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High-resolution multi-scale air pollution system:Evaluation of.modelling perf.rmance and emission control strategies

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Journal of.Environmental Sciences 2024年第3期137卷 65-81页

作者： Diogo Lopes Joana f.rreira Sandra Raf.el Ka In Hoi Xin Li Yuan Liu Ka-Veng Yuen Kai Meng Mok ana Isabel miranda Department of.Environment and Planning&CESAM University of AveiroAveiroPortugal Department of.Civil&Environmental Engineering Faculty of Science and TechnologyUniversity of MacaoMacao SARChina

A high percentage of.the world's population lives in areas where air pollutant concentrations exceed the World Health Organization *** work aims to develop and test,a high-resolution multi-scale air pollution modelling system by integrating a set of.adequate *** system is able to provide detailed air pollutant concentrations in urban areas and support air quality management strategies through a better identif.cation of.dif.erent atmospheric *** also allows f.rthering the design and assessment of.air pollution control measures f.r a specif.c *** evaluate its perf.rmance and suitability,the system was applied to the Macao Special Administrative Region(SAR),China,one of.the most densely populated areas on earth,during a winter period when this area is af.ected by high levels of.Particulate Matter(PM).Although the developed system tends to underestimate the PM concentrations,it revealed a good perf.rmance in reproducing the temporal and spatial air pollution *** exceedances of.the Chinese air quality standards were calculated and high population exposure to PM pollution was *** tested urban atmospheric emission reduction scenarios have shown air quality improvements,indicating that emission reduction measures at urban level should f.cus on the domestic ***,it is crucial to implement joint pollution prevention strategies with neighbouring regions to improve the air quality in Macao *** approach developed in this work can support policymakers in def.ning new strategies to reduce atmospheric pollution in urban areas.

关键词： Urban areas High-resolution emission inventory Particulate matter Population exposure

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Assessment of.CO_(2)storage prospect based on physical properties of.Rio Bonito f.rmation rock units

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Energy Geoscience 2024年第1期5卷 321-330页

作者： Richardson M.Abraham-A Stephanie San Martín Cañas Isabella f.S.miranda Colombo C.G.Tassinari Institute of.Energy and Environment(IEE) University of São Paulo(USP)Brazil Research Centre f.r Greenhouse Gas Innovation(RCGI) University of Sãao Paulo(USP)Brazil

The physical properties of.the rock units associated with the Rio Bonito f.rmation are presented in this study with the f.cus on modelling reservoir quality based on petrophysics-derived parameters to evaluate CO_(2)storage *** involves the modelling of.the reservoir depths,thicknesses,f.ow zone indicators(f.I),and ef.ective permeability(Kef.)and presenting the CO_(2)storage ef.iciency f.ctors peculiar to the rock units of.the study *** results presented by this study f.r the stated objectives are not quite common in the *** values range f.om 200 mD to higher than 2000 mD,and f.I values are generally above 1.0 mm and up to 13.0 mm within the portions covered by the drilled *** sandstone units recorded are up to 20 m thick in some *** Kef. and f.I models indicate the sandstone reservoirs as permeable units to support the injection and circulation of.CO_(2)within the potential reservoir units of.the Rio Bonio f.rmation across São Paulo *** f.om some points in the southeastern part of.the study location,where the Rio Bonito are delineated at depths less than 800 m(minimum CO_(2)storage depth based on best practices),other portions are deeper,ranging f.om 950 m to 3500 ***-bedded layers will af.ect the integrity of.the rocks as CO_(2)storage tanks or reservoir seals/traps/overburden within the *** bed thicknesses are up to 20 m in some ***,hybrid CO_(2)reservoir units are f.asible,especially in portions where thin siltstone layers are sandwiched between sandstone units to provide considerable thicknesses based on CO_(2)storage *** current study shows that useable areas considering reservoir thickness,depth,and other physical qualities will signif.cantly control the CO_(2)storage ef.iciency of.the study *** studies f.aturing a detailed geophysical exploration of.the site to conf.rm the availability and saturations of.preexisting f.uid(hydrocarbon and water)are encouraged

关键词： Rio Bonito Ef.ective permeability f.uid transmissibility CO_(2)storage prospect Reservoir quality Overburden integrity f.ow zones

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Application of.Aquatic Plants f.r the Treatment of.Selenium-Rich Mining Wastewater and Production of.Renewable f.els and Petrochemicals

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Journal of.Sustainable Bioenergy Systems 2014年第1期4卷 97-112页

作者： ana f. miranda Nazim Muradov Amit Gujar Trevor Stevenson Dayanthi Nugegoda Andrew S. Ball Aidyn Mouradov Royal Melbourne Institute of.Technology University Melbourne Australia University of.Central f.orida Florida Solar Energy Centre Cocoa USA

Aquatic plants aggressively colonising wetlands are widely used f.r the biosorption of.the soluble contaminants f.om wastewater and represent an attractive f.edstock f.r biof.el production. Three common Australian aquatic plants, duckweed (Landoltia punctata), elodea, (Elodea canadensis) and water clover (Marsilea quadrif.lia), colonizing dif.erent depths of.wetlands were tested f.r their ability to treat the selenium-rich mining wastewater and f.r their potential f.r production of.petrochemicals. The results showed that these plants could be ef.ective at biof.ltration of.selenium and heavy metals f.om mining wastewater accumulating them in their f.st growing biomass. Along with production of.bio-gas and bio-solid components, pyrolysis of.these plants produced a range of.liquid petrochemicals including straight-chain C14-C20 alkanes, which can be directly used as a diesel f.el supplement or as a glycerine-f.ee component of.biodiesel. Other identif.ed bio-oil components can be converted into petrochemicals using existing techniques such as catalytic hydrodeoxygenation. A dual application of.aquatic plants f.r wastewater treatment and production of.value-added chemicals of.ers an ecologically f.iendly and cost-ef.ective solution f.r water pollution problems and renewable energy production.

关键词： Biof.el Bioremediation Pyrolysis Mining Wastewater Thermochemical Conversion

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Towards ef.icient strain engineering of.2D materials:A f.ur-points bending approach f.r compressive strain

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Nano Research 2024年第6期17卷 5317-5325页

作者： Hao Li f.lix Carrascoso ana Borrás Gloria P.Moreno f.ancisco J.Aparicio Ángel Barranco Andrés Castellanos Gómez Campus de Cantoblanco Instituto de Ciencia de Materiales de MadridC.Sor Juana Inés de la Cruz328049 MadridSpain Nanotechnology on Surf.ces and Plasma Lab Instituto de Ciencia de Materiales de Sevilla(CSIC-Universidad de Sevilla).C/Americo Vespucio 49E-41092 SevilleSpain Departamento de f.sica Aplicada I Escuela Politécnica SuperiorUniversidad de Sevillac/Virgen deÁfrica 7E-41011 SevilleSpain

Strain engineering,as a powerf.l strategy to tune the optical and electrical properties of.two-dimensional(2D)materials by def.rming their crystal lattice,has attracted signif.cant interest in recent years.2D materials can sustain ultra-high strains,even up to 10%,due to the lack of.dangling bonds on their surf.ce,making them ideal brittle *** remarkable mechanical resilience,together with a strong strain-tunable band structure,endows 2D materials with a broad optical and electrical response upon ***,strain engineering based on 2D materials is restricted by their nanoscale and strain quantif.cation *** this study,we have modif.ed a homebuilt three-points bending apparatus to transf.rm it into a f.ur-points bending apparatus that allows f.r the application of.both compressive and tensile strains on 2D *** approach allows f.r the ef.icient and reproducible construction of.a strain system and minimizes the buckling ef.ect caused by the van der Waals interaction by adamantane encapsulation *** results demonstrate the f.asibility of.introducing compressive strain on 2D materials and the potential f.r tuning their optical and physical properties through this approach.

关键词： uniaxial compressive strain polymer encapsulation dif.erential ref.ectance spectroscopy exciton tunability

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Anomalies in the short-range local environment and atomic dif.usion in single crystalline equiatomic CrMnf.CoNi highentropy alloy

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Nano Research 2024年第6期17卷 5336-5348页

作者： Alevtina Smekhova Daniel Gaertner Alexei Kuzmin ana Guilherme Buzanich Goetz Schuck Ivo Zizak Gerhard Wilde Kirill V.Yusenko Sergiy Divinski Helmholtz-Zentrum Berlin f.r Materialien und Energie(HZB) D-12489 BerlinGermany Institute of.Materials Physics University of MünsterD-48149 MünsterGermany Institute of.Solid State Physics University of LatviaLV-1063 RigaLatvia Bundesanstalt f.r Materialf.rschung und–prüf.ng(BAM) D-12489 BerlinGermany

Multi-edge extended X-ray absorption f.ne structure(EXAf.)spectroscopy combined with reverse Monte Carlo(RMC)simulations was used to probe the details of.element-specif.c local coordinations and component-dependent structure relaxations in single crystalline equiatomic CrMnf.CoNi high-entropy alloy as a f.nction of.the annealing *** representative states,namely a high-temperature state,created by annealing at 1373 K,and a low-temperature state,produced by long-term annealing at 993 K,were compared in *** f.atures identif.ed in atomic conf.gurations of.particular principal components indicate variations in the local environment distortions connected to dif.erent degrees of.compositional disorder at the chosen representative *** detected changes provide new atomistic insights and correlate with the existence of.kinks previously observed in the Arrhenius dependencies of.component dif.usion rates in the CrMnf.CoNi high-entropy alloy.

关键词： high-entropy alloys dif.usion short-range order extended X-ray absorption f.ne structure(EXAf.) reverse Monte Carlo

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Combining thermal scanning probe lithography and dry etching f.r grayscale nanopattern amplif.cation

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Microsystems & Nanoengineering 2024年第1期10卷 335-344页

作者： Berke Erbas ana Conde-Rubio Xia Liu Jof.rey Pernollet Zhenyu Wang Arnaud Bertsch Marcos Penedo Georg f.ntner Mitali Banerjee Andras Kis Giovanni Boero Juergen Brugger Microsystems Laboratory École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Center of.MicroNanoTechnology(CMi) EPFLLausanne 1015Switzerland Laboratory of.Nanoscale Electronics and Structures École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Laboratory f.r Bio-and Nano-Instrumentation École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Laboratory of.Quantum Physics Topology and CorrelationsÉcole Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Present address:Institute of.Materials Science of.Barcelona ICMAB-CSIC Campus UABBellaterra 08193Spain Present address:School of.Integrated Circuits and Electronics MIIT Key Laboratory for Low-Dimensional Quantum Structure and DevicesBeijing Institute of TechnologyBeijing 100081China

Grayscale structured surf.ces with nanometer-scale f.atures are used in a growing number of.applications in optics and *** scanning probe lithography achieves a lateral resolution below 10 nm and a vertical resolution below 1 nm,but its maximum depth in polymers is ***,we present an innovative combination of.nanowriting in thermal resist and plasma dry etching with substrate cooling,which achieves up to 10-f.ld amplif.cation of.polymer nanopatterns into SiO_(2) without proportionally increasing surf.ce *** nanopatterns in SiO_(2) with 400 nm pitch and 150 nm depth are f.bricated f.ee of.shape distortion af.er dry *** exemplif. the possible applications of.the proposed method,grayscale dielectric nanostructures are used f.r scalable manuf.cturing through nanoimprint lithography and f.r strain nanoengineering of.2D *** a method f.r aspect ratio amplif.cation and smooth grayscale nanopatterning has the potential to f.nd application in the f.brication of.photonic and nanoelectronic devices.

关键词： lithography thermal pattern

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CD4^(+)T cells produce If.-I to license cDC1s f.r induction of.cytotoxic T-cell activity in human tumors

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Cellular & Molecular Immunology 2024年第4期21卷 374-392页

作者： Xin Lei Daniël C.de Groot Marij J.P.Welters Tom de Wit Ellen Schrama Hans van Eenennaam Saskia J.Santegoets Timo Oosenbrug Annemarthe van der Veen Joris L.Vos Charlotte L.Zuur Noel f.C.C.de miranda Heinz Jacobs Sjoerd H.van der Burg Jannie Borst Yanling Xiao Department of.Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands Department of.Tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of.Medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOS B.V. OssThe Netherlands Division of.Medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of.Otorhinolaryngology Leiden University Medical Center LeidenThe Netherlands Department of.Pathology Leiden University Medical CenterLeidenThe Netherlands

CD4^(+)T cells can"help"or"license" conventional type 1 dendritic cells(cDC1s)to induce CD8^(+)cytotoxic T lymphocyte(CTL)anticancer responses,as proven in mouse *** recently identif.ed cDC1s with a transcriptomic imprint of.CD4^(+)T-cell help,specif.cally in T-cell-inf.ltrated human cancers,and these cells were associated with a good prognosis and response to PD-1-targeting ***,we delineate the mechanism of.cDC1 licensing by CD4^(+)T cells in *** CD4^(+)T cells produce If.βvia the STING pathway,which promotes MHC-I antigen(cross-)presentation by cDC1s and thereby improves their ability to induce CTL anticancer *** cooperation with CD40 ligand(L),If.βalso optimizes the costimulatory and other f.nctions of.cDC1s required f.r CTL response ***-I-producing CD4^(+)T cells are present in diverse T-cell-inf.ltrated cancers and likely deliver“help”signals to CTLs locally,according to their transcriptomic prof.le and colocalization with“helped/licensed”cDCs and tumor-reactive CD8^(+)T *** agreement with this scenario,the presence of.If.-I-producing CD4^(+)T cells in the TME is associated with overall survival and the response to PD-1 checkpoint blockade in cancer patients.

关键词： CD4^(+)T-cell help cDC1 licensing If.-I signaling CD40 costimulation (cross-)presentation CTL priming Tumor control

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Ef.ect of.Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-f.ee diet

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World Journal of.Gastroenterology 2024年第11期30卷 1545-1555页

作者： Juan Pablo Stef.nolo Verónica Segura Martina Grizzuti Abel Heredia Isabel Comino ana f.orencia Costa Roberto Puebla María Paz Temprano Sonia Isabel Niveloni Gabriel de Diego María E Oregui Edgardo Gustavo Smecuol Mauricio C de Marzi Elena f.Verdú Carolina Sousa Julio César Bai Small Bowel Section Department of MedicineGastroenterology Hospital of Buenos Aires“Dr.C.Bonorino Udaondo”Buenos Aires 1264Argentina Department of.Microbiology and Parasitology Faculty of PharmacyUniversity of SevilleSeville 41080Spain Department of.Medicine Dr.C.Bonorino Udaondo Gastroenterology HospitalBuenos Aires 1264Argentina Basic and Applied Research Group in Immunology and Bioactives(GIBAIB) Institute of Ecology and Sustainable Development(INEDES)National University of LujanLuján 6700Buenos AiresArgentina Department of.Medicine Farncombe Family Digestive Health Research InstituteMcMaster UniversityHamilton L8S 4L8OntarioCanada f.cultad de Medicina Universidad del SalvadorBuenos Aires C1051ABBArgentina

BACKGROUND The gluten-f.ee diet(Gf.)has limitations,and there is intense research in the development of.adjuvant *** To examine the ef.ects of.orally administered Aspergillus niger prolyl endopeptidase protease(AN-PEP)on inadvertent gluten exposure and symptom prevention in adult celiac disease(CeD)patients f.llowing their usual *** This was an exploratory,double-blind,randomized,placebo-controlled trial that enrolled CeD patients on a long-term *** a 4-wk run-in period,patients were randomized to 4 wk of.two AN-PEP capsules(GliadinX;AVI Research,LLC,United States)at each of.three meals per day or *** endpoints were:(1)Average weekly stool gluten immunogenic peptides(GIP)between the run-in and end of.treatments and between AN-PEP and placebo;(2)celiac symptom index(CSI);(3)CeD-specif.c serology;and(4)quality of.*** samples were collected f.r GIP testing by ELISA every Tuesday and f.iday during run-ins and *** f.rty patients were randomized f.r the intention-to-treat analysis,and three were excluded f.om the per-protocol ***,628/640(98.1%)stool samples were *** was undetectable(f.samples,and no dif.erences between treatment arms were *** 0.5%of.samples had GIP concentrations suf.iciently high(>0.32μg/g)to potentially cause mucosal *** GIP concentration in the AN-PEP arm was 44.7%lower than in the run-in ***-third of.patients exhibiting GIP>0.08μg/g during run-in had lower or undetectable GIP af.er AN-PEP *** with the run-in period,the proportion of.symptomatic patients(CSI>38)in the AN-PEP arm was signif.cantly lower(Pf.c *** This exploratory study conducted in a real-lif. setting revealed high adherence to the *** AN-PEP treatment did not signif.cantly reduce the overall GIP stool ***,given the observation of.a signif.cantly lower prevale

关键词： Celiac disease Aspergillus niger prolyl endoprotease Gluten immunogenic peptides Trial Symptoms Real-lif. trial

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The Iberian Roma Population Variant Server(IRPVS)

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Journal of.Genetics and Genomics 2024年第7期51卷 769-773页

作者： f.biola Mavillard Javier Perez-f.orido f.ancisco M.Ortuño Amador Valladares Miren L.Álvarez-Villegas Gema Roldán Rosario Carmona Manuel Soriano Santiago Susarte Pilar f.entes Daniel López-López ana María Nuñez-Negrillo Alejandra Carvajal Yolanda Morgado Daniel Arteaga Rosa Uf.no Pablo Mir Juan f.Gamella Joaquín Dopazo Carmen Paradas Macarena Cabrera-Serrano Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación Biomédica en Red Enf.rmedades Neurodegenerativas(CIBERNED) Instituto de Salud CarlosⅢSevillaSpain Plataf.rma Andaluza de Medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica f.ncional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinf.rmática en Enf.rmedades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain Departamento de Ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain Centro de Servicios Sociales Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain Departamento de Enf.rmería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain Departamento de Neurología Hospital Virgen de las NievesGranadaSpain Departamento de Neurología Hospital Virgen de ValmeSevillaSpain Centro de Salud Utrera Sur SevillaSpain Centro de Salud Polígono Sur SevillaSpain Unidad de Trastornos del Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain Departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain Departamento de Antropología Social Universidad de GranadaSpain Unidad Enf.rmedades Neuromusculares Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of.known disease genes has exponentially grown due to the widespread adoption of.cost-ef.ective massive parallel *** identif. new disease variants,especially in monogenic disorders,a f.equen... 详细信息

关键词： Server f.ltering massive

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Epidemiology and Clinical f.atures of.Mycobacterium avium Complex Pulmonary Disease in a Brazilian Amazon Cohort

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Advances in Microbiology 2024年第6期14卷 287-302页

作者： Jose Tadeu Colares Monteiro Adriana Rodrigues Barretto Ruan Seguin Azevedo Quaresma Bianca miranda Gouveia Ismari Perini f.rlaneto Victória Menezes da Costa Yan Corrêa Rodrigues Layana Ruf.no Ribeiro Ricardo J. de Paula Souza e Guimarães Alex Brito Souza ana Roberta f.sco da Costa Karla Valéria Batista Lima Joao de Barros Barreto University Hospital Federal University of Par Belm Brazil Center f.r Biological and Health Sciences Ph.D. Program in Parasitic Biology in the Amazon Region (PPGBPA) State University of Par (UEPA) Belm Brazil Department of.Medicine Centro Universitrio do Par CESUPA Belm Brazil Bacteriology and Mycology Section Evandro Chagas Institute (SABMI/IEC) Ministry of Health Ananindeua Brazil Geoprocessing Laboratory Evandro Chagas Institute/SVSA/MS Ananineua Brazil

The incidence of.Mycobacterium avium complex pulmonary disease (MACPD) has been globally increasing. The present study aims to provide a comprehensive analysis of.clinical characteristics and treatment response among patients in the Amazon region of.Brazil and conduct a retrospective cohort study at a prominent ref.rral hospital in the State of.Par, Brazil, f.om 2012 to 2020. The M. avium group represented 58.9% of.cases, f.llowed by M. intracellulare (35.7%), M. colombiense (3.6%), and M. chimaera (1.8%). The majority of.patients (73.2%) were f.male and with an average age of.63 years. Primary clinical manif.stations included persistent cough and sputum production. The Charlson comorbidity index (CCI) averaged 2.47, with 36.3% of.patients having a CCI score equal to higher than 3. Notably, over 70% of.patients had received treatment f.r pulmonary tuberculosis bef.re initiating treatment f.r MAC inf.ction. The f.brocavitary radiologic f.rm was the most prevalent (55.4%), f.equently exhibiting a bilateral distribution (53.6%). Antimicrobial susceptibility revealed a signif.cant prevalence of.MAC resistance to drugs in the therapeutic regimen. Despite this, most of.the patients experienced clinical improvement (50%). In conclusion, this study highlights a higher prevalence of.MAC inf.ctions among middle-aged women, with a history of.pulmonary tuberculosis treatment and presenting the f.brocavitary radiological f.rm was predominant.

关键词： MACDP Nontuberculous Mycobacteria Mycobacterium avium Lung Disease

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