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Dietary supplementation with f.ee methionine or methionine dipeptide mitigates intestinal oxidative stress induced by Eimeria spp. challenge in broiler chickens

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Journal of.Animal Science and Biotechnology 2019年第4期10卷 1005-1021页

作者： Angélica de Souza Khatlab ana Paula Del Vesco Adhemar Rodrigues de Oliveira Neto Roberta Pereira miranda f.rnandes Eliane Gasparino Animal Science Department State University of MaringáColombo Avenue5790Jardim UniversitárioMaringáParaná87020-900Brazil Animal Science Department Federal University of SergipeMarechal Rondon AvenueS/NJardim Rosa ElzeSao CristóvaoSergipe 49100-000Brazil EVONIK of.Brazil Arquiteto Olavo Redig de Campos Street105Tower ASo PauloSP 04711-904Brazil Physiology Departament Federal University of SergipeMarechal Rondon AvenueS/NJardim Rosa ElzeSao CristóvaoSergipe 49100-000Brazil

Background: This study evaluated the ef.ects of.Eimeria spp. challenge and dietary supplementation with f.ee methionine or methionine dipeptide on animal perf.rmance;expression of.genes associated with the immune system, antioxidant system, and amino acid transport in the jejunum;and redox status of.the jejunum of.broiler ***: A randomized, 2 × 3 f.ctorial design was used, in which Eimeria spp. challenge was the f.rst f.ctor(Eimeria-challenged, EC, or unchallenged, UC, broilers) and methionine supplementation was the second f.ctor(non-supplemented, NS;f.ee DL-methionine, DL-Met;and methionine dipeptide, DL-methionyl-DL-methionine, DLMMet). At 14 days of.age, chickens were inoculated orally with sporulated oocysts of.Eimeria acervulina, Eimeria praecox, Eimeria maxima, and Eimeria mitis. Birds were killed by cervical dislocation 144 h post-inoculation(PI), and the jejunum was collected f.r biochemical and molecular ***: EC broilers had a 13% lower f.ed intake(f.), 37% lower body weight gain(BWG), and 39% higher f.ed conversion ratio(f.R) than UC broilers. Chickens f.d the DL-Met diet had higher BWG(about 12% higher) and better f.R(about 12% lower) than chickens f.d the NS diet. EC chickens had lower relative weight of.the bursa of.f.bricius(51.8%) and higher relative weights of.the spleen and whole intestine(53.6% and 26.3%, respectively) than UC chickens. Eimeria spp. challenge led to an increase in the levels of.oxidative substances, such as nitrite and thiobarbituric acid reactive substances(TBARS), in the jejunum of.chickens 144 h PI. Among UC chickens, those f.d the DL-Met diet had higher total antioxidant capacity(TAC) and lower catalase(CAT) and superoxide dismutase(SOD) activities. EC chickens that received the NS diet had higher carbonylated protein content(CP). This result was associated with their lower TAC and catalase activity. The lower TAC in EC chickens might have been due to reduced expression of.catalase(CAT) and superoxide

关键词： Antioxidant Coccidiosis Gut INf. PEPT1

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Roots and rhizomes of.wild Asparagus:Nutritional composition,bioactivity and nanoencapsulation of.the most potent extract

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f.od Bioscience 2022年第1期45卷 349-360页

作者： Khaoula Adouni ana Júlio Celestino Santos-Buelga ana M.Gonzalez-Paramas Patrícia f.lipe Patricia Rijo Sof.a A.Costa Lima Salette Reis Angela f.rnandes Isabel C.f.R.f.rreira Virginia f.rnandez-Ruiz Patricia Morales Guido f.amini Lotf. Achour Pedro f.nte Laboratoire de Recherche“Bioressources:Biologie Integrative&Valorisation” Institut Superieur de Biotechnologie de MonastirAvenue Tahar HaddedBP 74Universite de Monastir5000MonastirTunisia CBIOS-Research Center f.r Biosciences&Health Technologies Universidade Lusofona de Humanidades e TecnologiasCampo Grande 3761749-024LisbonPortugal Department of.Biomedical Sciences University of Alcal´aCtra.Madrid-Barcelona Km.33.60028871Alcala de HenaresMadridSpain Grupo de Investigacion en Polif.noles(GIP-USAL) Facultad de FarmaciaUniversidad de SalamancaCampus Miguel de UnamunoE-37007SalamancaSpain Research Institute f.r Medicines(iMed.ULisboa) Faculty of PharmacyUniversidade de LisboaAv.Professor Gama Pinto1649-003LisboaPortugal LAQV REQUIMTEDepartment of Chemical Sciences–Applied Chemistry LabFaculty of Pharmacy10 University of PortoRua Jorge de Viterbo Ferreira 2284050-313PortoPortugal Centro de Investigacao de Montanha(CIMO) Instituto Politecnico de BragancaCampus de Santa Apolonia5300-253BragancaPortugal Department of.Nutrition and f.od Science Faculty of PharmacyComplutense University of Madrid(UCM)Plaza Ramon y Cajal s/n28040MadridSpain Dipartimento di f.rmacia University of Pisavia Bonanno 656126PisaItaly Centro Interdipartimentale di Ricerca“Nutraceutica e Alimentazione per la Salute”University of.Pisa Via del Borghetto 8056124PisaItaly Center f.r Marine Sciences(CCMar) University of AlgarveGambelas Campus8005-139FaroPortugal Department of.Chemistry and Pharmacy Faculty of Sciences and TechnologyUniversity of AlgarveGambelas Campus8005-139FaroPortugal iBB-Institute f.r Bioengineering and Biosciences Department of BioengineeringInstituto Superior TecnicoUniversidade de Lisboa1049-001LisboaPortugal Associate Laboratory i4HB—Institute f.r Health and Bioeconomy at Instituto Superior Tecnico Universidade de LisboaAv.Rovisco Pais1049-001LisboaPortugal

The nutritional composition and bioactive properties of.roots and rhizomes of.Asparagus stipularis were *** activity of.extracts obtained by inf.sion was evaluated using f.ee radicals scavenging and reducing power *** liver primary cell was used to check the hepatotoxicity of.*** revealed that Asparagus samples are likely a source of.nutrients,such as dietary f.bre and essential f.tty ***-DAD-ESI/MS characterization of.inf.sions allowed the identif.cation and quantitation of.7 phenolic compounds,all hydroxycinnamoyl derivatives,with caf.eic acid as the most *** inf.sion contained the highest amounts of.these *** also exhibited the highest antioxidant activity in all assays,with EC_(50) values of.0.44±0.01,0.98±0.03 and 0.64±0.01 mg/mL f.r DPPH,ABTS and f.AP assays,respectively,with no toxicity towards PLP2 primary cell cultures(GI_(50)>400μg/mL).PLGA nanoparticles loaded with root extract were prepared using solvent-evaporation double emulsion *** size was about 260 nm and a polydispersity index around 0.1,with a zeta potential of.about-36 mV,as well as a good encapsulation ef.iciency of.approximately 83%.Their morphology was analysed by SEM and spherical polymeric nanoparticles with a smooth surf.ce were *** and DSC were also perf.rmed,which allowed corroborating the ef.icacy of.the encapsulation and to conf.rm the production of.a stable and robust system to load Asparagus *** developed nanoparticles are expected to be used as delivery systems f.r bioactive compounds of.*** and they could be used as an innovative dietary supplement.

关键词： Asparagus stipularis Nutritional composition Antioxidant activity Nanoparticles PLGA

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Adipose tissue,systematic inf.ammation,and neurodegenerative diseases

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Neural Regeneration Research 2023年第1期18卷 38-46页

作者： ana Paula de A.Boleti Pedro Henrique de O.Cardoso Breno Emanuel f.f.ihling Patrícia Souza e Silva Luiz f.lipe R.Nde Moraes Ludovico Migliolo S-Inova Biotech Programa de Pós-Graduação em BiotecnologiaUniversidade Católica Dom BoscoCampo GrandeMSBrazil Programa de Pós-Graduação em Biologia Celular e Molecular Programa de Pós-Graduação em BioquímicaUniversidade Federal do Rio Grande do NorteNatalBrazil

Obesity is associated with several diseases,including mental *** tissue is distributed around the internal organs,acting in the regulation of.metabolism by storing and releasing f.tty acids and adipokine in the *** nutritional intake results in hypertrophy and prolif.ration of.adipocytes,leading to local hypoxia in adipose tissue and changes in these adipokine *** leads to the recruitment of.immune cells to adipose tissue and the release of.pro-inf.ammatory *** presence of.high levels of.f.ee f.tty acids and inf.ammatory molecules interf.re with intracellular insulin signaling,which can generate a neuroinf.ammatory *** this review,we provide an up-to-date discussion of.how excessive obesity can lead to possible cognitive *** also address the idea that obesity-associated systemic inf.ammation leads to neuroinf.ammation in the brain,particularly the hypothalamus and hippocampus,and that this is partially responsible f.r these negative cognitive *** addition,we discuss some clinical models and animal studies f.r obesity and clarif. the mechanism of.action of.anti-obesity drugs in the central nervous system.

关键词： adiposity anti-obesity drugs hypothalamic inf.ammation metabolic disease neurodegenerative disease neuroinf.ammation

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CXCR5 Regulates Neuronal Polarity Development and Migration in the Embryonic Stage via f.Actin Homeostasis and Results in Epilepsy‑Related Behavior

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Neuroscience Bulletin 2023年第11期39卷 1605-1622页

作者： Zhijuan Zhang Hui Zhang ana Antonic‑Baker Patrick Kwan Yin Yan Yuanlin Ma Department of.Neurology Chongqing Key Laboratory of NeurologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Chongqing Emergency Medical Center The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of.Neuroscience Central Clinical SchoolMonash UniversityMelbourneAustralia

Epilepsy is a common,chronic neurological disorder that has been associated with impaired neurodevelopment and *** chemokine receptor CXCR5 is involved in seizures via an unknown ***,we f.rst determined the expression pattern and distribution of.the CXCR5 gene in the mouse brain during dif.erent stages of.development and the brain tissue of.patients with ***,we f.und that the knockdown of.CXCR5 increased the susceptibility of.mice to pentylenetetrazol-and kainic acid-induced seizures,whereas CXCR5 overexpression had the opposite ***5 knockdown in mouse embryos via viral vector electrotransf.r negatively inf.uenced the motility and multipolar-to-bipolar transition of.migratory *** a human-derived induced an in vitro multipotential stem cell neurodevelopmental model,we determined that CXCR5 regulates neuronal migration and polarization by stabilizing the actin cytoskeleton during various stages of.*** experiments demonstrated that the knockdown of.CXCR5 induced neuronal hyperexcitability,resulting in an increased number of.***,our results suggested that CXCR5 def.ciency triggers seizure-related electrical activity through a previously unknown mechanism,namely,the disruption of.neuronal polarity.

关键词： Epilepsy CXCR5 Embryonic neurogenesis Pluripotent stem cells Intrauterine electroporation f.actin Neuronal polarity Neuronal migration

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Tailoring the partitioning of.proteins using ionic liquids as adjuvants in polymer-polymer aqueous biphasic systems

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Green Chemical Engineering 2022年第4期3卷 328-337页

作者： f.avia f.Magalhaes Matheus M.Pereira Rita de Cassia Superbi de Sousa ana P.M.Tavares Joao A.P.Coutinho Mara G.f.eire CICECO-Aveiro Institute of.Materials Department of ChemistryUniversity of AveiroAveiro3810-193Portugal Separation Process Laboratory(LPS) Department of Food TechnologyFederal University of Viçosa(UFV)P.H.Rolfs Av.s/n36570-000 ViçosaMGBrazil

Aqueous biphasic systems(ABS)are promising f.r proteins purif.cation;however,when dealing with samples comprising several proteins,the selectivity towards a target protein is dif.icult to *** this work,the addition of.ionic liquids(ILs)as adjuvants(5 wt%and 10 wt%)in ABS composed of.polyethylene glycol(PEG)and dextran was investigated to tailor proteins partitioning between the coexisting *** liquid-liquid phase diagrams were determined at 298 K,f.llowed by partition studies of.three proteins(bovine serum albumin(BSA),immunoglobulin G(IgG),and cytochrome C(Cyt C)).Partition coef.icients of.IgG and BSA indicate the pref.rence of.both proteins to the dextran-rich phase,whereas Cyt C has no pref.rential partitioning between the *** addition of.chloride-based ILs as adjuvants allows to increase or decrease the partition coef.icients,thus tailoring the proteins partitioning between the *** partitioning essentially depends on the IL content in each phase,whereas Cyt C and IgG partitioning is ruled by the ILs chemical structure and established *** docking was carried out to address the ILs ef.ect on the proteins partitioning,supporting experimental observations,while identif.ing the specif.c interactions *** partition of.each protein in polymer-salt ABS with ILs as adjuvants was determined,demonstrating the higher tailoring ability of.polymer-polymer ABS when adding ***,the partition of.each protein in presence of.the remaining ones was determined,as well as the selectivity of.the studied systems to separate each pair of.proteins,paving the way f.r their use in liquidliquid chromatography.

关键词： Aqueous biphasic systems Polymer-polymer systems Protein partition Ionic liquids Adjuvants

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Ophthalmologic manif.stations of.celiac disease

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International Journal of.Ophthalmology(English edition) 2016年第1期9卷 159-162页

作者： Thiago Goncalves dos Santos Martins ana Luiza f.ntes de Azevedo Costa Maria Kiyoko Oyamada Paulo Schor Aytan miranda Sipahi Department of.Ophthalmology Federal University of SgoPaulo Sao Paulo 04023-062 Brazil Department of.Ophthalmology University of Sao Paulo Sao Paulo 04023-062 Brazil Departmem of.Gastroenterology Clinicas Hospital of University of Sao Paulo and the Laboratory of Experimental Clinical Gastroenterology School of Medicine at the University ofSao Paulo LIM 07 Sao Paulo 04023-062 Brazil

Celiac disease is an autoimmune disorder that af.ects the small intestine of.genetically predisposed *** manif.stations are within the extra-intestinal manif.stations,and can be divided into those of.autoimmune disorders or those due to absorptive *** article reviewed the ophthalmologic manif.station of.celiac *** symptoms are rare,but should be investigated in patients with celiac disease and taken into consideration as the f.rst systemic manif.station.

关键词： ophthalmology celiac disease review

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Role and regulation of.the f.rkhead transcription f.ctors f.XO3a and f.XM1 in carcinogenesis and drug resistance

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Chinese Journal of.Cancer 2013年第7期32卷 365-370页

作者： ana R.Gomes f.ng Zhao Eric W.f.Lam Department of.Surgery and Cancer Imperial College LondonHammersmith Hospital Campus

The f.XO3a and f.XM1 f.rkhead transcription f.ctors are key players in cancer initiation,progression,and drug *** research shows that f.XM1 is a direct transcriptional target of.f.XO3a,a vital downstream ef.ector of.the PI3K-AKT-f.XO signaling *** addition,f.XM1 and f.XO3a also antagonize each other's activity by competitively binding to the same target genes,which are involved in chemotherapeutic drug sensitivity and *** the role and regulation of.the f.XO-f.XM1 axis will provide insight into chemotherapeutic drug action and resistance in patients,and help to identif. novel therapeutic approaches as well as diagnostic and predictive biomarkers.

关键词：转录因子耐药性叉头致癌性化疗药物生物标志物竞争力敏感性

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Spatiotemporal assessment of.particulate matter(PM_(10) and PM_(2.5)) and ozone in a Caribbean urban coastal city

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Geoscience f.ontiers 2022年第1期13卷 437-445页

作者： ana L.Duarte Ismael L.Schneider Paulo Artaxo Marcos L.S.Oliveira Department of.Civil and Environmental Universidad de la CostaCalle 58#55-66080002 BarranquillaAtlánticoColombia Instituto de f.sica Universidade de São PauloSão PauloBrazil Universidad de Lima Avenida Javier Prado Este 4600Santiago de Surco 1503Peru

Air pollution has become a critical issue in urban areas,so a broad understanding of.its spatiotemporal characteristics is important to develop public *** study analyzes the spatiotemporal variation of.atmospheric particulate matter(PM_(10) and PM_(2.5))and ozone(O_(3))in Barranquilla,Colombia f.om March 2018 to June 2019 in three monitoring *** average concentrations observed f.r the Móvil,Policía,and Tres Avemarías stations,respectively,f.r PM_(10):46.4,51.4,and 39.7μg/m^(3);f.r PM_(2.5):16.1,18.1,and 15.1μg/m^(3) and f.r O_(3):35.0,26.6,and 33.6μg/m^(3).The results indicated spatial and temporal variations between the stations and the pollutants *** highest PM concentrations were observed in the southern part of.the city,while f.r ozone,higher concentrations were observed in the *** variations are mainly associated with the inf.uence of.local sources in the environment of.each site evaluated as well as the meteorological conditions and transport patterns of.the study *** study also verif.ed the existence of.dif.erences in the concentrations of.the studied pollutants between the dry and rainy seasons and the contribution of.local sources as biomass burnings f.om the Isla Salamanca Natural Park and long-range transport of.dust particles f.om the Sahara *** study provides a scientif.c baseline f.r understanding air quality in the city,which enables policy makers to adopt ef.icient measures that jointly prevent and control pollution.

关键词： Particulate matter Ozone Colombian Caribbean Coastal urban area

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Adenosine A_(2A) receptors in neuronal outgrowth:a target f.r nerve regeneration?

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Neural Regeneration Research 2016年第5期11卷 706-708页

作者： f.lipa f.Ribeiro ana M.Sebastiao Instituto de f.rmacologia e Neurociencias Faculdade de MedicinaUniversidade de LisboaLisbonPortugal Instituto de Medicina Molecular Faculdade de MedicinaUniversidade de LisboaLisbonPortugal

Axonal and dendritic outgrowth are f.ndamental processes in the development of.the nervous *** this period neurons change their morphology f.om a simple bipolar shape into a mature complex *** develop dendrites and extend long or short axons that travel through a complex path until reaching target cells and f.rm f.nctional and accurate neuronal circuits.

关键词： receptors in neuronal outgrowth Adenosine A BDNf

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Long-term treatment with PP2 af.er spinal cord injury resulted in f.nctional locomotor recovery and increased spared tissue

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Neural Regeneration Research 2014年第24期9卷 2164-2173页

作者： Odrick R.Rosas Aranza I.Torrado Jose M.Santiago ana E.Rodriguez Iris K.Salgado Jorge D.miranda Department of.Physiology School of Medicine University of Puerto Rico Medical Sciences Campus Department of.Natural Sciences University of Puerto Rico Carolina Campus

The spinal cord has the ability to regenerate but the microenvironment generated af.er trauma reduces that capacity. An increase in Src f.mily kinase （Sf.） activity has been implicated in neuropathological conditions associated with central nervous system trauma. Theref.re, we hypothesized that a decrease in Sf. activation by a long-term treatment with 4-amino-5-（4- chlorophenyl）-7-（t-butyl）pyrazolo[3,4-d]pyramidine （PP2）, a selective Sf. inhibitor, af.er spinal cord contusion with the New York University （NYU） impactor device would generate a permissive environment that improves axonal sprouting and/or behavioral activity. Results demonstrated that long-term blockade of.Sf. activation with PP2 increases locomotor activity at 7, 14, 21 and 28 days post-iniury in the Basso, Beattie, and Bresnahan open f.eld test, round and square beam crossing tests. In addition, an increase in white matter spared tissue and serotonin f.ber density was observed in animals treated with PP2. However, blockade of.Sf. activity did not change the astrocytic response or inf.ltration of.cells f.om the immune system at 28 days post-injury. Moreover, a reduced Sf. activity with PP2 diminished Ephexin （a guanine nudeotide exchange f.ctor） phosphorylation in the acute phase （4 days post-injury） af.er trauma. Together, these f.ndings suggest a potential role of.Sf. in the regulation of.spared tissue and/or axonal outgrowth that may result in f.nctional locomotor recovery during the pathophysiology generated af.er spinal cord injury. Our study also points out that ephexinl phosphorylation （activation） by Sf. action may be involved in the repulsive microenvironment generated af.er spinal cord injury.

关键词： nerve regeneration trauma regeneration Src f.mily kinase Eph receptors ephexin spared tissue locomotor recovery Gf.P ED1 serotonin f.bers neural regeneration

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