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Cytokine release syndrome induced by anti-programmed death-1 treatment in a psoriasis patient:A dark side of immune checkpoint inhibitors

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World Journal of Clinical Cases 2024年第35期12卷 6782-6790页

作者： Joséluis maldonado-garcía ana Fragozo lenin Pavón Departamento de Bioquímica Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoCoyoacán 04510Ciudad de MéxicoMexico Departamento de Inmunología Escuela Nacional de Ciencias BiológicasMexico City 1134Ciudad de MéxicoMexico Unidad de Desarrollo e Investigación en Bioterapéuticos Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico City 11340Ciudad de MéxicoMexico laboratorio de Psicoinmunología Instituto Nacional de Psiquiatría Ramón de la Fuente MuñizMexico City 11340Mexico

In recent years,cancer immunotherapy has introduced novel treatments,such as monoclonal antibodies,which have facilitated targeted therapies against tumor *** death-1(PD-1)is an immune checkpoint expressed in T cells that regulates the immune system’s activity to prevent over-activation and tissue damage caused by ***,PD-1 is also expressed in tumor cells and functions as an immune evasion mechanism,making it a therapeutic target to enhance the immune response and eliminate tumor ***,immune checkpoint inhibitors(ICIs)have emerged as an option for certain tumor ***,blocking immune checkpoints can lead to immune-related adverse events(irAEs),such as psoriasis and cytokine release syndrome(CRS),as exemp-lified in the clinical case presented by Zhou et al involving a patient with adva-nced gastric cancer who received sintilimab,a monoclonal antibody targeting ***,the patient experienced exacerbation of psoriasis and *** objective of this editorial article is to elucidate potential immunologic mechanisms that may contribute to the development of CRS and psoriasis in patients receiving *** is crucial to acknowledge that while ICIs offer superior safety and efficacy compared to conventional therapies,they can also manifest irAEs affecting the skin,gastrointestinal tract,or respiratory *** severe cases,these irAEs can lead to life-threatening complications such as circulatory shock or multiorgan ***,it is recommended that patients receiving ICIs undergo regular monitoring to identify and manage these adverse events effectively.

关键词： Immune checkpoints inhibitors Programmed death-1 Cancer immunotherapy Psoriasis Cytokine release syndrome Immune-related adverse events

multiple radial phosphorus segregations in GaAsP core-shell nanowires

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Nano Research 2021年第1期14卷 157-164页

作者： H.Aruni Fonseka Yunyan Zhang James A.Gott Richard Beanland Huiyun liu ana m.Sanchez Department of Physics University of WarwickCoventry CV47ALUK Department of Electronic and Electrical Engineering University College LondonLondon WC1E 7JEUK

Highly faceted geometries such as nanowires are prone toform self-formed features,especially those that are driven by *** these features is important in preventing their formation,understanding their effects on nanowire properties,or engineering them for *** elemental segregation lines that run along the radii of the hexagonal cross-section have been a common observation in alloy semiconductor ***,in GaAsP nanowires,two additional P rich bands are formed on either side of the primary band,resulting in a total of three segregation bands in the vicinity of three of the alternating *** bands are less intense than the primary band and their formation can be attributed to the inclined nanofacets that form in the vicinity of the *** formation of the secondary bands requires a higher composition of P in the shell,and to be grown under conditions that increase the diffusivity difference between As and ***,it is observed that the primary band can split into two narrow and parallel *** can take place in all six radii,making the cross sections to have up to a maximum of 18 radial segregation *** controlled growth,these features could be exploited to assemble multiple different quantum structures in a new dimension(circumferential direction)within nanowires.

关键词： compound semiconductor alloys radial segregations three-fold symmetry surface chemical potential

Degradation of duloxetine: Identification of transformation products by UHPlC-ESI(+)-HRmS/mS,in silico toxicity and wastewater analysis

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Journal of Environmental Sciences 2019年第8期31卷 113-123页

作者： Rodrigo A.Osawa ana P.Carvalho Olinda C.monteiro m.Conceicao Oliveira m.Helena Florêncio Centro de Química e Bioquímica Faculdade de Ciências Universidade de Lisboa laboratório de FTICR e Espectrometria de massa Estrutural Faculdade de Ciências Universidade de Lisboa Centro de Química Estrutural Instituto Superior Técnico Universidade de Lisboa

Duloxetine(DUl), an antidepressant drug, has been detected in surface water and wastewater effluents, however, there is little information on the formation of its transformation products(TPs). In this work, hydrolysis, photodegradation(UV irradiation) and chlorination experiments were performed on spiked distillated water, under controlled experimental conditions to simulate abiotic processes that can occur in the environment and wastewater treatment plants(WWTPs). Eleven TPs, nine from reaction with UV light and two from chlorine contact, were formed and detected by ultra-high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry, and nine of them had their chemical structures elucidated upon analyses of their fragmentation patterns in mS/mS spectra. The formation and degradation of the TPs were observed. The parent compound was completely degraded after30 min in photodegradation and after 24 hr in chlorination. Almost all TPs were completely degraded in the experiments. The ecotoxicity and mutagenicity of the TPs were predicted based on several in silico models and it was found that a few of these products presented more ecotoxicity than DUl itself and six TPs showed positive mutagenicity. Finally, wastewater samples were analyzed and DUl and one TP, possibly formed by chlorination process, were detected in the effluent, which showed that WWTP not only did not remove DUl, but also formed a TP.

关键词： High resolution mass spectrometry Duloxetine Degradation processes Transformation products Wastewater analysis In silico toxicity

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modeling of biodiesel production: Performance comparison of Box–Behnken, face central composite and full factorial design

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Chinese Journal of Chemical Engineering 2019年第7期27卷 1690-1698页

作者： Vlada B.Veljkovic ana V. Velickovic Jelena m. Avramovic Olivera S. Stamenkovic University of Nis Faculty of TechnologyBulevar oslobodenja 124Leskovac 16000Serbia Research&Development Center "Alfatec" Bulevar Nikole Tesle 63/5Nis 18000Serbia

The performances of the response surface methodology(RSm)in connection with the Box–Behnken,face central composite or full factorial design(BBD,FCCD or FFD,respectively)were compared for the use in modeling of the NaOH-catalyzed sunflower oil *** influence of temperature,catalyst loading,and ethanol-to-oil molar ratio(EOmR)on fatty acid ethyl esters(FAEE)content was *** three multivariate strategies were efficient in the statistical modeling and optimization of the influential process variables but BBD and FCCD realization involved less number of experiments,generating smaller costs,requiring less work and consuming shorter time than the corresponding *** three designs resulted in the same optimal catalyst loading(1.25%of oil)and EOmR(12:1).The reduced two-factorinteraction(2 FI)models based on the BBD and FCCD defined a range of optimal reaction temperature(25℃–75℃)and 25℃,respectively while the same model based on the 33 FFD appointed 75℃.The predicted FAEE content of about 97%–98.0%was close to the experimentally obtained FAEE content of about 97.0%–97.6%under the optimal reaction ***,the simpler BBD or FCCD might successfully be applied for statistical modeling of biodiesel production processes instead of the more extensive,more laborious and more expensive FFD.

关键词： Biodiesel Box-Behnken design model reduction Face central composite design Full factorial design Optimization

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Neuroinflammatory modulators of oligodendrogenesis

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Neuroimmunology and Neuroinflammation 2015年第1期2卷 263-273页

作者： ana Armada-moreira Filipa F.Ribeiro ana m.Sebastião Sara Xapelli Instituto de Farmacologia e Neurociências Faculdade de Medicina da Universidade de Lisboa1649-028 LisboaPortugal Instituto de medicina molecular Faculdade de Medicina da Universidade de Lisboa1649-028 LisboaPortugal

Oligodendrocytes are key neural cells that are responsible for producing myelin sheaths that wrap around neuronal axons in the central nervous *** is essential to insulate neurons and maintain a fast and saltatory propagation of action potentials along the ***,oligodendrocytes are very susceptible to damage,and thus demyelination may arise from a brain lesion or a neurodegenerative ***,demyelination produces a loss of axonal insulation leading to sensory or motor neuron *** adulthood,there are two main sources of oligodendrocytes:parenchymal oligodendrocyte precursor cells(OPCs)and subventricular zone derived *** this review,we will discuss oligodendrogenesis derived from these two sources,and also highlight their main extrinsic and intrinsic *** addition,the neuroinflammatory mediators of oligodendrogenesis will also be assessed.

关键词： Demyelination inflammation neural stem cells oligodendrocyte remyelination

Genotoxicity evaluation of two derived products from Allium extracts:s-propylmercaptocysteine and s-propyl mercaptoglutathione

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Food Bioscience 2023年第3期53卷 1603-1611页

作者： Antonio Cascajosa-lir Concepción medrano-Padial ana Isabel Prieto Alberto Baños José m.de la Torre Angeles Jos ana m.Cameán Área de Toxicología Facultad de FarmaciaUniversidad de SevillaProfesor García González n 241012SevilleSpain DmC Research Center Camino de Jayena 8218620AlhendínSpain

Propyl-propane-thiosulfonate(PTSO)is one of the main organosulfur compounds present in Allium essential oils with a widely documented biological *** this reason,it could be used as a food and feed additive in the agri-food industry.A genotoxicity evaluation of substances and their metabolites present in food is necessary to guarantee the consumer’s health following the recommendations of the European Food Safety Authority(EFSA).To evaluate the toxicological profile of derivatives of PTSO,the cytotoxicity,an Ames test,a micronucleus test and the comet assay were *** showed that non-cytotoxic effects were observed in Caco-2 exposed to s-propyl mercaptocysteine(CSSP)and s-propyl mercaptoglutathione(GSSP)(0-450μm).The mutagenicity index remained in the range of 0.6-1.4 for both compounds,showing no mutagenic effects for the concentrations of 5000-312.5μg GSSP/plate and 250-15.63μg CSSP/***,the%binucleated cells with micronuclei were 1.3-2.2 and 1.6-2.7 for GSSP and GSSP,*** comet assays there was no DNA-genotoxic or oxidative damage in a concentration range of 112.5-450μ***,we can conclude that these compounds are not genotoxic at the conditions *** results support that the presence of CSSP and GSSP in the food/feed is not of concern,although further studies are needed to complete their safety profile.

关键词： Cytotoxicity Genotoxicity mutagenicity Organosulfur compounds Allium Propyl-propane-thiosulfonate

Exocytosis,endocytosis and recycling of secretory vesicles in neuroendocrine cells,and its regulation by cortical actin

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BIOCEll 2022年第8期46卷 1867-1873页

作者： ana m.CÁRDENAS I.GAllO FERNANDO D.mARENGO Centro Interdisciplinario de Neurociencia de Valparaíso Facultad de CienciasUniversidad de ValparaísoValparaíso2360102Chile Instituto de Fisiología Biología Molecular y NeurocienciasCONICET.Departamento de Fisiología y Biología Molecular y CelularFacultad de Ciencias Exactas y Naturales Universidad de Buenos AiresBuenos Aires1428Argentina

The cortical actin network is a mesh of filaments distributed beneath the plasmalemma that dynamically reacts in response to *** dynamic network of cortical filaments,together with motor myosin partners,adjusts the plasmalemma tension,organizes membrane protein microdomains,remodels the cell surface and drives vesicle motion in order to fine-tune exocytosis,endocytosis and recycling of secretory *** this review,we discuss how these mechanisms work in secretory cells.

关键词： Cortical actin Neuroendocrine cell Chromaffin cell Exocytosis Endocytosis

Heterostructure and Q-factor engineering for low-threshold and persistent nanowire lasing

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light(Science & Applications) 2020年第1期9卷 1609-1618页

作者： Stefan Skalsky Yunyan Zhang Juan Arturo Alanis HAruni Fonseka ana m.Sanchez Huiyun liu Patrick Parkinson Department of Physics and Astronomy and The Photon Science Institute The University of ManchesterManchester M139PLUK Department of Electronic and Electrical Engineering University College LondonLondon WC1E 7JEUK Department of Physics University of WarwickCoventry CV47ALUK

Continuous room temperature nanowire lasing from silicon-integrated optoelectronic elements requires careful optimisation of both the lasing cavity Q-factor and population inversion *** apply time-gated optical interferometry to the lasing emission from high-quality GaAsP/GaAs quantum well nanowire laser structures,revealing high Q-factors of 1250±90 corresponding to end-facet reflectivities of R=0.73±*** using optimised direct-indirect band alignment in the active region,we demonstrate a well-refilling mechanism providing a quasifour-level system leading to multi-nanosecond lasing and record low room temperature lasing thresholds(~6μJ cm^(−2) pulse−1)for Ⅲ-Ⅴ nanowire *** findings demonstrate a highly promising new route towards continuously operating silicon-integrated nanolaser elements.

关键词： lasing alignment interferometry

Cardiopulmonary resuscitation in the elderly: a clinical and ethical perspective

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Journal of Geriatric Cardiology 2007年第2期4卷 117-119页

作者： ana l. Huerta-Alardín manuel Guerra-Cantú Joseph Varon Dorrington medical Associates Houston Texas Universidad de monterrey School of Medicine Monterrey México The University of Texas Health Science Center St. Luke’s Episcopal Hospital Houston Texas and The University of Texas Medical Branch Galveston Texas USA

The daily practice of cardiopulmonary resuscitation (CPR) in elderly patients has brought up the attention of outcome research and resource allocation. Determinants to predict survival have been well identified. There has been empirical evidence that CPR is of doubtful utility in the geriatric population, more studies have showed controversial data. Sometimes situations in which CPR needs to be given in the elderly, causes stress to healthcare providers, due to lack of communication of the patient’s wishes and the belief that it will not be successful. It is of importance to state that we have the duty to identify on time the patients that will most likely benefit from CPR, and find out the preferences of the same. Whenever it is possible to institute these guidelines, we will avoid patient suffering.

关键词： cardiopulmonary resuscitation advanced directives

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