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A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities

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Military Medical Research 2024年第2期11卷 228-267页

作者： Miguel A.Ortega Oscar Fraile-Martinez Cielo García-Montero Sergio Haro Miguel Ángel Álvarez-Mon Diego De Leon-Oliva ana M.Gomez-Lahoz Jorge Monserrat Mar Atienza-Pérez David Díaz Elisa Lopez-Dolado Melchor Álvarez-Mon Department of Medicine and Medical Specialities University of Alcala28801 Alcala de HenaresSpain Ramón y Cajal Institute of Sanitary Research(IRYCIS) 28034 MadridSpain Department of Psychiatry and Mental Health Hospital Universitario Infanta Leonor28031 MadridSpain Service of Rehabilitation National Hospital for Paraplegic PatientsCarr.de la PeraledaS/N45004 ToledoSpain Immune System Diseases‑Rheumatology Service and Internal Medicine University Hospital Príncipe de Asturias(CIBEREHD)28806 Alcala de HenaresSpain

Spinal cord injury(SCI)is a devastating and disabling medical condition generally caused by a traumatic event(primary injury).This initial trauma is accompanied by a set of biological mechanisms directed to ameliorate neural damage but also exacerbate initial damage(secondary injury).The alterations that occur in the spinal cord have not only local but also systemic consequences and virtually all organs and tissues of the body incur important changes after SCI,explaining the progression and detrimental consequences related to this ***(PNIE)is a growing area of research aiming to integrate and explore the interactions among the different systems that compose the human organism,considering the mind and the body as a *** initial traumatic event and the consequent neurological disruption trigger immune,endocrine,and multisystem dysfunction,which in turn affect the patient's psyche and *** the present review,we will explore the most important local and systemic consequences of SCI from a PNIE perspective,defining the changes occurring in each system and how all these mechanisms are ***,potential clinical approaches derived from this knowledge will also be collectively presented with the aim to develop integrative therapies to maximize the clinical management of these patients.

关键词： Spinal cord injury(SCI) Psychoneuroimmunoendocrinology(PNIE) Secondary injury Immunoinflammatory dysfunction Gut microbiota Translational opportunities

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Mineralogical signatures and sources of recent sediment in a large tropical lake

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International Journal of Sediment Research 2018年第2期33卷 183-190页

作者： Jorge Feliciano Ontiveros-Cuadras ana Carolina Ruiz-fernández Joan-Albert Sanchez-Cabeza Libia Hascibe Pérez-Bernal Michel Preda Federico Páez-Osuna Polytechnic University of Sinaloa (UPSIN) Mazatlan Academic Unit Institute of Marine Sciences and LimnologyNational Autonomous University of Mexico (UNAM) Oceanic and Coastal Processes Academic Unit Institute of Marine Sciences and LimnologyNational Autonomous University of Mexico (UNAM).University City Department of Earth and Atmospheric Sciences University of Quebec in Montreal (UQAM)

Two lead-210(210Pb) dated sediment cores from Chapala Lake were studied to identify the mineral composition of the sediments and to discuss its relation with trace metals. Minerals and trace metals reflected the domain of volcanic rocks(i.e. basalts, rhyolite and andesite) that characterize Chapala Lake and the Lerma River watershed. Redundancy analyses(RDA) were used to identify the sedimentary variables(magnetic susceptibility, organic matter, sand content, and mineral composition) that could be related to elemental composition. Despite the distance between the two cores(7.3 km) and hydrodynamic circulation the RDA showed that the main mechanism that controls the input of mineral species,and, therefore, element distributions in the lacustrine sediment of Chapala Lake, is related to the weathering of volcanic rocks in the Lerma-Chapala watershed, the consequent runoff and transport of fine grained catchment materials, and later in-lake processes. These findings highlight the importance of controlling watershed erosion to contribute to the improvement of the environmental quality of the lake.

关键词： Chapala Lake Trace metals Mineralogy Lacustrine sediments

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Synthesis of activated carbons from black sapote seeds,characterization and application in the elimination of heavy metals and textile dyes

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Chinese Journal of Chemical Engineering 2020年第2期28卷 613-623页

作者： Alejandra Alicia Peláez-Cid Vincent Romero-Hernández ana María Herrera-González Alejandro Bautista-Hernández Oscar Coreno-Alonso Facultad de Ingeniería Benemérita Universidad Autónoma de PueblaMexico Instituto de Ciencias Básicas e Ingeniería Universidad Autónoma del Estado de HidalgoMexico División de Ingenierías Universidad de GuanajuatoMexico

Many different techniques may be used to remove industrial pollutants from wastewater. Adsorption using activated carbon has been reported to be an effective method. This work proposes the use of a vegetable residue(black sapote seeds) as a raw material for its synthesis. These carbons were chemically activated using phosphoric acid and carbonized at 673 and 873 K. Adsorption isotherms were constructed for the textile dyes on the carbons, and this data was treated using Langmuir’s equation to quantitatively describe the adsorption process. The synthesized carbons were characterized using FTIR, EA, SEM, Nitrogen adsorption(specific surface areas of 879 and 652 m2·g-1), and their points of zero charge(2.1 and 2.3). It was possible to adsorb both heavy metals and textile dyes present in aqueous solutions and wastewaters using these activated carbons. Heavy metals were adsorbed almost completely by both carbons. Cationic dyes where adsorbed(58–59.8 mg·g-1) in greater amounts compared to anionic dyes(10–58.8 mg·g-1). The amount of anionic dyes adsorbed increased almost 30% by changing the pH of the solutions. One of the carbons was thermally regenerated on three occasions without losing its adsorption capacity and it was proved in a flow system.

关键词： Activated carbons Black sapote seeds Heavy metal adsorption Textile dye adsorption Wastewater treatment

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棒与星系整体恒星形成性质关系的统计研究

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天文学进展 2024年第1期42卷 115-127页

作者：穆子豪沈世银 Rafael S.de Souza ana L.Chies-Santos 中国科学院上海天文台星系宇宙学重点实验室上海200030 中国科学院大学北京100049 星系和宇宙学半解析研究重点实验室上海200034 赫特福德大学天体物理研究中心英国哈特菲尔德学院巷AL109AB 南里奥格兰德州联邦大学科学研究所巴西阿雷格里港9500

盘状星系中的棒结构特征与星系自身所处环境及整体恒星形成特征之间存在复杂的相互关系。利用细致的星系形态特征测量计划Galaxy Zoo DECaLS中的数据构建了一组目前最大的具有同样恒星质量分布的强棒、弱棒和无棒星系样本。通过引入星... 详细信息

盘状星系中的棒结构特征与星系自身所处环境及整体恒星形成特征之间存在复杂的相互关系。利用细致的星系形态特征测量计划Galaxy Zoo DECaLS中的数据构建了一组目前最大的具有同样恒星质量分布的强棒、弱棒和无棒星系样本。通过引入星系所处暗晕质量及相空间特征来控制星系所处的环境效应之后,进一步对比研究强棒、弱棒和无棒星系的恒星形成特征。研究表明,有棒星系中的恒星形成熄灭的比例系统地高于无棒星系,且强棒的效应更为明显。但是,对于仍处于恒星形成主序上的星系来说,强棒、弱棒和无棒星系的恒星形成特征并没有显著差别。以上结果表明,星系中的棒特征在其存在的时标中可能使部分星系迅速地从恒星形成转入熄灭状态。

关键词：棒旋星系恒星形成环境

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Bye Bye Bie

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The World of Chinese 2024年第3期 40-45页

作者： ana Chen 无不详 VCG

As the coastal town of Humen urbanizes, its softshell turtle industry is losing its appeal Business is slow in the turtle ***-year-old Chen Zhiman, who began farming softshell turtles in 1992,ceased all operations in 2012. His farm in Humen, a coastal town in southern China’s Guangdong province, bears no trace of the million or so softshell turtles, or bie (鳖), that he raised for over 20 years.

关键词： coastal town operations

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Effect of the filling season on aquatic plants in Mediterranean temporary ponds

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Journal of Plant Ecology 2018年第3期11卷 502-510页

作者： Rocío fernández-Zamudio Pablo García-Murillo Carmen Díaz-Paniagua Doñana Biological Station-CSIC Avda.Américo Vespucio s/n41092 SevilleSpain Department of Plant Biology and Ecology Faculty of PharmacyUniversity of SevilleSevilleSpain

Aims Pond environmental conditions may differ among years with regards to the season in which ponds begin to *** experimen-tally evaluated how seedling emergence,plant growth and phe-nology differed among years in which filling occurred in winter,autumn or *** We collected sediments from a natural temporary pond and located them in *** were placed in a climatic chamber that simulated annual variation in field environmental temperatures and light *** were assigned to one of three treat-ments,which differed in the date on which they were filled with water(autumn,winter and spring).We counted the number of seed-lings of different species emerged and recorded data about the pres-ence of flowers,seeds or spores every *** experiment was finished in June,when we harvested the plants and estimated their *** Findings In most species,seedling emergences were primarily related to time after filling,and thus synchronized their life cycles with the unpre-dictably timed wet phase of the *** filling resulted in the highest numbers of seeds/***,winter filling pro-moted plant growth the *** the spring filling treatment,more terrestrial plant seedlings emerged and fewer seeds/spores were *** ponds are flooded earlier,plants may produce a higher number of ***,in years when inundation is delayed to spring and hydroperiods are short,seedling emergence deplete the seed bank and there is little to no seed production,while terrestrial monocots are able to colonize pond basin.

关键词： Aquatic plants temporary ponds seed bank seedlings germination

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Relevance of Family in Academic Success on Children

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Health 2017年第2期9卷 279-288页

作者： Patricia Martínez Lanz ana Cristina Losada fernández Fabiola Pecchioni fernández Martha Patricia Hernández Valdez Universidad Aná huac Mé xico M&eacute xico City M&eacute xico

The purpose of this study was to analyze the relationship between academic success and functional and dysfunctional families. A non-experimental, cross-sectional, descriptive correlational design was used. A convenience sample of 200 children between 6 and 13 years old, primary and junior high school students was conducted (32.3% were female and 67.7% were male). To assess the relationship, a study case of 21 reagents was designed to empty the obtained information from medical review records from a psychopedagogic clinic. Academic success was measured as from the revision of informal tests and standardized tests. Results showed that the population levels of academic success were average. However, a significant relationship between the age of the parents and the level of academic success was found, indicating that these variables are associated with this problem. Besides that, it was found that there is a tendency in children with cognitive, emotional and sensory problems reflected in low academic success. The findings provide information that could be considered for the development of programs of psychopedagogic intervention to treat children with learning disabilities and low academic success.

关键词： Academic Success Low Academic Success Functional Family Dysfunctional Family Children

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Tax avoidance and earnings management:a neural network approach for the largest European economies

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Financial Innovation 2023年第1期9卷 558-582页

作者： Francisco J.Delgado Elena fernández‑Rodríguez Roberto García‑fernández Manuel Landajo Antonio Martínez‑Arias Department of Economics Faculty of Economics and BusinessUniversity of OviedoAvda.del CristoS/N33071 OviedoSpain Department of Accounting Faculty of Economics and BusinessUniversity of OviedoAvda.del CristoS/N33071 OviedoSpain Department of Applied Economics Faculty of Economics and BusinessUniversity of OviedoAvda.del CristoS/N33071 OviedoSpain

In this study,we investigate the relationship between tax avoidance and earnings management in the largest five European Union economies by using artificial neural network *** methodology allows us to deal with nonlinearities detected in the data,which is the principal contribution to the previous *** ana-lyzed Compustat data for Germany,the United Kingdom,France,Italy,and Spain for the 2006–2015 period,focusing on discretionary *** considered three tax avoidance measures,two based on the effective tax rate(ETR)and one on book-tax differences(BTD).Our results indicate the presence of nonlinear patterns and a posi-tive,statistically significant relationship between discretionary accruals and both ETR indicators implying that when companies resort to earnings management,a larger tax-able income—and thus higher ETR and lesser tax avoidance–would ***,as also highlighted by the fact that discretionary accruals do not appear to affect BTD,our evidence does not suggest that companies are exploiting tax manipulation to reduce their tax payments;thus,the gap between accounting and taxation seems largely unaf-fected by earnings management.

关键词： Tax avoidance Earnings management Artificial neural networks European Union

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Low prevalence of germline hMSH6 mutations in colorectal cancer families from Spain

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World Journal of Gastroenterology 2005年第37期11卷 5770-5776页

作者： ana Sánchez de Abajo Miguel de la Hoya Alicia Tosar Javier Godino Juan Manuel fernández Jose Lopez Asenjo Beatriz Perez Villamil Pedro Perez Segura Eduardo Diaz-Rubio Trinidad Caldes Laboratorio de Oncología Molecular Hospital Clinico San Carlos Madrid Spain Servicio de anatomía Patológica Hospital Clinico San Carlos Madrid Spain Servicio de Oncología Médica Hospital Clinico San Carlos Madrid Spain

AIM: To investigate the prevalence and penetrance of hMSH6 mutations in Spanish HNPCC families that was negative for mutation in hMLH1 or ***: We used PCR-based DGGE assay and direct Sequencing to screen for hMSH6 gene in 91 HNPCC ***: we have identified 10 families with germ-line mutations in the DNA sequence. These mutations included two intronic variation, three missense mutation, one nonsense mutation, and four silent mutations. Among the 10 germ-line mutations identified in the Spanish cohort,8 were novel, perhaps, suggesting different mutational spectra in the Spanish population. Detailed pedigrees were constructed for the three families with a possible pathogenic hMSH6 mutation. The two silent mutations H388H and L758L, detected in a person affected of colorectal cancer at age 29, produce loss of the wild-type allele in the tumor sample. Immunohistochemical analysis showed that expression of MSH6 protein was lost only in the tumors from the carriers of V878A and Q263X ***: Altogether, our results indicate that disease-causing germ-line mutations of hMSH6 are very less frequent in Spanish HNPCC families.

关键词： HNPCC MMR hMSH6 MSI IHC SPANISH

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Alpha-1 antitrypsin deficiency and Pi^(*)Z allele as important co-factors in the development of liver fibrosis

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World Journal of Hepatology 2024年第8期16卷 1099-1110页

作者： ana Isabel Ferreira Catarina Guimarães Vitor Macedo Silva Sofia Xavier Joana Magalhães JoséCotter Department of Gastroenterology Hospital da Senhora da Oliveira-GuimarãesGuimarães 4835-044Portugal Life and Health Sciences Research Institute School of MedicineUniversity of MinhoBraga 4710-057Portugal Life and Health Sciences Research Institute/3B’s PT Government Associate LaboratoryBraga 4710-057Portugal Department of Pulmonology Hospital Senhora da Oliveira-GuimarãesGuimarães 4835-044Portugal

BACKGROUND Alpha-1 antitrypsin deficiency(AATD)is a codominant autosomal hereditary condition that predisposes patients to the development of lung and/or liver disease,and Pi*Z allele is the most clinically relevant *** To evaluate the impact of clinical parameters and AATD phenotypes,particularly the Pi*Z allele,in liver *** Cross-sectional cohort study including consecutive patients with AATD followed in Pulmonology or Hepatology *** Included 69 patients,49.3%had Pi*MZ phenotype and 10.1%Pi**** age≥55 years,age at diagnosis≥41 years and AAT at diagnosis<77 mg/dL predicted a nonalcoholic fatty liver disease fibrosis score(NFS)not excluding advanced fibrosis[area under the curve(AUC)=0.840,P<0.001;AUC=0.836,P<0.001;AUC=0.681,P=0.025].An age≥50 years and age at diagnosis≥41 years predicted a fibrosis-4 index of moderate to advanced fibrosis(AUC=0.831,P<0.001;AUC=0.795,P<0.001).Patients with hypertension,type 2 diabetes mellitus(DM),dyslipidaemia,metabolic syndrome,and regular alcohol consumption were more likely to have a NFS not excluding advanced fibrosis(P<0.001,P=0.002,P=0.008,P<0.001,P=0.033).Patients with at least one Pi*Z allele and type 2 DM were 8 times more likely to have liver stiffness measurement≥7.1 kPa(P=0.040).CONCLUSION Risk factors for liver disease in AATD included an age≥50 years,age at diagnosis≥41 years,metabolic risk factors,regular alcohol consumption,at least one Pi*Z allele,and AAT value at diagnosis<77 mg/*** created an algorithm for liver disease screening in AATD patients to use in primary care,selecting those to be referred to Hepatology consultation.

关键词： Alpha-1 antitrypsin deficiency Liver fibrosis Nonalcoholic fatty liver disease fibrosis score Fibrosis-4 index Liver stiffness measurement

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