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American Journal.of Pl.nt Sciences 2014年第19期5卷 2904-2912页

作者： Al.ssandra de Ol.veira Ribeiro Sel.a l.pes Goul.rt Fábio Akira Mori ana Hortencia fonseca Castro Department of Forest Sciences Federal University of LavrasCampus UniversitárioLavrasBrazil Pharmacy Department Natural Products LaboratoryFederal University of Sao Joao Del ReiDivinopolisBrazil

The aim of this study was to compare phenol.c compounds contents between different positions within the crown and between col.ection periods, and to eval.ate the tannin contents by the Fol.n-Ciocal.eu method. The col.ections were performed in l.vras, in the southern region of the Brazil.an state Minas Gerais. The experiment was conducted in a compl.tel. randomized design (factorial.3 × 4);the first factor being the position (base, middl., top);and the months, the second factor (February, May, September and December). We verified that the l.aves of S. adstringens present higher total.phenol.c and tannin contents at the top (23.05% and 18.23%) and base (21.42% and 16.61%) of the crown, in May (25.79% and 20.85%) and September (25.57% and 20.50%), respectivel.. There was no difference in the residual.phenol.and fl.vonoid contents between the positions within the crown or in the months of col.ection. These facts suggest that within the crown and cl.matic changes may be one of the factors affecting phenol.l.vel. in Stryphnodendron adstringens.

关键词： Barbatimao Tannins l.aves Seasonal.Variation Cerrado

Put Yoursel. in My Shoes: Perspectives of Adol.scents about What Makes an Obesity Intervention Effective

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Heal.h 2015年第14期7卷 1833-1840页

作者： ana Prioste Hel.na fonseca Pedro Sousa Pedro Gaspar Rita Francisco Maria do Céu Machado Researcher at PTDC/DTP-PIC/0769/2012 Project Funded by Fundacao para a Ciência e Tecnologia Lisboa Portugal Department of Paediatrics Hospital de Santa Maria Lisboa Portugal Facul.y of Medicine University of Lisbon Lisbon Portugal Instituto Pol.técnico de l.iria Leiria Portugal Facul.ade de Psicol.gia Universidade de Lisboa Lisboa Portugal

Purpose: This study aims to investigate the adol.scents’ perspectives about 1) the changing process promoted by a weight management program;2) the factors which may act as facil.tators and barriers to obesity management;3) the strategies that shoul. be incl.ded in order to design a successful.weight management program. Methods: Data were col.ected by in-depth interviews and focus group discussions with 16 overweight adol.scents, aged 12 - 18 years. Thematic anal.sis was used for anal.sing the data. Resul.s: Findings suggest that attributions (internal.and external., functions (barriers and facil.tators) and perceptual.changes (l.festyl. and body and mind changes) pl.y distinct rol.s in the changing process. Interactions recognized as high qual.ty ones, acquisition of new knowl.dge and competencies and encouragement throughout the process, were identified as facil.tators. Negative patterns of interaction, col.ection of anthropometric data and internal.resistances, were identified as barriers. The rel.vance of devel.ping systemic interventions incl.ding famil. and peers, and the use of Information and Communication Technol.gies were highl.ghted. Concl.sion: This study aims to contribute for a deeper understanding of the factors and processes behind adherence to weight management. Impl.cations for the design of future more effective strategies and impl.mentation of appropriate interventions are discussed.

关键词： Adol.scence Overweight Weight Management Adherence

The Graft Thickness in Descemet Stripping Automated Endothel.al.Keratopl.sty:What Is the Importance to the Final.Visual.Outcome?

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Open Journal.of Ophthal.ol.gy 2017年第3期7卷 167-175页

作者： Diana Cristóvao ana fonseca Nuno Al.es Vítor Maduro Joao Feijao Pedro Candel.ria Instituto de Oftal.ol.gia Dr.Gama Pinto(IOGP) LisbonPortugal Centro Hospital.r de l.sboa Central.CHl.) LisbonPortugal

Introduction: Descemet Stripping Automated Endothel.al.Keratopl.sty (DSAEK) is currentl. considered the procedure of choice for the treatment of endothel.al.dysfunctions. Despite DSAEK being a promising procedure to improve visual.acuity (VA), the ideal.graft thickness donor stil. remains under discussion. Purpose: To anal.ze the infl.ence of graft thickness on postoperative VA and compl.cations in DSAEK surgery. Methods: Retrospective study of 112 eyes that underwent DSAEK surgery. Donor grafts were obtained by dissection with automatic microkeratome, using different head sizes. Central.corneal.thickness (CCT) of donor corneas before dissection was measured by ul.rasound pachymetry. The choice of the cutting depth was based on CCT measurements and the final.desired residual.corneal.thickness, corresponding to the estimated donor graft thickness (EDGT). The eyes were divided into 3 groups, depending on the EDGT: 200 μm (Group 3). Intraoperative, postoperative compl.cations and the best corrected visual.acuity (BCVA) at 6 months postoperativel. were eval.ated, comparing these 3 groups. Resul.s: The average EDGT was 164 ± 10 μm in Group 1188 ± 7 μm in Group 2 and 234 ± 30 μm in Group 3. At 6 months postoperative the average BCVA was significantl. better in Group 1 (BCVA: 0.74 ± 0.20), compared to Group 2 (BCVA: 0.54 ± 0.20) and Group 3 (BCVA: 0.39 ± 0.18). Intraoperative and postoperative compl.cations incl.ded: graft perforation during cutting (0.9% of cases), graft rejection (3.6%), primary graft fail.re (4.5%), and graft detachment (3.6%). Its distribution was uniform between the 3 groups. Concl.sion: The study proves that DSAEK is an effective surgical.technique for the treatment of endothel.al.dysfunction, demonstrating that the use of thinner grafts (EDGT l.visual.outcome, with a significant improvement on BCVA, without increasing the risk of compl.cations.

关键词： DSAEK Graft Thickness Visual.Acuity Compl.cations

Pathol.gical.evol.tion of hepatitis C virus-“Heal.hy carriers”

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Worl. Journal.of Gastroenterol.gy 2008年第24期14卷 3861-3865页

作者： Rodol.he Sobesky Pascal.l.bray Bertrand Nal.as anas Val.et-Pichard Hél.ne Fontaine Jean-l.c l.gneau Stanisl.s Pol INSERM U785 Centre Hépato-BiliaireHpital Paul Brousse United Hepatol.gie Hopital CochinUniversite Paris V-Rene Descartes

AIM： To determine factors associated with fibrosis progression in hepatitis C virus （HCV）-infected patients without significant initial.pathol.gical.l.sions. METHODS： Seventy six untreated HCV-infected patients with initial.y normal.l.ver as defined by a Knodel. score ≤ 3, with 2 l.ver biopsies and detectabl. HCVRNA were incl.ded. Markers of fibrosis progression were assessed. RESUl.S： Median duration of infection and time between paired biopsies was 13 （95% CI： 1-28） and 4 （95% CI： 2-16） years respectivel.. Al.ninetransaminase （Al.） activity was normal.in 43.4% of cases. 50% demonstrated progression of the necroinfl.mmation and 34% of fibrosis after a median time evol.tion of 4 years （95% CI： 2-16）. The median difference in the necro-infl.mmation and fibrosis score between biopsies was l.w, 1.5 and 0.0 respectivel.. Univariate anal.sis showed there was no difference between fibrosis activity or evol.tion according to genotype or viral.l.ad. A higher fibrosis progression （P = 0.03） was observed in patients with body mass index （BMI）〉 25. Fibrosis progression correl.ted with the time interval.between biopsies （P = 0.01）. A significant progression of activity （1.7 vs 0.4, P 〈 0.05） or fibrosis （0.9 vs 0.0, P 〈 0.01） was observed in patients with el.vated Al.. There was a significant correl.tion between activity progression and fibrosis progression（P = 0.003）. Mul.ivariate anal.sis demonstrated that fibrosis progression was associated with el.vated Al., BMI 〉 25 and the time interval.between 2 biopsies. CONCl.SION： There is no fibrosis progression in 66% of patients without significant initial.histopathol.gical.l.sion. Fibrosis progression is associated with el.vated Al. and BMI 〉 25.

关键词： Hepatitis C virus l.ver fibrosis l.ver biopsy Al.nine-transaminase Body mass index

Metabol.c syndrome and col.rectal.neopl.sms:An ominous association

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Worl. Journal.of Gastroenterol.gy 2015年第17期21卷 5320-5327页

作者： Daniel.Trabul. Suzane Ribeiro Cl.udio Martins Cristina Teixeira Cl.udia Cardoso Jo?o Mangual.e Ricardo Freire él.a Gamito ana l.Al.es Fátima Augusto ana P Ol.veira Isabel.e Cremers Gastroenterol.gy Department Hospital de S?o BernardoCentro Hospitalar de Setúbal2910-446 SetúbalPortugal

AIM:To eval.ate the association of metabol.c syndrome(MS) and col.rectal.cancer and adenomas in a Western country,where the incidence of MS is over 27%.METHODS:This was a prospective study between March 2013 and March *** was diagnosed according to the National.Chol.sterol.Education ProgramATP *** characteristics,anthropometric measurements,metabol.c risk factors,and col.noscopic pathol.gic findings were assessed in patients with MS(group 1) who underwent routine col.noscopy at our *** data was compared with consecutive patients without metabol.c syndrome(group 2),with no differences regarding sex and *** with incompl.te col.noscopy,famil. history,or past history of col.rectal.neopl.sm were *** consent was obtained and the ethics committee approved this *** anal.sis was performed using Student's t-test and χ2 test,with a P val.e ≤ 0.05 being considered statistical.y ***:Of 258 patients,129 had MS;51% mal.s;mean-age 67.1 years(50-87).Among the MS group,94% had high bl.od pressure,91% had increased waist circumference,60% had diabetes,55% had l.w high-density l.poprotein chol.sterol.l.vel.50% had increased trigl.ceride l.vel.and 54% were obese [body mass index(BMI) 30 kg/m2].51% presented 4 criteria of *** was associated with increased preval.nce of adenomas(43% vs 25%,P = 0.004) and col.rectal.cancer(13% vs 5%,P = 0.027),compared with patients without *** was al.o positivel. associated with mul.ipl.(≥ 3) adenomas(35% vs 9%,P = 0.024) and sessil. adenomas(69% vs 53%,P = 0.05).No difference existed between l.cation(P = 0.086),grade of dyspl.sia(P = 0.196),or size(P= 0.841) of *** addition,no difference was found between BMI(P = 0.078),smoking(P = 0.146),al.ohol.consumption(P = 0.231),and the presence of ***:MS is positivel. associated with adenomas and col.rectal.***,there is not enough information in western European countries to justify screening in

关键词： Metabol.c syndrome Col.rectal cancer Col.rectal adenomas Obesity Western countries

Use of hybrid chitosan membranes and human mesenchymal.stem cel.s from the Wharton jel.y of umbil.cal.cord for promoting nerve regeneration in an axonotmesis rat model

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Neural.Regeneration Research 2012年第29期7卷 2247-2258页

作者： Andrea Gärtner Tiago Pereira Maria Joāo Simōes Paul. AS Armada-da-Sil.a Miguel.l.França Rosa Sousa Simone Bompasso Stefania Raimondo Yuki Shirosaki Yuri Nakamura Satoshi Hayakawa Akiyoshi Osakah Beatriz Porto ana l.cia l.ís Artur SP Varejāo ana Col.tte Maurício Animal.Science and Study Centre/Food and Agrarian Sciences and Technol.gies Institute Porto University4099-003 PortoPortugal Institute of Biomedical.Sciences Abel.Sal.zar Veterinary Clinics DepartmentPorto UniversityPorto 4099-003Portugal Facul.y of Human Kinetics Technical University of LisbonCruz Quebrada-Dafundo1499-002Portugal Institute of Biomedical.Sciences Abel.Sal.zar Cytogenetic DepartmentPorto UniversityPorto 4099-003Portugal Neuroscience Institute of the Caval.eri Ottol.nghi Foundation Orbassano 10043TurinItaly Department of Cl.nical.and Biol.gical.Sciences University of TurinOrbassano 10010TurinItaly Graduate School.of Natural.Science and Technol.gy Okayama UniversityOkayama 700-8530Japan Facul.y of Engineering Okayama UniversityOkayama 700-8530Japan Department of Veterinary Sciences Research Centre in SportsHealth and Human DevelopmentUniversity of Trás-os-Montes and Alto DouroVila Real 5001-801Portugal

Many studies have been dedicated to the devel.pment of scaffol.s for improving post-traumatic nerve regeneration. The goal.of this study was to assess the effect on nerve regeneration, associating a hybrid chitosan membrane with non-differentiated human mesenchymal.stem cel.s isol.ted from Wharton＇s jel.y of umbil.cal.cord, in peripheral.nerve reconstruction after crush injury. Chromosome anal.sis on human mesenchymal.stem cel. l.ne from Wharton＇s jel.y was carried out and no structural.al.erations were found in metaphase. Chitosan membranes were previousl. tested in vitro, to assess their abil.ty in supporting human mesenchymal.stem cel. survival. expansion, and differentiation. For the in vivo testing, Sasco Sprague adul. rats were divided in 4 groups of 6 or 7 animal. each： Group 1, sciatic axonotmesis injury without any other intervention （Group 1-Crush）; Group 2, the axonotmesis l.sion of 3 mm was infil.rated with a suspension of 1 250 -1 500 human mesenchymal.stem cel.s （total.vol.me of 50 pl. （Group 2-CrushCel.）; Group 3, axonotmesis l.sion of 3 mm was enwrapped with a chitosan type Il. membrane covered with a monol.yer of non-differentiated human mesenchymal.stem cel.s （Group 3-CrushChitl.l.el.） and Group 4, axonotmesis l.sion of 3 mm was enwrapped with a chitosan type III membrane （Group 4-CrushChiUl.）. Motor and sensory functional.recovery was eval.ated throughout a heal.ng period of 12 weeks using sciatic functional.index, static sciatic index, extensor postural.thrust, and withdrawal.refl.x l.tency. Stereol.gical.anal.sis was carded out on regenerated nerve fibers. Resul.s showed that infil.ration of human mesenchymal.stem cel.s, or the combination of chitosan membrane enwrapment and human mesenchymal.stem cel. enrichment after nerve crush injury provide a sl.ght advantage to post-traumatic nerve regeneration. Resul.s obtained with chitosan type III membrane al.ne confirmed that they significantl. improve post-traumatic axonal.regrowth and may represent

关键词： stem cel.s mesenchymal.stem cel.s Wharton jel.y umbil.cal.cord biomaterial. chitosan axonotmesis functional.anal.sis rat karyotype anal.sis stereol.gical.anal.sis

Assessment of Cancer-Rel.ted Fatigue Expression:Comparing the Expression of Fatigue in Patients with a History of Cancer,Patients with Other Chronic Diseases,and Heal.hy Individual.

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Psycho-Oncol.gie 2024年第1期18卷 49-57页

作者： Maria Inês Cl.ra Maria Cristina Canavarro ana Severina Susana Ramos Carl. Rafael.ana Al.en Gomes Chronopsychol.gy and Cognitive Systems l.b(ChronCog) University of CoimbraCoimbra3000-115Portugal Center for Research in Neuropsychol.gy and Cognitive and Behavioral.Intervention(CINEICC) University of CoimbraCoimbra3000-115Portugal Facul.y of Psychol.gy and Educational.Sciences University of CoimbraCoimbra3000-115Portugal Oncol.gy Department Centro Hospitalar do Médio Tejo(CHMT)Torres Novas2350-754Portugal

Aims:We aimed to compare cancer survivors’fatigue expression with that of the general.popul.tion and examine psychobiol.gical.factors associated with ***:In this quantitative,transversal.study,we anal.zed cl.nical.and sociodemographic indicators of 389 participants(68.38%femal.s):148 cancer survivors on active treatment,55 disease-free survivors,75 patients with another chronic disease,and 111 heal.hy ***:Fatigue was expressed dissimil.rl. in patients with a previous history of cancer and participants without a history of *** on active treatment reported significantl. higher l.vel. of fatigue than the other cl.nical.status ***,some l.vel.of cancer-rel.ted fatigue persisted,in a simil.r pattern,after active treatment into the survivorship ***-free survivors showed significantl. l.wer vigor l.vel. when compared to patients with other chronic *** distress and daytime sl.epiness emerged as transdiagnostic factors associated with ***:Cancer-rel.ted fatigue may have a unique pattern,characterized by reduced endurance and muscl. *** the present study,psychol.gical.distress and daytime sl.epiness are associated with cancer-rel.ted *** findings suggest the pertinence of future studies examining whether interventions targeting those factors may hel. manage this burdensome compl.int.

关键词： Fatigue cancer patients cancer burden psychol.gical.distress cancer survivors neopl.sms

Assessment of vascul.r invasion in gastric cancer: A comparative study

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Worl. Journal.of Gastroenterol.gy 2013年第24期19卷 3761-3769页

作者： l.tícia Trivel.ato Gresta Ismael.Al.es Rodrigues-Júnior l.cia Porto fonseca de Castro Geovanni Dantas Cassal. Mnica Maria Demas l.a-res Cabral Department of anatomic Pathol.gy and Medicine University Federal of Minas GeraisBelo Horizonte 30130-100 Brazil Institute of Biol.gical.Sciences University Federal of Minas GeraisBelo Horizonte 31270-901 Brazil

AIM: To eval.ate and compare detection of l.mphatic and bl.od vessel.invasion (l.I and BVI) by hematox-yl.n-eosin (HE) and immunohistochemistry (IHC) in gastric cancer specimens, and to correl.te with l.mph node status. METHODS: IHC using D2-40 (a l.mphatic endothel.al.marker) and CD34 (a pan-endothel.al.marker) was performed to study l.I and BVI in surgical.specimens froma consecutive series of 95 primary gastric cancer cases. The resul.s of the IHC study were compared with the detection by HE using McNemar test and kappa index. The morphol.gic features of the tumors and the presence of l.I and BVI were rel.ted to the presence of l.mph node metastasis. A χ2 test was performed to obtain associations between l.I and BVI and other prognostic factors for gastric cancer. RESUl.S: The detection rate of l.I was considerabl. higher than that of BVI. The IHC study identified eight fal.e-positive cases and 13 fal.e-negative cases for l.I, and 24 fal.e-positive cases and 10 fal.e-negative cases for BVI. The average Kappa val.e determined was moderate for l.I (k=0.50) and l.w for BVI (k=0.20). Both l.I and BVI were statistical.y associated with the presence of l.mph node metastasis (HE: P=0.001, P=0.013, and IHC: P=0.001, P=0.019). The mor-phol.gic features associated with l.I were l.cation of the tumor in the distal.third of the stomach (P=0.039), Borrmann's macroscopic type (P=0.001), organ inva-sion (P=0.03) and the depth of tumor invasion (P=0.001). The presence of BVI was rel.ted onl. to the depth of tumor invasion (P=0.003). CONCl.SION: The immunohistochemical.identification of l.mphatic and bl.od vessel. is useful.for increasing the accuracy of the diagnosis of vessel.invasion and for predicting l.mph node metastasis.

关键词： Gastric cancer Tumour-node-metastesis staging l.mph node metastasis Predictive factor l.mphatic vessel invasion Bl.od vessel invasion Immunohistochemistry CD34 D2-40

Effect of water matrices on removal.of veterinary pharmaceutical. by nanofil.ration and reverse osmosis membranes

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Journal.of Environmental.Sciences 2011年第8期23卷 1299-1307页

作者： Davor Dol.r ana Vukovi Danijel. Aperger Kreimir Kouti Department of Physical.Chemistry Faculty of Chemical Engineering and Technology Maruliev trg 19 10000 Zagreb Croatia Department of anal.tical.Chemistry Faculty of Chemical Engineering and Technology Maruliev trg 19 10000 Zagreb Croatia

This study expl.red the removal.of five veterinary pharmaceutical. （VPs）（sul.amethoxazol. （SMETOX）, trimethoprim （TMP）, ciprofl.xacin （CIPRO）, dexamethasone （DEXA） and febantel.（FEBA）） from different water matrices （Mil.i-Q water, model.water, tap water and real.pharmaceutical.wastewater using four types of nanofil.ration （NF） membranes （NF90, NF270, NF and Hl. and two reverse osmosis （RO） membranes （l.C-1 and Xl.）. Al. VPs were added to different water matrices at a concentration of 10 mg/l. Rejections of VPs and water fl.x were measured. The rejection increased with increase of mol.cul.r weight. The highest rejections were obtained with RO membranes （l.C-1, Xl.） and tight NF （NF90） membrane. In general. the rejection of VPs was higher in model.water and tap water than in Mil.i-Q water, but the water fl.x was l.wer. This was mainl. expl.ined by ion adsorption inside the membranes pores. Narrower pore size counteracted the effect of presence of l.w concentration of natural.organic matter （NOM） in tap water. The NOM was assumed to enhance the adsorption of VPs onto membrane surface, increased the size excl.sion and el.ctrostatic repul.ion al.o appeared during the transport. Investigated water matrices had infl.ence on water fl.x decl.ne due to their compl.xity.

关键词： veterinary pharmaceutical. water matrix RO/NF treatment rejection

Micropol.utant Removal.from Water by Membrane and Advanced Oxidation Processes—A Review

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Journal.of Water Resource and Protection 2017年第5期9卷 411-431页

作者： l.rissa l. S. Sil.a Carol.na G. Moreira Bianca A. Curzio Fabiana V. da fonseca Chemistry School Rio de Janeiro Federal University Rio de Janeiro Brazil

Micropol.utants are defined as contaminants found in trace concentrations in water bodies that are persistent and bioactive, meaning they are not compl.tel. biodegradabl. and cannot be removed by conventional.water treatment methods. Because of these aspects, their detection and removal.pose a chal.enge to the scientific community. Among them are endocrine disruptors, drugs, agricul.ural.chemical., personal.grooming products, industrial.additives and others. These micropol.utants are the cause for gl.bal.concern, because their presence in water suppl. systems is suspected of causing heal.h probl.ms in humans and animal.. To devel.p efficient techniques to remove them, it is fundamental.to understand their physico-chemical.properties and the avail.bl. treatment types and conditions. Membrane separation processes (MSPs) and advanced oxidation processes (AOPs) are the focus of this l.terature review, as potential.treatment methods to remove micropol.utants. The former process stands out for high rejection rates (above 90%) of various micropol.utants, but it generates a concentrated secondary waste stream. In turn, the l.tter process can remove micropol.utants without generating secondary wastes, and can al.o be appl.ed and combined with other treatment methods.

关键词： Micropol.utants MSP AOP