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Journal of Rare Earths 2024年第4期42卷 775-782页

作者： Glaydson S.dos Reis Diana pinto Sabrina F.Lütke Eder C.lima Luis F.O.Silva Irineu A.S.de Brum Guilherme L.Dotto department of Forest Biomaterials and Technology Biomass Technology Centre Swedish University of Agricultural SciencesUmeaE13Swedn Universidad de La Costa Calle 58#55-66080002BarranquillaAtlanticoColombia Research Group on Adsorptive and Catalytic Process Engineering(ENGEPAC) Federal University of Santa MariaAv.Roraima100079705900Santa MariaRSBrazil Institute of Chemistry Federal University of Rio Grande do Sul90040060Porto AlegreBrazil

Chitin powder and chitin-aerogel were prepared from shrimp wastes and used to uptake Y^(3+)from aqueous solutions and concentrate this rare earth element from phosphogypsum(PG).Chitin aerogel displays a specific surface area of 945 m^(2)/g,while chitin powder is 3.6 m^(2)/g,which largely influences its adsorption ability.Regarding the adsorption in synthetic solutions,the effect of pH on Y^(3+)removal is strong for chitin powder adsorbent.In contrast,no big pH influence was detected for chitin aerogel.Electrostatic interactions and chelation can highlight the proposed mechanism of Y^(3+)on chitin adsorbents for the powder and aerogel.Furthermore,in addition to these interactions,pore filling/pore diffusion is the main mechanism of Y^(3+)removal in the chitin aerogel.Chitin aerogel is efficient in concentrating 8 times the Y^(3+)from PG,a very complex matrix.The complex chitin aerogel-Y^(3+)can be a secondary source of rare earth elements for other applications.

关键词： Rare earths Sustainable material Chitin powder Chitin porous aerogel Yttrium adsorption and recovery

Urea breath test for Helicobacter pylori infection in adult dyspeptic patients: A meta-analysis of diagnostic test accuracy

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World Journal of Gastroenterology 2024年第6期30卷 579-598页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Marcel Silva Luz Gabriel Reis Rocha Gabriel lima Correa Santos Luís Guilherme de Oliveira Silva Mariana Santos Calmon Cláudio lima Souza ana Carla Zarpelon-Schutz Kádima Nayara Teixeira Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Instituto de Saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919-899ParanáBrazil Laboratory of Research in Bacteriology UFMGBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Helicobacter pylori(H.pylori)infection has been well-established as a significant risk factor for several gastrointestinal disorders.The urea breath test(UBT)has emerged as a leading non-invasive method for detecting H.pylori.despite numerous studies confirming its substantial accuracy,the reliability of UBT results is often compromised by inherent limitations.These findings underscore the need for a rigorous statistical synthesis to clarify and reconcile the diagnostic accuracy of the UBT for the diagnosis of H.pylori infection.AIM To determine and compare the diagnostic accuracy of 13C-UBT and 14C-UBT for H.pylori infection in adult patients with dyspepsia.METHODS We conducted an independent search of the PubMed/MEDLINE,EMBASE,and Cochrane Central databases until April 2022.Our search included diagnostic accuracy studies that evaluated at least one of the index tests(^(13)C-UBT or ^(14)C-UBT)against a reference standard.We used the QUADAS-2 tool to assess the methodo-logical quality of the studies.We utilized the bivariate random-effects model to calculate sensitivity,specificity,positive and negative test likelihood ratios(LR+and LR-),as well as the diagnostic odds ratio(DOR),and their 95%confidence intervals.We conducted subgroup analyses based on urea dosing,time after urea administration,and assessment technique.To investigate a possible threshold effect,we conducted Spearman correlation analysis,and we generated summary receiver operating characteristic(SROC)curves to assess heterogeneity.Finally,we visually inspected a funnel plot and used Egger’s test to evaluate publication bias.endorsing both as reliable diagnostic tools in clinical practice.CONCLUSION In summary,our study has demonstrated that ^(13)C-UBT has been found to outperform the ^(14)C-UBT,making it the preferred diagnostic approach.Additionally,our results emphasize the significance of carefully considering urea dosage,assessment timing,and measurement techniques for both tests to enhance diagnostic precision.Nevertheless,it is cru

关键词： Helicobacter pylori Urea breath test Diagnosis Diagnostic test accuracy Meta-analysis

Protective Effect of <i>Camellia sinensis</i>on Methotrexate-Induced Small Intestinal Mucositis in Mice

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Food and Nutrition Sciences 2014年第5期5卷 443-448页

作者： Samuel Brito de Almeida Manuel Carlos Serra Azul Monteiro ana valêska pinto de lima Dalgimar Beserra de Menezes Sandra Maria Nunes Monteiro Center of Endocrinology Metabolism and Nutrition Studies of Brazilian Northeast Medicine Faculty/Federal University of Ceará Fortaleza Brazil department of Nutrition/Health Sciences Center/Federal University of Rio Grande do Norte Natal Brazil. department of Pathology and Forensic Medicine/ Medicine Faculty/Federal University of Ceará Fortaleza Brazil department of Physiology and Pharmacology/Medicine Faculty/Federal University of Ceará Fortaleza Brazil Medicine/Health Sciences Center University of Fortaleza Fortaleza Brazil

Background: Green tea has been used as a daily beverage for several years. Anti-inflammatory effect of tea has also been depicted in different papers. Therefore we had set forward this study to examine the potential anti- inflammatory activity of green tea in small intestine mucositis experimental models. Aims: Evaluation of anti- inflammatory effects of green tea on mice. Materials and Methods: Green tea decoction (20%) was prepared by soaking 20 g of green tea in 100 ml boiled water separately, soaked for 2 minutes and thereafter filtered. In- flammatory activity was induced using methotrexate (2.75 g/kg/24 h sc), and a protecting effect of mucositis con- dition was investigated by vitamin E and Camellia sinensis decoction. Study design: An experimental study was approved by an Animal Ethical Commitee. Results: Green tea decoction (20%) has shown significant anti-in- flammatory effects (65% and 70%) on methotrexate-induced acute mucositis model. In villous atrophy Green tea decoction (10% and 20%) has shown no protecting action at different intestinal segments. But at intestinal crypt hyperplasia, green tea decoction has shown 65.74%, as compared to mucositis group. An increase of apoptotic bodies were acchieved at MTX group, CS reduced this occurrence. Conclusion: Taken together, our data indi- cate that green tea (20%) has a potential anti-inflammatory compared vitamin E antioxidant action and cor- roborates with the current trend of tea being promoted as “health drink”. However more pharmacological and biochemical assays is necessary to elucidate mechanisms.

关键词： Mucositis Vitamin E Camellia Sinensis Morphometry Mice Cathechins

Epidemiology and Clinical Features of Mycobacterium avium Complex Pulmonary Disease in a Brazilian Amazon Cohort

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Advances in Microbiology 2024年第6期14卷 287-302页

作者： Jose Tadeu Colares Monteiro Adriana Rodrigues Barretto Ruan Seguin Azevedo Quaresma Bianca Miranda Gouveia Ismari Perini Furlaneto Victória Menezes da Costa Yan Corrêa Rodrigues Layana Rufino Ribeiro Ricardo J. de Paula Souza e Guimarães Alex Brito Souza ana Roberta Fusco da Costa Karla valéria Batista lima Joao de Barros Barreto University Hospital Federal University of Par Belm Brazil Center for Biological and Health Sciences Ph.D. Program in Parasitic Biology in the Amazon Region (PPGBPA) State University of Par (UEPA) Belm Brazil department of Medicine Centro Universitrio do Par CESUPA Belm Brazil Bacteriology and Mycology Section Evandro Chagas Institute (SABMI/IEC) Ministry of Health Ananindeua Brazil Geoprocessing Laboratory Evandro Chagas Institute/SVSA/MS Ananineua Brazil

The incidence of Mycobacterium avium complex pulmonary disease (MACPD) has been globally increasing. The present study aims to provide a comprehensive analysis of clinical characteristics and treatment response among patients in the Amazon region of Brazil and conduct a retrospective cohort study at a prominent referral hospital in the State of Par, Brazil, from 2012 to 2020. The M. avium group represented 58.9% of cases, followed by M. intracellulare (35.7%), M. colombiense (3.6%), and M. chimaera (1.8%). The majority of patients (73.2%) were female and with an average age of 63 years. Primary clinical manifestations included persistent cough and sputum production. The Charlson comorbidity index (CCI) averaged 2.47, with 36.3% of patients having a CCI score equal to higher than 3. Notably, over 70% of patients had received treatment for pulmonary tuberculosis before initiating treatment for MAC infection. The fibrocavitary radiologic form was the most prevalent (55.4%), frequently exhibiting a bilateral distribution (53.6%). Antimicrobial susceptibility revealed a significant prevalence of MAC resistance to drugs in the therapeutic regimen. despite this, most of the patients experienced clinical improvement (50%). In conclusion, this study highlights a higher prevalence of MAC infections among middle-aged women, with a history of pulmonary tuberculosis treatment and presenting the fibrocavitary radiological form was predominant.

关键词： MACDP Nontuberculous Mycobacteria Mycobacterium avium Lung Disease

Post-mortem Microstructural Study of Aluminous Refractory Brick Used in Channels of Blast Furnaces

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China's Refractories 2023年第1期32卷 40-43页

作者： ana valéria de Sousa COSTA Belmira Benedita de lima-KUHN Antonio Renato BIGANSOLLI department of Chemical Engineering Technology InstituteFederal Rural University of Rio de JaneiroSeropédica 23851-970Brazil

Aluminous refractory materials with high alumina contents are widely used in the steel industry,and the higher the alumina content,the higher the working temperature.Properties such as high refractoriness and thermal shock resistance lead these refractory materials to be used as channel linings of blast furnaces,where they are exposed to the attack by slag,molten steel,working cycles and sudden temperature changes between 25℃(room temperature)and 1520℃(the temperature of molten pig iron).In this work,microstructural changes in post-mortem aluminous refractory bricks were investigated by apparent porosity,X-ray diffraction analysis(XRD),Fourier transform infrared spectroscopy(FTIR),scanning electron microscopy,and X-ray dispersion energy spectrometry(SEM/EDS).The results showed an increase in the apparent porosity and the bulk density and the presence of the phases mullite,sillimanite,alumina,and quartz in the post-mortem brick.Calcium and magnesium were not detected in the microstructure of the post-mortem brick,indicating that slags did not corrode these refractory materials.Therefore,the microstructural changes that occurred in the post-mortem bricks must be due to thermal cycling.In the X-ray diffraction(XRD)test,mullite,sillimanite,quartz,andα-alumina phases were identified.These results indicate that the aluminous refractory was obtained from sillimanite.In infrared spectroscopy(FTIR)it was possible to identify the vibration bands referring to the Si-O and Al-O bonds.The increase in the porosity is a result of cracks caused by work cycles at high temperatures and the temperature gradient to which the refractory was subjected during use.Through the micrograph it was possible to identify the presence of acicular mullite.The absence of magnesium and calcium in the microanalysis results by energy dispersed X-ray spectrometry(EDS)indicates that there was no infiltration by slag or liquid iron.These results indicate that the microstructural changes that occurred in the post-mortem aluminous refractory were of a th

关键词： aluminous refractories steel industry microstructural blast furnace

Differential diagnosis between autism spectrum disorder and other developmental disorders with emphasis on the preschool period

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世界儿科杂志:英文版 2023年第8期19卷 715-726页

作者： Taynara Amancio de lima Patricia Aparecida Zuanetti Marina Estima Neiva Nunes ana Paula Andrade Hamad department of Neurosciences and Behavioral Sciences Ribeirão Preto Medical SchoolUniversity of São PauloAv.Bandeirantes3900Monte AlegreRibeirão PretoSP14049-900Brazil University Hospital Ribeirão Preto Medical SchoolUniversity of São Paulo(HCFMRP-USP)Ribeirão PretoSPBrazil

Background Neurodevelopmental disorders are a heterogeneous group of conditions that manifest as delays or deviations in the acquisition of expected developmental milestones and behavioral changes.Autism spectrum disorder(ASD)is a neurodevelopmental disorder characterized by deficits in communication and social interaction and by repetitive and restricted patterns of behavior,interests and activities.The aim of this review is to discuss the clinical features of the differential diagnoses of ASD that are prevalent among preschoolers,focusing on their similarities and disparities.Data sources The international medical literature search was conducted using PubMed and was revised regarding the subject using single and/or combined keywords as follows:differential diagnosis,preschoolers,diagnostic challenge,attention deficit hyperactivity disorder,intellectual disability,high abilities/giftedness,childhood apraxia of speech,social communication disorder,Landau–Kleffner syndrome,stereotyped movement disorder and excessive screen time.Results We describe conditions commonly found in clinical practice,taking ASD as a reference.We addressed converging and divergent aspects of behavior,cognition,communication,language,speech,socialization,and stereotypes for the diagnosis of ASD and other disorders identified as potential differential or comorbid diagnoses.Conclusions The ranking and characterization of symptoms appear to be essential for better understanding the underlying common ground between children with developmental disorders and children with ASD,thus properly diagnosing and directing social,professional,or medication interventions.This detailed discussion adds to the literature since,although ASD differential diagnoses are frequently mentioned and discussed in textbooks and journal articles,they rarely occupy a prominent place as we aimed herein.

关键词： Autism spectrum disorder Clinical features Differential diagnosis Neurodevelopmental disorders Preschool

Downregulation of TNFR2 decreases survival gene expression,promotes apoptosis and affects the cell cycle of gastric cancer cells

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World Journal of Gastroenterology 2022年第24期28卷 2689-2704页

作者： ana Flávia Teixeira Rossi Fernanda da Silva Manoel-Caetano Joice Matos Biselli Ágata Silva Cabral Marilia de Freitas Calmon Saiki Marcelo lima Ribeiro ana Elizabete Silva department of Biological Sciences Sao Paulo State University(UNESP)São Josédo Rio Preto 15054-000São PauloBrazil Clinical Pharmacology and Gastroenterology Unit São Francisco University(USF)Bragança Paulista 12916-900São PauloBrazil

BACKGROUND Chronic inflammation due to Helicobacter pylori(H.pylori)infection promotes gastric carcinogenesis.Tumour necrosis factor-α(TNF-α),a key mediator of inflammation,induces cell survival or apoptosis by binding to two receptors(TNFR1 and TNFR2).TNFR1 can induce both survival and apoptosis,while TNFR2 results only in cell survival.The dysregulation of these processes may contribute to carcinogenesis.AIM To evaluate the effects of TNFR1 and TNFR2 downregulation in AGS cells treated with H.pylori extract on the TNF-αpathway.METHODS AGS cell lines containing TNFR1 and TNFR2 receptors downregulated by specific shRNAs and nonsilenced AGS cells were treated with H.pylori extract for 6 h.Subsequently,quantitative polymerase chain reaction with TaqMan®assays was used for the relative quantification of the mRNAs(TNFA,TNFR1,TNFR2,TRADD,TRAF2,CFLIP,NFKB1,NFKB2,CASP8,CASP3)and miRNAs(miR-19a,miR-34a,miR-103a,miR-130a,miR-181c)related to the TNF-αsignalling pathway.Flow cytometry was employed for cell cycle analysis and apoptosis assays.RESULTS In nonsilenced AGS cells,H.pylori extract treatment increased the expression of genes involved in cell survival and inhibited both apoptosis(NFKB1,NFKB2 and CFLIP)and the TNFR1 receptor.TNFR1 downregulation significantly decreased the expression of the TRADD and CFLIP genes,although no change was observed in the cellular process or miRNA expression.In contrast,TNFR2 downregulation decreased the expression of the TRADD and TRAF2 genes,which are both important downstream mediators of the TNFR1-mediated pathway,as well as that of the NFKB1 and CFLIP genes,while upregulating the expression of miR-19a and miR-34a.Consequently,a reduction in the number of cells in the G0/G1 phase and an increase in the number of cells in the S phase were observed,as well as the promotion of early apoptosis.CONCLUSION Our findings mainly highlight the important role of TNFR2 in the TNF-αpathway in gastric cancer,indicating that silencing it can reduce the expression of survival and anti-apoptotic genes

关键词： Gastric cancer Helicobacter pylori Tumour necrosis factor-αsignalling pathway TNFR1 TNFR2 miRNAs

Therapeutic Properties of Flavonoids in Treatment of Cancer through Autophagic Modulation:A Systematic Review

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Chinese Journal of Integrative Medicine 2023年第3期29卷 268-279页

作者： Guilherme Vinicio de Sousa Silva ana Luiza Vieira Ferreira Guimaraes Lopes Isis Carolina Viali Lucas Zannini Medeiros lima Matheus Ribeiro Bizuti Fabiana Brum Haag Débora Tavares de Resende e Silva department of Medicine Federal University of Fronteira SulChapecóSanta CatarinaBrazil department of Nursing Federal University of Fronteira SulChapecóSanta CatarinaBrazil department of Graduate Studies in Biomedical Sciences Federal University of Fronteira SulChapecóSanta CatarinaBrazil

Cancers have high morbidity and mortality rates worldwide.Current anticancer therapies have demonstrated specific signaling pathways as a target in the involvement of carcinogenesis.Autophagy is a quality control system for proteins and plays a fundamental role in cancer carcinogenesis,exerting an anticarcinogenic role in normal cells and can inhibit the transformation of malignant cells.Therefore,drugs aimed at autophagy can function as antitumor agents.Flavonoids are a class of polyphenolic secondary metabolites commonly found in plants and,consequently,consumed in diets.In this review,the systematic search strategy was used,which included the search for descriptors"flavonoids"AND"mTOR pathway"AND"cancer"AND"autophagy",in the electronic databases of PubMed,Cochrane Library,Web of Science and Scopus,from January 2011 to January 2021.The current literature demonstrates that flavonoids have anticarcinogenic properties,including inhibition of cell proliferation,induction of apoptosis,autophagy,necrosis,cell cycle arrest,senescence,impaired cell migration,invasion,tumor angiogenesis and reduced resistance to multiple drugs in tumor cells.We demonstrate the available evidence on the roles of flavonoids and autophagy in cancer progression and inhibition.(Registration No.CRD42021243071 at PROSPERO)

关键词： anti-cancer effects apoptosis cell proliferation cell survival flavonoids

Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines

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Journal of Pharmaceutical analysis 2022年第3期12卷 424-435页

作者： Ihatanderson A.Silva ana Luiza lima Tais Gratieri Guilherme M.Gelfuso Livia L.Sa-Barreto Marcilio Cunha-Filho Laboratory of Food Drugand Cosmetics(LTMAC)School of Health SciencesUniversity of Brasilia70910-900BrasíliaDFBrazil Faculty of Ceilandia University of Brasilia(UnB)72220-900BrasíliaDFBrazil

One of the challenges in developing three-dimensional printed medicines is related to their stability due to the manufacturing conditions involving high temperatures.This work proposed a new protocol for preformulation studies simulating thermal processing and aging of the printed medicines,tested regarding their morphology and thermal,crystallographic,and spectroscopic profiles.Generally,despite the strong drug-polymer interactions observed,the chemical stability of the model drugs was preserved under such conditions.In fact,in the metoprolol and Soluplus®composition,the drug's solubilization in the polymer produced a delay in the drug decomposition,suggesting a protective effect of the matrix.Paracetamol and polyvinyl alcohol mixture,in turn,showed unmistakable signs of thermal instability and chemical decomposition,in addition to physical changes.In the presented context,establishing protocols that simulate processing and storage conditions may be decisive for obtaining stable pharmaceutical dosage forms using three-dimensional printing technology.

关键词： Three-dimensional printing Preformulation Hot-melt extrusion Thermal analysis Drug-polymer compatibility

Genetic variables of the glutamatergic system associated with treatment-resistant depression:A review of the literature

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World Journal of Psychiatry 2022年第7期12卷 884-896页

作者： Estela Saez Leire Erkoreka Teresa Moreno-Calle Belen Berjano ana Gonzalez-pinto Nieves Basterreche Aurora Arrue department of Psychiatry Barrualde-Galdakao Integrated Health OrganizationOsakidetza-Basque Health ServiceGaldakao 48960Spain Mental Health Network Group Biocruces Bizkaia Health Research InstituteBarakaldo 48903Spain department of Neurosciences University of the Basque Country UPV/EHULeioa 48940Spain department of Psychiatry Araba Integrated Health OrganizationOsakidetza-Basque Health ServiceCIBERSAMVitoria-Gasteiz 01004Spain Severe Mental Disorders Group Bioaraba Health Research InstituteVitoria-Gasteiz 01009Spain Zamudio Hospital Bizkaia Mental Health NetworkOsakidetza-Basque Health ServiceZamudio 48170Spain Integrative Research Group in Mental Health Biocruces Bizkaia Health Research InstituteBarakaldo 48903Spain Neurochemical Research Unit Bizkaia Mental Health NetworkOsakidetza-Basque Health ServiceBarakaldo 48903Spain

depression is a common,recurrent mental disorder and one of the leading causes of disability and global burden of disease worldwide.Up to 15%-40%of cases do not respond to diverse pharmacological treatments and,thus,can be defined as treatment-resistant depression(TRD).The development of biomarkers predictive of drug response could guide us towards personalized and earlier treatment.Growing evidence points to the involvement of the glutamatergic system in the pathogenesis of TRD.Specifically,the N-methyl-D-aspartic acid receptor(NMDAR)andα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor(AMPAR),which are targeted by ketamine and esketamine,are proposed as promising pathways.A literature search was performed to identify studies on the genetics of the glutamatergic system in depression,focused on variables related to NMDARs and AMPARs.Our review highlights GRIN2B,which encodes the NR2B subunit of NMDAR,as a candidate gene in the pathogenesis of TRD.In addition,several studies have associated genes encoding AMPAR subunits with symptomatic severity and suicidal ideation.These genes encoding glutamatergic receptors could,therefore,be candidate genes for understanding the etiopathogenesis of TRD,as well as for understanding the pharmacodynamic mechanisms and response to ketamine and esketamine treatment.

关键词： Genetics N-methyl-D-aspartic acid receptor α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor Treatment-resistant depression Ketamine Esketamine