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Presacral venous bleeding during mobilization in rectal cancer

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World Journal of Gastroenterology 2017年第9期23卷 1712-1719页

作者： Jose Enrique Casal Núnez Vincenzo Vigorita Alejandro Ruano Poblador ana mar.a Gay Fernández mar.a ángeles Toscano Novella Nieves Cáceres Alvarado Lucinda Pérez Dominguez Coloproctology Unit and General and Digestive Surgery Unit Vigo University Hospital Complex36212 VigoSpain

To analyze the anatomy of sacral venous plexus flow, the causes of injuries and the methods for controlling presacral hemorrhage during surgery for rectal *** review of the databases MEDLINE® and Embase™ was conducted, and relevant scientific articles published between January 1960 and June 2016 were examined. The anatomy of the sacrum and its venous plexus, as well as the factors that influence bleeding, the causes of this complication, and its surgical management were *** is a review of 58 published articles on presacral venous plexus injury during the mobilization of the rectum and on techniques used to treat presacral venous bleeding. Due to the lack of cases published in the literature, there is no consensus on which is the best technique to use if there is presacral bleeding during mobilization in surgery for rectal cancer. This review may provide a tool to help surgeons make decisions regarding how to resolve this serious *** series of alternative treatments are described; however, a conventional systematic review in which optimal treatment is identified could not be performed because few cases were analyzed in most publications.

关键词： Presacral hemorrhaging Rectal surgery Sacral venous plexus Pelvic surgery Sacral anatomy

A rare pigmented keratitis caused by Aspergillus fumigatus

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 208-210页

作者： Mauricio Vélez Kepa Balparda ana mar.a Díaz Universidad Pontificia Bolivariana

Dear Sir,I am Mauricio Vélez,from the Department of Ophthalmology,Cornea Service Director,Universidad Pontificia Bolivariana in Medellín,***,I would like to share an interesting case I managed recently,which I’ve entitled"A rare pigmented keratitis caused by Aspergillus fumigatus".Fungi are a relatively uncommon cause of microbial keratitis

关键词： A rare pigmented keratitis caused by Aspergillus fumigatus

Long-term open circuit microbial electrosynthesis system promotes methanogenesis

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Journal of Energy Chemistry 2020年第2期29卷 3-6页

作者： Raúl Mateos Adrián Escapa mar.a Isabel San-mar.ín Heleen De Wever ana Sotres Deepak Pant Chemical and Environmental Bioprocess Engineering Group Natural Resources Institute(IRENA)University of LeonLeon 24071Spain Department of Electrical Engineering and Automatic Systems Universidad de LeonLeon 24071Spain Reparation and Conversion Technology Flemish Institute for Technological Research(VITO)Mol 2400Belgium

Microbial electrosynthesis(MES) can potentially provide a mean for storing renewable energy surpluses as chemical energy. However, the fluctuating nature of these energy sources may represent a threat to MES, as the microbial communities that develop on the biocathode rely on the continuous existence of a polarized electrode. This work assesses how MES performance, product generation and microbial community evolution are affected by a long-period(6 weeks) power off(open circuit). Acetogenic and H2-producing bacteria activity recovered after reconnection. However, few days later syntrophic acetate oxidation bacteria and H2-consuming methanogens became dominant, producing CH4 as the main product, via electromethanogenesis and the syntrophic interaction between eubacterial and archaeal communities which consume both the acetic acid and the hydrogen present in the cathode environment. Thus,the system proved to be resilient to a long-term power interruption in terms of electroactivity. At the same time, these results demonstrated that the system could be extensively affected in both end product generation and microbial communities.

关键词： Biocathode Electromethanogenesis Microbial electrosynthesis Microbial community dynamics Methanogens Acetogens

Bioguided isolation of antimicrobial polyphenols from Cuspidaria convoluta leaves and their synergistic effect with antibiotics

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Asian Pacific Journal of Tropical Biomedicine 2019年第10期9卷 434-442页

作者： Carola A.Torres mar.o A.Sturla ana M.Romero mar.a A.Judis Department of Basic and Applied Sciences Microbiology LaboratoryUniversidad Nacional del Chaco AustralComandante Fernández 755Presidencia Roque Sáenz PenaChacoArgentina Consejo Nacional de Investigaciones Científicas y Técnicas Buenos AiresArgentina Department of Basic and Applied Sciences Laboratory of Organic ChemistryUniversidad Nacional del Chaco AustralArgentina Department of Basic and Applied Sciences Food Industry LaboratoryUniversidad Nacional del Chaco AustralArgentina

Objective:To identify and isolate phenolic compounds from Cuspidaria convoluta,and to evaluate their antibacterial activity and synergistic effect with ***:The crude extract was prepared by maceration with methanol(5%).The dry extract was suspended in water and fractionated *** most active extract was selected by its antibacterial activity and its total phenol content was determined by spectrophotometry and by HPLC-MS/*** fractions of the most active extract were separated by column chromatography and evaluated by *** compounds were *** inhibitory concentration(MIC)of these compounds was determined by microdilution broth method,and synergism with antibiotics(ampicillin,gentamicin and oxacillin)was tested by checkerboard and time-kill ***:Coumar.c acid,catechin/epicatechin,and luteolin were purified and identified from the *** was an increase in the antibacterial activity of antibiotics when they were combined with these *** combination of luteolin and ampicillin had the most potent antibacterial *** MICs of oxacillin for each of methicillin-resistant Staphylococcus aureus strains were reduced between 4 and 8-fold when these strains were coincubated with sub-MIC(≤?MIC)levels of these compounds,demonstrating that the combination had synergistic effect for all ***:Cuspidaria convoluta contains important pharmacologically active substances that can be used to improve antibiotic efficacy.

关键词： Luteolin Ampicillin MIC reduction Antimicrobial agents

Abnormal Linguistic Lateralization and Sensory Processing in High Functioning Children with Autism Spectrum Conditions

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Journal of Behavioral and Brain Science 2014年第9期4卷 432-442页

作者： Sonia mar.ínez-Sanchis mar.a Consuelo Bernal ana Costa mar.en Gadea Department of Psychobiology University of Valencia Valencia Spain Neurodevelopmental Disorders Research Unit University of Valencia Valencia Spain Department of Social Psychology University of Valencia Valencia Spain IDOCAL University of Valencia Valencia Spain Pediatric Neurorehabilitation Unit Hospital of Manises Valencia Spain

Brain lateralization for language in high-functioning children with autism spectrum conditions (ASC) and sensory processing were explored as a part of a neuropsychological profile. A dichotic listening test and the Luria laterality subtest were administered to all participants (including controls) and the sensory profile test only to the ASC group. The usual right ear advantage was not exhibited by children with ASC and anomalies in auditory filtering were found. The sensory profile of 60% of the sample was characterized by hypersensitivity to auditory stimuli, hyposensitivity to vestibular information, high emotional reactions to sensory experiences, poor psychosocial coping strategies, high distractibility and inability to interpret body and facial language. Hyper-responsiveness to environmental auditory stimuli was significantly associated with impaired attention. Similarly, non-adaptive responses to sensory quotidian experiences were strongly connected to poor coping strategies. Our results, although preliminary, contribute to emphasizing the importance of including additional assessment methods such as the dichotic listening and the sensory profile questionnaire in the evaluation of cognitive profile in high-functioning children with ASC to plan an individualized psycho-educative intervention.

关键词： Children High-Functioning Autism Linguistic Lateralization Neuropsychology Sensory Profile

Does light-intensity physical activity moderate the relationship between sitting time and adiposity mar.ers in adolescents?

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Journal of Sport and Health Science 2022年第5期11卷 613-619页

作者： ana mar.a Contardo Ayala Jo Salmon David W.Dunstan Lauren Arundell Anna Timperio Institute for Physical Activity and Nutrition(IPAN) School of Exercise and Nutrition SciencesDeakin UniversityGeelongVIA 3125Australia Physical Activity Laboratory Baker Heart and Diabetes InstituteMelbourneVIA 3004Australia mar. MacKillop Institute for Health Research Australian Catholic UniversityMelbourneVIA 3000Australia

Background:While the relationship between sedentary time and adiposity mar.ers may be independent of moderate-to-vigorous intensity physical activity(MVPA) among adolescents,little is known about the role of light-intensity physical activity(LIPA) in this *** aim of this cross-sectional study was to examine whether device-measured LIPA and MVPA moderate the associations between objectively measured sitting time and adiposity mar.ers(body mass index(BMI)) and waist circumference(WC)) among ***:This study included accelerometer and inclinometer data obtained from 219 adolescents(age=14.9±1.6 years,mean± SD),collected during 2014 and 2015 in Melbourne,*** GT3 X accelerometers were used to determine time spent in total-LIPA(101 counts/min to 3.99 metabolic equivalents(METs)) was dichotomized into low-LIPA(101-799 counts/min) and high LIPA(800 counts/min to 3.99 METs),and MVPA(> 4 METs).The average time spent sitting was obtained from activPAL *** measures were assessed by trained *** between sitting and total-LIPA,low-LIPA,high-LIPA,and MVPA on BMI z-score(zBMI) and WC z-score(zWC),respectively,were examined using linear regression,adjusting for age and sex;and moderation by total-LIPA,low-LIPA,high-LIPA,and MVPA were examined by adding interaction *** interaction effects were probed by comparing associations at the mean and at 1 SD below and above the ***:Total-LIPA significantly moderated the association between sitting time and zBMI,and low-LIPA significantly moderated the association between sitting time and zBMI and *** other associations were found for total-LIPA,high-LIPA,or ***,at high levels of total-LIPA(+1 SD),there is a negative association between sitting time and *** addition,at high levels of low-LIPA(+1 SD),there is a negative association between sitting time and zBMI and ***:Associations between sitting and adiposit

关键词： Adolescents Anthropometric measures Obesity Physical activity Sedentary behavior Sitting time

Stroke care during the COVID-19 outbreak in Spain: the experience of Spanish stroke units

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Stroke & Vascular Neurology 2021年第2期6卷 267-273页

作者： mar.a Alonso de Lecinana mar.Castellanos Oscar Ayo-mar.in ana Morales the Stroke Group-Spanish Society of Neurology Department of Neurology and Stroke Center Hospital La Paz Institute for Health Research-IdiPAZ.La Paz University Hospital.Universidad Autonoma de MadridMadridSpain Department of Neurology Complexo Hospitalario Universitario A Coruna.Biomedical Research Institute of A CorunaA CorunaSpain Department of Neurology Complejo Hospitalario Universitario de AlbaceteAlbaceteSpain Department of Neurology University Clinic Hospital Virgen de la ArrixacaMurciaSpain 不详

Background and purpose Spain has been heavily affected by *** of resources for managing the outbreak might have caused a disruption in stroke *** study analyses the impact on stroke care of reorganising the healthcare system in response to the first COVID-19 outbreak peak in Spain and the strategies adopted by Spanish stroke units to deal with this *** and methods We obtained data from a structured survey sent to the responsible of stroke units across the *** recorded the number of strokes,stroke code activations,intravenous thrombolysis treatments and mechanical thrombectomies during February and mar.h 2019 and *** also collected information on the impact on workflow metrics and on the availability of specialised neurological care and rehabilitation treatments,the characteristics of stroke care for patients with SARS-CoV-2 infection and the impact on human *** compared the activity data between 2019 and 2020 and the information on activity and impact on stroke care between regions classified according to the disease incidence *** Fifty-seven(75%)of all stroke units in Spain responded to the *** was an overall reduction in admissions for all stroke types during the outbreak’s peak and in the number of stroke code activations and intravenous thrombolysis treatments,results that were independent of the COVID-19 incidence *** reported a delay in workflow metrics and a reduction of admissions to stroke units,outpatient clinics and rehabilitation *** pathways and protocols for managing stroke patients with SARS-CoV-2 infection have been *** The COVID-19 outbreak has jeopardised all phases of stroke *** a consequence,some patients with stroke did not receive adequate treatment.

关键词： Spanish consequence outbreak

Hepatotoxicity induced by acute and chronic paracetamol overdose in children: Where do we stand?

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World Journal of Pediatrics 2017年第1期13卷 76-83页

作者： Hoi Yan Tong Nicolás Medrano Alberto Manuel Borobia JoséAntonio Ruiz ana mar.a mar.ínez Julia mar.ín Manuel Quintana Santos Garcfa Antonio Jos6 Carcas Elena Ramirez Department of Clinical Pharmacology Hospital Universitario La PazIdiPAZSchool of MedicineUniversidad Autónoma de MadridMadridSpain Pediatric Emergency Department Hospital Universitario La PazIdiPAZMadridSpain General Emergency Department Hospital Universitario La PazIdiPAZMadridSpain

Background:There are few data Oll hepatotoxicity induced by acute or chronic paracetamol poisoning in the pediatric *** poisoning data can reveal the weakn嗍ofparacetamol poisoning management ***:We retrospectively studied the patients of less than 18 years old with measurable paracetamol levels,who were brought to the emergency department(ED)of La Paz University Hospital,Madrid,Spain,for suspected paracetamol overdoses between 2005 and 2010.

关键词： acute liver failure hepatotoxicity paracetamol poisoning

Caerulin-induced pancreatitis in rats: Histological and genetic expression changes from acute phase to recuperation

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World Journal of Gastroenterology 2006年第25期12卷 3999-4003页

作者： Javier Magaa-Gómez Guillermo López-Cervantes ana mar.a Calderón de la Barca Departamento de Nutrición Centro de Investigación en Alimentación y Desarrollo A.C. HermosilloSonoraMéxicoDepartamento de Patología Hospital Infantil del Estado de SonoraHermosilloSonoraMéxicoDepartamento de Nutrición Centro de Investigación en Alimentación y DesarrolloA.C.HermosilloSonoraMéxico

AIM： To study the histological and pancreatitis-associated protein mRNA accumulation changes of pancreas from acute phase of caerulin-induced pancreatitis to recuperation in rats. METHODS： Acute pancreatitis was induced by caerulein in male Wistar rats and followed up for 90 d by histological and mRNA analyses of pancreas. Pancreases were dissected at 0, 9, 24 h and 3, 5, 15, 30, 60, 90 d post-induction. Edema （E）, polymorphonuclear neutrophU （pIVlN） infiltration, cytoplasmic vacuolization （V）, zymogen granule depletion （ZD） and acinar disorganization （AD） were microscopically evaluated. Accumulation of pancreatitis- associated protein （PAP） and L13A mRNAs were quantified by real-time PCR. RESULTS： The main histological changes appeared at 9 h post-induction for PMN infiltration and cytoplasmic V, while at 24 h and 3 d for E and ZD, respectively. All the parameters were recovered after 5 d, except for ZD which delayed more than 30 d. The main AD was observed after 15 d and values returned to normal after 30 d. Similarly to histological changes, accumulation of the PAP mRNA was increased at 9 h with the highest accumulation at 24 h and differences disappeared after 5 d. CONCLUSION： From the acute phase to recuperation of pancreatitis, regeneration and re-differentiation of pan- creas occur and PAP expression is exclusively an acute response of pancreatitis.

关键词： Acute pancreatitis Histological changes PAP mRNA L13A mRNA