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Treatment of spinal cord injury with biomaterials and stem cell therapy in non-human primates and humans

Neural Regeneration Research 2025年第2期20卷 343-353页

作者： ana Milena Silva Olaya Fernanda Martins al.eida ana Maria Blanco Martinez Suelen Adriani Marques PhD Program in Pathological anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Biomedical Science Institute Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological anatomy(PPGAP/UFRJ) Department of Neurobiology/Institute of BiologyCampus do GragoatáNiteróiRio de JaneiroBrazil

Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical ***,in the search for more effective treatments than those already applied for years,which are not entirely efficient,researches have been able to demonstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord *** of these strategies has been developed and meticulously evaluated in several animal models with the aim of analyzing the potential of interventions for neuronal repair and,consequently,boosting functional *** the majority of experimental research has been conducted in rodents,there is increasing recognition of the importance,and need,of evaluating the safety and efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in *** article is a literature review from databases(PubMed,Science Direct,Elsevier,Scielo,Redalyc,Cochrane,and NCBI)from 10 years ago to date,using keywords(spinal cord injury,cell therapy,non-human primates,humans,and bioengineering in spinal cord injury).From 110 retrieved articles,after two selection rounds based on inclusion and exclusion criteria,21 articles were ***,this review arises from the need to recognize the experimental therapeutic advances applied in non-human primates and even humans,aimed at deepening these strategies and identifying the advantages and influence of the results on extrapolation for clinical applicability in humans.

关键词： bioengineering biomaterials cell therapy humans non-human primates spinal cord injury stem cell therapy

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Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-Núñez María Fernanda González ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and Notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

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Nanofluid based on 1-dodecylpyridinium chloride for enhanced oil recovery

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Petroleum Science 2023年第1期20卷 600-610页

作者： Akram al-Asadi alba Somoza alberto Arce Eva Rodil ana Soto CRETUS.Department of Chemical Engineering Universidade de Santiago de CompostelaE-15782Santiago de CompostelaSpain Chemical and Petrochemical Techniques Eng.Department Basra Engineering Technical CollegeSothern Technical UniversityMinistry of Higher Education and Scientific ResearchIraq School of Engineering Universidade de A CorunaE-15403FerrolSpain

The use of nanoparticles is considered promising for enhanced oil recovery(EOR),especially when they are combined with ***,the combination of nano-sized material with surface-active ionic liquids(SAILs)is an unexplored EOR *** this work,the advantages of mixing al2O3 nanoparticles with the SAIL 1-dodecylpyridinium chloride were *** nanofluids in brine could only be achieved using the polymer polyvinylpyrrolidone(PVP)as a stabilizing *** was found that the addition of nanoparticles(and PVP)to the surfactant formulation helped to:slightly increase its viscosity,enhance its water-oil interfacial tension(IFT)reduction capacity,and reduce the adsorption on carbonate rocks(adsorption on sandstone was found to be excessive).IFT was selected as target property to minimize for the design of EOR *** flooding tests were carried out with surfactant(0.5 wt%[C_(12)py]Cl),surfactant-polymer(0.5 wt%[C_(12)py]Cl,1.0 wt%PVP)and nanofluid(0.05 wt%al_(2)O_(3),1.0 wt%PVP,0.5 wt%[C12py]Cl)formulations in brine(0.5 wt%NaCl).Additional oil recoveries of 3.4%,7.4%and 12.0%OOIP were achieved,respectively,the nanofluid formulation being the most promising for the ***,it was found capable of changing the wettability of carbonate rocks from oilwet to *** significance of this work lies in showing the new possibilities resulting from the combination of SAILs and nanoparticles for EOR,specifically the combination of[C_(12)py]Cl with al_(2)O_(3).

关键词： Nanofluid Viscosity Interfacial tension Adsorption Wettability EOR

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Anti-Candida and anti-Cryptococcus evaluation of 15 non-alkaloidal compounds from Pterogyne nitens

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Asian Pacific Journal of Tropical Biomedicine 2016年第10期6卷 841-845页

作者： Caroline Sprengel Lima Carlos Roberto Polaquini Mariana Bastos dos Santos Fernanda Patricia Gullo Fernanda Sangalli Leite Liliane Scorzoni Vanderlan da Silva Bolzani Maria Jose Soares Mendes-Giannini ana marisa fusco-al.eida Andréia alves Rezende Luis Octavio Regasini Laboratory of Green and Medicinal Chemistry Department of Chemistry and Environmental Sciences Institute of Biosciences Letters and Exact Sciences Sao Paulo State University (UNESP) Department of Clinical analysis School of Pharmaceutical Sciences Sao Paulo State University (UNESP) Department of Organic Chemistry Institute of Chemistry Sao Paulo State University (UNESP) Department of Biology and Animal Sciences Faculty of Engineering Sao Paulo State University (UNESP)

Objective: To evaluate anti-Candida and anti-Cryptococcus activities of 15 nonalkaloidal compounds from Pterogyne nitens Tulasne(Leguminosae), a South American medicinal ***: Compounds were submitted to antifungal assays, using microdilution method described by Clinical and Laboratory Standards Institute document, with minor modifications. Five species of Candida and two species of Cryptococcus, including clinical isolates were screened. Antifungal activity was expressed by minimum inhibitory concentration(MIC). Amphotericin B and fluconazole were used as standard antifungal ***: Among tested compounds, six substances presented fungal growth inhibition(MIC al activity,demonstrating MIC value of 3.90 mg/m L against Candida glabrata ATCC 90030, Cryptococcus gattii 118 and fluconazole-resistant clinical isolate of Cryptococcus neoformans var. grubii. Pedalin(2) and nitensoside B(3), two glycosylated flavone derivatives, were active against Cryptococcus neoformans ATCC 90012(MIC = 7.80 mg/m L).Conclusions: Flavone derivatives from Pterogyne nitens can serve as prototypes for the design and development of innovative anti-Candida and anti-Cryptococcus hits.

关键词： Candida Cryptococcus Antifungal Pterogyne nitens Flavonoid Opportunistic fungi

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Microalgal-based feed:promising alternative feedstocks for livestock and poultry production

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Journal of Animal Science and Biotechnology 2021年第4期12卷 1252-1266页

作者： Imen Saadaoui Rihab Rasheed ana Aguilar Maroua Cherif Hareb al Jabri Sami Sayadi Schonna R.Manning Center for Sustainable Development College of Arts and SciencesQatar UniversityP.O.Box.2713 DohaQatar Department of Molecular Biosciences UTEX Culture Collection of AlgaeUniversity of Texas at AustinAustinTX 78712USA

There is an immediate need to identify alternative sources of high-nutrient feedstocks for domestic livestock productionand poultry,not only to support growing food demands but also to produce microalgae-source functional foods withmultiple health *** species of microalgae and cyanobacteria are used to supplement existing *** review,microalgae have been defined as a potential feedstock for domestic animals due to their abundance ofproteins,carbohydrates,lipids,minerals,vitamins,and other high-value ***,the positive physiologicaleffects on products of animals fed with microalgal biomass have been compiled and recommendations are listed toenhance the assimilation of biomolecules in ruminant and nonruminant animals,which possess differing ***,the role of microalgae as prebiotics is also *** regards to large scale cultivation ofmicroalgae for use as feed,many economic trade-offs must be considered such as the selection of strains with desirednutritional properties,cultivation systems,and steps for downstream *** factors are highlighted withfurther investigations needed to reduce the overall costs of ***,this review outlines the pros and cons ofutilizing microalgae as a supplementary feedstock for poultry and cattle,existing cultivation strategies,and theeconomics of large-scale microalgal production.

关键词： Functional feed High-value metabolite Livestock production Microalgae Poultry product

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Snow Cover Area Estimation Using Radar and Optical Satellite Information

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Atmospheric and Climate Sciences 2014年第4期4卷 514-523页

作者： ana Paula Salcedo marisa G. Cogliati Department of Geography Faculty of Humanities National University of Comahue Neuquén Argentina

Obtaining the seasonal variation of snow cover in areas of the Argentinian Andes is important for hydrological studies and can facilitate proper planning of water resources, with regard to irrigation, supply, flood attenuation and hydroelectricity. Remote sensors that work in the visible and infrared wavelength range are operational tools for monitoring the snow in clear skies. However, microwave satellites are able to obtain data regardless of atmospheric conditions. The advantage of using radar images is that they are very useful to obtain highly accurate parameters such as snow moisture depth, density and water equivalent resulting in improved forecasting models. In this paper, we analyze an ERS-2 image of the Andes mountain range in the northern region of the Neuquén province, Patagonia, Argentina. The objective was to obtain the spatial distribution of wet and dry snow and to compare these results with data from optical sensors (LANDSAT) in order to understand the topographic variables that influence the spatial distribution of wet snow. Optical information from sensors like LANDSAT TM 5 was analyzed to obtain fractional and binary snow indexes during a passage simultaneously with radar data. Surface temperature is used to study the association between the different types of snow altitudinal ranges and surface temperature. In this paper, we selected a scene on October 8th 2005. The entire methodology was systematized in a code implemented in IDL language.

关键词： Radar Satellite Snow Surface Temperature

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The Convex-Set algebra and Intersection Theory on the Toric Riemann–Zariski Space

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Acta Mathematica Sinica,English Series 2022年第3期38卷 465-486页

作者： ana María BOTERO Institut Für Mathematik Universität RegensburgUniversitätsstr.3193053RegensbergGermany

In previous work of the author,a top intersection product of toric b-divisors on a smooth complete toric variety is *** is shown that a nef toric b-divisor corresponds to a convex set and that its top inetersection number equals the volume of this convex *** goal of this article is to extend this result and define an intersection product of sufficiently positive toric b-classes of arbitrary *** this,we extend the polytope algebra of McMullen to the so called convex-set algebra and we show that it embeds in the toric b-Chow *** this way,the convex-set algebra can be viewed as a ring for an intersection theory for sufficiently positive toric *** an application,we show that some Hodge type inequalities are satisfied for the convex set algebra.

关键词： Convex geometry intersection theory toric varieties b-Chow groups Riemann–Zariski spaces

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Hydrocarbons in particulate samples from wildfire events in central Portugal in summer 2010

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Journal of Environmental Sciences 2017年第3期29卷 122-131页

作者： ana Vicente ana Calvo ana P.Fernandes Teresa Nunes Cristina Monteiro Casimiro Pio Célia alves Centre for Environmental and Marine Studies (CESAM) Department of EnvironmentUniversity of Aveiro Department of Physics IMARENABUniversity of León

In summer 2010, twenty eight （14 PM=2.5 samples plus 14 samples PM2.5-10） smoke samples were collected during wildfires that occurred in central Portugal. A portable high-volume sampler was used to perform the sampling, on quartz fibre filters of coarse （PM=2.5-10） and fine （PM2.5） smoke samples. The carbonaceous content （elemental and organic carbon） of particulate matter was analysed by a thermal-optical technique. Subsequently, the particulate samples were solvent extracted and fractionated by vacuum flash chromatog- raphy into three different classes of organic compounds （aliphatics, polycyclic aromatic hydrocarbons （PAHs） and carbonyl compounds）. The organic speciation was performed by gas chromatography-mass spectrometry （GC-MS）. Emissions were dominated by the fine particles, which represented around 92% of the PM10. A clear predominance of carbonaceous constituents was observed, with organic to elemental carbon （OC/EC） ratios ranging between 1.69 and 245 in both size fractions. The isoprenoid ketone 6,10,14-trimethyl-2-pentadecanone, a tracer for secondary organic aerosol formation, was one of the dominant constituents in both fine and coarse particles. Retene was the most abundant compound in all samples. Good correlations were obtained between OC and both aliphatic and PAH compounds. Pyrogenic processes, thermal release of biogenic com- pounds and secondary processing accounted for 97% of the apportioned PM2.5 levels.

关键词： WildfiresOrganic carbonOrganic compoundsBiomarkersParticulate matterPortugal

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Comparison of Different Washing and Disinfection Protocols Used by Food Services in Southern Brazil for Lettuce (<i>Lactuca sativa</i>)

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Food and Nutrition Sciences 2012年第1期3卷 28-33页

作者： ana Beatriz al.eida de Oliveira ana Carolina Ritter Eduardo Cesar Tondo marisa Itapema Cardoso 不详

Different protocols have been used for washing and disinfecting leafy vegetables in Brazilian food services, however its effect on microbial reduction was barely studied. The aim of this study was to evaluate the effectiveness of lettuce washing and disinfecting protocols used by food services. The treatments evaluated were: washing in potable tap water (T1);washing and dipping in potable tap water (T2);washing with potable tap water and dipping in a solution of sodium hypochlorite (200 ppm of free chlorine) for 15 min (T3);and 30 min (T4);washing with potable tap water and dipping in 2% vinegar solution (T5);and 20% vinegar solution (T6). After the treatments, the samples were microbiologically evaluated to measure bacterial reductions. The microbial counts showed that the mean total mesophile reductions were: 0.64 log for T1, 0.75 log for T2, 2.06 log for T3, 2.46 log for T4, 1.68 log for T5 and 1.72 log for T6, and the mean total coliform reductions were: 1.11 log for T1, 1.09 log for T2, 2.29 log for T3, 2.35 log for T4, 1.6 log for T5 and 2.09 log for T6. Based on these results it can be concluded that protocols which used 200 ppm sodium hypochlorite for 15 to 30 min (T3 e T4), were the most effective, followed by treatment with 20% vinegar solution (T6). The latter method, however, turned the lettuce dark during the distribution period.

关键词： Lettuce Disinfection Food Services

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Oxygen-evolving SnO_(2)-based Ceramic Anodes in aluminium Electrolysis

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Chemical Research in Chinese Universities 2014年第5期30卷 800-805页

作者： POPESCU ana-Maria Ilie Murgulescu Institute of Physical Chemistry of the Romanian Academy 060021-Bucharest Romania

This study deals with SnO2-based ceramic anodes doped with Sb203 and CuO, aiming at contributing new data regarding their electrochemical behavior in cryolite melts. The performances of the anodes were evaluated by anodic polarization, cyclic voltammetry, and current efficiency and corrosion measurements. The investigation proves that the anodic process of SnO2-based inert anodes occurs at a low overvoltage and the oxygen discharge takes place in one step with an exchange of two electrons. The current efficiency and corrosion were proved to be dependent on the electrolysis parameters and composition of electrolysis bath. For a long term electrolysis, the dissolution of the anode in the cryolite-alumina melt produced small aluminium contamination（ca. 0.2%, mass fraction）.

关键词： Inert anode aluminium electrolysis Polarization Voltammetry

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