges Pompidou European HospitalParisFrance Paris-Cardiovascular-Research-Center INSERM U970ParisFrance

Background Despite advances in asthma treatments,severe asthma exacerbation(SAE)remains a life-threatening condition in adults,and there is a lack of data derived from adult patients admitted to intensive care units(ICUs)for *** current study investigated changes in adult patient characteristics,management,and outcomes of SAE over a 20-year period in 40 ICUs in the greater Paris *** In this retrospective observational study,admissions to 40 ICUs in the greater Paris area for SAE from January 1,1997,to December 31,2016 were *** primary outcome was the proportion of ICU admissions for SAE during 5-year *** outcomes were ICU and hospital mortality,and the use of mechanical ventilation and *** analysis was performed to assess factors associated with ICU *** A total of 7049 admissions for SAE were *** each 5-year period,the proportion decreased over time,with SAE accounting for 2.84%of total ICU admissions(n=2841)between 1997 and 2001,1.76%(n=1717)between 2002 and 2006,1.05%(n=965)between 2007 and 2011,and 1.05%(n=1526)between 2012 and *** median age was 46 years(interquartile range[IQR]:32–59 years),55.41%were female,the median Simplified Acute Physiology Score II was 20(IQR:13–28),and 19.76%had mechanical *** use of mechanical ventilation remained infrequent throughout the 20-year period,whereas the use of catecholamine *** and hospital mortality rates *** associated with ICU mortality were renal replacement therapy,catecholamine,cardiac arrest,pneumothorax,acute respiratory distress syndrome,sepsis,and invasive mechanical ventilation(IMV).Non-survivors were older,had more severe symptoms,and were more likely to have received *** ICU admission for SAE remains uncommon,and the proportion of cases decreased over *** a slight increase in symptom severity during a 20-year period,ICU and hospital mortality *** requirin

关键词： Epidemiology Intensive care unit Mechanical ventilation Severe asthma exacerbation

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场景与银幕之间:早期罗马尼亚电影与重新发现“消失的”女性电影先驱

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上海大学学报（社会科学版） 2024年第4期41卷 55-70页

作者：安娜·葛雷吉克(文) 冯芃芃(译) 吕睿(译) 巴比什-博雅依大学电影与媒体系罗马尼亚克卢日-纳波卡400084 中山大学外国语学院广州510275 香港大学现代语言及文化学院中国香港999077

虽然具有创新精神的女性人物对一些早期电影的制作与放映有所贡献,但很少有女性的名字出现在巴尔干电影史中。原始档案与当时的报刊重现了罗马尼亚女性戏剧导演兼演员马里奥拉·沃伊库列斯库的电影制作活动,沃伊库列斯库的明星形象和戏... 详细信息

虽然具有创新精神的女性人物对一些早期电影的制作与放映有所贡献,但很少有女性的名字出现在巴尔干电影史中。原始档案与当时的报刊重现了罗马尼亚女性戏剧导演兼演员马里奥拉·沃伊库列斯库的电影制作活动,沃伊库列斯库的明星形象和戏剧经验对里昂·M.波佩斯库艺术电影公司早期故事片的制作产生了重要影响。沃伊库列斯库一生成就斐然,有丰富多彩的舞台生涯,并在1912年成立了自己的剧团,在早期电影的制作中发挥了关键作用。以沃伊库列斯库对罗马尼亚早期电影的贡献为切入点,可以充分阐释罗马尼亚社会现代化进程中女性在大众文化中所占据的空间和扮演的角色。

关键词：早期电影女性电影先驱罗马尼亚电影电影文化妇女运动

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The Drought of Amazonia in 2023-2024

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American Journal of Climate Change 2024年第3期13卷 567-597页

作者： Jose A. Marengo ana P. Cunha Jhan-Carlo Espinoza Rong Fu Jochen Schöngart Juan C. Jimenez Mabel C. Costa Joao M. Ribeiro Sly Wongchuig Siyu Zhao National Center for Monitoring and Early Warning of Natural Disasters/CEMADEN So Jos dos Campos Brazil UNESP/CEMADEN So Jos dos Campos Brazil Graduate School of International Studies Korea University Seoul South Korea Institut des Gosciences de lEnvironnement (IGE) Institut de Recherche pour le Dvelopement (IRD) Saint Martin dHeres France Instituto de Investigacin sobre la Enseanza de las Matemticas (IREM PUCP) Pontificia Universidad Catlica del Per Lima Peru Department of Atmospheric and Oceanic Sciences University of California Los Angeles Los Angeles CA USA Departament of Environmental Dynamics Instituto Nacional de Pesquisas da Amaznia (INPA) Manaus Brazil Global Change Unit (GCU) of the Image Processing Laboratory (IPL) Universitat de Valncia Estudi General (UVEG) Paterna Spain Laboratoire dEtudes en Gophysique et Ocanographie Spatiales (LEGOS) Universit de Toulouse CNES/CNRS/IRD/UT3 Toulouse France

The Amazon basin has experienced an extreme drought that started in the austral summer of 2022-23 and extends into 2024. This drought started earlier than other previous droughts. Although some rain fell during the austral summer, totals remained below average. Higher temperatures during austral winter and spring 2023, which affected most of Central South America, then aggravated drought conditions. This coincided with an intense El Niño and abnormally warm tropical North Atlantic Ocean temperatures since mid-2023. Decreased rainfall across the Amazon basin, negative anomalies in evapotranspiration (derived from latent heat) and soil moisture indicators, as well as increased temperatures during the dry-to-wet transition season, September-October-November (SON) 2023, combined to delay the onset of the wet season in the hydrological year 2023-24 by nearly two months and caused it to be uncharacteristically weak. SON 2023 registered a precipitation deficit of the order of 50 to 100 mm/month, and temperatures +3˚C higher than usual in Amazonia, leading to reduced evapotranspiration and soil moisture indicators. These processes, in turn, determined an exceptionally late onset and a lengthening of the dry season, affecting the 2023-2024 hydrological year. These changes were aggravated by a heat wave from June to December 2023. Drought-heat compound events and their consequences are the most critical natural threats to society. River levels reached record lows, or dried up completely, affecting Amazonian ecosystems. Increased risk of wildfires is another concern exacerbated by these conditions.

关键词： El Niño SST in the Tropical Atlantic Amazon Drought River Levels Heatwave Dry Season Length

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Standardizing MI-TLIF, a Proposal for a Reproducible Technique

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Open Journal of Modern Neurosurgery 2024年第2期14卷 91-103页

作者： Iván Ulises Sámano López Jesús Alberto Pérez Contreras Emmanuel Cantú Chávez Diana Chávez Lizárraga ana Sofía Peña Blesa Thania Karina Gutiérrez Anchondo Á ngeles Pedregal Ciudad de México México

Background: Minimally invasive transforaminal lumbar interbody fusion (MI TLIF) is a widely known and performed technique, however its versatility among different physicians continues to hinder its replication and results. Therefore, this study aimed to provide a step-by-step surgical guide to perform a safe MI-TLIF, based on the results obtained in patients operated on by a single surgeon over a period of 12 years. Patients and methods: A retrospective, single center, longitudinal, and observational cohort study was conducted with 931 patients who underwent MI TLIF by a single surgeon between 2010 and 2022 using the technique described on this paper, each with a minimum follow-up of 12 months. Criteria included Schizas classification, listhesis according to Meyerding classification, number of levels treated, cage size, and complications (screw repositioning or cerebrospinal fluid leak). Patient clinical outcomes were assessed using the Oswestry Disability Index (ODI), Visual analog Scale (VAS) for pre- and postoperative radicular pain. Thin slice CT scans were used to assess the progression of the fusion using the Bridwell classification. In the statistical analysis, percentages, median, and interquartile range (IQR) were calculated. Results: Nine hundred and thirty one patients underwent MI TLIF using the technique described, eight hundred and eighty (94.5%) had a single level treated and fifty one (5.5%) had a 2 level procedure (982 levels), an 8mm cage was placed on five hundred and seventeenlevels (52.7%), six hundred and sixty three levels(67.6%) achieved grade I fusion, two hundred and sixty six levels (27.1%) achieved grade II fusion, 52 levels (5.3) achieved grade III fusion and one level (0.1) achieved a grade IV fusion or non-union. Revision surgery was performed on 3 patients (0.3%) for screw repositioning, cerebrospinal fluid leak was present on 2 patients during surgery and treated before closure. VAS scores and ODI were improved at 12 months postop (V

关键词： MITLIF Lumbar Interbody Fusion Technique Pain Relief and Disability

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The Iberian Roma Population Variant Server(IRPVS)

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Journal of Genetics and Genomics 2024年第7期51卷 769-773页

作者： Fabiola Mavillard Javier Perez-Florido Francisco M.Ortuño Amador Valladares Miren L.Álvarez-Villegas Gema Roldán Rosario Carmona Manuel Soriano Santiago Susarte Pilar Fuentes Daniel López-López ana María Nuñez-Negrillo Alejandra Carvajal Yolanda Morgado Daniel Arteaga Rosa Ufano Pablo Mir Juan F.Gamella Joaquín Dopazo Carmen Paradas Macarena Cabrera-Serrano Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud CarlosⅢSevillaSpain Plataforma Andaluza de Medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica Funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática en Enfermedades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain Departamento de Ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain Centro de Servicios Sociales Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain Departamento de Enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain Departamento de Neurología Hospital Virgen de las NievesGranadaSpain Departamento de Neurología Hospital Virgen de ValmeSevillaSpain Centro de Salud Utrera Sur SevillaSpain Centro de Salud Polígono Sur SevillaSpain Unidad de Trastornos del Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain Departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain Departamento de Antropología Social Universidad de GranadaSpain Unidad Enfermedades Neuromusculares Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponentially grown due to the widespread adoption of cost-effective massive parallel *** identify new disease variants,especially in monogenic disorders,a frequen... 详细信息

关键词： Server filtering massive

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Hydrocarbons in particulate samples from wildfire events in central Portugal in summer 2010

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Journal of Environmental Sciences 2017年第3期29卷 122-131页

作者： ana Vicente ana Calvo ana P.Fernandes Teresa Nunes Cristina Monteiro Casimiro Pio Célia Alves Centre for Environmental and Marine Studies (CESAM) Department of EnvironmentUniversity of Aveiro Department of Physics IMARENABUniversity of León

In summer 2010, twenty eight （14 PM=2.5 samples plus 14 samples PM2.5-10） smoke samples were collected during wildfires that occurred in central Portugal. A portable high-volume sampler was used to perform the sampling, on quartz fibre filters of coarse （PM=2.5-10） and fine （PM2.5） smoke samples. The carbonaceous content （elemental and organic carbon） of particulate matter was analysed by a thermal-optical technique. Subsequently, the particulate samples were solvent extracted and fractionated by vacuum flash chromatog- raphy into three different classes of organic compounds （aliphatics, polycyclic aromatic hydrocarbons （PAHs） and carbonyl compounds）. The organic speciation was performed by gas chromatography-mass spectrometry （GC-MS）. Emissions were dominated by the fine particles, which represented around 92% of the PM10. A clear predominance of carbonaceous constituents was observed, with organic to elemental carbon （OC/EC） ratios ranging between 1.69 and 245 in both size fractions. The isoprenoid ketone 6,10,14-trimethyl-2-pentadecanone, a tracer for secondary organic aerosol formation, was one of the dominant constituents in both fine and coarse particles. Retene was the most abundant compound in all samples. Good correlations were obtained between OC and both aliphatic and PAH compounds. Pyrogenic processes, thermal release of biogenic com- pounds and secondary processing accounted for 97% of the apportioned PM2.5 levels.

关键词： WildfiresOrganic carbonOrganic compoundsBiomarkersParticulate matterPortugal

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