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Where to seek help? Barriers to beginning treatment during the first-episode psychosis

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International Journal of Nursing Sciences 2018年第3期5卷 249-254页

作者： Isabela dos Santos Martin Bianca Cristina Ciccone Giacon Kelly Graziani Giacchero Vedana ana carolina Guidorizzi Zanetti Lorena Fendrich Sueli Aparecida Frari Galera Department of Psychiatric Nursing and Human Sciences of University of Sao Paulo Ribeirao Preto College of NursingBrazil Federal University of Mato Grosso do Sul Brazil

Objective:As decreasing the duration of untreated psychosis has been highlighted as key indicator in relation to improved prognosis,this study aims to identify the access barriers to beginning early treatment of young people in first-episode psychosis(FEP),based on family reports on the experience of perceiving illness and ***:A qualitative research was carried out with 12 relatives of 12 young people passing through their first psychiatric hospital admission as a result of their *** interviews were used for data collection and thematic content method for data ***:Barriers to beginning treatment were lack of knowledge and difficulty in recognizing mental illness,lack of knowledge on where to seek specialized treatment,and stigma and resistance to psychiatric ***:It was demonstrated that the family members are protagonists in the search for treatment of young people in their FPE,given that the initiative for seeking treatment came from them.

关键词： Caregivers Family Mental health Psychiatry Psychotic disorders

Comparison of Different Washing and Disinfection Protocols Used by Food Services in Southern Brazil for Lettuce (<i>Lactuca sativa</i>)

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Food and Nutrition Sciences 2012年第1期3卷 28-33页

作者： ana Beatriz Almeida de Oliveira ana carolina Ritter Eduardo Cesar Tondo Marisa Itapema Cardoso 不详

Different protocols have been used for washing and disinfecting leafy vegetables in Brazilian food services, however its effect on microbial reduction was barely studied. The aim of this study was to evaluate the effectiveness of lettuce washing and disinfecting protocols used by food services. The treatments evaluated were: washing in potable tap water (T1);washing and dipping in potable tap water (T2);washing with potable tap water and dipping in a solution of sodium hypochlorite (200 ppm of free chlorine) for 15 min (T3);and 30 min (T4);washing with potable tap water and dipping in 2% vinegar solution (T5);and 20% vinegar solution (T6). After the treatments, the samples were microbiologically evaluated to measure bacterial reductions. The microbial counts showed that the mean total mesophile reductions were: 0.64 log for T1, 0.75 log for T2, 2.06 log for T3, 2.46 log for T4, 1.68 log for T5 and 1.72 log for T6, and the mean total coliform reductions were: 1.11 log for T1, 1.09 log for T2, 2.29 log for T3, 2.35 log for T4, 1.6 log for T5 and 2.09 log for T6. Based on these results it can be concluded that protocols which used 200 ppm sodium hypochlorite for 15 to 30 min (T3 e T4), were the most effective, followed by treatment with 20% vinegar solution (T6). The latter method, however, turned the lettuce dark during the distribution period.

关键词： Lettuce Disinfection Food Services

Meta-analysis of CO_(2) conversion,energy efficiency,and other performance data of plasma-catalysis reactors with the open access PIONEER database

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Journal of Energy Chemistry 2023年第11期86卷 318-342,I0007页

作者： Antoine Salden Maik Budde carolina A.Garcia-Soto Omar Biondo Jairo Barauna Marzia Faedda Beatrice Musig ChloéFromentin Minh Nguyen-Quang Harry Philpott Golshid Hasrack Domenico Aceto Yuxiang Cai Federico Azzolina Jury Annemie Bogaerts Patrick Da Costa Richard Engeln María Elena Gálvez Timo Gans Tomas Garcia Vasco Guerra Carlos Henriques Monika Motak Maria Victoria Navarro Vasile I.Parvulescu Gerard Van Rooij Bogdan Samojeden ana Sobota Paolo Tosi Xin Tu Olivier Guaitella Department of Physics University of Trento38100 PovoItaly Department of Applied Physics and Science Education Eindhoven University of Technology5600 MB EindhovenThe Netherlands Instituto de Plasmas e Fusão Nuclear Instituto Superior TécnicoUniversidade de Lisboa1049-001 LisboaPortugal LPP CNRSÉcole PolytechniqueSorbonne UniversitéUniversitéParis-SaclayIP-Paris 91128 PalaiseauFrance Department of Organic Chemistry Biochemistry and CatalysisUniversity of BucharestBucharestRomania Research Group PLASMANT Department of ChemistryUniversity of AntwerpUniversiteitsplein 1Wilrijk B-2610Belgium DIFFER 5612AJ EindhovenThe Netherlands Instituto de Carboquímica ICB-CSIC Zaragoza 50018Spain Faculty of Energy and Fuels AGH University of KrakowKrakowPoland Institut Jean le Rond d’Alembert CNRS UMR 7190-Sorbonne UniversitéSaint-Cyr l’Ecole 78210France Laboratoire Catalyse et Spectrochimie(LCS) CNRS-ENSICAEN-Universitéde Caen6 boulevard du Maréchal-Juin14000 CaenFrance CQE Centro de Química EstruturalInstituto Superior TécnicoUniversidade de LisboaAv.Rovisco Pais1049-001 LisboaPortugal School of Physical Sciences and National Centre for Plasma Science and Technology Faculty of Science and HealthDublin City UniversityDublinIreland ASML De Run 65015504 DR VeldhovenThe Netherlands Faculty of Science and Engineering Maastricht University6229 GS MaastrichtThe Netherlands CNR Istituto per la Scienza e Tecnologia dei Plasmi(ISTP)Italy Department of Electrical Engineering and Electronics University of LiverpoolLiverpool L693GJUK

This paper brings the comparison of performances of CO_(2)conversion by plasma and plasma-assisted catalysis based on the data collected from literature in this field,organised in an open access online *** tool is open to all users to carry out their own analyses,but also to contributors who wish to add their data to the database in order to improve the relevance of the comparisons made,and ultimately to improve the efficiency of CO_(2)conversion by *** creation of this database and database user interface is motivated by the fact that plasma-catalysis is a fast-growing field for all CO_(2)conversion processes,be it methanation,dry reforming of methane,methanolisation,or *** a result of this rapid increase,there is a need for a set of standard procedures to rigorously compare performances of different ***,this is currently not possible because the fundamental mechanisms of plasma-catalysis are still too poorly understood to define these standard *** however,the accumulated data within the CO_(2)plasma-catalysis community has become large enough to warrant so-called“big data”studies more familiar in the fields of medicine and the social *** enable comparisons between multiple data sets and make future research more effective,this work proposes the first database on CO_(2)conversion performances by plasma-catalysis open to the whole *** database has been initiated in the framework of a H_(2)0_(2)0 European project and is called the“PIONEER Data Base”.The database gathers a large amount of CO_(2)conversion performance data such as conversion rate,energy efficiency,and selectivity for numerous plasma sources coupled with or without a *** data set is associated with metadata describing the gas mixture,the plasma source,the nature of the catalyst,and the form of coupling with the *** the database itself,a data extraction tool with direct visualisation features or advance

关键词： Open-access database on plasma-catalysis experiment CO_(2) conversion Plasma-catalysis Carbon capture and utilisation(CCU) Energy efficiency Specific energy input Dielectric barrier discharge Packed bed reactor Methanation Dry reforming of methane

Behavior of CD44 Receptors in Mammary Tumors of Dogs

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Open Journal of Veterinary Medicine 2012年第2期2卷 48-51页

作者： Georgia MMagalhaes ana carolina TSilveira Danisio PMunari Antonio CAlessi Department of Veterinary Pathology Sao Paulo State UniversitySao PauloBrazil Department of Animal Science Sergipe Federal UniversitySergipeBrazil

CD44 is a cell adhesion molecule closely related to tumor progression in humans. In canine mammary tumors, little information is available about this molecule. The aim of this study was to analyze, by immunohistochemistry, the behavior of this molecule in canine mammary tumors with or without the presence of metastasis. The dogs were divided in groups without metastasis (G1) and with metastasis (G2, with subsets A—original neoplasia and B—metastatic neoplasia). Tumors were classified according to the World Health Organization (WHO) criteria. The cells were counted whereby the plasma membrane and/or cytoplasm are stained. There was a significant increase in the number of cells immunostained for CD44 in the metastastic masses (G2B) as compared to groups G1 and G2A. It is concluded that in metastatic mass there was a significant increase in CD44 receptors, probably important for biology of the mammary tumor of dogs.

关键词： Dogs Oncology Mammary Tumors

Cultural Adaptation and Psychometric Evaluation of Physical Activity Social Cognitive Scales for Brazilian Adolescents

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Journal of Sports Science 2014年第3期2卷 134-143页

作者： Sonia Tucunduva Philippi ana carolina Barco Leme Deborah L. Dewar Department of Nutrition School of Public Health University of Sao Paulo S6o Paulo 01246-904 Brazil Priority Research Centre in Physical Activity and Nutrition School of Education University of Newcastle New South Wales NSW2308 Australia

SCT (social cognitive theory) provides a useful framework to explain why people acquire and maintain PA (physical activity) behaviors among adolescents. This study aimed to adapt modernized Australian social cognitive scales of PA to the Portuguese language and evaluate their factorial and convergent validity and reliability. The adapted scales were tested in an adolescent sample from low-income communities in the city of S?o Paulo, Brazil (n = 173; 56.1% male). Confirmatory factor analysis was employed to examine model-fit for each scale. The scales were assessed against self-report measures of moderate-to-vigorous physical activity for convergent validity. Reliability properties (ICC (Intra class confidence) and Cronbach?s Alpha) were also determined. Each social cognitive scale represented a statistically sound measure: fit indices indicated each model to be adequate-to-exact fit to the data; significant correlations between most scales and either light, moderate or vigorous intensity PA behavior demonstrated good convergent validity; internal consistency was acceptable-to-good (α = 0.51-0.80); rank order repeatability was acceptable-to-strong (ICC = 0.62-0.92). Adapted social cognitive scales for physical activity for use among adolescents in the Brazilian context showed acceptable reliability and validity properties and may be useful to identify potential social cognitive correlates of PA, mediators of PA behavior change and the testing of theoretical models of SCT.

关键词：运动科学体育运动体育训练运动训练

Chronic exposure to ethanol causes steatosis and inflammation in zebrafish liver

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World Journal of Hepatology 2017年第8期9卷 418-426页

作者： ana Claudia Reis Schneider Cleandra Gregório carolina Uribe-Cruz Ranieli Guizzo Tais Malysz Maria Cristina Faccioni-Heuser Larisse Longo Themis Reverbel da Silveira La-boratório Experimental de Hepatologia e Gastroenterologia Hospital de Clínicas de Porto Alegre Programa de Pós- Graduacao em Ciências Médicas Gastroenterologia e HepatologiaUniversidade Federal do Rio Grande do Sul Programa de Pós-Graduacao em Genética e Biologia Molecular(UFRGS) Instituto de Ciências Básicas da Saúde(UFRGS) Departamento de Ciências Morfológicas(UFRGS) Centro de Microscopia Eletronica(UFRGS)

AIM To evaluate the effects of chronic exposure to ethanol in the liver and the expression of inflammatory genesin *** Zebrafish(n = 104),wild type,adult,male and female,were divided into two groups:Control and ethanol(0.05 v/v).The ethanol was directly added into water;tanks water were changed every two days and the ethanol *** animals were fed twice a day with fish food until *** two and four weeks of trial,livers were dissected,histological analysis(hematoxilineosin and Oil Red staining) and gene expression assessment of adiponectin,adiponectin receptor 2(adipor2),sirtuin-1(sirt-1),tumor necrosis factor-alpha(tnf-a),interleukin-1b(il-1b) and interleukin-10(il-10) were *** evaluations were conducted at fourth *** Exposing zebrafish to 0.5% ethanol developed intense liver steatosis after four weeks,as demonstrated by oil red *** ethanol-treated animals,the main ultrastructural changes were related to cytoplasmic lipid particles and droplets,increased number of rough endoplasmic reticulum cisterns and glycogen *** two and four weeks,hepatic mR NA expression of il-1b,sirt-1 and adipor2 were upregulated,indicating that ethanol triggered signaling molecules which are key elements in both hepatic inflammatory and protective *** was not detected in the liver of animals exposed and not exposed to ethanol,and il-10 did not show significant *** Data suggest that inflammatory signaling and ultrastructural alterations play a significant role during hepatic steatosis in zebrafish chronically exposed to ethanol.

关键词： Ethanol Hepatic steatosis Inflammation Zebrafish Alcoholic fatty liver

Association of Brazilian Adolescents with Healthy Eating: Knowledge, Perceptions and Food Choices

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Food and Nutrition Sciences 2011年第9期2卷 1036-1042页

作者： ana carolina Barco Leme Sonia Tucunduva Philippi érika Christiane Toassa da Silva 不详

The aim of this study is to identify the adolescents’ knowledge and perceptions of healthy and unhealthy eating. It is a qualitative cross section study with 83 adolescents of both genders between 10 and 16 years old enrolled in a public school in the city of S?o Paulo, Brazil. The participants answered two discursive questions that assessed their knowledge and perception of their actual diet. These questions were later analyzed by a qualitative technique, “Discourse of Collective Subject” based on the Theory of Social Representations. Overall, the youth presented an adequate knowledge about healthy eating. About half (52.6%) reported a balanced and varied diet;and 56.3% considered their actual diet as being healthy. Adolescents’ knowledge about healthy eating isn’t the only determinant for their food choices;and so traditional nutritional interventions focusing on concepts about healthy eating should be modified, aiming at behavioral changes.

关键词： Adolescents Healthy Eating Qualitative Study Knowledge and Perceptions

Clinical-pathological and molecular characterization of long-term survivors with advanced non-small cell lung cancer

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Cancer Biology & Medicine 2020年第2期17卷 444-457页

作者： Juan Moreno-Rubio Santiago Ponce Rosa Alvarez Maria Eugenia Olmedo Sandra Falagan Xabier Mielgo Fatima Navarro Patricia Cruz Luis Cabezon-Gutierrez Carlos Aguado Gonzalo Colmenarejo Marta Munoz-Fernandez de Leglaria ana Belen Enguita Maria Cebollero Amparo Benito Isabel Alemany carolina del Castillo Ricardo Ramos ana Ramirez de Molina Enrique Casado Maria Sereno ana Ramirez de Molina1 Enrique Casado5Maria Sereno5 XIMDEA Food InstituteCEI UAM+CSICMadrid 28702Spain 12 de Octubre University Hospital Madrid 28041Spain Gregorio Maranon University Hospital Madrid 28009Spain Ramon y Cajal University Hospital Madrid 28034Spain Infanta Sofia University Hospital San Sebastian De Los ReyesMadrid 28702Spain Fundacion Alcorcon University Hospital AlcorconMadrid 28922Spain Prlncipe de Asturias University Hospital Alcala De HenaresMadrid 28805Spain La Paz University Hospital Madrid 28046Spain University Hospital of Torrejon Torrejon De ArdozMadrid 28850Spain Clinico San Carlos University Hospital Madrid 28040Spain Parque Cientifico de Madrid Foundation Madrid 28049Spain

Objective:Long-term survivors(LS)of non-small cell lung cancer(NSCLC)without driver alterations,displaying an overall survival(OS)of more than 3 years,comprise around 10%of cases in several series treated with *** are classical prognosis factors for these cases[stage,Eastern Cooperative Oncology Group(ECOG),etc.],but more data are required in the *** this multi-center study,we focused on LS of advanced NSCLC with OS above 36 months to perform a clinical-pathological and molecular ***:In the first step,we conducted a clinical-pathological characterization of the ***,we carried out a genetic analysis by comparing LS to a sample of short-term survivors(SS)(with an OS less than 9 months).We initially used whole-genome RNA-seq to identify differentiating profiles of LS and SS,and later confirmed these with reverse transcription-polymerase chain reaction(RT-PCR)for the rest of the ***:A total of 94 patients were included,who were mainly men,former smokers,having adenocarcinoma(AC)-type NSCLC with an ECOG of *** obtained an initial differential transcriptome expression,displaying 5 over-and 33 under-expressed genes involved in different pathways:namely,the secretin receptor,surfactant protein,trefoil factor 1(T FF1),serpin,Ca-channels,and Tolllike receptor(TLRs)***,RT-PCR analysis of 40(20 LS/20 SS)samples confirmed that four genes(surfactant proteins and SFTP)were significantly down-regulated in SS compared to LS by using an analysis of covariance(ANCOVA)model:SFTPA1(P=0.023),SFTPA2(P=0.027),SFTPB{P=0.02),and SFT PC(P=0.047).Conclusions:We present a sequential genetic analysis of a sample of NSCLCLS with no driver alterations,obtaining a differential RNA-seq/RT-PCR profile showing an abnormal expression of SF genes.

关键词： Long-term survivors non-small cell lung cancer surfactant proteins

Temperature Gradient Gel Electrophoresis as a Valuable Accessory Tool for Assessment of Dysbiosis in Crohn’s Disease

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Advances in Microbiology 2016年第8期6卷 549-554页

作者： Vanessa Rafaela de Carvalho Rogeria Keller ana carolina da Silva Santos Josias Rodrigues Laboratory of Medical Bacteriology Department of Microbiology and Immunology Institute of Biosciences of the State University of Sao Paulo (UNESP) Botucatu Brazil University of Western Sao Paulo Presidente Prudente Brazil

Escherichia coli and other Proteobacteria are augmented and several other bacteria are diminished in Crohn’s (CD) disease patients’ intestine. This imbalance in bacterial species composition—termed dysbiosis—seems to be determinant of CD manifestation. Since a great part of intestinal bacteria are not cultivable, detection of CD dysbiosis is accomplished by molecular tools, involving sequences analysis of the 16SrRNA gene (16SrDNA) present in the patient’s clinical samples, which can be done by sequencing or electrophoresis in denaturing gels of 16SrDNA amplicons. By analyzing, by temperature gradient gel electrophoresis (TGGE) and next generation sequencing of 16SV6-V8rDNA amplicons present in gram negative cultures from four distinct clinical samples of a control subject and a CD patient, this study demonstrates that both techniques were able to detect E. coli overgrowth and reduction in species richness in CD and that TGGE can discriminate sequences collectively labeled as “unclassified” in 16SrDNA databases. Although TGGE per se does not identify the sequences, the discriminatory power that it confers represents valuable accessory information to next generation DNA sequencing (NGS), and as such must be used as a NGS complementary tool.

关键词： Dysbiosis Proteobacteria Escherichia coli Crohn’s Disease