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Field evaluation of COVID-19 rapid antigen test:Are rapid antigen tests less reliable among the elderly?

World Journal of Clinical Cases 2022年第19期10卷 6456-6463页

作者： Irena Tabain Djivo Cucevic Nikola Skreb Anna Mrzljak Ivana Ferencak Zeljka Hruskar Anita Misic Josipa Kuzle ana marija skoda Hrvojka Jankovic Tatjana Vilibic-Cavlek Department of Virology Croatian Institute of Public HealthZagreb 10000Croatia Department of Emergency Medicine Institute of Emergency Medicine of the City of ZagrebZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Department of Gastroenterology and Hepatology University Clinical Hospital ZagrebZagreb 10000Croatia

BACKGROUND The global outbreak of coronavirus disease 2019(COVID-19)leads to the development of accessible and cost-effective rapid antigen-detection tests(RATs),as quick and accurate diagnosis is crucial to curb the *** To evaluate the Humasis COVID-19 Ag Test(Humasis Co.,Ltd.,Gyeonggi-do,Republic of Korea)in the diagnosis of severe acute respiratory syndrome coronavirus-2(SARS-CoV-2).METHODS This retrospective study was carried out at the Croatian Institute of Public Health and included patients with clinical symptoms of COVID-19 lasting no longer than 5 d prior to testing,whose nasopharyngeal swabs were primarily tested with *** RAT samples underwent confirmatory real-time reverse transcription-polymerase chain reaction(RT-PCR).Diagnostic efficacy was determined compared to *** patients were divided into three age groups(65 years).Statistical analysis was performed with the significance level set at P<*** total,2490 symptomatic patients were tested;953 samples were positive on RAT,and 1537 *** negative RAT samples were subjected to RT-PCR;266 samples were positive andmarked as false-negative results on *** calculated negative predictive value as a measure ofRAT efficacy was 82.69%.The χ^(2) test and Kruskal-Wallis test showed a significant difference in theproportion of false negatives(P<0.001)and RT-PCR cycle(Ct)values for false-negative RATs(P=0.012)among the age *** young age group was significantly less likely to be falsenegative,whereas the false negatives from the elderly group experienced significantly lower Ctvalues than the other two age *** RAT demonstrated satisfactory performance with more reliable results in *** COVID-19 Ag RAT is potentially a valuable tool in areas where access tomolecular methods is limited;however,RT-PCR remains a gold standard for SARS-CoV-2detection.

关键词： Coronavirus disease 2019 Severe acute respiratory syndrome coronavirus-2 Rapid antigen test Real-time reverse transcription-polymerase chain reaction Croatia

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