检索结果-南通市图书馆

Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C

引用

World Journal of Gastroenterology 2015年第17期21卷 5421-5426页

作者： Sabela lens Jose l Calleja ana Campillo Jose A Carrion Teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino maria-Carlota londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns liver Unit Hospital ClinicIDIBAPSCIBERehd08036 BarcelonaSpain liver Unit Hospital Puerta del HierroIDIPHIMCIBERehd28222 MajadahondaMadridSpain Gastroenterology Department Hospital Reina Sofia31500 TudelaNavarraSpain liver Unit Hospital Del MarIMIMCIBERehd08003 BarcelonaSpain Hematology Unit Hospital Clinic08036 BarcelonaSpain

Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and *** due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been *** collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in *** 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of *** age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver *** pancytopenia was diagnosed a median of 10 wk after the initiation of *** patients had pre-treatment hematological abnormalities related to *** six patients,antiviral treatment was interrupted at the onset of hematological *** patients died due to septic complications and one patient due to acute alveolar *** remaining patients *** pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver *** monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications.

关键词： Aplastic anemia Hepatitis C Telaprevir Interferon Protease inhibitors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Role of ammonia in predicting the outcome of patients with acuteon- chronic liver failure

引用

World Journal of Clinical Cases 2021年第3期9卷 552-564页

作者： Stefan Chiriac Carol Stanciu Camelia Cojocariu ana-maria Singeap Catalin Sfarti Tudor Cuciureanu Irina Girleanu Razvan Alexandru Igna Anca Trifan Department of Gastroenterology “Grigore T.Popa”University of Medicine and PharmacyIasi 700115Romania Institute of Gastroenterology and Hepatology "St.Spiridon"Emergency HospitalIasi 700111Romania Intensive Care “Grigore T.Popa”University of Medicine and PharmacyIasi 700115Romania

BACKGROUND High venous ammonia(VA)values have been proven to be a part of the mechanism of hepatic encephalopathy in patients with liver cirrhosis(lC)as well as acute ***,VA has been associated with poor prognosis and high mortality in these clinical ***,the role of ammonia in acuteon-chronic liver failure(AClF)has not yet been clearly *** To assess the role of VA in predicting the outcome of cirrhotic patients with AClF in a tertiary care *** We performed a retrospective observational study including consecutive patients with lC hospitalized for acute non-elective indications such as ascites,hepatic encephalopathy(HE),upper gastrointestinal bleeding,or bacterial infections that fulfilled the Asian Pacific Association for the Study of the liver(APASl)criteria for *** study was conducted in“***”University Hospital,Iasi,Romania,a tertiary care center,between January 2017 and January *** APASl AClF Research Consortium(AARC)score was calculated and AClF grade was established ***-haven classification was used for *** analysis was performed using IBM SPSS version *** Four hundred and forty-six patients were included,aged 59(50-65)years,57.4%***-Pugh,model for end-stage liver disease(MElD)and AARC scores were 11(10-12),19.13±6.79,and 7(6-8),respectively.66.4%had AClF grade I,31.2%AClF grade II,and 2.5%AClF grade *** was diagnosed in 83.9%,34%grade I,37.2%grade II,23.5%grade III,and 5.3%grade *** mortality was 7.8%.VA was 103(78-148)μmol/*** operating characteristic analysis showed good accuracy for the prediction of in-hospital mortality for the AARC score[Area under the curve(AUC)=0.886],MElD score(AUC=0.816),VA(AUC=0.812)and a fair accuracy for the Child-Pugh score(AUC=0.799).Subsequently,a cut-off value for the prediction of mortality was identified for VA(152.5μmol/l,sensitivity=0.706,1-specificity=0.190).Univariate analysis found acute kidney in

关键词： Venous ammonia Hepatic encephalopathy Acute-on-chronic liver failure Asian Pacific Association for the Study of the liver Acute-on-chronic liver Failure Research Consortium score Cirrhosis Mortality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An Outlook on Implantable Biosensors for Personalized Medicine

引用

Engineering 2021年第12期7卷 1696-1699页

作者： Rita Rebelo ana Isabel Barbosa Vitor M.Correlo Rui l.Reis Research Institute on Biomaterials Biodegradablesand BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineBarcoGuimarães 4805-017Portugal ICVS/3B’s-PT Government-Associated laboratory BragaGuimarães 4710-057Portugal

Biosensors are a fast-growing field,as they have been shown to be very helpful in our daily life,playing roles in industries such as agriculture,food safety,homeland security,bioprocessing,environmental monitoring,and industrial *** these,the application of biosensing in medicine and biomedical engineering may have the highest potential for growth and for affecting human quality of life in the near *** potential is driven by the need for new and improved devices and technologies with improved sensitivity,specificity,reliability,and biocompatibility.

关键词： Outlook specificity playing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Study on enzymes of industrial interest in digestive viscera: Greater amberjack (Seriola dumerili)

引用

Journal of Coastal life Medicine 2017年第6期5卷 233-238页

作者： Vagne Melo Oliveira Thiago PajeúNascimento Caio Rodrigo Dias Assis Ranilson de Souza Bezerra ana l.cia Figueiredo Porto laboratory of Bioactive Product Technology–lABTECBIO Department of Morphology and Animal PhysiologyFederal Rural University of PernambucoRecife-PEBrazil laboratory of Enzymology–lABENZ Department of BiochemistryFederal University of PernambucoRecife-PEBrazil laboratory of Immunopathology Keizo Asami Federal University of PernambucoRecife-PEBrazil

Objective:To investigate the presence of industrial enzymes (trypsin and chymotrypsin) as well as collagenolytic and fibrinolytic activities of the neglected processing waste of greater amberjackSeriola dumerili(S. dumerili). Methods: The investigations on trypsin, chymotrypsin, collagenolytic and fibrinolytic activities in residues in digestive viscera were performed. The enzymes trypsin and chymotrypsin were physicochemically characterized (including pH- and thermo-stabilities and sensitivity to metal ions and inhibitors). The kinetic parameters were also determined. Collagenolytic and fibrinolytic activities of the crude extract were also investigated. Results:The crude extract ofS. dumerili showed enzymatic activity of (1.4600 ± 0.0011 and (0.7100 ± 0.0079) IU/mg protein for trypsin and chymotrypsin, respectively. The optimal temperature and pH was 60°C and 9 for trypsin and 40°C and 8 for chymotrypsin. The main inhibitory ions were in the following order: Fe3+> Cu2+> Zn2+> Cd2+> Hg2+ (trypsin) and Hg2+> Fe3+> Zn2+> Cd2+> Mn2+(chymotrypsin). TlCK and benzamidine were the strongest inhibitors for both enzymes. The crude extract also presented collagenolytic activity [(42.44 ± 0.01) IU/mg] and fibrinolytic activity ((26.70 ± 0.05) IU/ml)Conclusions:The crude extract ofS. dumerili showed potential for reuse of its residues and to provide biomolecules of industrial interest like trypsin and to be a source of fibrinolytic enzymes.

关键词： Biomolecules Enzymes Residues Digestive viscera

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Minimizing sperm oxidative stress using nanotechnology for breeding programs in rams

引用

Journal of Animal Science and Biotechnology 2023年第6期14卷 2395-2410页

作者： Alejandro Jurado‑Campos Pedro Javier Soria‑Meneses maria Arenas‑Moreira Carlos Alonso‑Moreno Virginia Rodriguez‑Robledo ana Josefa Soler Jose Julian Garde maria del Rocio Fernandez‑Santos SaBio IREC(CSIC-UClM-JCCM) Campus UniversitarioS/N02071 AlbaceteSpain. Departamento de Quimica Inorganica Organica Y Bioquimica‑Centro de Innovacion en Quimica Avanzada(ORFEO‑CINQA)Facultad de FarmaciaUniversidad de Castilla-La Mancha02008 AlbaceteSpain. Centro Regional de Investigacion Biomedicas Unidad nanoDrugUniversidad de Castilla-La Mancha02008 AlbaceteSpain. Facultad de Farmacia Universidad de Castilla La Mancha02071 AlbaceteSpain.

Background Artificial insemination(AI)is a routine breeding technology in animal ***,the temperature-sensitive nature and short fertile lifespan of ram sperm samples hamper its use in *** this sense,nanotechnology is an interesting tool to improve sperm protection due to the development of nanomaterials for AI,which could be used as delivery *** this work,we explored the feasibility of vitamin E nanoemulsion(NE)for improving sperm quality during *** With the aim of evaluating this proposal,ejaculates of 7 mature rams of Manchega breed were collected by artificial vagina and extended to 60×10^(6)spz/ml in *** containing control and NE(12 mmol/l)with and without exogenous oxidative stress(100μmol/l Fe2+/ascorbate)were stored at 22 and 15℃and motility(CASA),viability(YO-PRO/PI),acrosomal integrity(PNA-FITC/PI),mitochondrial membrane potential(Mitotracker Deep Red 633),lipoperoxidation(C11 BODIPY 581/591),intracellular reactive oxygen species(ROS)production and DNA status(SCSAR)monitored during 96 *** results show that NE could be used to maintain ram spermatozoa during transport at 15 and 22℃for up to 96 h,with no appreciable loss of kinematic and physiological characteristics of freshly collected *** The storage of ram spermatozoa in liquid form for 2-5 d with vitamin E nanoemulsions may lead more flexibility to breeders in AI *** view of the potential and high versatility of these nanodevices,further studies are being carried out to assess the proposed sperm preservation medium on fertility after artificial insemination.

关键词： Breeding technology Nanoemulsions Nanotechnology Sperm oxidative stress Vitamin E

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Amyotrophic lateral sclerosis: a complex syndrome that needs an integrated research approach

引用

Neural Regeneration Research 2019年第2期14卷 193-196页

作者： Javier Riancho Francisco J.Gil-Bea ana Santurtun Adolfo lópez de Munaín Service of Neurology Hospital Sierrallana-Idival CIBERNED (Center for Networked Biomedical Research on Neurodegenerative Diseases Ministry of Economy and Competitiveness Institute Carlos Ⅲ) Neurosciences Area Institute Biodonostia Department of Physiology and Pharmacology University of Cantabria-Idival Department of Neurology University Hospital Donostia Department of Neurosciences University of the Basque Country Universidad País Vasco-Euskal Herria Unibertsitatea

Amyotrophic lateral sclerosis, the most common neurodegenerative disease affecting motor neurons, lacks an effective treatment. A small fraction of amyotrophic lateral sclerosis cases have a familial origin, related to mutations in causative genes, while the vast majority of amyotrophic lateral sclerosis cases are considered to be sporadic, resulting from the interaction between genes and environmental factors in predisposed individuals. During the past few years, dozens of drugs have been postulated as promising strategies for the disease after showing some beneficial effects in preclinical cellular and murine models. However, the translation into clinical practice has been largely unsuccessful and the compounds failed when were tested in clinical trials. This might be explained, at least partially, by the enormous complexity of the disease both from clinico-epidemiological and a pathogenic points of view. In this review, we will briefly comment on the complexity of the disease focusing on some recent findings, and we will suggest how amyotrophic lateral sclerosis research might be reoriented to foster the advance in the diagnostic and therapeutic questions.

关键词： amyotrophic lateral sclerosis AlS environment epidemiology genes phenotype therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

NEW HYBRID CONJUGATE GRADIENT METHOD AS A CONVEX COMBINATION OF lS AND FR METHODS

引用

Acta Mathematica Scientia 2019年第1期39卷 214-228页

作者： Sne?ana S.DJORDJEVI? Faculty of Technology University of Nis

In this paper, we present a new hybrid conjugate gradient algorithm for unconstrained optimization. This method is a convex combination of liu-Storey conjugate gradient method and Fletcher-Reeves conjugate gradient method. We also prove that the search direction of any hybrid conjugate gradient method, which is a convex combination of two conjugate gradient methods, satisfies the famous D-l conjugacy condition and in the same time accords with the Newton direction with the suitable condition. Furthermore, this property doesn't depend on any line search. Next, we also prove that, moduling the value of the parameter t,the Newton direction condition is equivalent to Dai-liao conjugacy *** strong Wolfe line search conditions are *** global convergence of this new method is *** comparisons show that the present hybrid conjugate gradient algorithm is the efficient one.

关键词： hybrid conjugate gradient method convex combination Dai-liao conjugacy condition Newton direction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Angle-tunable intersubband photoabsorption and enhanced photobleaching in twisted bilayer graphene

引用

Nano Research 2021年第8期14卷 2797-2804页

作者： Eva A.A.Pogna Xianchong Miao Driele von Dreifus Thonimar V.Alencar Marcus V.O.Moutinho Pedro Venezuela Cristian Manzoni Minbiao Ji Giulio Cerullo ana maria de Paula Istituto di Nanoscienze CNR-NANO Laboratory NESTPiazza San Silvestro 12Pisa 56127Italy State Key laboratory of Surface Physics and Department of Physics Fudan UniversityShanghai 200433China Departamento de Fisica Institute de Ciencias ExatasUniversidade Federal de Minas GeraisBelo Horizonte-MG 31270-901Brazil Departamento de Fisica Institute de Ciencias Exatas e BiologicasUniversidade Federal de Ouro PretoOuro Preto-MG 35400-000Brazil Ndcleo Multidisciplinar de Pesquisas em Computagao-NUMPEX-COMP Campus Duque de CaxiasUniversidade Federal do Rio de JaneiroDuque de Caxias-RJ25265-970Brazil Institute de Fisica Universidade Federal FluminenseUFFNiteroi-RJ24210-346Brazil IFN-CNR Dipartimento di FisicaPolitecnico di MilanoPiazza L.da Vinci 32Milano 20133Italy

Van der Waals heterostructures obtained by artificially stacking two-dimensional crystals represent the frontier of material engineering,demonstrating properties superior to those of the starting *** control of the interlayer twist angle has opened new possibilities for tailoring the optoelectronic properties of these *** bilayer graphene with a strong interlayer coupling is a prototype of twisted heterostructure inheriting the intriguing electronic properties of *** the effects of the twist angle on its out-of-equilibrium optical properties is crucial for devising optoelectronic *** this aim,we here combine excitation-resolved hot photoluminescence with femtosecond transient absorption *** hot charge carrier distribution induced by photo-excitation results in peaked absorption bleaching and photo-induced absorption bands,both with pronounced twist angle *** simulations of the electronic band structure and of the joint density of states enable to assign these bands to the blocking of interband transitions at the van Hove singularities and to photo-activated intersubband *** tens of picoseconds relaxation dynamics of the observed bands is attributed to the angle-dependence of electron and phonon heat capacities of twisted bilayer graphene.

关键词： twisted bilayer graphene transient absorption microscopy hot-photoluminescence van der Waals heterostructures optoelectronic properties van Hove singularities

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

COMPARISON BETWEEN SWIMMING PRACTICE lEVElS AND SElF IMAGE PERCEPTION IN PHYSICAllY HANDICAPPED PEOPlE

COMPARISON BETWEEN SWIMMING PRACTICE LEVELS AND SELF IMAGE P...

引用

The 2004 Pre-Olympic Congress

作者： Santiago ana l.cia S.P. Souza Maurício T. Florindo Alex A. Camilo Castelo Branco University-Physical Education College-Sao Paulo-BRAZIl

＜正＞Introduction The present investigation had as objective to compare the self-image perception of physically handicapped swimming practitioners in three different levels of *** consisted in a descriptive study,of qualitative nature,in which the Self Image Scale（SIS）-originally elaborated by Singelis in 1994 and adapted by Coelho et al.（2000）-was used as

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Hazardous elements and amorphous nanoparticles in historical estuary coal mining area

引用

Geoscience Frontiers 2019年第3期10卷 927-939页

作者： ana l.Duarte Kátia DaBoit Marcos l.S.Oliveira Elba C.Teixeira Ismael l.Schneider luis F.O.Silva Department of Civil and Environmental Universidad de la Costa Faculdade Meridional IMED FEPAM-Funda■o Estadual de Prote■o Ambiental Henrique luis Roessler

In Brazil, intense coal exploitation activities have led to environmental deterioration, including soil mortification, water contamination, loss of ecosystem, and atmospheric contamination. In addition,considerable quantities of sulfur-rich residues are left behind in the mining area; these residues pose grave environmental issues as they undergo sulfide oxidation reactions. When sulfur oxides come in contact with water, extreme acid leachate is produced with great proportions of sulfate, and hazardous elements(HEs), which are identified as coal drainage(CMD). CMD is an environmental pollution challenge, particularly in countries with historic or active coal mines. To prevent CMD formation or its migration, the source must be controlled; however, this may not be feasible at many locations. In such scenarios, the mine water should be collected, treated, and discharged. In this study, data from 2005 to2010 was gathered on the geochemistry of 11 CMD discharges from ten different mines. There are several concerns and questions on the formation of nanominerals in mine acid drainage and on their reactions and interfaces. The detailed mineralogical and geochemical data presented in this paper were derived from previous studies on the coal mine areas in Brazil. Oxyhydroxides, sulfates, and nanoparticles in these areas possibly go through structural transformations depending on their size and formation conditions. The geochemistry of Fe-precipitates(such as jarosite, goethite, and hematite) existent in the CMD-generating coal areas and those that could be considered as a potential source of hazardous elements(HEs)(e.g., Cr) were also studied because these precipitates are relatively stable in extremely low pH conditions. To simplify and improve poorly ordered iron, strontium, and aluminum phase characterization, field emission scanning electron microscopy(FE-SEM), high-resolution transmission electron microscopy(HR-TEM), micro-Raman spectroscopy, and X-ray diffraction(XRD) a

关键词： Brazilian coal mining Environmental impacts Minerals

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：