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Health 2015年第13期7卷 1782-1787页

作者： ana Rafaela Dantas dos Santos ana mayara gomes de sousa Fernanda Diniz de Sá Adriana gomes Magalhaes Fábia Barbosa de Andrade Higo Luiz Amorim Belo Maia Faculty of Health Sciences of Trairi(FACISA) Federal University of Rio Grande do Norte(UFRN)Santa CruzBrazil

This article is about a report of the experiment of PRO/PET-Saúde students in the anti-HIV tests implementation in the town of Santa Cruz-RN. The goal is to report the importance and discuss the aspects of the moment experienced above inside the basic health unit in the town of Santa Cruz-RN. The experience occurred in the months from February to March 2014 and they were conducted within 8 hours per week. This way, it is observed that the period lived made possible great reflection about the making of the examination in the pre-natal appointment routines, cataloguing challenges which come up during their adequacy within the services. Lastly, the action developed aimed for the aggregation of an active learning process in the search for a critical sense in the experienced practice, allowing and prioritizing the basic health unit as a scope of reference and counter-reference in the public health service, increasing concrete answers and the needs of the population, guaranteeing an adequate service delivery and strengthening the SUS more and more. The insertion of students through the PRO/PET-Saúde-Rede Cegonha enables a reorientation of professional formation, from the integration between service and teaching.

关键词： Pregnant Student Teaching-Service HIV Tests Vertical Transmissions

A geomechanics classification for the rating of railroad subgrade performance

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Railway Engineering Science 2022年第3期30卷 323-359页

作者： Antonio gomes Correia ana Ramos department of Civil Engineering ISISEUniversity of MinhoGuimara˜esPortugal

The type of subgrade of a railroad foundation is vital to the overall performance of the track *** the train speed and tonnage increase,as well as environmental changes,the evaluation and influence of subgrade are even more paramount in the railroad track structure performance.A geomechanics classification for subgrade is proposed coupling the stiffness(resilient modulus)and permanent deformation behaviour evaluated by means of repeated triaxial loading *** classification covers from fine-to coarse-grained soils,grouped by UIC and *** this achievement,we first summarize the main models for estimating resilient modulus and permanent deformation,including the evaluation of their robustness and their sensitivity to mechanical and environmental *** is followed by the procedure required to arrive at the geomechanical classification and rating,as well as a discussion of the influence of environmental *** work is the first attempt to obtain a new geomechanical classification that can be a useful tool in the evaluation and modelling of the foundation of railway structures.

关键词： Subgrade Resilient modulus Permanent deformation Geomechanical classification

Targeting the premetastatic niche:epigenetic therapies in the spotlight

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1871-1872页

作者： Vivien Low John Blenis ana P.gomes Meyer Cancer Center Weill Cornell MedicineNew YorkNYUSA department of Pharmacology Weill Cornell MedicineNew YorkNYUSA

The treatment of metastatic cancers remains a challenge in the clinic,with recurrences persisting at high rates even after surgical resection of primary *** the perseverance of circulating tumor cells after resection,this phenomenon is abetted by the formation of the premetastatic niche(PMN),a distant environment ripe for the colonization of new metastases,which is conditioned by factors and extracellular vesicles secreted by the primary *** their recent paper,Lu et *** how such PMNs in the lung can be disrupted by low-dose adjuvant epigenetic therapy,and propose a novel therapeutic avenue to supplement tumor resection.

关键词： metastatic epigenetic al

Novel avocado oil-functionalized yogurt with anti-obesity potential:Technological and nutraceutical perspectives

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Food Bioscience 2022年第6期50卷 161-170页

作者： Manuela Machado Sérgio sousa Pilar Morais Arménio Miranda Luís M.Rodriguez-Alcalá ana Maria gomes Manuela Pintado Universidade Católica Portuguesa CBQF Centro de Biotecnologia e Química Fina-Laboratório AssociadoEscola Superior de BiotecnologiaRua Diogo Botelho 13274169-005PortoPortugal Frulact S.ARua do Outeiro589Gemunde4475-150MaiaPortugal

Studies on bioactive lipids have been increasing in the last years due to their proven health *** purpose of this research work was to develop a yogurt with bioactive lipids with anti-obesity *** this purpose,yogurts were produced with avocado oil in free form or encapsulated as a *** presence of avocado oil enhanced the nutritional quality of yogurts through a reduction(more than 75%)of their atherogenic and thrombogenic *** high nutritional value was particularly evident in samples with bigel,as these yogurts presented eight-fold higher levels of total fatty acids than the yogurts with avocado oil in free *** addition,yogurts with avocado bigel presented better stability throughout the gastrointestinal tract-results showed a higher recovery percentage of oleic acid(47.2%)when compared to 24%in the yogurts with avocado in free *** results from the in vitro studies demonstrated that these functional yogurts can increase the lipolytic rate in adipocytes,translated by an increase of ca.20%in glycerol release in yogurts with ***,the hepatic lipid accumulation in cells subjected to steatosis induced by chloroquine was reduced by 35%in cells treated with yogurt digested *** results showed the potential of these functional yogurts to modulate obesity-related metabolism.

关键词： Lipid metabolism Obesity Dairy products Functional foods

Doxycycline induces bone repair and changes in Wnt signalling

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International Journal of Oral Science 2017年第3期9卷 158-166页

作者： kátia do nascimento gomes ana paula negreiros nunes alves paula góes pinheiro dutra glauce socorro de barros viana faculty of dentistry pharmacy and nursingfederal university of cearáFortalezaBrazil faculty of medicine federal university of cearáFortaleza Brazil

Doxycycline （DOX） exhibits anti-inflammatory and MMP inhibitory properties. The objectives of this study were to evaluate the effects of DOX on alveolar bone repair. Controls （CTL） and DOX-treated （10 and 25 mg. kg- 1） molars were extracted, and rats were killed 7 or 14 days later. The maxillae were processed and subjected to histological and immunohistochemical assays. Hematoxylin-eosin staining （7th day） revealed inflammation in the CTL group that was partly reversed after DOX treatment. On the 14th day, the CTL group exhibited bone neoformation, conjunctive tissue, re-epithelization and the absence of inflammatory infiltrate. DOX-treated groups exhibited complete re-epithelization, tissue remodelling and almost no inflammation. Picrosirius red staining in the DOXlO group （7th and 14th days） revealed an increased percentage of type I and III collagen fibres compared with the CTL and DOX25 groups. The DOXlO and DOX25 groups exhibited increases in osteoblasts on the 7th and 14th days. However, there were fewer osteoclasts in the DOXlO and DOX25 groups on the 7th and 14th days. Wnt-lOb- immunopositive cells increased by 130% and 150% on the 7th and 14th days, respectively, in DOX-treated groups compared with the CTL group. On the 7th day, Dickkopf （Dkk）-I immunostaining was decreased by 63% and 46% in the DOXlO and DOX25 groups, respectively. On the 14th day, 69% and 42% decreases in immunopositive cells were observed in the DOXlO and DOX25 groups, respectively, compared with the CTL group. By increasing osteoblasts, decreasing osteoclasts, activating Wnt lOb and neutralising Dkk, DOX is a potential candidate for bone repair in periodontal diseases.

关键词： alveolar bone loss bone diseases bone repair doxycycline Dickkopf-1 immunohistochemistry Wnt-lOb

Influence of train speed and its mitigation measures in the short-and long-term performance of a ballastless transition zone

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Railway Engineering Science 2023年第4期31卷 309-324页

作者： ana Ramos Rui Calçada António gomes Correia department of Civil Engineering Faculty of EngineeringUniversity of PortoCONSTRUCT-LESEPortoPortugal department of Civil Engineering University of MinhoISISEGuimarãesPortugal

The ballastless track is nowadays the most popular railway system due to the required low number of maintenance opera-tions and costs,despite the high *** gradual change from ballasted to ballastless tracks has been occurring in Asia,but also in Europe,increasing the number of transition *** transition zones are a special area of the railway networks where there is an accelerated process of track degradation,which is a major concern of the railway infrastructure ***,the accurate prediction of the short-and long-term performance of ballastless tracks in transition zones is an important topic in the current paradigm of building/rehabilitating high-speed *** work purposes the development of an advanced 3D model to study the global performance of a ballastless track in an embankment-tunnel transition zone considering the influence of the train speed(220,360,500,and 600 km/h).Moreover,a mitigation measure is also adopted to reduce the stress and displacements levels of the track in the transition.A resilient mat placed in the tunnel and embank-ment aims to soften the *** behaviour of the track with the resilient mat is evaluated considering the influence of the train speed,with special attention regarding the critical *** used methodology is a novel and hybrid approach that allows including short-term and long-term performance,through the development of a powerful 3D model combined with the implementation of a calibrated empirical permanent deformation model.

关键词： Ballastless track Train speed Numerical modelling Transition zone Critical speed

Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance

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Chinese Journal of Cancer 2013年第7期32卷 365-370页

作者： ana R.gomes Fung Zhao Eric W.F.Lam department of Surgery and Cancer Imperial College LondonHammersmith Hospital Campus

The FOXO3a and FOXM1 forkhead transcription factors are key players in cancer initiation,progression,and drug *** research shows that FOXM1 is a direct transcriptional target of FOXO3a,a vital downstream effector of the PI3K-AKT-FOXO signaling *** addition,FOXM1 and FOXO3a also antagonize each other's activity by competitively binding to the same target genes,which are involved in chemotherapeutic drug sensitivity and *** the role and regulation of the FOXO-FOXM1 axis will provide insight into chemotherapeutic drug action and resistance in patients,and help to identify novel therapeutic approaches as well as diagnostic and predictive biomarkers.

关键词：转录因子耐药性叉头致癌性化疗药物生物标志物竞争力敏感性

A review on the scale-up of high-shear wet granulation processes and the impact of process parameters

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Particuology 2024年第9期92卷 180-195页

作者： ana Rita Alves Marta Filipe Simões Sérgio Simões João gomes University of Coimbra CERESDepartment of Chemical EngineeringFaculty of Sciences and TechnologyRua Sílvio Lima3030-790CoimbraPortugal Bluepharma-Indústria Farmacêutica São Martinho do BispoCoimbra3045-016Portugal Faculty of Pharmacy University of CoimbraAzinhaga de Santa Comba3000-548CoimbraPortugal

Wet granulation is one of the most important agglomeration processes,and high-shear granulation(HSG)one of the most employed technologies in the pharmaceutical *** most critical process parameters of HSG are discussed in this *** main concern in scaling up the wet granulation process is the differences between scales,which prevent the particles from having the same experience across all *** scale-up of wet granulation processes is commonly divided into two categories:engineering and attribute-based *** engineering-based scale-up approach is a strategy based on dimensional analysis and an attribute-based supported on the principles of“equifinality”,where process variables are adjusted to obtain equivalent granule *** work presents the effect of different HSG process parameters on the scale-up,as well as the use of process analytical tools(PAT)and modelling *** aim is to review applied scale-up approaches in HSG and discuss benefits and *** is proven why the scale-up for oral solid pharmaceutical products is still considered a hot topic and a very challenging task for development and engineering teams.

关键词： High-shear wetgranulation Parametric-based Attribute-based Physics-based modelling Impeller design Scale-up

Risk assessment of CO_2 injection processes and storage in carboniferous formations:a review

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Journal of Rock Mechanics and Geotechnical Engineering 2011年第1期3卷 39-56页

作者： sousa Luis sousa Rita gomes ana Vargas Jr.Eurípedes State Key Laboratory for Geomechanics and deep Underground Engineering China University of Mining and Technology University of Porto Massachusetts Institute of Technology Catholic University of Rio de Janeiro

Over the last decades,people from almost all over the world have realized that it is necessary to quickly develop strategies for the control and reduction of greenhouse gases (GHG) *** various GHGs,carbon dioxide (CO2) is the most abundant *** underground storage involves less risk and lower levels of *** paper briefly describes the most effective technologies available in the market for background processes to storage (capture and transport) CO2,as well as the more secure solutions for its storage,in particular for the geological storage in carboniferous *** paper also outlines the methodologies for the risk assessment involved in storage of CO2,with a particular focus on cases where the injection is made into unminable coal seams and in abandoned *** used for risk analysis are described in detail with particular emphasis on Bayesian network (BN).Some applications regarding the risk assessment of CO2 injection processes and CO2 storage in carboniferous formations and contamination of aquifers are presented and ***,based on the applications of BN,several conclusions are drawn.

关键词： risk assessment underground storage of CO2 coalmines monitoring

Assessment of Cancer-Related Fatigue Expression:Comparing the Expression of Fatigue in Patients with a History of Cancer,Patients with Other Chronic Diseases,and Healthy Individuals

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Psycho-Oncologie 2024年第1期18卷 49-57页

作者： Maria Inês Clara Maria Cristina Canavarro ana Severina Susana Ramos Carla Rafael ana Allen gomes Chronopsychology and Cognitive Systems Lab(ChronCog) University of CoimbraCoimbra3000-115Portugal Center for Research in Neuropsychology and Cognitive and Behavioral Intervention(CINEICC) University of CoimbraCoimbra3000-115Portugal Faculty of Psychology and Educational Sciences University of CoimbraCoimbra3000-115Portugal Oncology department Centro Hospitalar do Médio Tejo(CHMT)Torres Novas2350-754Portugal

Aims:We aimed to compare cancer survivors’fatigue expression with that of the general population and examine psychobiological factors associated with ***:In this quantitative,transversal study,we analyzed clinical and sociodemographic indicators of 389 participants(68.38%females):148 cancer survivors on active treatment,55 disease-free survivors,75 patients with another chronic disease,and 111 healthy ***:Fatigue was expressed dissimilarly in patients with a previous history of cancer and participants without a history of *** on active treatment reported significantly higher levels of fatigue than the other clinical status ***,some level of cancer-related fatigue persisted,in a similar pattern,after active treatment into the survivorship ***-free survivors showed significantly lower vigor levels when compared to patients with other chronic *** distress and daytime sleepiness emerged as transdiagnostic factors associated with ***:Cancer-related fatigue may have a unique pattern,characterized by reduced endurance and muscle *** the present study,psychological distress and daytime sleepiness are associated with cancer-related *** findings suggest the pertinence of future studies examining whether interventions targeting those factors may help manage this burdensome complaint.

关键词： Fatigue cancer patients cancer burden psychological distress cancer survivors neoplasms