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A single administration of fish oil inhibits the acute inflammatory response in rats

Asian Pacific Journal of Tropical Medicine 2017年第8期10卷 830-837页

作者： Laura Licia Milani de Arruda Franciele Queiroz Ames Damila Rodrigues de Morais Renata Grespan ana paula maziero gil Maria Angelica Raffaini Covas Pereira Silva Jesui Vergilio Visentainer Roberto Kenji Nakamura Cuman Ciomar Aparecida Bersani-Amado Department of Pharmacology and Therapeutics State University of MaringaMaringa-PRBrazil Department of Chemistry State University of MaringaMaringa-PRBrazil

Objective: To investigate the antiinflammatory effects of a single administration of fish oil(FO) on the acute inflammatory response. Methods: The paw edema and pleurisy models were used to evaluate the effects of FO dissolved in olive oil(FOP) orally administered in a single dose in rats. Nitric oxide(NO) concentrations in the pleural exudate were performed according to the Griess method and the cytokine concentrations were determined by Luminex bead-based multiplex assay. Results: FOP treatment(30 and 300 mg/kg) significantly reduced paw edema. FOP treatment at 18.75, 37.5, 75.0, 150.0, and 300 mg/kg decreased both the volume of pleural exudate and cellular migration into the pleural cavity and each of these doses presented the same effectiveness. Treatment with FOP(300 mg/kg) reduced NO, TNF-α, IL-1β, and IL-6 concentrations in the pleural exudate. Conclusions: The present data provide evidence that FO has inhibitory effects on the acute inflammatory response when administered in a single dose in rats. This effect might be attributable to a direct inhibitory effect of FO on the production or release of inflammatory mediators that are involved in the pathological processes evaluated herein.

关键词： Omega-3 fatty acid Polyunsaturated fatty acid Pleurisy Leukocyte migration EPA DHA

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Synthesis and applications of lanthanoid complexes of pentadentate and hexadentate N_(5) and N_(6) macrocycles:A review

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Journal of Rare Earths 2024年第1期42卷 1-15,I0001页

作者： Julio Corredoira-Vázquez Cristina González-Barreira paula Oreiro-Martínez ana M.García-Deibe Jesús Sanmartín-Matalobos Matilde Fondo Departamento de Química Inorganica Facultade de QuímicaUniversidade de Santiago de CompostelaCampus Vida15782Santiago de CompostelaSpain Phantom-g CICECO-Aveiro Institute of MaterialsDepartment of PhysicsUniversity of Aveiro3810-193AveiroPortugal Institute of Materials(iMATUS) Universidade de Santiago de Compostela15782Santiago de CompostelaSpain

In this paper,the lanthanoid complexes of N_(5) and N_(6) macrocycle ligands,without pendant arms or additional heteroatoms,are *** review covers the period from 2015 to the current date,since in 2014 Schiff base macrocyclic ligands incorporating the pyridine moiety,and their complexes,were revised,and in 2015 the chemistry of pentaaza macrocycle ligands with rare earth metals was also *** and phthalocyanine ligands are not included in this review,which primarily focuses on complexes with Schiff bases and amines without pendant arms or any additional donor other than *** synthetic methods,structural characterization,based on single X-ray crystal data,and properties of the lanthanoid complexes,with special attention to magneto-structural correlations,are presented herein.

关键词： Lanthanoid N_(5),N_(6)macrocycle Coordination chemistry Chirality Biological activity Molecule magnet

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Endoscopic ultrasound artificial intelligence-assisted for prediction of gastrointestinal stromal tumors diagnosis:A systematic review and meta-analysis

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World Journal of Gastrointestinal Endoscopy 2023年第8期15卷 528-539页

作者： Rômulo Sérgio Araújo Gomes Guilherme Henrique Peixoto de Oliveira Diogo Turiani Hourneaux de Moura ana paula Samy Tanaka Kotinda Carolina Ogawa Matsubayashi Bruno Salomão Hirsch Matheus de Oliveira Veras João Guilherme Ribeiro Jordão Sasso Roberto Paolo Trasolini Wanderley Marques Bernardo Eduardo Guimarães Hourneaux de Moura Department of Gastroenterology Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 05403-010Brazil Division of Hepatology and Endoscopy Department of GastroenterologyHarvard Medical SchoolBrigham and Women’s HospitalBostonMA 02115United States

BACKGROUND Subepithelial lesions(SELs)are gastrointestinal tumors with heterogeneous malignant *** ultrasonography(EUS)is the leading method for evaluation,but without histopathological analysis,precise differentiation of SEL risk is *** intelligence(AI)is a promising aid for the diagnosis of gastrointestinal lesions in the absence of *** To determine the diagnostic accuracy of AI-assisted EUS in diagnosing SELs,especially lesions originating from the muscularis propria *** Electronic databases including PubMed,EMBASE,and Cochrane Library were *** of any sex and>18 years,with SELs assessed by EUS AIassisted,with previous histopathological diagnosis,and presented sufficient data values which were extracted to construct a 2×2 *** reference standard was *** primary outcome was the accuracy of AI for gastrointestinal stromal tumor(GIST).Secondary outcomes were AI-assisted EUS diagnosis for GIST vs gastrointestinal leiomyoma(gil),the diagnostic performance of experienced endoscopists for GIST,and GIST vs *** sensitivity,specificity,positive,and negative predictive values were *** corresponding summary receiver operating characteristic curve and post-test probability were also *** Eight retrospective studies with a total of 2355 patients and 44154 images were included in this *** AI-assisted EUS for GIST diagnosis showed a sensitivity of 92%[95%confidence interval(CI):0.89-0.95;Pgil by AI-assisted EUS,specificity was 90%(95%CI:0.88-0.95;P=0.02)and AUC of *** experienced endoscopists’values were sensitivity of 72%(95%CI:0.67-0.76;Pgil,the experts achieved a sensitivity of 73%(95%CI:0.65-0.80;P<0.01)and an AUC of ***

关键词： Subepithelial lesions Ultrasound endoscopy Artificial intelligence

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