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Journal of Civil Engineering and Architecture 2017年第10期11卷 921-932页

作者： Valderez Ferreira Fraga ana paula Gomes M. Pinto Institute of Economic (Ecex) Federal University of Rio de Janeiro Rio de Janeiro CEP 22.290-902 R J Brazil Department of Production and Civil Engineering University Unilasalle Niteroi CEP 24240-030 R J Brazil

Urban spaces vulnerable to recurrent adverse climatic phenomena present specific, consecutive problems, requiring a reflective view of their socio-spatial reality. This article presents a case study about the towns of Amadora, Greater Lisbon, and Petr6polis, Rio de Janeiro State, Brazil, which, originally, bore a common Portuguese urbanistic praxis. Their urban contexts are characterized by the occurrence of extreme risks of flooding and landslides caused by intense rainfall. Both places feature aggravation of the risks due to accelerated urban growth and disorderly land occupation. From the phenomenological perspective, what happens to the human being leads to fruitful and/or dramatic experiences. The important point is that there occurs learning for favourable action, with solutions for each individual and for ＂the other＂. Thus, it is proposed to qualitatively analyse, with a posture that values the community experience and urban practices of the towns that contribute to the development of the culture of resilience which promotes practices of prevention, precaution and vigilance founded on the experience of communities that have been exposed. Besides this, it is intended to verify challenges in the implementation of public policies aimed at sustainable urban development, those that contemplate, among others： risk management action to deal with natural disasters.

关键词： Urban spaces culture of resilience phenomenology community natural catastrophe/disaster

Vanishing bile duct syndrome in human immunodeficiency virus infected adults:A report of two cases

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World Journal of Gastroenterology 2013年第1期19卷 115-121页

作者： ana paula Oppenheimer Christopher Koh Mary McLaughlin John C Williamson Thomas D Norton Jennifer Laudadio Theo Heller David E Kleiner Kevin P High Caryn G Morse Section of Infectious Diseases Department of MedicineWake Forest School of MedicineWinston-SalemNC 27109-7205United States Liver Diseases Branch National Institute of DiabetesDigestive and Kidney DiseasesNational Institutes of Health Clinical CenterBethesdaMD 20892-1403United States Laboratory of Immunoregulation National Institute of Allergy and Infectious DiseasesNational Institutes of Health Clinical CenterBethesdaMD 20892-1403United States Division of Infectious Diseases and Immunology Department of MedicineNew York University School of MedicineNew YorkNY 10016United States Laboratory of Pathology Wake Forest School of MedicineWinston-SalemNC 27109-7205United States Laboratory of Pathology National Cancer InstituteNational Institutes of Health Clinical CenterBethesdaMD 20892-1403United States Department of Critical Care Medicine National Institutes of Health Clinical CenterBethesdaMD 20892-1403United States

Vanishing bile duct syndrome(VBDS) is a group of rare disorders characterized by ductopenia,the progressive destruction and disappearance of intrahepatic bile ducts leading to *** in association with medications,autoimmune disorders,cancer,transplantation,and infections,the specific mechanisms of disease are not *** date,only 4 cases of VBDS have been reported in human immunodeficiency virus(HIV) infected *** report 2 additional cases of HIV-associated VBDS and review the features common to the HIV-associated *** includes hyperbilirubinemia,normal liver imaging,and negative viral and autoimmune hepatitis *** HIV-infected subjects,VBDS occurred at a range of CD4+ T-cell counts,in some cases following initiation or change in antiretroviral *** was associated with two cases;nevirapine,antibiotics,and viral co-infection were suggested as etiologies in the other *** HIV-positive patients with progressive cholestasis,early identification of VBDS and referral for transplantation may improve outcomes.

关键词： Human immunodeficiency virus Antiretroviral therapy Vanishing bile duct syndrome Ductopenia Liver biopsy

Robotic Surgery: An Effective Treatment Option for Epiphrenic Diverticulum Associated with Nutcracker Esophagus

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Surgical Science 2024年第1期15卷 1-6页

作者： Augusto Tinoco Gilberto Carvalho Leonardo Tinoco ana paula Quintão Department of Digestive Surgery Hospital S&#227o Jos&#233 do Ava&#237 Itaperuna Brazil

Background: Epiphrenic Diverticulum is frequently associated with esophageal motility disorders, such as nutcrackers esophagus. The diagnosis is usually made using imaging studies such as a Barium esophagogram, and esophageal manometry. Surgical treatment options for epiphrenic diverticulum and EN include diverticulectomy and wide myotomy. Aim: The resection of three epiphrenic diverticula and extensive myotomy were performed by robotic thoracoscopy uneventfully. Case presentation: A 65-year-old female complaining of dysphagia for solid foods, Chest pain and regurgitation. Esophagogastroduodenoscopy (EDG) with difficulty in advancing the endoscope at 25 cm and demonstrating an ED, no hiatal hernia and normal stomach and duodenum. Barium Esophagogram showed multiple diverticula and tortuosity throughout the esophagus. Conclusion: With robotic surgery, surgeons can perform highly precise operations with enhanced 3D vision and control. Through this cutting-edge approach, the treatment of ED associated with EN can be drastically changed, promising better outcomes for patients.

关键词： Robotic Surgery Myotomy Nutcracker Esophagus Epiphrenic Diverticulum

Resistance mechanism to cisplatin in NCI-H460 non-small cell lung cancer cell line:investigating apoptosis,autophagy,and cytogenetic damage

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Cancer Drug Resistance 2018年第1期1卷 72-81页

作者： Érica Ballestreri Daniel Simon ana paula de Souza Camila Schultz Grott Débora Dreher Nabinger Rafael Rodrigues Dihl Ivana Grivicich Laboratory of Cancer Biology Graduate Program in Cellular and Molecular Biology Applied to HealthLutheran University of BrazilCanoasRS 92425-900Brazil Laboratory of Human Molecular Genetics Graduate Program in Cellular and Molecular Biology Applied to HealthLutheran University of BrazilCanoasRS 92425-900Brazil Laboratory of Genetic Toxicity Graduate Program in Cellular and Molecular Biology Applied to HealthLutheran University of BrazilCanoasRS 92425-900Brazil

Aim:To investigate the effects of cisplatin on the human non-small cell lung carcinoma(NCI-H460)cell line regarding cytotoxicity,genotoxicity,and expression of genes associated with apoptosis(BIRC5)and autophagy(BECN1).Methods:Cell cultures were treated with cisplatin concentrations(0.16-33.3μmol/L)for 48 *** and acute and chronic cytotoxicities were assessed using the MTT,clonogenic,and cytokinesis-block micronucleus *** expression of BIRC5 and BECN1 was evaluated by reverse transcription-polymerase chain ***:Cisplatin IC50(0.33μmol/L)increased micronucleus frequency 2.50 *** was also cytotoxic in the 0.6-33.3μmol/L range,with reduced expression of the BIRC5 gene,suggesting induction of *** reducing the expression of the BIRC5 gene,33.3μmol/L cisplatin increased the expression of the BECN1 gene,suggesting that autophagy can be related to cisplatin ***:Cisplatin inhibited NCI-H460 growth,and cisplatin IC50 induced genotoxic *** higher cisplatin concentrations are used,the expression of genes associated with apoptosis and autophagy was *** results points to a further investigation of the role of autophagy in cisplatin resistance.

关键词： BECN1 BIRC5 cisplatin cytotoxicity lung cancer

Phase angle and non-alcoholic fatty liver disease before and after bariatric surgery

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World Journal of Hepatology 2020年第11期12卷 1004-1019页

作者： Joise Teixeira Claudio Augusto Marroni paula Rosales Zubiaurre ana Henz Lais Faina Lilian KethelynPinheiro Claudio Cora Mottin Sabrina Alves Fernandes Department of Postgraduate Program in Medicine:Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050170RSBrazil Department of Gastroenterology and Hepatology Universidade Federal de Ciências da Saúde de Porto Alegre(UFCSPA)Porto Alegre 91760470RSBrazil Department of Center of Morbid Obesity Pontificia Universidade Catolica do Rio Grande do Sul(PUCRS)Porto Alegre 90610000RSBrazil Department of Nutrition Centro Universitario Metodista(IPA)Porto Alegre 90420060RSBrazil Department of Vascular Surgery Hospital Federal dos Servidores do Estado do Rio de JaneiroRio de Janeiro 20221161RJBrazil Department of Obesity and Metabolic Syndrome Center Pontificia Universidade Catolica do Rio Grande do Sul(PUCRS)Porto Alegre 90619-900RSBrazil

BACKGROUND Obesity is a global health problem that is continuing to increase in the young *** Brazil,the frequency of obesity in 2018 was 19.8%.Several comorbidities are directly associated with obesity,such as non-alcoholic fatty liver disease(NAFLD),which is considered the most common liver disorder in Western countries and affects up to 46%of *** surgery is effective in treating obesity and can improve NAFLD;however,the effect of bariatric surgery on body composition,phase angle(PA),and improving NAFLD needs to be further *** To analyze the PA in the postoperative period of bariatric surgery and to correlate it with changes in body composition and liver *** This study is a retrospective cohort study of the analysis of the medical records of patients undergoing bariatric surgery in a reference center of a teaching hospital in Porto Alegre over a 2-year *** older than 18 years whose record contained all information relevant to the study were *** data analyzed were body composition and PA through electrical bioimpedance and NAFLD through liver biopsy in the pre-and postoperative *** level of significance adopted for the statistical analyses was 5%.RESULTS We evaluated 379 patients with preoperative *** PA,169 patients were analyzed,and 33 patients had liver biopsy pre-and postoperatively with NAFLD *** total,79.4%were female,with a mean age of 39.1±10.6 *** average body mass index(BMI)was 45.9±7.5 kg/m².The PA showed a mean of 5.8±0.62°in the preoperative period and a significant reduction in the postoperative period.A postoperative reduction in body composition data(skeletal muscle mass,fat percentage,fat mass,body cell mass,BMI and visceral fat area)was shown as *** liver disease,all patients presented a reduction in the degrees and stages of liver disease in the postoperative period,and some had no degree of liver disease at *** PA decreased af

关键词： Obesity Body composition Bariatric surgery Phase angle Non-alcoholic fatty liver disease Liver disease

Correction of Acidity of a Brazilian Cerrado Oxisol with Limestone and Wood Ash on the Initial Growth of Cowpea

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Agricultural Sciences 2019年第7期10卷 841-851页

作者： Edna Maria Bonfim-Silva Alisson Silva Costa Jefferson vieira José André Pereira Freire Ferraz ana paula Alves Barreto Damasceno Tonny José Araújo da Silva Department of Agricultural and Environmental Engineering Institute of Agricultural Sciences and Technology Federal University of Mato Grosso Rondonópolis Brazil

Among Brazilian soils orders, there are some of it classified as acid soils, which need correction to guarantee crop productivity. Currently, limestone is the most used soil corrective and wood ash has been a sustainable alternative to this process. Thus, the objective was to evaluate the effect of two correctives of soil acidity on an Oxisol collected in the Brazilian Cerrado area using limestone and wood ash and the effect of soil correction on initial growth of cowpea. Two greenhouse experiments were carried out: 1) with limestone, using base saturation levels (V%) of 0, 20, 40, 60 and 80;and 2) wood ash, with doses of 0, 8, 16, 24 and 32 g⋅dm−3, both in five randomized blocks. At 40 days after sowing, it was verified that pH values were within the range considered ideal for soil (pH of 5 to 7), according to the increase of base saturation levels and wood ash doses, but limestone provided faster results. Initial growth of cowpea was positively influenced by soil correction with use of both correctives. Wood ash and limestone increased soil pH to adequate values and resulted in better initial crop development.

关键词： Vigna unguiculata Solid Waste Disposal Alternative Soil Corrective Soil pH

Trichomonas vaginalis and Chlamydia trachomatis Prevalence,Incidence and Associated Factors in Pregnant Adolescents from Belém City,in the Brazilian Amazon

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Open Journal of Obstetrics and Gynecology 2015年第12期5卷 677-687页

作者： Camila Marconi Marli Teresinha Cassamassimo Duarte Márcia Guimaraes da Silva Larissa Doddi Marcolino Jossimara Polettini ana paula Goncalves Adriano Dias Marilza vieira Cunha Rudge Basic Pathology Department UFPR—Universidade Federal do Paraná Parana Brazil UNOESTE The University of Western Sao Paulo Sao Paulo Brazil Department of Pathology Botucatu Medical School UNESP—Universidade Estadual Paulista Sao Paulo Brazil Department of Nursing Botucatu Medical School UNESP—Universidade Estadual Paulista Sao Paulo Brazil Department of Nursing Institute of Health Sciences UFPA—Universidade Federal do Pará Belém Brazil Department of Public Health Botucatu Medical School UNESP—Universidade Estadual Paulista Sao Paulo Brazil Department of Gynecology and Obstetrics Botucatu Medical School UNESP—Universidade Estadual Paulista Sao Paulo Brazil

Background: Adolescents are disproportionally affected by sexually transmitted infections (STI). Chlamydia trachomatis (CT) and Trichomonas vaginalis (TV) are the most frequent curable STI in adolescents, causing serious consequences for their reproductive health. Therefore, we aimed to determine the prevalence and incidence of CT and TV, as well as their risk factors in pregnant adolescents from Belém, northern Brazilian Amazon. Methods: This prospective study enrolled 199 adolescents up to 20 weeks of pregnancy. They were scheduled for follow-up visit between 28 and 29 weeks of pregnancy. Sociodemographic and behavioral data were obtained by interview. Cervicovaginal samples were taken to test for TV, CT, Neisseria gonorrhoeae and bacterial vaginosis. Univariate and multivariate analyses were performed to test the association of prevalent/incident CT and TV with the variables. Results: Prevalence of cervical CT infection was 33.7% (n = 67/ 199), and for trichomoniasis it was 4.0% (n = 8/199). Cervical ectopy increased the risk for prevalent CT (OR, 1.93;95% CI, 1.01 - 3.70), while having treated vaginal discharge in the past (OR, 0.51;95% CI, 0.26 - 0.98) and being married (OR, 0.10;95% CI, 0.01 - 0.83) were protective against current CT and TV, respectively. Among the 95 (47.7%) adolescents who completed follow-up, 15 cases of incident CT were identified. Incident CT was associated with having a formal or informal job (OR, 28.4;95% CI, 2.1 - 391.6) and bacterial vaginosis treatment at the baseline (OR, 0.08;95% CI, 0.01 - 0.69). Conclusion: Prevalence and incidence rates of TV and CT are high in this population devoid of STI routine screening. Treatment of bacterial vaginosis may benefit this population by reducing risk for CT acquisition.

关键词： Adolescence Pregnancy Sexually Transmitted Infection Chlamydia trachomatis Trichomonas vaginalis

An Exploratory Behavioral Study in Children of Four Years of Age on the Hypothesis of a Two Streams System in Touch Perception and Language Development

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Psychology Research 2018年第11期8卷 567-571页

作者： David Catela Catarina Silva Joana Reis ana paula Seabra Polytechnic Institute of Santarém SantarémPortugal

A two streams system seems to exist for tactile *** asked kindergarten children to identify(semantic)and describe the function of grasped unseen instruments of their daily life(fork,knife,spoon,brush,toothbrush,pencil,and scissor),and then,to simulate its use(pragmatic).The capacity to describe the function of the set of instruments was significantly superior to that of identifying them by name,although there was a significant direct association between identification and description of the function in the responses to the set of *** simulation of the instrument function was of two types:(i)use―the child simulated how the instrument is grasped and used;and(ii)incorporation―the child simulated the function of the instrument with her/his own *** results support the hypothesis of a two streams tactile system(semantic and pragmatic),and that kindergarten children have the ability to incorporate functional properties of instruments of their daily life,probably as a support for language development.

关键词： children language development tactile perception tool two streams system

Lichen planus affecting a 12-year-old girl

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Open Journal of Stomatology 2012年第4期2卷 358-361页

作者： Natalie Kelner ana paula Vivas Rosana Morelatto Fabio Alves ACCamargo Hospital Sao PauloBrazil University of Sao Paulo Sao PauloBrazil National University of Cordoba CordobaBrazil

Lichen planus (LP) is a chronic inflammatory mucocutaneous condition which is relatively common in adults but rarely affects children. In addition, few cases with oral lesions affecting children have been reported in the literature. The purpose of this study is to report an unusual case of oral LP involving the tongue and buccal mucosa in a child. A 12-year-old girl complained of painless oral lesions with 18 months of evolution. On clinical evaluation, multiple white lesions in tongue and buccal mucosa were observed with no cutaneous lesions. Diagnosis was made based on clinical examination and histopathological features. No active treatment was necessary. The patient is currently under regular evaluation. Although rarely reported in childhood, lichen planus should be considered in a differential diagnosis of hyperkeratotic and/or reticular lesions of the oral mucosa in children.

关键词： Lichen Planus Oral Oral Diagnosis Child Diagnosis Differential

The biosynthetic pathway of the hallucinogen mescaline and its heterologous reconstruction

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Molecular Plant 2024年第7期17卷 1129-1150页

作者： paula Berman Luis Alejandro de Haro ana-Rita Cavaco Sayantan Panda Younghui Dong Nikolay Kuzmich Gabriel Lichtenstein Yoav Peleg Hila Harat Adam Jozwiaki Jianghua Cai Uwe Heinig Sagit Meir Ilana Rogachev Asaph Aharoni Department of Plant and Environmental Sciences Weizmann Institute of ScienceRehovot 7610001Israel Life Sciences Core Facilities Weizmann Institute of ScienceRehovot 7610001Israel The Maurice and Vivienne Wohl Institute for Drug Discovery Weizmann Institute of ScienceRehovot 7610001Israel Present address:Department of Cell and Metabolic Biology Leibniz Institute of Plant BiochemistryWeinberg 306120 Halle(Saale)Germany Department of Molecular&Cellular Pharmacology University of Miami Miler School of MedicineMiamiFL 33136USA Department of Botany and Plant Sciences University of California RiversideRiversideCA 92521USA Laboratory of Plant Hormones and Development Regulation of Chongqing School of Life SciencesChongqing UniversityChongqing 401331China

Mescaline,among the earliest identified natural hallucinogens,holds great potential in psychotherapy ***,despite the existence of a postulated biosynthetic pathway for more than half a century,the specific enzymes involved in this process are yet to be *** this study,we investigated the cactus Lophophora williamsii(Peyote),the largest known natural producer of the phenethylamine *** employed a multi-faceted approach,combining de novo whole-genome and transcriptome sequencing with comprehensive chemical profiling,enzymatic assays,molecular modeling,and pathway engineering for pathway *** identified four groups of enzymes responsible for the six catalytic steps in the mescaline biosynthetic pathway,and an N-methyltransferase enzyme that N-methylates all phenethylamine intermediates,likely modulating mescaline levels in ***,we reconstructed the mescaline biosynthetic pathway in both Nicotiana benthamiana plants and yeast cells,providing novel insights into several challenges hindering complete heterologous mescaline *** together,our study opens up avenues for exploration of sustainable production approaches and responsible utilization of mescaline,safeguarding this valuable natural resource for future generations.

关键词： mescaline Lophophora williamsi Peyote biosynthetic pathway de novo genome sequencing mo-lecular modeling