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Ergatoid reproductives in the Neotropical termite Nasutitermes aquilinus (Holmgren) (Blattaria: Isoptera: Termitidae): developmental origin, fecundity, and genetics

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Insect Science 2020年第6期27卷 1322-1333页

作者： Iago Bueno da silva Ives Haifig Edward LVargo Fabiana Elaine Casarin Marcelo Luiz da Mota Juliana Toledo Lima ana maria Costa-Leonardo Laboratorio de Cupins Departamento de BiologiaInstituto de BiocienciasUniversidade Estadual Paulista-UN ESPRio ClaroSPBrazil Centro de Ciencias Naturais e Humanas Universidade Federal do ABCSao Bernardo do CampoSPBrazil Department of Entomology Texas A&M UniversityCollege StationTexasUSA Departamento de Ciencias Biologicas Universidade Federal de Sao Paulo-UNIFESPDiademaSPBrazil Instituto de Ciencias Agrarias Universidade Federal de Uberlandia—UFUMonte CarmeloMGBrazil Centro de Estudos em Recursos Naturais Universidade Estadual de Mato Grosso do SulDouradosMSBrazil

Termite colonies are usully headed by primary reproductives,which estab-listh nests during the swar ming ***,secondary reproductives may develop in some specics and become supplementary or replacement breeders,extending colony *** we investigate the developmental origin,fecundity and genetic characterizaion of ergatoid reproductives in the Neotropical termite Nasuitermes aquilinus(Holmgren),using morphometrical and histological techniques,five micosiallitle loci and the COI mitochondrial *** measurements performed on 208 apterous individuals of Nuauidius revealed 10 groups,including ergatoid females,which developed from major workers through two successive *** were characterized by the presence of imaginal features such as eyes andl wing *** difentiation of these features was correlated to physogastric development in these ergatoids,Histology revealed ooeytes in all matu-ration sages in worker-derived reproductives of N aquidinus,presence of nonflagellate spermatozoa inside the spermatheea,and royal fa ***,ergatoid reproduwetives were reproductively *** to the genotypes of 221 individuals from 11 nests,and mitochondrial haplotypes of 43 ergatoids,73%of the colomies were simple families,whereas 27%were extendbed *** the oecurenee of related reproductives,low inbreeding rates were detected within and among *** values could be explained given that sib mating itself cannot result in a higher inbreeding rate but depend on several factors discussed in *** is the first study to investigate the genetic structure of termite colonies influenced by the development of ergatoids and further investigations are encouraged 10 understand the inflwence of these reproductives on colony lifespan.

关键词： breeding syslem caste ifrentiation COI genotyping micosallites reproduction

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Adult Education and Training in Portugal： A Multi-case Study Focused on Autobiographical Experiences

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Sociology Study 2012年第4期2卷 270-277页

作者： Mfircia Aguiar ana maria silva University of Minho Portugal

In our actual framework of constant social and cultural changing, we are witnessing a transformation of the adults＇ patterns and pathways of life. Currently, people＇s lives cannot be analyzed using a macro-perspective, marked by partitioning phases, but the various stages we undergo from childhood to the third age are being overlapped and this is reflected with particular relevance in the field of learning, where the notion of lifelong learning is present in our personal, social and professional everyday contexts, in Portugal, the New Opportunities Initiative is building new and innovative education and training pathways, which privilege the autobiographical methods, where adults, from their life stories, are challenged to resort to new ways of valuing their experiences, potentiating the acquisition of new skills, in a logic of personal, social and professional empowerments. This formative/training logic has shown to be the promoter of a growing autonomy from the adults. We will present, here, the qualitative multi-case study we are developing in this area, which is centered on adults＇/professionals＇ autobiographies and focuses on the understanding of adult education, lifelong learning and on the analysis of the mediation figures associated with them.

关键词： Lifelong learning autobiographical methods recognition of competences empowerment life experiences

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Antioxidant and antitumor potential of wild and IMT-Acultivated Osmundea pinnatifida

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Journal of Oceanology and Limnology 2019年第3期37卷 825-835页

作者： silva J.Paulo ALVES Celso PINTEUS Susete silva Joana VALADO ana PEDROSA Rui PEREIRA Leonel UCIBIO-REQUIMTE Department of ChemistryFaculty of Sciences and TechnologyUniversidade NOVA de LisboaCaparica 2829-516Portugal MARE-Marine and Environmental Sciences Centre School of Tourism and Maritime TechnologyPolytechnic Institute of LeiriaPeniche 2520-641Portugal Instituto Politécnico de Coimbra ESTESC-Coimbra Health SchoolBiomedical Sciences LaboratoryR.5 de OutubroS.Martinho do BispoAp.7006Coimbra 3046-854Portugal Centre of Pharmacology and Chemical Biopathology Faculty of MedicineUniversity of PortoPorto 4200-319Portugal MARE-Marine and Environmental Sciences Centre Department of Life SciencesFaculty of Sciences and TechnologyUniversity of CoimbraCoimbra 3000-456Portugal

Osmundea pinnatifida is a red edible seaweed known as pepper *** was cultivated in the farm of ALGAplus(ílhavo,Portugal).This farm is integrated with a seabream and seabass commercial aquaculture and uses the nutrient-enriched water resultant from the fish production as its cultivation medium in the integrated multi-trophic aquaculture(IMTA)*** and IMTA-cultivated samples of *** da were screened for antioxidant and antitumor *** antioxidant capacity of solvent extracts from wild and IMTA cultivated samples was assessed in two methods(2,2-diphenyl-1-picrylhydrazyl(DPPH)and oxygen radical absorbance capacity(ORAC)),and their total phenolic contents(TPC)were *** activity was evaluated in three different tumor cell lines(HepG-2,MCF-7,and SH-SY5Y)through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)*** the solvents used for extraction,dichloromethane was the most eff ective to extract phenolic compounds and presented higher ORAC.A significant correlation was found between TPC and ORAC,which was also sustained by the principal components analysis(PCA).Dichloromethane extracts induced a cytostatic eff ect on MCF-7 cells and showed weak cytotoxicity to SH-SY5Y cells and weak impact on cell ***,there were no statistically signifi cant differences in the biological activities shown by the wild and IMTA-cultivated ***,*** can be obtained in an economical and environmentally sustainable way through IMTA,maintaining bioactive properties in a high potential for further nutraceutical purposes.

关键词： edible seaweed bioactive compounds polyphenols cytotoxic activity antiproliferative activity

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Medicinal plants from the Brazilian Amazonian region and their antileishmanial activity:a review

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Journal of Integrative Medicine 2018年第4期16卷 211-222页

作者： Bruno Jose Martins Da silva Amanda anastacia Pinto Hage Edilene Oliveira silva ana Paula Drummond Rodrigues Laboratory of Parasitology and Laboratory of Structural Biology Institute of Biological SdencesFederal University of PardBelemPard 66075-110Brazil National Institute of Science and Technology in Structural Biology and Bioimaging Rio de JaneiroRio de Janeiro 21941-901Brazil Laboratory of Electron Microscopy Department of Health SurveillanceMinistry of HealthEvandro Chagas InstituteBelemPard 66087-082Brazil

Leishmaniasis, a neglected disease caused by Leishmania protozoans, primarily affects people in tropical and subtropical areas. Chemotherapy based on the use of pentavalent antimonials, amphotericin B, paromomycin, miltefosine and liposomal amphotericin B is currently the only effective treatment. However, adverse effects, long-term treatment and the emergence of parasite resistance have led to the search for alternative treatments. Natural products used in traditional medicine provide an unlimited source of molecules for the identification of new drugs, and the Amazon region has abundant biodiversity that includes several species of plants and animals, providing a rich source of new products and com- pounds. Although the literature describes numerous promising compounds and extracts for combating Leishmania protozoans, the results of such research have not been embraced by the pharmaceutical industry for the development of new drugs. Therefore, this review focused on the antileishmanial activity of extracts, isolated compounds and essential oils commonly used by the local population in the Brazilian Amazonian region to treat several illnesses and described in the literature as promising compounds for combating leishmaniasis.

关键词： Amazonian plants Leishmaniasis treatment Plant compounds Plant extracts Plant oils

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Relationship between angiotensin-(1-7) and angiotensin Ⅱ correlates with hemodynamic changes in human liver cirrhosis

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World Journal of Gastroenterology 2009年第20期15卷 2512-2519页

作者： Walkíria Wingester Vilas-Boas Antnio Ribeiro-Oliveira Jr Regina maria Pereira Renata da Cunha Ribeiro Jerusa Almeida ana Paula Nadu ana Cristina Simoes e silva Robson Augusto Souza dos Santos Laboratory of Hypertension Department of Physiology Biological Sciences institute Federal University of Minas Gerais Av. Antonio Carlos 6627 Belo Horizonte MG 31270-901 Brazil Laboratory of Endocrinology Department of Medicine Faculty of Medicine Federal University of Minas Gerais Av. Alfredo Balena 190 Belo Horizonte MG 30130-100 Brazil Hospitalar Foundation of the State of Minas Gerais FHEMIG Belo Horizonte MG Brazil Department of Pediatrics Faculty of Medicine Federal University of Minas Gerais Av.Alfredo Balena 190 Belo Horizonte MG 30130-100 Brazil

AIM： To measure circulating angiotensins at different stages of human cirrhosis and to further evaluate a possible relationship between renin angiotensin system （RAS） components and hemodynamic changes. METHODS： Patients were allocated into 4 groups： mild-to-moderate liver disease （MLD）, advanced liver disease （ALD）, patients undergoing liver transplantation, and healthy controls. Blood was collected to determine plasma renin activity （PRA）, angiotensin （Ang） Ⅰ, Ang Ⅱ, and Ang-（1-7） levels using radioimmunoassays. During liver transplantation, hemodynamic parameters were determined and blood was simultaneously obtained from the portal vein and radial artery in order to measure RAS components. RESULTS： PRA and angiotensins were elevated in ALD when compared to MLD and controls （P 〈 0.05）. In contrast, Ang Ⅱ was significantly reduced in MLD. Ang-（1-7）/Ang Ⅱ ratios were increased in MLD when compared to controls and ALD. During transplantation, Ang Ⅱ levels were lower and Ang-（1-7）/Ang Ⅱ ratios were higher in the splanchnic circulation than in the peripheral circulation （0.52 ± 0.08 vs 0.38 ±0.04, P 〈 0.02）, whereas the peripheral circulating Ang Ⅱ/Ang Ⅰ ratio was elevated in comparison to splanchnic levels （0.18 ±0.02 vs 0.13 ±0.02, P 〈 0.04）. Ang-（1-7）/ Ang Ⅱ ratios positively correlated with cardiac output （r = 0.66） and negatively correlated with systemic vascular resistance （r = -0.70）. CONCLUSION： Our findings suggest that the relationship between Ang-（1-7） and Ang Ⅱ may play a role in the hemodynamic changes of human cirrhosis.

关键词： Renin-angiotensin system Liver cirrhosis Angiotensin-(1-7) Angiotensin Ⅱ Splanchnic circulation Angiotensin converting enzyme 2

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Downregulation of TNFR2 decreases survival gene expression,promotes apoptosis and affects the cell cycle of gastric cancer cells

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World Journal of Gastroenterology 2022年第24期28卷 2689-2704页

作者： ana Flávia Teixeira Rossi Fernanda da silva Manoel-Caetano Joice Matos Biselli Ágata silva Cabral Marilia de Freitas Calmon Saiki Marcelo Lima Ribeiro ana Elizabete silva Department of Biological Sciences Sao Paulo State University(UNESP)São Josédo Rio Preto 15054-000São PauloBrazil Clinical Pharmacology and Gastroenterology Unit São Francisco University(USF)Bragança Paulista 12916-900São PauloBrazil

BACKGROUND Chronic inflammation due to Helicobacter pylori(***)infection promotes gastric *** necrosis factor-α(TNF-α),a key mediator of inflammation,induces cell survival or apoptosis by binding to two receptors(TNFR1 and TNFR2).TNFR1 can induce both survival and apoptosis,while TNFR2 results only in cell *** dysregulation of these processes may contribute to *** To evaluate the effects of TNFR1 and TNFR2 downregulation in AGS cells treated with *** extract on the TNF-α*** AGS cell lines containing TNFR1 and TNFR2 receptors downregulated by specific shRNAs and nonsilenced AGS cells were treated with *** extract for 6 ***,quantitative polymerase chain reaction with TaqMan®assays was used for the relative quantification of the mRNAs(TNFA,TNFR1,TNFR2,TRADD,TRAF2,CFLIP,NFKB1,NFKB2,CASP8,CASP3)and miRNAs(miR-19a,miR-34a,miR-103a,miR-130a,miR-181c)related to the TNF-αsignalling *** cytometry was employed for cell cycle analysis and apoptosis *** In nonsilenced AGS cells,*** extract treatment increased the expression of genes involved in cell survival and inhibited both apoptosis(NFKB1,NFKB2 and CFLIP)and the TNFR1 ***1 downregulation significantly decreased the expression of the TRADD and CFLIP genes,although no change was observed in the cellular process or miRNA *** contrast,TNFR2 downregulation decreased the expression of the TRADD and TRAF2 genes,which are both important downstream mediators of the TNFR1-mediated pathway,as well as that of the NFKB1 and CFLIP genes,while upregulating the expression of miR-19a and ***,a reduction in the number of cells in the G0/G1 phase and an increase in the number of cells in the S phase were observed,as well as the promotion of early *** Our findings mainly highlight the important role of TNFR2 in the TNF-αpathway in gastric cancer,indicating that silencing it can reduce the

关键词： Gastric cancer Helicobacter pylori Tumour necrosis factor-αsignalling pathway TNFR1 TNFR2 miRNAs

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Industry return lead‑lag relationships between the US and other major countries

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Financial Innovation 2023年第1期9卷 1055-1102页

作者： ana Monteiro Nuno silva Helder Sebastiao CeBER Faculty of EconomicsUniv CoimbraAv Dias da Silva 1653004‑512 CoimbraPortugal

In this study,we analyze the lead-lag relationships between the US industry index and those of six other major countries from January 1973 to May *** identify the leading role played by the US internationally by showing that the weekly returns of US industries,especially the US basic materials and energy industries,significantly Granger cause the returns of most other countries’industries,suggesting that non-US industries react with some delay to new *** delayed reaction is even more notice-able during periods of recession in the US when cross-country correlations are *** implies that the ability of the lagged returns of US industries to predict industries’returns from other countries is even more pronounced when the US experienced an economic recession.A similar asymmetric relationship is found between the volatil-ity of US industries and that of industries in other *** analysis of causality in the distribution of returns and volatility shows that causality runs mainly from the US to other countries,particularly in the presence of extreme negative ***,we demonstrate that our predictions are valuable to real-world ***-short strategies generate sizable and statistically significant alphas,and a constant relative risk-averse investor obtains certainty equivalent returns well above the risk-free rate.

关键词： International diversification Industry equity indexes Granger causality Causality in distribution

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Helicobacter pylori infection: Host immune response, implications on gene expression and microRNAs

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World Journal of Gastroenterology 2014年第6期20卷 1424-1437页

作者： Aline Cristina Targa Cadamuro ana Flávia Teixeira Rossi Nathália Maciel Maniezzo ana Elizabete silva Department of Biology UNESP-So Paulo State University Campus So José do Rio Preto

Helicobacter pylori(H. pylori) infection is the most common bacterial infection worldwide. Persistent infection of the gastric mucosa leads to inflammatory processes and may remain silent for decades or progress causing more severe diseases, such as gastric adenocarcinoma. The clinical consequences of H. pylori infection are determined by multiple factors, including host genetic predisposition, gene regulation, environmental factors and heterogeneity of H. pylori virulence factors. After decades of studies of this successful relationship between pathogen and human host, various mechanisms have been elucidated. In this review, we have made an introduction on H. pylori infection and its virulence factors, and focused mainly on modulation of host immune response triggered by bacteria, changes in the pattern of gene expression in H. pylori-infected gastric mucosa, with activation of gene transcription involved in defense mechanisms, inflammatory and immunological response, cell proliferation and apoptosis. We also highlighted the role of bacteria eradication on gene expression levels. In addition, we addressed the recent involvement of different microRNAs in precancerous lesions, gastric cancer, and inflammatory processes induced by bacteria. New discoveries in this field may allow a better understanding of the role of major factors involved in the pathogenic mechanisms of H. pylori.

关键词： Helicobacter pylori Inflammation Virulence factors Immune response Gastric lesions Gastric cancer Gene expression MicroRNAs

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How do greenhouse gas emissions vary with biofertilizer type and soil temperature and moisture in a tropical grassland?

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Pedosphere 2020年第5期30卷 607-617页

作者： Abmael da silva CARDOSO Juliana Bega JUNQUEIRA Ricardo Andrade REIS ana Claudia RUGGIERIAnimal Science Departament College of Agricultural and Veterinarian SciencesSao Paulo State UniversityJaboticabal 14884-900(Brazil) Kenji Agricultural and Environmental Consultancy Ribeirdo Preto 14010-079(Brazil)

Greenhouse gases are known to play an important role in global *** this study,we determined the effects of selected soil and climate variables on nitrous oxide(N2O),methane(CH4),and carbon dioxide(CO2)emissions from a tropical grassland fertilized with chicken slurry,swine slurry,cattle slurry,and cattle *** N2O emissions did not differ between treatments and varied from 29.26 to 32.85 mg N m^-***,cumulative CH4 emissions were not significantly different among the treatments and ranged from 6.34 to 57.73 mg CH4 m^-*** and compost application induced CO2 emissions that were significantly different from those in the control *** CH4 conversion factors measured were 0.21%,1.39%,4.39%,and 5.07%for cattle compost,chicken slurry,swine slurry,and cattle slurry,respectively,differing from the recommendations of the Intergovernmental Panel on Climate Change(IPCC).The fraction of added Nemitted as N2O was 0.39%,which was lower than the IPCC default value of 2%.Our findings suggest that N2O emissions could be mitigated by replacing synthetic fertilizer sources with either biofertilizer or *** results indicate the following:N2O emission was mainly controlled by soil temperature,followed by soil moisture and then soil NH^"content;CH4 fluxes were mainly controlled by soil moisture and chamber headspace temperature;and CO2 fluxes were mainly controlled by chamber headspace temperature and soil moisture.

关键词： emission factor methane conversion factor methane oxidation methane production capacity slurry fertilizer soil moisture

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Appropriateness of the study of iron deficiency anemia prior to referral for small bowel evaluation at a tertiary center

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World Journal of Gastroenterology 2017年第24期23卷 4444-4453页

作者： Jaime Pereira Rodrigues Rolando Pinho Joana silva ana Ponte Mafalda Sousa Joao Carlos silva Joao Carvalho Department of Gastroenterology Centro Hospitalar Vila Nova de Gaia/EspinhoRua Conceicao FernandesVila Nova de Gaia

To evaluate the adequacy of the study of iron deficiency anemia (IDA) in real life practice prior to referral to a gastroenterology department for small bowel evaluation. METHODSAll consecutive patients referred to a gastroenterology department for small bowel investigation due to iron deficiency anemia, between January 2013 and December 2015 were included. Both patients referred from general practitioners or directly from different hospital departments were selected. Relevant clinical information regarding prior anemia workup was retrospectively collected from medical records. An appropriate pre-referral study was considered the execution of esophagogastroduodenoscopy (EGD) with Helicobacter pylori (H. pylori) investigation, colonoscopy with quality standards (recent, total and with adequate preparation) and celiac disease (CD) screening (through serologic testing and/or histopathological investigation). RESULTSA total of 77 patients (58.4% female, mean age 67.1 ± 16.7 years) were included. Most (53.2%) patients were referred from general practitioners, 41.6% from other hospital specialties and 5.2% directly from the emergency department. The mean pre-referral hemoglobin concentration was 8.8 ± 2.0 g/dL and the majority of anemias had microcytic (71.4%) and hypochromic (72.7%) characteristics. 77.9% of patients presented with an incomplete pre-referral study: EGD in 97.4%, with H. pylori investigation in 58.3%, colonoscopy with quality criteria in 63.6%, and CD screening in 24.7%. Patients with an appropriate study at the time of referral were younger (48.7 ± 17.7 vs 72.3 ± 12.3 years, P < 0.001). Small bowel evaluation was ultimately undertaken in 72.7% of patients, with a more frequent evaluation in patients with a quality colonoscopy at referral (78.6% vs 23.8%); P < 0.001 (OR = 11.7, 95%CI: 3.6-38.6). The most common diagnosis regarded as the likely cause of IDA was small bowel angioectasia (18.2%) but additional causes were also found in the upper and lower ga

关键词： Iron deficiency anemia Colonoscopy Celiac disease Esophagogastroduodenoscopy Helicobacter pylori Small bowel

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