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In vivo testing of mucus-permeating nanoparticles for oral insulin delivery using Caenorhabditis elegans as a model under hyperglycemic conditions

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Acta Pharmaceutica Sinica B 2021年第4期11卷 989-1002页

作者： ana lMartínez-lópez Carlos JGonzález-Navarro Paula Aranaz JosélVizmanos Juan MIrache NANO-VAC Research Group Department of Chemistry and Pharmaceutical TechnologySchool of Pharmacy and NutritionUniversity of NavarraPamplona 31080Spain Center for Nutrition Research School of Pharmacy and NutritionUniversity of NavarraPamplona 31080Spain Department of Biochemistry&Genetics School of ScienceUniversity of NavarraPamplona 31080Spain Navarra Institute for Health Research(IdiSNA) Pamplona 31080Spain

The aim was to evaluate the potential of mucus-permeating nanoparticles for the oral administration of *** nanocarriers,based on the coating of zein nanoparticles with a polymer conjugate containing PEG,displayed a size of 260 nm with a negative surface charge and an insulin payload of 77 mg/*** intestinal pig mucus,the diffusivity of these nanoparticles(PPA-NPs)was found to be 20-fold higher than bare nanoparticles(NPs).These results were in line with the biodistribution study in rats,in which NPs remained trapped in the mucus,whereas PPA-NPs were able to cross this layer and reach the epithelium *** therapeutic effcacy was evaluated in Caenorhabditis elegans grown under high glucose *** this model,worms treated with insulin-loaded in PPA-NPs displayed a longer lifespan than those treated with insulin free or nanoencapsulated in *** finding was associated with a signifcant reduction in the formation of reactive oxygen species(ROS)as well as an important decrease in the glucose and fat content in *** effects would be related with the mucus-permeating ability of PPA-NPs that would facilitate the passage through the intestinal peritrophic-like dense layer of worms(similar to mucus)and,thus,the absorption of insulin.

关键词： Nanoparticles Oral delivery Mucus-permeating Biodistribution Insulin Caenorhabditis elegans ROS

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3D Printed Gelatin Scaffold with Improved Shape Fidelity and Cytocompatibility by Using Antheraea pernyi Silk Fibroin Nanofibers

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Advanced Fiber Materials 2022年第4期4卷 758-773页

作者： Shengzhi Zou Suna Fan ana l.Oliveira Xiang Yao Yaopeng Zhang Huili Shao State Key laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano‑Biomaterials and Regenerative MedicineCollege of Materials Science and EngineeringDonghua UniversityShanghai 201620People’s Republic of China CBQF‑Centro de Biotecnologia e Quimica Fina‑laboratorio Associado Escola Superior de BiotecnologiaUniversidade Catolica PortuguesaRua Diogo Botelho 13274169‑005 PortoPortugal

Gelatin(G)is a commonly used natural biomaterial owing to its good biocompatibility and easy ***,using pure gelatin as a bioink can barely achieve an ideal shape fidelity in 3D *** this study,Antheraea pernyi silk fibroin nanofibers(ASFNFs)with arginine-glycine-aspartic acid(RGD)peptide and partial natural silk structure are extracted and combined with pure gelatin bioink to simultaneously improve the shape fidelity and cytocompatibility of corresponding 3D printed *** show that the optimum printing temperature is 30℃ for these *** printed filaments using 16G/4ASFNFs bioink(16wt%gelatin and 4wt%ASFNFs)demonstrate better morphology and larger pore size than those printed by pure gelatin bioink(20G,20wt%gelatin),thus successfully improve the shape fidelity and porosity of the 3D printed *** 16G/4ASFNFs scaffold also demonstrate higher swelling ratio and faster degradation rate than the pure gelatin ***,the cell viability and proliferation ability of Schwann cells cultured on the 16G/4ASFNFs scaffold are significantly superior than those cultured on the pure 20G *** ASFNFs enhanced 16G/4ASFNFs scaffold reported here are expected to be a candidate with excellent potential for biomedical applications.

关键词： Antheraea pernyi silk fibroin nanofiber 3D printed scaffold Shape fidelity Cytocompatibility Gelatin

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length–mass allometries in amphibians

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Integrative Zoology 2018年第1期13卷 36-45页

作者： luca SANTINI ana BENÍTEZ-lÓPEZ Gentile Francesco FICETOlA Mark A.J.HUIJBREGTS Department of Environmental Science Institute for Wetland and Water ResearchFaculty of ScienceRadboud UniversityNijmegenthe Netherlands Department of Bioscience University of MilanMilanItaly Alpine Ecology laboratory Grenoble Alpes UniversityGrenobleFrance PBl Netherlands Environmental Assessment Agency The Haguethe Netherlands

Body mass is rarely recorded in amphibians,and other body measurements(*** to vent length,SVl)are generally collected ***,length measurements,when used as proxies of body mass in comparative analyses,are problematic if different taxa and morphotypes are *** developed allometric relationships to derive body mass from SVl *** fitted phylogenetic generalized least square models for frogs(Anura)and salamanders(Caudata)and for several families *** tested whether allometric relationships differed between species with different habitat preferences and between morphs in *** were fitted with SVl-mass measurements for 88 frog and 42 salamander *** assessed the predictive performance of the models by ***,the models showed high explained variance and low forecasting *** differed among semi-aquatic,terrestrial and arboreal frogs,and between paedomorphic and non-paedomorphic *** mass estimates derived from our models allow for comparability of studies on multiple taxa and can be used for testing theories built upon evolutionary and ecological processes which are directly related to body mass.

关键词： Anura body size body weight Caudata SVl

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Fertilization of Tifton 85 with Swine liquid Manure

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Agricultural Sciences 2019年第7期10卷 918-926页

作者： Marinho Rocho da Silva Joadil Goncalves de Abreu Oscarlina l.cia dos Santos Weber Flabiele Soares da Silva Edna maria Bonfim-Silva ana Paula Alves Barreto Damasceno Faculty of Agronomy and Animal Science Federal University of Mato GrossoCuiabáBrasil Department of Agricultural and Environmental Engineering Institute of Agricultural Sciences and TechnologyFederal University of Mato GrossoRondonópolisBrazil

The objective was to verify the possibility of supplying the nutritional requirement of Tifton 85 grass with swine liquid manure in an intensive management system. The experiment was carried out in a randomized block design, with four treatments of swine liquid manure doses: 0, 70, 140 and 210 m3·ha-1, divided into seven applications and a treatment of mineral fertilization of 200 kg of nitrogen ha-1·year-1. Samples of the collected plant material were weighed to obtain fresh mass taken for drying and then ground for bromatological determination. The dry mass production data were obtained by dry matter accumulation during the cuts and averages were made for the variables;plant height, crude protein, NDF, ADF, neutral detergent insoluble protein (NDIP) and acid detergent insoluble protein (ADIP). The data were subjected to variance analysis, performing regression for swine liquid manure doses and averages test (Dunnett test) to compare the doses with the mineral fertilization. Higher plant heights, dry mass production, crude protein content, neutral detergent insoluble protein content and lower neutral detergent fiber content in Tifton 85 grass were observed with mineral fertilization. In the variables, acid detergent fiber and acid detergent insoluble protein there was no difference (P = 0.05) between the mineral fertilization and the swine liquid manure doses. There was a linear increase (P = 0.05) of swine liquid manure doses only in dry matter production. Swine liquid manure doses up to 210 m3·ha-1·year-1 do not meet the entire nutritional requirement of Tifton 85 grass, recommending the evaluation of higher swine liquid manure doses or complementation with mineral fertilization.

关键词： Bromatology Cynodon spp. Organic Fertilization Waste Reuse

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Growth and Production of Crambe Submitted to Doses of Nitrogen and Potassium

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American Journal of Plant Sciences 2016年第1期7卷 8-16页

作者： Ramara Sena de Souza l.cia Helena Garófalo Chaves Josely Dantas Fernandes ana Carolina Feitosa de Vasconcelos Federal University of Campina Grande Campina Grande Brazil State University of Paraiba Campus II Lagoa Seca Brazil

The dependence on non-renewable fuels of countries around the world increased the interest for the gradual replacement of fossil fuels with renewable ones. Thus, several development programs for the use of renewable sources for power generation have been created and, in this perspective, biofuels have been highlighted. Crambe is an alternative crop for the production of biodiesel due to its rusticity, precocity, high oil content and adaptability to different climates. Optimum management practices of fertilizer use in crambe cultivation are little known and there are no specific recommendations for its fertilization. Therefore, the objective of this research was to study the effects of mineral fertilizers concerning the nitrogen and potassium elements in the growth and production of crambe. The experiment was installed in a greenhouse, with a completely randomized design. Nitrogen doses used were 30, 60, 90 and 120 kg·ha-1and 50, 75, 100 to 125 kg·ha-1 for potassium. The increase in production was directly proportional to the increase in nitrogen levels. The potassium doses did not cause significant effect on the growth of crambe.

关键词： Biofuels Fertilization Crambe abyssinica N K

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Uterine Arteriovenous Malformation Acquired after Cesarean Section: A Case Report

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Open Journal of Obstetrics and Gynecology 2021年第11期11卷 1512-1516页

作者： ana l.cia Isotton leandro Armani Scaffaro Ellen Machado Arlindo Anne Bergmann Nicolas Karpouzas Vicentini Janete Vettorazzi Service of Obstetrics and Gynecology and Interventional Radiology Department Hospital Moinhos de Vento Porto Alegre Por-to Alegre/RS Brazil Medicina Fetal Porto Alegre Porto Alegre/RS Brazil Post Graduation Program in Health Sciences: Gynecology and Obstetrics Faculdade de Medicina da Universidade Federal do Rio Grande do Sul (UFRGS) RS Brazil

Background: Uterine arteriovenous malformation (AVM) is a rare, potentially life-threatening cause of abnormal uterine bleeding that can be acquired following a cesarean section. The diagnosis is difficult, often misdiagnosed with retained products of conception and placenta accreta. Transarterial embolization (TAE) is an efficacious and effective method of treating AVM, particularly in patients of reproductive age. Case Report: A 41-year-old, nulliparous woman, started with a history of abnormal uterine bleeding 30 days after a cesarean section. She didn’t have anaemia and beta-human chorionic gonadotropin (beta-hCG) was negative. The transvaginal color Doppler ultrasound showed multiple vascular channels within myometrium showing colored mosaic patterns suggesting AVM, confirmed by Magnetic Resonance Imaging. The patient was referred to perform a Computed Tomography Angiography and right uterine artery embolization without any vascular complications. ana;">ana;">ana;">Conclusion: AVM is a rare consequence of cesarean section but has to be considered in cases of persistent uterine bleeding in the puerperium. Embolization is a sa

关键词： Arteriovenous Malformation Embolization Therapeutic Vaginal Bleeding Cesarean Section

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Crambe (<i>Crambe abyssinica</i>) Cultivation under Different levels of Fertilization with Nitrogen, Phosphorus and Potassium

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American Journal of Plant Sciences 2017年第9期8卷 2031-2039页

作者： ana Carolina F. de Vasconcelos l.cia Helena G. Chaves Josely Dantas Fernandes Gilvanise Alves Tito Department of Agricultural Engineering Federal University of Campina Grande Paraiba State Brazil Department of Agroecology and Agropecuaria State University of Paraiba Paraiba State Brazil

The effects of fertilization on crambe are poorly understood;in this sense, this study aimed to evaluate the crambe growth under different levels of nitrogen (0, 40, 80, 120 kg·ha-1), phosphorus (0, 50, 100, 150 kg·ha-1), and potassium (0, 30, 60, 90 kg·ha-1) in a greenhouse. The height of the plants, the production of dried biomass and that of 1000 grains of crambe were evaluated. The height of the plants was impaired as a function of increasing doses of nitrogen. The interaction of nitrogen and phosphorus in the crambe crop increased the number of grains and dry shoot biomass. The growth and yield of the crop were not influenced by the use of potassium in mineral fertilization.

关键词： Biodiesel Semiarid Region Mineral Fertilization Crambe Growth

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Polymorphisms of folate metabolism genes in patients with cirrhosis and hepatocellular carcinoma

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World Journal of Hepatology 2016年第29期8卷 1234-1243页

作者： Nathália Perpetua Peres ana lívia Silva Galbiatti-Dias Marcia maria Urbanin Castanhole-Nunes Renato Ferreira da Silva Erika Cristina Pavarino Eny maria Goloni-Bertollo mariangela Torreglosa Ruiz-Cintra Genetics and Molecular Biology Research Unit UPGEM Sao Jose do Rio Preto Medical School FAMERP and Medical School Fundation FUNFARME Study Group of liver Tumors GETF Hospital de Base Federal University of the Triangulo Mineiro UFTM

AIM To evaluated the association of the risk factors and polymorphisms in MTHFR C677 T, MTHFR A1298 C, MTR A2756 G and MTRR A66 G *** Patients with cirrhosis(n = 116), hepatocellular carcinoma(HCC)(n = 71) and controls(n = 356) were included. Polymerase chain reaction followed by enzymatic digestion and allelic discrimination technique real-time PCR techniques were used for analysis. MINITAB-14.0and SNPstats were utilized for statistical analysis. RESUlTS Showed that age ≥ 46 years(OR = 10.31; 95%CI: 5.66-18.76; P ciated with cirrhosis. Age ≥ 46 years(OR = 16.36; 95%CI: 6.68-40.05; P lcohol habit(OR = 2.01; 95%CI: 1.03-3.89; P = 0.039) were associated with HCC. MTHFR A1298 C in codominant model(OR = 3.37; 95%CI: 1.52-7.50; P = 0.014), recessive model(OR = 3.04; 95%CI: 1.43-6.47; P = 0.0051) and additive model(OR = 1.71; 95%CI: 1.16-2.52; P = 0.0072) was associated with HCC, as well as MTR A2756 G in the additive model(OR = 1.68; 95%CI: 1.01-2.77; P = 0.047), and MTRR A66 G in the codominant model(OR = 3.26; 95%CI: 1.54-6.87; P l(OR = 2.55; 95%CI: 1.24-5.25; P = 0.007) and overdominant model(OR = 3.05; 95%CI: 1.66-5.62; P l(OR = 1.54; 95%CI: 1.02-2.33; P = 0.042) and smokers who presented at least one polymorphic allele for MTRR A66G(OR = 1.71; 95%CI: 0.77-3.82; P = 0.0051) showed increased risk for cirrhosis. There was no association between clinical parameters and polymorphisms. CONClUSION Age ≥ 46 years, alcohol habit and MTR A2756 G, MTHFR A1298 C and MTRR A66 G polymorphisms are associated with an increased risk of HCC development; age ≥ 46 years, tobacco habit and the MTR A2756 G polymorphism are associated with cirrhosis.

关键词： Polymorphism Folate metabolism liver cirrhosis Hepatocellular carcinoma

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Dry Matter Production and Nutritional Status of Sunflower Grown in Nutrient Solution under Macronutrient Omission

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Agricultural Sciences 2018年第11期9卷 1479-1486页

作者： Allan Nunes Alves Felipe Guedes de Souza l.cia Helena Garófalo Chaves ana Carolina Feitosa de Vasconcelos Department of Agricultural Engineering Federal University of Campina Grande Campina Grande Brazil

The objective of this study was to evaluate the effect of omission of macronutrients on dry matter production and on the nutritional status of sunflower cv. BRS 122. The experiment was carried out in a greenhouse, in randomized blocks, with seven treatments corresponding to the Hoagland & Arnon standard solution (1950) and the individual omission of N, P, K, Ca, Mg and S, in three replicates. After 50 days of sowing, the dry matter and the nutritional status of the plants were evaluated. The omission of N, P, K, Ca, Mg and S limited the dry mass production of sunflower cv. BRS 122 in relation to the complete solution, besides causing nutritional imbalance due to the interaction between the nutrients. The omission of the macronutrients K, Ca, and Mg caused the higher imbalances in the plants, highlighting the elevated N contents in these treatments comparing to the complete solution.

关键词： Helianthus annuus Nutritional Diagnosis Omission of Nutrients

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Electrospinning as a route to advanced carbon fibre materials for selected low-temperature electrochemical devices:A review

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Journal of Energy Chemistry 2021年第8期30卷 492-529,I0011页

作者： Yue Wen Matt D.R.Kok Jorge Pavel Victoria Tafoya ana BJorge Sobrido Ellsworth Bell Jeff T.Gostick Servann Herou Philipp Schlee maria-Magdalena Titirici Dan J.l.Brett Paul R.Shearing Rhodri Jervis The Electrochemical Innovation lab Dept.of Chemical EngineeringUniversity College LondonTorrington PlaceWC1E 7JE LondonUK Queen Mary University of london School of Engineering and Materials ScienceMile End RoadE14NS LondonUK Department of Chemical Engineering University of WaterlooWaterlooCanada Department of Chemical Engineering Imperial College LondonSouth Kensington CampusSW72AZ LondonUK

Electrospinning has been proven as a highly versatile fabrication method for producing nano-structured fibres with controllable morphology,of both the fibres themselves and the void structure of the ***,it is possible to use heteroatom doped polymers or to include catalytic precursors in the electrospinning solution to control the surface properties of the *** factors make it an ideal method for the production of electrodes and flow media for a variety of electrochemical devices,enabling reduction in mass transport and activation overpotentials and therefore increasing ***,the use of biomass as a polymer source has recently gained attention for the ability to embed sustainable principles in the materials of electrochemical devices,complementing their ability to allow an increase in the use of renewable electricity via their *** this review,the historical and recent developments of electrospun materials for application in redox flow batteries,fuel cells,metal air batteries and supercapacitors are thoroughly reviewed,including an overview of the electrospinning process and a guide to best ***,we provide an outlook for the emerging use of this process in the field of electrochemical energy devices with the hope that the combination of tailored microstructure,surface functionality and computer modelling will herald a new era of bespoke functional materials that can significantly improve the performance of the devices in which they are used.

关键词： Electrospinning Redox flow batteries Fuel cells Metal-air batteries Supercapacitors

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