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Intravenous vs intraperitoneal mesenchymal stem cells administration:What is the best route for treating experimental colitis?

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World Journal of Gastroenterology 2014年第48期20卷 18228-18239页

作者： Fabiany da costa Goncalves Natália Schneider Fernanda Otesbelgue Pinto Fabíola Schons Meyer Fernanda Visioli Bianca Pfaffenseller Patrícia Luciana da costa Lopez Eduardo Pandolfi Passos Elizabeth Obino Cirne-Lima Luíse Meurer ana Helena Paz Centro de Pesquisa Experimental do Hospital de Clínicas de Porto Alegre Porto Alegre 90035-903Rio Grande do SulBrazil Programa de Pós-Gradua??o:Ciências em Gastroenterologia e Hepatologia Universidade Federal do Rio Grande do SulPorto Alegre 90035-903Rio Grande do SulBrazil Faculdade de Odontologia Universidade Federado Rio Grande do SulPorto Alegre 90035-003Rio Grande doSulBrazil

AIM:To investigate the therapeutic effects of mesenchymal stem cells(MSCs)transplanted intraperitoneally andintravenously in a murine model of ***:MSCs were isolated from C57BL/6 mouse adipose *** cultures were analyzed according to morphology,cellular differentiation potential,and surface molecular *** acute colitis was induced in C57BL/6 mice by oral administration of2%dextran sulfate sodium(DSS)in drinking water ad libitum from days 0 to *** mice were treated with1×106 MSCs via intraperitoneal or intravenous injection on days 2 and *** disease activity index was determined daily based on the following parameters:weight loss,stool consistency and presence of blood in the feces and *** compare morphological and functional differences in tissue regeneration between different MSC injection modalities,mice were euthanized on day 8,and their colons were examined for length,weight,and histopathological *** responses were determined by measuring the levels of different serum cytokines using a CBA Th1/Th2/Th17 *** rates were evaluated by terminal deoxynucleotidyl transferase-mediated d UDPbiotin nick end labeling ***:Intravenous infusion of MSCs was more effective than intraperitoneal treatment(P<0.001)in reducing the clinical and histopathologic severity of colitis,which includes weight loss,diarrhea and *** histological evaluation demonstrated decreased colonic inflammation based on reduced crypt loss and reduced infiltration of inflammatory *** therapeutic effect was most likely mediated by the down-regulation of pro-inflammatory cytokines[interleukin(IL)-6 and tumor necrosis factor(TNF)];and by the up-regulation of anti-inflammatory cytokines(IL-10 and IL-4).Intravenous transplantation alsoinduced high levels of IFN that lead to activation of the immunosuppressive activity of the MSCs,which did not occur with intraperitoneal transplantation(P=0.006).An increase in a

关键词： Ulcerative colitis Dextran sulfate sodium Inflammatory bowel disease Mesenchymal stem cell Cell transplantation Intravenous injection Immunomodulation

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Obesity: Body Relief Surgeries before Bariatric Surgery for Risk Reduction

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Modern Plastic Surgery 2020年第3期10卷 31-37页

作者： José Humberto Cardoso Resende ana Letícia Pinto Guimarã es Brunna Abreu Perillo ana Carolina Melo Maluf Laura Ribeiro da costa Rafaella Cristina Gomes Bernardes Arthur Camargo Pires Thalles Gonç alves Souza Menezes Murilo Calil Alves Emídio Silva Falcã o Brasileiro UNIFAN Work Coordinator Aparecida de Goi&#226 nia Brazil UNIFAN Medicine Academics Aparecida de Goi&#226 nia Brazil UNIFAN Research Coordinator Aparecida de Goi&#226 nia Brazil

Depending on the treatment and weight of the breasts or abdomen, they may exceed volumes considered giant and morbidly obese. In these cases, and when the patient’s BMI is high above 40 kg/m2, the weight of the breasts or abdomen produces what we consider suffocation when the patient is placed in horizontal position on surgical tables, decreasing his respiratory capacity and increasing the difficulty in treating respiratory or embolic risks. An 8-kg breast on the patient’s chest prevents normal breathing. An abdomen with a volume of 30 kg causes difficulties in all senses, making the physiological expansion of the lungs impossible and even preventing surgical assistance to patients. These patients are almost always customers who sleep in the sitting position to breathe better. The gigantic extirpation of the surgical parts facilitates a better respiratory expansion reducing by a large percentage the risk of death, what we call body relief. This relief does not free the patient from bariatric surgery for a possible weight loss, which is vital for the proper functioning of the organs and decreasing arterial hypertension and diabetes.

关键词： Obesity Disease Surgery Bariatric Risk Hypertension and Diabetes

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Sociodemographic, Clinical and Quality of Life Aspects of People Aged over 50 Years Living with HIV/AIDS

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Open Journal of Nursing 2016年第6期6卷 435-442页

作者： Alexsandra Rodrigues Feijão Klebia Karoline dos Santos Neco Jéssica Dayane Dantas costa Isabelle Christine Marinho de Oliveira ana Luisa Brandão de Carvalho Lira Bertha Cruz Enders Nursing Department Federal University of Rio Grande do Norte Natal Brazil Multicampi School of Medical Sciences Federal University of Rio Grande do Norte Natal Brazil

Introduction: In the last few years, there has been a growth in the number of cases of people with HIV/AIDS aged 50 years and older. This is explained by the inclusion of antiretroviral therapy, increased survival of patients as well as by the growth in the number of infected people in this age group. Objective: To analyze the association between sociodemographic and clinical characteristics with the QOL of people aged 50 years or older living with HIV/AIDS. Methods: Quantitative, cross-sectional study conducted in the outpatient clinic of a reference hospital in Natal, Brazil. The sample consisted of 50 subjects, aged over 50, seropositive for HIV and with cognitive conditions to answer the interview. Authors used sociodemographic and clinical evaluation tools and the WHOQOL-HIV BREF scale. Results: Sociodemographic: respondents’ average age was 57.32 years, 58% male, 38% brown, 26% incomplete primary education, 46% single, 56% retired, 70% with a monthly income of 1 to 2 minimum wages and 70% Catholic. Clinical: 60% have a partner without the diagnosis of HIV/AIDS;62% had not been hospitalized previously;66% did not have opportunistic infections;40% indicated that there was a change in the physiological sexual function after the onset of the disease. Quality of life: people living with HIV/AIDS had low scores in QOL domains. When associating sociodemographic and clinical aspects, it was observed that they had associations with QOL, especially in regard to education, income, religion, change in sexual function and feelings. Conclusion: The spiritual domain was highlighted with the best performance, collaborating to facing, hope and resilience of HIV/AIDS.

关键词： AIDS Quality of Life Aging

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Acute effect of moderate intensity physical exercise on postprandial hyperlipaemia of individuals with central obesity

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Health 2012年第12期4卷 1546-1550页

作者： Djeyne Silveira Wagmacker Karla Kurzendorff Souza Julia Vieira da Graca Geodania da costa Barreto Paula Caroline Souza Macêdo Tamara Felix Ferreira ana M. Ladeia Bahian School of Medicine and Public Health Science Development Foundation of Bahia Bahia Brazil College of Adventist Bahia Bahia Brazil

Introduction: High postprandial triglyceride levels and obesity are associated with coronaropathy, and influence the pathogenesis and progression of atherosclerosis. Objective: To evaluate the effect of immediate acute physical exercise on postprandial hyperlipaemia in individuals with central obesity. Methods: Study included sedentary, normolipidemic individuals aged 18 - 30 years, with waist circumference >80 in for women and >94 for men. The physical exercise was performed for 45 minutes with 55% - 60% of the heart rate reserve. Triglyceride level tests were performed after fasting, and at time intervals of 1h and 3 h after lipid overload, a week before and immediately after a session of physical exercise. Results: Thirty-six individuals were evaluated (mean age 23.74 ± 4.05 years, 88.2% women, BMI = 28.4 ± 3.4). Fasting and post-prandial triglyceride levels were similar before and after the exercise (p = 0.87). A smaller rise in triglyceride levels was observed in the 1st hour in obese individuals (5%) compared with over-weight individuals (21%) p = 0.001. Conclusion: In individuals with central obesity, moderate intensity physical exercise performed immediately before lipid overload does not reduce the hyperlipidemic peak.

关键词： Postprandial Hyperlipaemia Exercise Central Obesity

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Phylogeny of Bacteria from Steelmaking Wastes and Their Acidic Enrichment Cultures

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Advances in Microbiology 2014年第12期4卷 816-828页

作者： Mariana P. Reis Flaviane A. Pinheiro Patrícia S. costa ana Paula C. Salgado Paulo S. Assis Edmar Chartone-Souza Andréa M. A. Nascimento Departamento de Biologia Geral Instituto de Ciências Biológicas Universidade Federal de Minas Gerais Belo Horizonte Brazil Departamento de Engenharia Metalúrgica e de Materiais Escola de Minas Universidade Federal de Ouro Preto Ouro Preto Brazil

Currently, millions of tons of steel are produced worldwide. This has become a serious economic and environmental challenge because the ores used for steel production are nonrenewable resources and the production generates huge amount of waste. In this study, we identified and investigated the ability of bacteria from steelmaking waste with low and high zinc concentration to promote leaching of zinc, when enriched by acidic (pH 2) culture conditions. The bioleaching assays indicated removal of Zn, as in chemical leaching. Bacterial communities from crude and enrichment culture wastes were characterized by the 16S rRNA gene. Phylogenetic analysis of the generated clone libraries revealed predominance of Proteobacteria and Firmicutes. The Actino- bacteria, Bacteroidetes, Cyanobacteria, and Deinococcus-Thermus phyla were also encountered. The clones were most closely related to cultivable heterotrophic bacteria. Different genera were identified including iron redox cycling and leaching bacteria such as Chromobacterium, Aeromonas, Escherichia, Bacillus, and Ochrobactrum. These data add significant new information on bacteria which survive in extremely acidic conditions. They are distantly related to typical acidophiles responsible for the leaching process, which makes them good candidates for future studies on metal bioleaching.

关键词： Bacteria 16S rRNA Diversity Zinc Steelmaking Wastes

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Survival to first- and second-line chemotherapy in gastric cancer according to MMSET,53BP1,UBC9 and BRCA1 mRNA levels

Survival to first- and second-line chemotherapy in gastric c...

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2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议

作者： Jia Wei Carlota costa Jie Shen Lixia Yu Jose Javier Sanchez Zhengyun Zou Xiaoping Qian Xia Sun ana Gimenez-Capitan Wenxian Guan Rafael Rosell Baorui Liu

Background & Aims BRCA1 expression affects outcome to *** response DSBs,MDCl binds to H2AX,promoting DSB repair by 53BP1 and *** is required for the accretion of 53BP1 and UBC9 to DSB *** hypothesized that the mRNA

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New Sulfonamides Derived from Carvacrol: Compounds with High Antibacterial Activity against Resistant Staphylococcus aureus Strains

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Journal of Biosciences and Medicines 2016年第7期4卷 105-114页

作者： Aldo Sena de Oliveira Luana Canzian Llanes Inês Maria costa Brighente Ricardo José Nunes Rosendo Augusto Yunes Nilton Máximo Junior ana Milda Karsten Baumgart anays Noumeh Aust Alexandre Bella Cruz Department of Chemistry Federal University of Santa Catarina Florianópolis Brazil Graduate Program in Pharmaceutical Sciences University of Valley of ltajaí Itajaí Brazil

Nine new sulfonamides derived from carvacrol were prepared through a reaction between 4-hydroxy-2-isopropyl-5-methyl benzene sulfonyl chloride with various amines in excellent yields (76% - 92%). The sulfonamides were characterized using spectrometric and spectroscopic methods. Among these compounds, three derivatives showed excellent results in antibacterial activity against resistant S. aureus strains, with MIC values ranging from 3.9 to 62.50 ppm. The sulfonamide derivative of 4-methylaniline (SULF-1) had the best performance for all tested strains of bacteria (MIC = 3.9 to 15.62 ppm). Furthermore, the sulfonamide derivative of 4-fluoro aniline (SULF-3), which also presented promising results, was found to have a synergistic effect when combined with tetracycline and partial synergistic effect when combined with ampicillin, exhibiting an FIC index between 0.50 and 0.75. The sulfonamide derivative of 4-methylaniline had a synergistic effect in combination with erythromycin exhibiting an FIC index of 0.37. Carvacrol in association with the antibiotics tested did not have a synergistic effect.

关键词： Sulfonamides Carvacrol Antibacterial Staphylococcus aureus Synergism

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Accountability Simulacra: Fraud Cases from South and North America

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Journal of Business Administration Research 2019年第1期2卷 34-44页

作者： ana Paula Paulino da costa FIPE-Economic Research Foundation Institute Brazil

Cases of corporate frauds with financial instruments count on simulacra of *** on grounded research,this study considered cases that were conducted for years without being detected causing billionaire injury to *** objective was to present how they bypassed internal controls,corporate governance,and all regulatory apparatus using substantive and symbolic resources at organization level *** extensive analysis allowed perceive a common modus operandi that is described here organized by *** paper also suggests a direction for accountability improvement.

关键词： Corporate fraud Financial statements fraud Financial fraud Corporate governance Accountability

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Meta-analysis of CO_(2) conversion,energy efficiency,and other performance data of plasma-catalysis reactors with the open access PIONEER database

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Journal of Energy Chemistry 2023年第11期86卷 318-342,I0007页

作者： Antoine Salden Maik Budde Carolina A.Garcia-Soto Omar Biondo Jairo Barauna Marzia Faedda Beatrice Musig ChloéFromentin Minh Nguyen-Quang Harry Philpott Golshid Hasrack Domenico Aceto Yuxiang Cai Federico Azzolina Jury Annemie Bogaerts Patrick Da costa Richard Engeln María Elena Gálvez Timo Gans Tomas Garcia Vasco Guerra Carlos Henriques Monika Motak Maria Victoria Navarro Vasile I.Parvulescu Gerard Van Rooij Bogdan Samojeden ana Sobota Paolo Tosi Xin Tu Olivier Guaitella Department of Physics University of Trento38100 PovoItaly Department of Applied Physics and Science Education Eindhoven University of Technology5600 MB EindhovenThe Netherlands Instituto de Plasmas e Fusão Nuclear Instituto Superior TécnicoUniversidade de Lisboa1049-001 LisboaPortugal LPP CNRSÉcole PolytechniqueSorbonne UniversitéUniversitéParis-SaclayIP-Paris 91128 PalaiseauFrance Department of Organic Chemistry Biochemistry and CatalysisUniversity of BucharestBucharestRomania Research Group PLASMANT Department of ChemistryUniversity of AntwerpUniversiteitsplein 1Wilrijk B-2610Belgium DIFFER 5612AJ EindhovenThe Netherlands Instituto de Carboquímica ICB-CSIC Zaragoza 50018Spain Faculty of Energy and Fuels AGH University of KrakowKrakowPoland Institut Jean le Rond d’Alembert CNRS UMR 7190-Sorbonne UniversitéSaint-Cyr l’Ecole 78210France Laboratoire Catalyse et Spectrochimie(LCS) CNRS-ENSICAEN-Universitéde Caen6 boulevard du Maréchal-Juin14000 CaenFrance CQE Centro de Química EstruturalInstituto Superior TécnicoUniversidade de LisboaAv.Rovisco Pais1049-001 LisboaPortugal School of Physical Sciences and National Centre for Plasma Science and Technology Faculty of Science and HealthDublin City UniversityDublinIreland ASML De Run 65015504 DR VeldhovenThe Netherlands Faculty of Science and Engineering Maastricht University6229 GS MaastrichtThe Netherlands CNR Istituto per la Scienza e Tecnologia dei Plasmi(ISTP)Italy Department of Electrical Engineering and Electronics University of LiverpoolLiverpool L693GJUK

This paper brings the comparison of performances of CO_(2)conversion by plasma and plasma-assisted catalysis based on the data collected from literature in this field,organised in an open access online *** tool is open to all users to carry out their own analyses,but also to contributors who wish to add their data to the database in order to improve the relevance of the comparisons made,and ultimately to improve the efficiency of CO_(2)conversion by *** creation of this database and database user interface is motivated by the fact that plasma-catalysis is a fast-growing field for all CO_(2)conversion processes,be it methanation,dry reforming of methane,methanolisation,or *** a result of this rapid increase,there is a need for a set of standard procedures to rigorously compare performances of different ***,this is currently not possible because the fundamental mechanisms of plasma-catalysis are still too poorly understood to define these standard *** however,the accumulated data within the CO_(2)plasma-catalysis community has become large enough to warrant so-called“big data”studies more familiar in the fields of medicine and the social *** enable comparisons between multiple data sets and make future research more effective,this work proposes the first database on CO_(2)conversion performances by plasma-catalysis open to the whole *** database has been initiated in the framework of a H_(2)0_(2)0 European project and is called the“PIONEER Data Base”.The database gathers a large amount of CO_(2)conversion performance data such as conversion rate,energy efficiency,and selectivity for numerous plasma sources coupled with or without a *** data set is associated with metadata describing the gas mixture,the plasma source,the nature of the catalyst,and the form of coupling with the *** the database itself,a data extraction tool with direct visualisation features or advance

关键词： Open-access database on plasma-catalysis experiment CO_(2) conversion Plasma-catalysis Carbon capture and utilisation(CCU) Energy efficiency Specific energy input Dielectric barrier discharge Packed bed reactor Methanation Dry reforming of methane

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Influence of Photoperiod over Morphometric and Hematological Parameters of Juvenile Piracanjubas （Brycon orbygnianus）

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Journal of Agricultural Science and Technology(B) 2016年第5期6卷 350-359页

作者： Monica Rodrigues Ferreira Machado] Eliane Aparecida de Andrade Estefania de Souza Andrade Daniella Aparecida de Jesus Paula Julia Alvarenga Oliveira Adriano Carvalho costa ana Paula Peconick Luis David Solis Murgas Department of Biological Science Federal University of Goias (UFG) Campus Cidade Universitaria CEP 75801-615 JataiGoias Brazil Department of Veterinary Medicine Cdmpus Universitario Federal University of Lavras (UFLA) Lavras Minas Gerais CEP3 7200-000 Brazil Department of Animal Science Federal Institute of Rio Verde (IFR V) Rio Verde Goias CEP 75901-970 Brazil

The aim of this study was to evaluate morphometric and hematological parameters of juveniles Piracanjubas treated with two distinct photoperiod. Twenty nine fish with 100 g, in a factorial design were performed in 18 h light：6 h dark （18L：6D） and 6L：lSD two different photoperiod, and morphometric and hematological parameters were evaluated at 45 d and 90 d after photoperiod treatment. Benzocaine 1% was used for euthanasia. Fish were weighed and measured, so as visceral fat, liver and gonads. Hematocrit, total count of white cells, lymphocytes and neutrophils were counted. Results showed that there was no significant relationship between bodyweight and standard length. Significant interaction （P = 0.00018） had been found between the fat index （FI） and gonado-somatic index （GSI） and the photoperiod and time. At 90 d, the fish kept in 18L：6D had a lower rate of fat than the fish kept in 6L：18D （P 〈 0.05）. The GSI was higher in the group 6L.＇18D compared with the 18L：6D （P 〈 0.005）. There was no interaction between photoperiod and period of treatment for total leukocyte count, however with 90 d, the total leukocyte count was decreased （P 〈 0.05）. Moreover, decrease of the hematocrit from 58.1% to 46.9% and an increase of lymphocytes from 31.5% to 43.5% had been found in fish kept in 18L：6D after 90 d （P 〈 0.05）. Fish kept in 6L：ISD presented an increase in segmented neutrophils and lymphocytes （P 〈 0.05）. It is concluded that photoperiod maintained at 6L： 18D for Piracanjubas permits a greater gonadal development and an amount of immune cells over the photoperiod maintained in 18L： 6D.

关键词： Circadian rhythm fish maturity cellular immune response photoperiod.

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