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Engineering 2024年第1期32卷 57-68页

作者： Vedrana Vicic Bockor Nika Foglar Goran Josipovic Marija Klasic ana Vujic Branimir Plavsa Toma Keser Samira Smajlovic Aleksandar Vojta Vlatka Zoldos Laboratory for Epigenetics Department of BiologyFaculty of ScienceUniversity of ZagrebZagreb 10000Croatia Genos Glycoscience Research Laboratory Zagreb 10000Croatia Faculty of Pharmacy and Biochemistry University of ZagrebZagreb 10000Croatia

Hepatocyte nuclear factor 1 alpha(HNF1A),hepatocyte nuclear factor 4 alpha(HNF4A),and forkhead box protein A2(FOXA2)are key transcription factors that regulate a complex gene network in the liver,cre-ating a regulatory transcriptional *** Encode and ChIP-Atlas databases identify the recognition sites of these transcription factors in many glycosyltransferase *** in silico analysis of HNF1A,*** FOXA2 binding to the ten candidate glyco-genes studied in this work confirms a significant enrich-ment of these transcription factors specifically in the *** previous studies identified HNF1A as a master regulator of fucosylation,glycan branching,and galactosylation of plasma ***,we aimed to functionally validate the role of the three transcription factors on downstream glyco-gene transcriptional expression and the possible effect on glycan *** used the state-of-the-art clus-tered regularly interspaced short palindromic repeats/dead Cas9(CRISPR/dCas9)molecular tool for the downregulation of the HNF1A,HNF4A,and FOXA2 genes in HepG2 cells-a human liver cancer cell *** results show that the downregulation of all three genes individually and in pairs affects the transcrip-tional activity of many glyco-genes,although downregulation of glyco-genes was not always followed by an unambiguous change in the corresponding glycan *** effect is better seen as an overall change in the total HepG2 N-glycome,primarily due to the extension of biantennary *** propose an alternative way to evaluate the N-glycome composition via estimating the overall complexity of the glycome by quantifying the number of monomers in each glycan *** also propose a model showing feedback loops with the mutual activation of HNF1A-FOXA2 and HNF4A-FOXA2 affecting glyco-genes and protein glycosylation in HepG2 cells.

关键词： Clustered regularly interspaced short palindromic repeats/dead Cas9(CRISPR/dCas9) Epigenetics Hepatocyte nuclear factor 1 alpha(HNF1A) Hepatocyte nuclear factor 4 alpha(HNF4A) Forkhead box protein A2(FOXA2) N-glycosylation HepG2 cells

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Households' Risk Perception and Behavioral Responses to Natech Accidents

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International Journal of Disaster Risk Science 2017年第1期8卷 1-15页

作者： Junlei Yu ana maria Cruz Akihiko Hokugo School of Humanities and Social Science Nanyang Technological University Disaster Prevention Research Institute Kyoto University Research Center for Urban Safety and Security Kobe University

This study analyzes data on households' risk perception and protective behavior following a natural disaster triggered technological accident(Natech accident)that occurred at an industrial park in Sendai during the Great East Japan Earthquake and Tsunami, on 11 March2011. The results indicate that some households carried out multiple evacuations and that households' risk perceptions changed throughout the Natech accident evacuation process. Risk perception differed according to household location and demographic characteristics. We also found differences in the protective measures adopted for households in different locations. Specifically, those living closer to the Natech accident tended to evacuate immediately,whereas those living further away tended to shelter in place. Wind direction is discussed as a factor that influences households' risk perception and evacuation response to a Natech accident. The findings of this study advance knowledge of household behavior in response to a Natech accident and can assist emergency managers in developing strategies for better management of evacuation processes.

关键词： Evacuation behavior Great East Japan Earthquake and Tsunami Natech accidents Protective actions Risk perception

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Vulnerability Factors of Afghan Rural Women to Disasters

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International Journal of Disaster Risk Science 2019年第4期10卷 573-590页

作者： Marina Hamidazada ana maria Cruz Muneta Yokomatsu Disaster Prevention Research Institute (DPRI) Kyoto UniversityKyoto 611-0011 Japan

Disaster management is a global challenge, but disasters do not affect men and women equally. In most of the world’s disasters, more females are impacted than males, and in Afghanistan the disparity between female and male victims is even greater. This study identifies and maps the relationships between the factors that make Afghan rural women more vulnerable to natural hazard-induced disasters. Data for this study were obtained through focus group discussions with rural women and men, as well as person-to-person interviews with employees of government and nongovernmental organizations at the national and local levels in Afghanistan. The study uses Grounded Theory and Interpretive Structural Modeling, not widely used before for this type of study, to analyze the data collected and to map the factors of vulnerability identified and their relationships. In agreement with previous studies,our findings show that insufficient disaster education,inadequate protection measures, and powerful cultural issues, both pre-and post-disaster, increase women’s vulnerability during and after disasters. In particular, cultural issues play a role after disasters by affecting women’s security, access to disaster aid, and health care. The study also found that perception regarding these cultural issues and how they affect women during disasters differs among men and women. Finally, by using Interpretive Structural Modeling, we show how the importance of the factors and their interrelationships change in predisaster and post-disaster situations. We conclude the article with some policy recommendations such as finding ways to allow women to participate in disaster planning activities and decision-making processes related to disaster risk reduction, as well as securing dedicated funds for the mainstreaming of gender in disaster risk reduction policies in Afghanistan.

关键词： Afghanistan Disaster vulnerability Gender roles Grounded Theory Rural area Women’s vulnerability

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A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities

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Military Medical Research 2024年第2期11卷 228-267页

作者： Miguel A.Ortega Oscar Fraile-Martinez Cielo García-Montero Sergio Haro Miguel Ángel Álvarez-Mon Diego De Leon-Oliva ana M.Gomez-Lahoz Jorge Monserrat Mar Atienza-Pérez David Díaz Elisa Lopez-Dolado Melchor Álvarez-Mon Department of Medicine and Medical Specialities University of Alcala28801 Alcala de HenaresSpain Ramón y Cajal Institute of Sanitary Research(IRYCIS) 28034 MadridSpain Department of Psychiatry and Mental Health Hospital Universitario Infanta Leonor28031 MadridSpain Service of Rehabilitation National Hospital for Paraplegic PatientsCarr.de la PeraledaS/N45004 ToledoSpain Immune System Diseases‑Rheumatology Service and Internal Medicine University Hospital Príncipe de Asturias(CIBEREHD)28806 Alcala de HenaresSpain

Spinal cord injury(SCI)is a devastating and disabling medical condition generally caused by a traumatic event(primary injury).This initial trauma is accompanied by a set of biological mechanisms directed to ameliorate neural damage but also exacerbate initial damage(secondary injury).The alterations that occur in the spinal cord have not only local but also systemic consequences and virtually all organs and tissues of the body incur important changes after SCI,explaining the progression and detrimental consequences related to this ***(PNIE)is a growing area of research aiming to integrate and explore the interactions among the different systems that compose the human organism,considering the mind and the body as a *** initial traumatic event and the consequent neurological disruption trigger immune,endocrine,and multisystem dysfunction,which in turn affect the patient's psyche and *** the present review,we will explore the most important local and systemic consequences of SCI from a PNIE perspective,defining the changes occurring in each system and how all these mechanisms are ***,potential clinical approaches derived from this knowledge will also be collectively presented with the aim to develop integrative therapies to maximize the clinical management of these patients.

关键词： Spinal cord injury(SCI) Psychoneuroimmunoendocrinology(PNIE) Secondary injury Immunoinflammatory dysfunction Gut microbiota Translational opportunities

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Appetite for Natech Risk Information in Japan:Understanding Citizens'Communicative Behavior Towards Risk Information Disclosure Around Osaka Bay

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International Journal of Disaster Risk Science 2022年第3期13卷 372-390页

作者： Dimitrios Tzioutzios Jeong-Nam Kim ana maria Cruz Department of Urban Management Graduate School of EngineeringKyoto UniversityKyoto615-8540Japan Gaylord College of Journalism and Mass Communication University of OklahomaNormanOK73019USA Disaster Prevention Research Institute Kyoto UniversityKyoto611-0011Japan

Effective risk communication is essential for disaster risk *** from empowering communities to make informed risk choices,risk information disclosure can also drastically enhance their disaster preparedness,especially concerning conjoint scenarios of technological and natural hazards(Natech).A fundamental precondition is the actual demand for such *** study ventures to assess whether residents around Osaka Bay have this demand,or"appetite,"for risk information disclosure,as well as to understand their communicative behavior and perceived challenges in the Japanese context through the prism of the Situational Theory of Problem *** test this framework under realistic conditions,data were collected through a household questionnaire survey from two urban areas near industrial complexes in Osaka *** results show that identifying Natech risk information deficiency as a problem was not a statistically significant predictor for individuals'motivation to ***,their motivation increased as their perceived personal involvement with the situation rose,while the perceived obstacles in doing something about it exerted a negative influence on their ***'motivation intensified their communicative actions to solve this *** segmentation underscored the elevated public perceptions concerning the issue of risk information deficiency in nearly nine out of ten *** findings indicate a strong community appetite for chemical and Natech risk information,which subsequently led to high situational motivation to engage in communicative action,particularly information *** management policy is suggested to focus on introducing chemical risk information disclosure regulatory initiatives to encourage citizen engagement.

关键词： Japan Natech risk information Participatory risk management Risk communication Situational Theory of Problem Solving(STOPS)

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