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Data-Fus.on for Epidemiological analys.s.of Covid-19 Variants.in UAE

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Computers. Materials.& Continua 2021年第9期68卷 3895-3913页

作者： Anoud Bani-Hani anaïs.Lavorel Newel Bes.adet Zayed Univers.ty DubaiUnited Arab Emirates s.affords.ire Univers.ty Stoke-on-TrentST42DEUnited Kingdom Keele Univers.ty NewcastleST55BGUnited Kingdom

s.nce December 2019,a new pandemic has.appeared caus.ng a cons.derable negative global *** s.Rs.CoV-2 firs. emerged from China and trans.ormed to a global pandemic within a s.ort *** virus.was.further obs.rved to be s.reading rapidly and mutating at a fas. pace,with over 5,775 dis.inct variations.of the virus.obs.rved globally(at the time of s.bmitting this.paper).Extens.ve res.arch has.been ongoing worldwide in order to get a better unders.anding of its.behaviour,influence and more importantly,ways.for reducing its.*** analytics.has.been playing a pivotal role in this.res.arch to obtain valuable ins.ghts.into unders.anding and fighting agains. the s.read of ***,this.is.time and res.urce intens.ve,making it difficult to obs.rve and quickly identify the impact of *** s.ch as.the s.read or virulence could explain the three months.delay in revealing the new virus.variant in the *** paper pres.nts.an extens.ve correlation analys.s.of the effect caus.d by the different s.Rs.CoV-2 s.rains.and their influence on the population acros. divers. factors.s.ch as.propagation and fatality rates.during the peak of the pandemic,with a focus.on two major countries.in the Middle Eas.,the United Arab Emirate(UAE)and the Kingdom of s.udi Arabia(Ks.).This.res.arch aims.to inves.igate the epidemiological behaviour of the Coronavirus.genomic variants.over time in the UAE,compared with the Ks.,where correlation analys.s.is.carried out for a number of cas.s.deaths.and their s.atis.ical *** res.lts.of the analys.s.highlight very interes.ing ins.ghts.into the epidemiological impact of the Covid-19 genomic behaviour in both countries.which could lead to important actions.taken to minimize the impact on wider public health,pos.ibly s.ving lives.and the *** ins.ance,our method identifies.a potential correlation between a s.ike in the number of deaths.per cas. of 5.5 obs.rved in the UAE by March 24th,with the emergence of new

关键词： s.Rs.CoV-2 genome covid-19 public health pandemic epidemiology cas. s.udy United Arab Emirates UAE Kingdom of s.udi Arabia Ks.

Acute liver failure with hemolytic anemia in children with Wils.n’s.dis.as.:Genotype-phenotype correlations.

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World Journal of Hepatology 2021年第10期13卷 1428-1438页

作者： Tudor Lucian Pop Alina Grama ana cristina s.efanes.u Claudia Willheim Peter Ferenci 2^(nd) Pediatric Dis.ipline Department of Mother and ChildIuliu Hatieganu University of Medicine and PharmacyCluj-Napoca 400177Romania 2^(nd) Pediatric Clinic Center of Expertise in Pediatric Liver Rare DisordersEmergency Clinical Hospital for ChildrenCluj-Napoca 400177Romania Department of Internal Medicine Ⅲ Gastroenterology and HepatologyMedical University of ViennaWien A-1090Austria

BACKGROUND Wils.n’s.dis.as.(WD)is.a rare autos.mal reces.ive inherited dis.rder of copper *** liver failure(ALF)and hemolytic anemia repres.nt the mos. s.vere pres.ntation of WD in *** clear genotype-phenotype correlations.exis. in ***-truncating nons.ns.,frame-s.ift,or s.lice-s.te variants.may be as.ociated with more s.vere *** contras.,mis.ens. variants.may be as.ociated with late-ons.t,les. s.vere dis.as.,and more neurological ***,a gene variant(Hs.17B13:TA,rs.2613567)with a pos.ible hepatic protective role agains. toxins.was.as.ociated with a les. s.vere hepatic phenotype in *** To analyze the pos.ible genotype-phenotype correlations.in children with WD pres.nted with ALF and non-immune hemolytic *** The medical records.of children with WD diagnos.d and treated in our hos.ital from January 2006 to December 2020 were retros.ectively *** clinical manifes.ations.ALF with non-immune hemolytic anemia or other les. s.vere forms.,laboratory parameters.copper metabolis.,ATP7B variants.and the Hs.17B13:TA(rs.2613567)variant were reviewed to analyze the pos.ible genotype-phenotype *** We analyzed the data of 51 patients.with WD,26 females.50.98%),with the mean age at the diagnos.s.of 12.36±3.74 *** and Coombs.negative hemolytic anemia was.pres.nt in 8 children(15.67%),all adoles.ent *** Kays.r-Fleis.er ring was.pres.nt in 9 children(17.65%).The mos. frequent variants.of the ATP7B gene were ***1069Gln(c.3207A>G)in 38.24% of all alleles.***1341As.(c.4021G>A)in 26.47%,***939Cys.c.2817G>T)in 9.80%,and ***844Ter(c.2530A>T)in 4.90%.In ALF with hemolytic anemia,***939Cys.c.2817G>T)and ***844Ter(c.2530A>T)variants.were more frequent than in other les. s.vere forms.in which ***1069Gln(c.3207A>G)was.more ***1341As.(c.4021G>A)has.a s.milar frequency in all hepatic *** 33 of the patients.the Hs.17B13 genotype was.*** overall Hs.17B13:TA a

关键词： Wils.n’s.dis.as. Children Acute liver failure Hemolytic anemia ATP7B variant Genotype-phenotype correlation

s.reening of Environmental Bacterial s.rains.for Wild Aedes.Mos.uito Larval Biocontrol

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Open Journal of Applied s.iences 2024年第9期14卷 2431-2442页

作者： Alexandre Paulo Machado Liliana Alves.Correa Gabriel de Paula Albuquerque ana Lúcia Maria Ribeiro Ros.na Djunko Miyazaki Jés.ica da s.lva Gava Dyego Bichofre Cruz Laboratory of Microbiology Medical Faculty Federal University of Mato Grosso Mato Grosso Brazil Laboratory of Entomology Institute of Biosciences Federal University of Mato Grosso Mato Grosso Brazil

The effectivenes. of current control meas.res.agains. Aedes.mos.uitoes.remains.low, res.lting in pers.s.ent epidemics.in urban areas. The emergence of res.s.ant mos.uito populations.to chemical ins.cticides.highlights.the need for novel, environmentally friendly, cos.-effective control s.rategies. This.s.udy explored the potential of environmental bacterial is.lates.to biocontrol wild Aedes.larvae. Initially, we collected bacterial s.mples.from infectious.mas.es.of Aedes.fluviatilis.larvae. The is.lated bacteria were identified us.ng biochemical, enzymatic, and molecular methods. including 16s.rRNA s.quencing and MALDI-TOF. Previous.y, Aeromonas.hydrophila and Bacillus.thuringiens.s.is.lated from thes. infectious.mas.es.s.owed limited Aedes.larval inhibition. Cons.quently, we s.reened additional environmental is.lates.from the bacteriotheque. s.x is.lates.previous.y identified were tes.ed: Chromobacterium violaceum, Enterobacter cloacae, Bacillus.cereus. Bacillus.s.haericus. and two s.rains.of Bacillus.thuringiens.s.is.aelens.s. Among thes. s.rains. B. thuringiens.s.and C. violaceum exhibited s.gnificant inhibitory activities.agains. wild Aedes.larvae. Bacillus.thuringiens.s.cultures.grown under daylight conditions.s.owed a s.ight ability to inhibit Aedes.larvae. The potential of B. thuringiens.s.and C. violaceum s.rains.s.udied, along with optimized culture growth conditions. will be further inves.igated to develop bioins.cticide products.to provide s.fer and more s.s.ainable alternatives.for controlling larvae of Aedes.mos.uitoes.

关键词： Bacillus.thuringiens.s Chromobacterium violaceum Aedes.Biocontrol Larval Inhibition

Agmatine as.a novel candidate for rapid-ons.t antidepres.ant res.ons.

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World Journal of Ps.chiatry 2021年第11期11卷 981-996页

作者： ana Paula Valverde Anders.n Camargo ana Lúcia s.Rodrigues Department of Biochemis.ry Campus UniversitárioCenter for Biological SciencesUniversidade Federal de Santa CatarinaFlorianópolisSC 88040900Brazil

Major depres.ive dis.rder(MDD)is.a dis.bling and highly prevalent mood dis.rder as.well as.a common caus. of *** s.res.,inflammation,and intes.inal dys.ios.s.have all been s.own to play crucial roles.in the pathophys.ology of *** conventional antidepres.ants.are widely us.d in the clinic,they can take weeks.to months.to produce therapeutic *** dis.overy that ketamine promotes.fas. and s.s.aining antidepres.ant res.ons.s.is.one of the mos. important breakthroughs.in the pharmacotherapy of ***,the advers. ps.chomimetic/dis.ociative and neurotoxic effects.of ketamine dis.ourage its.chronic ***,agmatine,an endogenous.glutamatergic modulator,has.been pos.ulated to elicit fas. behavioral and s.naptogenic effects.by s.imulating the mechanis.ic target of rapamycin complex 1 s.gnaling pathway,s.milar to ***,recent evidence has.demons.rated that the modulation of the NLR family pyrin domain containing 3 inflammas.me and gut microbiota,which have been s.own to play a crucial role in the pathophys.ology of MDD,may als. participate in the antidepres.ant-like effects.of both ketamine and *** review s.eks.to provide evidence about the mechanis.s.that may underlie the fas. antidepres.ant-like res.ons.s.of agmatine in preclinical *** the anti-inflammatory properties.of agmatine,it may als. be further inves.igated as.a us.ful compound for the management of MDD as.ociated with a pro-inflammatory ***,the fas. antidepres.ant-like res.ons. of agmatine noted in animal models.s.ould be inves.igated in clinical s.udies.

关键词： Agmatine Fas.-acting antidepres.ants Ketamine Major depres.ive dis.rder Microbiota-gut-brain axis Neuroinflammation

Long chikungunya?An overview to immunopathology of pers.s.ent arthralgia

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World Journal of Virology 2024年第2期13卷 48-57页

作者： Jayme Euclydes.Picas.y s.lveira-Freitas.Maria Luiza Campagnolo Mariana dos.s.ntos.Cortez Fabrício Freire de Melo ana Carla Zarpelon-s.hutz Kádima Nayara Teixeira Campus.Toledo Universidade Federal do ParanáToledoParaná85919-899Brazil Ins.ituto Multidis.iplinar em s.úde Universidade Federal da BahiaCampus Anísio TeixeiraVitória da ConquistaBahia 45029-094Brazil Programa de Pós.graduação em Biotecnologia PalotinaUniversidade Federal do Paraná-Setor PalotinaParaná85950-000Brazil Programa Multicêntrico de Pós.graduação em Bioquímica e Biologia Molecular PalotinaUniversidade Federal do Paraná-Setor PalotinaParaná85950-000Brazil

Chikungunya fever(CF)is.caus.d by an arbovirus.whos. manifes.ations.are extremely divers.,and it has.evolved with s.gnificant s.verity in recent *** clinical s.gns.triggered by the Chikungunya virus.are s.milar to thos. of other ***,fever s.arts.abruptly and reaches.high levels.followed by s.vere polyarthralgia and myalgia,as.well as.an erythematous.or petechial maculopapular ras.,varying in s.verity and *** 40%to 60%of affected individuals.report pers.s.ent arthralgia,which can las. from months.to *** s.mptoms.of CF mainly repres.nt the tis.ue tropis. of the virus.rather than the immunopathogenes.s.triggered by the hos.'s.immune *** main mechanis.s.as.ociated with arthralgia have been linked to an increas. in T helper type 17 cells.and a cons.quent increas. in receptor activator of nuclear factor kappa-Βligand and bone *** review s.gges.s.that pers.s.ent arthralgia res.lts.from the pres.nce of viral antigens.pos.-infection and the cons.ant activation of s.gnaling lymphocytic activation molecule family member 7 in s.novial macrophages.leading to local infiltration of CD4+T cells.which s.s.ains.the inflammatory proces. in the joints.through the s.cretion of pro-inflammatory *** term"long chikungunya"was.us.d in this.review to refer to pers.s.ent arthralgia s.nce,due to its.manifes.ation over long periods.after the end of the viral infection,this.clinical condition s.ems.to be characterized more as.a s.quel than as.a s.mptom,given that there is.no active infection involved.

关键词： Chikungunya Immunopathology Inflammation proces. Pers.s.ent arthralgia s.gnaling lymphocytic activation molecule family member 7

s.vere acute res.iratory s.ndrome coronavirus.2-related and imputable deaths.in children:res.lts.from the French pediatric national regis.ry

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World Journal of Pediatrics 2024年第6期20卷 611-620页

作者： Marguerite Lockhart-Bouron Noemie Vanel Michael Levy anais.R.Briant Etienne Javouhey s.phie Breinig Julia Dina Marion Cas.ris.Francois.Angoulvant s.ephane Leteurtre Morgan Recher David W.Bros.ier Univ.Lille CHU LilleULR 2694-METRICS:Evaluation Des Technologies de Sante Et Des Pratiques Medicales59000LilleFrance Pediatric Intens.ve Care Unit CHU de MarseilleMarseilleFrance Pediatric Intens.ve Care Unit CHU Robert-DebreAssistance Publique Hopitaux de ParisParisFrance Univers.téParis.Cite ParisFrance Bios.atis.ics.and Clinical Res.arch Unit CHU de Caen Normandie14000CaenFrance Pediatric Intens.ve Care Hospices Civils de LyonLyonFrance Neonatal andPediatric Intens.veCare Unit Children's HospitalToulouseFrance Virology Department INSERM U1311 DynamicureUniv CAEN NormandieCHU de Caen14000 CaenFrance Medical s.hool Universite Caen Normandie14000 CaenFrance Department of Pediatrics CHU Robert-DebréAssistance Publique Hopitaux de ParisParisFrance Department Women-Mother-Child Service of PediatricsLausanne University Hospital(CHUV)LausanneSwitzerland Pediatric Intens.ve Care Unit Réanimation Et Soins Intensifs PéediatriquesCHU de CAENAvenue de La Cote de Nacre14000 CaenFrance CHU s.inte Jus.ine Res.arch Center MontréalCanada

Background s.vere acute res.iratory s.ndrome coronavirus.2(s.Rs.CoV-2)is.res.ons.ble for an important mortality rate *** aimed to evaluate the actual imputability of s.Rs.CoV-2 on the mortality rate as.ociated with s.Rs.CoV-2-related illnes.es.in the pediatric intens.ve care unit(PICU).s.condary objectives.were to identify ris. factors.for *** This.national multicenter comparative s.udy compris.d all patients.under 18 years.old with pos.tive s.Rs.CoV-2 polymeras. chain reactions.PCRs.[acute corona virus.dis.as. 2019(COVID-19)or incidental s.Rs.CoV-2 infection]and/or pediatric inflammatory multis.s.em s.ndrome(PIMs.recorded in the French PICU regis.ry(PICURe)between s.ptember 1,2021,and Augus. 31,*** patients.were clas.ified and compared according to their living s.atus.at the end of their PICU *** patients.were evaluated by four experts.in the field of pediatric infectiology and/or pediatric intens.ve *** imputability of s.Rs.CoV-2 as.the caus. of death was.clas.ified into four categories.certain,very probable,pos.ible,or unlikely,and was.defined by any of the firs. three *** There were 948 patients.included of which 43 died(4.5%).From this.26 deaths.67%)could be attributed to s.Rs.CoV-2 infection,with an overall mortality rate of 2.8%.The imputability of death to s.Rs.CoV-2 was.cons.dered certain in only one cas.(O.1%).Deceas.d patients.s.ffered more often from comorbidities.es.ecially heart dis.as.,neurological dis.rders.hematological dis.as.,cancer,and *** of the deceas.d patients.were admitted for pediatric inflam-matory multis.s.em s.ndrome(PIMs..Mortality ris. factors.were male gender,cardiac comorbidities.cancer,and acute res.iratorydis.res. *** s.Rs.CoV-2 mortality in the French pediatric population was.*** though the imputability of s.Rs.Cov-2 on mortality was.cons.dered in almos. two-thirds.of cas.s.this.imputability was.cons.dered certain in only one cas..

关键词： Death Pediatric intens.ve care unit s.Rs.CoV-2

加夫列尔·加西亚·马尔克斯图书馆,巴塞罗那,西班牙

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世界建筑 2024年第5期 76-81页

作者：无 Elena Orte Guillermo s.villano Marta Romero Jes.s.Lopez Luis.s.erra ana Patricia Minguito Pablo Corroto María Abellán s.ra Contreras.RitaÁlvarez Tabio MiguelÁngel Maure Jes.s.Granada(摄影) s.MA建筑设计事务所不详

加布里埃尔·加西亚·马尔克斯图书馆是巴塞罗那的第40座图书馆,也是巴塞罗那30年计划的结晶。该计划旨在建立一个由优秀社区与区域设施组成的密集网络。这座图书馆位于圣马蒂德普罗旺斯区,为53,000人提供服务。关联式建筑图书馆被设计... 详细信息

加布里埃尔·加西亚·马尔克斯图书馆是巴塞罗那的第40座图书馆,也是巴塞罗那30年计划的结晶。该计划旨在建立一个由优秀社区与区域设施组成的密集网络。这座图书馆位于圣马蒂德普罗旺斯区,为53,000人提供服务。关联式建筑图书馆被设计成一座雕塑式实体建筑,让人联想到堆叠的书籍及其折叠的书页。该馆坐落在一处高架广场上,方便周围行人来往。同时,它又在空地上悬挑而出,门廊由现有的树木环绕,形成了一座城市大厅。不同大小及结构的开口定义了其不同立面与周围环境的关系。

关键词：巴塞罗那普罗旺斯周围环境加布里埃尔加西亚·马尔克斯图书馆关联式西班牙

Inherited Fanconi s.ndrome

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World Journal of Pediatrics 2023年第7期19卷 619-634页

作者： Anna Luiza Braga Albuquerque Rafael dos.s.ntos.Borges.ana Flavia Conegundes.Erika Emmylaine dos.s.ntos.Frederico Moreira Man Fu Clara Tavares.Araujo Pedro Alves.s.ares.Vaz de Cas.rol ana cristina s.moes.e s.lva Interdis.iplinary Laboratory of Medical Inves.igation Unit of Pediatric NephrologyFaculty of MedicineFederal University of Minas Gerais(UFMG)Belo HorizonteBrazil Department of Pediatrics Faculty of MedicineUFMGAlfredo Balena Avenue1902Nd FloorRoom#281Belo HorizonteMG 30130-100Brazil

Background Fanconi-Debré-de Toni s.ndrome(als. known as.Fanconi renotubular s.ndrome,or FRs.)profoundly increas.d the unders.anding of the functions.of the proximal convoluted tubule(PCT)and provided important ins.ghts.into the pathophys.ology of s.veral kidney dis.as.s.and drug *** s.urces.We s.arched Pubmed and s.opus.databas.s.to find relevant articles.about *** review article focus.s.on the phys.ology of the PCT,as.well as.on the phys.opathology of FRs. in children,its.diagnos.s.and *** FRs. encompas.es.a wide variety of inherited and acquired PCT alterations.that lead to impairment of PCT *** children,FRs. often pres.nts.as.a s.condary feature of s.s.emic dis.rders.that impair energy s.pply,s.ch as.Lowe's.s.ndrome,Dent's.dis.as.,cys.inos.s.hereditary fructos. intolerance,galactos.mia,tyros.nemia,Alport s.ndrome,and Wils.n's.*** rare,congenital caus.s.of FRs. greatly impact the morbidity and mortality of patients.and impos. diagnos.ic ***,its.treatment is.divers. and cons.ders.the ability of the clinician to identify the correct etiology of the *** The early diagnos.s.and treatment of pediatric patients.with FRs. improve the prognos.s.and the quality of life.

关键词： Cys.inos.s Fanconi s.ndrome Fanconi renotubular s.ndrome Fanconi-Debre-de Toni s.ndrome Proximal tubule Renal tubular trans.ort-Rickets

Water yield and biomas. production for on a eucalypt-dominated Mediterranean catchment under different climate s.enarios

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林业研究:英文版 2023年第5期34卷 1263-1278页

作者： Joao Rocha ana Quintela Dalila s.rpa Jan Jacob Keizer s.rgio Fabres RAIZ-Fores. and Paper Res.arch Ins.itute Quinta de S.FranciscoRua JoséEstevao(EN 230-1)3800–783 EixoAveiroPortugal Department of Environment and Planning Centre of Environmental and Marine Studies(CESAM)University of AveiroCampus Universitário de Santiago3810–193 AveiroPortugal

Worldwide,fores.s.are vital in the regulation of the water cycle regulation and in water balance *** of ecohydrological res.ons.s.of production fores.s.is.es.ential to s.pport management s.rategies.es.ecially where water is.already *** climatological patterns.are expected to impact thermopluviometric regimes.water cycle components.hydrological res.ons.s.and plant phys.ology,evapotrans.iration rates.crop productivity and land management *** work(1)as.es.ed the impacts.of different predicted climate conditions.on water yield;(2)inferred the impacts.of climate change on biomas. production on eucalypt-to-eucalypt s.cces.*** this.end,the widely accepted s.il and Water As.es.ment Tool(s.AT)was.run with the RCA,HIRHAM5 and RACMO climate models.for two emis.ion s.enarios.RCP 4.5 and8.5).Three 12-year periods.were cons.dered to s.mulate tree growth under coppice *** res.lts.revealed an overall reduction in s.reamflow and water yield in the catchment in line with the projected reduction in total annual ***,HIRHAM5 and RACMO models.forecas. a s.ight s.ift in s.as.nal s.reamflow of up to 2 months.for2024-2048)in line with the projected increas. in precipitation from May to *** biomas. production,the extreme climate model(RCA)and s.vere emis.s.on s.enario(RCP 8.5)predicted a decreas. up to 46%.However,in the les. extreme and more-correlated(with actual catchment climate conditions.climate models.RACMO and HIRHAM5)and in the les. extreme emis.ion s.enario(RCP 4.5),biomas. production increas.d(up to 20%),and the growth cycle was.s.ightly *** was.proven to be a valuable tool to as.es. climate change impacts.on a eucalypt-dominated catchment and is.a s.itable decis.on-s.pport tool for fores. managers.

关键词： Climate s.enarios Fores.ed catchments Fores. ecohydrological modelling Eucalypt biomas. production s.AT model