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Degradation of duloxetine: Identification of transformation products by UHPLC-ESI(+)-HRmS/mS,in silico toxicity and wastewater analysis

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Journal of Environmental Sciences 2019年第8期31卷 113-123页

作者： Rodrigo A.Osawa ana P.Carvalho Olinda C.monteiro m.Conceicao Oliveira m.Helena Florêncio Centro de Química e Bioquímica Faculdade de Ciências Universidade de Lisboa Laboratório de FTICR e Espectrometria de massa Estrutural Faculdade de Ciências Universidade de Lisboa Centro de Química Estrutural Instituto Superior Técnico Universidade de Lisboa

Duloxetine(DUL), an antidepressant drug, has been detected in surface water and wastewater effluents, however, there is little information on the formation of its transformation products(TPs). In this work, hydrolysis, photodegradation(UV irradiation) and chlorination experiments were performed on spiked distillated water, under controlled experimental conditions to simulate abiotic processes that can occur in the environment and wastewater treatment plants(WWTPs). Eleven TPs, nine from reaction with UV light and two from chlorine contact, were formed and detected by ultra-high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry, and nine of them had their chemical structures elucidated upon analyses of their fragmentation patterns in mS/mS spectra. The formation and degradation of the TPs were observed. The parent compound was completely degraded after30 min in photodegradation and after 24 hr in chlorination. Almost all TPs were completely degraded in the experiments. The ecotoxicity and mutagenicity of the TPs were predicted based on several in silico models and it was found that a few of these products presented more ecotoxicity than DUL itself and six TPs showed positive mutagenicity. Finally, wastewater samples were analyzed and DUL and one TP, possibly formed by chlorination process, were detected in the effluent, which showed that WWTP not only did not remove DUL, but also formed a TP.

关键词： High resolution mass spectrometry Duloxetine Degradation processes Transformation products Wastewater analysis In silico toxicity

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modeling of biodiesel production: Performance comparison of Box–Behnken, face central composite and full factorial design

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Chinese Journal of Chemical Engineering 2019年第7期27卷 1690-1698页

作者： Vlada B.Veljkovic ana V. Velickovic Jelena m. Avramovic Olivera S. Stamenkovic University of Nis Faculty of TechnologyBulevar oslobodenja 124Leskovac 16000Serbia Research&Development Center "Alfatec" Bulevar Nikole Tesle 63/5Nis 18000Serbia

The performances of the response surface methodology(RSm)in connection with the Box–Behnken,face central composite or full factorial design(BBD,FCCD or FFD,respectively)were compared for the use in modeling of the NaOH-catalyzed sunflower oil *** influence of temperature,catalyst loading,and ethanol-to-oil molar ratio(EOmR)on fatty acid ethyl esters(FAEE)content was *** three multivariate strategies were efficient in the statistical modeling and optimization of the influential process variables but BBD and FCCD realization involved less number of experiments,generating smaller costs,requiring less work and consuming shorter time than the corresponding *** three designs resulted in the same optimal catalyst loading(1.25%of oil)and EOmR(12:1).The reduced two-factorinteraction(2 FI)models based on the BBD and FCCD defined a range of optimal reaction temperature(25℃–75℃)and 25℃,respectively while the same model based on the 33 FFD appointed 75℃.The predicted FAEE content of about 97%–98.0%was close to the experimentally obtained FAEE content of about 97.0%–97.6%under the optimal reaction ***,the simpler BBD or FCCD might successfully be applied for statistical modeling of biodiesel production processes instead of the more extensive,more laborious and more expensive FFD.

关键词： Biodiesel Box-Behnken design model reduction Face central composite design Full factorial design Optimization

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Neuroinflammatory modulators of oligodendrogenesis

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Neuroimmunology and Neuroinflammation 2015年第1期2卷 263-273页

作者： ana Armada-moreira Filipa F.Ribeiro ana m.Sebastião Sara Xapelli Instituto de Farmacologia e Neurociências Faculdade de Medicina da Universidade de Lisboa1649-028 LisboaPortugal Instituto de medicina molecular Faculdade de Medicina da Universidade de Lisboa1649-028 LisboaPortugal

Oligodendrocytes are key neural cells that are responsible for producing myelin sheaths that wrap around neuronal axons in the central nervous *** is essential to insulate neurons and maintain a fast and saltatory propagation of action potentials along the ***,oligodendrocytes are very susceptible to damage,and thus demyelination may arise from a brain lesion or a neurodegenerative ***,demyelination produces a loss of axonal insulation leading to sensory or motor neuron *** adulthood,there are two main sources of oligodendrocytes:parenchymal oligodendrocyte precursor cells(OPCs)and subventricular zone derived *** this review,we will discuss oligodendrogenesis derived from these two sources,and also highlight their main extrinsic and intrinsic *** addition,the neuroinflammatory mediators of oligodendrogenesis will also be assessed.

关键词： Demyelination inflammation neural stem cells oligodendrocyte remyelination

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Genotoxicity evaluation of two derived products from Allium extracts:s-propylmercaptocysteine and s-propyl mercaptoglutathione

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Food Bioscience 2023年第3期53卷 1603-1611页

作者： Antonio Cascajosa-Lir Concepción medrano-Padial ana Isabel Prieto Alberto Baños José m.de la Torre Angeles Jos ana m.Cameán Área de Toxicología Facultad de FarmaciaUniversidad de SevillaProfesor García González n 241012SevilleSpain DmC Research Center Camino de Jayena 8218620AlhendínSpain

Propyl-propane-thiosulfonate(PTSO)is one of the main organosulfur compounds present in Allium essential oils with a widely documented biological *** this reason,it could be used as a food and feed additive in the agri-food industry.A genotoxicity evaluation of substances and their metabolites present in food is necessary to guarantee the consumer’s health following the recommendations of the European Food Safety Authority(EFSA).To evaluate the toxicological profile of derivatives of PTSO,the cytotoxicity,an Ames test,a micronucleus test and the comet assay were *** showed that non-cytotoxic effects were observed in Caco-2 exposed to s-propyl mercaptocysteine(CSSP)and s-propyl mercaptoglutathione(GSSP)(0-450μm).The mutagenicity index remained in the range of 0.6-1.4 for both compounds,showing no mutagenic effects for the concentrations of 5000-312.5μg GSSP/plate and 250-15.63μg CSSP/***,the%binucleated cells with micronuclei were 1.3-2.2 and 1.6-2.7 for GSSP and GSSP,*** comet assays there was no DNA-genotoxic or oxidative damage in a concentration range of 112.5-450μ***,we can conclude that these compounds are not genotoxic at the conditions *** results support that the presence of CSSP and GSSP in the food/feed is not of concern,although further studies are needed to complete their safety profile.

关键词： Cytotoxicity Genotoxicity mutagenicity Organosulfur compounds Allium Propyl-propane-thiosulfonate

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Exocytosis,endocytosis and recycling of secretory vesicles in neuroendocrine cells,and its regulation by cortical actin

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BIOCELL 2022年第8期46卷 1867-1873页

作者： ana m.CÁRDENAS I.GALLO FERNANDO D.mARENGO Centro Interdisciplinario de Neurociencia de Valparaíso Facultad de CienciasUniversidad de ValparaísoValparaíso2360102Chile Instituto de Fisiología Biología Molecular y NeurocienciasCONICET.Departamento de Fisiología y Biología Molecular y CelularFacultad de Ciencias Exactas y Naturales Universidad de Buenos AiresBuenos Aires1428Argentina

The cortical actin network is a mesh of filaments distributed beneath the plasmalemma that dynamically reacts in response to *** dynamic network of cortical filaments,together with motor myosin partners,adjusts the plasmalemma tension,organizes membrane protein microdomains,remodels the cell surface and drives vesicle motion in order to fine-tune exocytosis,endocytosis and recycling of secretory *** this review,we discuss how these mechanisms work in secretory cells.

关键词： Cortical actin Neuroendocrine cell Chromaffin cell Exocytosis Endocytosis

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Heterostructure and Q-factor engineering for low-threshold and persistent nanowire lasing

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Light(Science & Applications) 2020年第1期9卷 1609-1618页

作者： Stefan Skalsky Yunyan Zhang Juan Arturo Alanis HAruni Fonseka ana m.Sanchez Huiyun Liu Patrick Parkinson Department of Physics and Astronomy and The Photon Science Institute The University of ManchesterManchester M139PLUK Department of Electronic and Electrical Engineering University College LondonLondon WC1E 7JEUK Department of Physics University of WarwickCoventry CV47ALUK

Continuous room temperature nanowire lasing from silicon-integrated optoelectronic elements requires careful optimisation of both the lasing cavity Q-factor and population inversion *** apply time-gated optical interferometry to the lasing emission from high-quality GaAsP/GaAs quantum well nanowire laser structures,revealing high Q-factors of 1250±90 corresponding to end-facet reflectivities of R=0.73±*** using optimised direct-indirect band alignment in the active region,we demonstrate a well-refilling mechanism providing a quasifour-level system leading to multi-nanosecond lasing and record low room temperature lasing thresholds(~6μJ cm^(−2) pulse−1)for Ⅲ-Ⅴ nanowire *** findings demonstrate a highly promising new route towards continuously operating silicon-integrated nanolaser elements.

关键词： lasing alignment interferometry

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Etiopathogenesis of primary biliary cirrhosis

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World Journal of Gastroenterology 2008年第21期14卷 3328-3337页

作者： ana Lleo Pietro Invernizzi Ian R mackay Harry Prince Ren-Qian Zhong m Eric Gershwin Division of Internal medicine and Liver Unit San Paolo Hospital School of Medicine University of Milan Milan 20142 Italy Division of Rheumatology Allergy and Clinical Immunology University of California at Davis Davis CA 95616 United States Department of Biochemistry & molecular Biology Monash University Clayton Victoria 3800 Australia Focus Diagnostics 5785 Corporate Avenue Cypress CA 90630 United States Laboratory Diagnostics of Changzheng Hospital Second Military Medical University and Clinical Immunology Center of PLA Shanghai 200003 China

Primary biliary cirrhosis(PBC) is an autoimmune disease of the liver characterized by progressive bile duct destruction eventually leading to cirrhosis and liver *** serological hallmark of the disease is the presence of circulating antimitochondrial antibodies(AmA).These reflect the presence of autoreactive T and B cells to the culprit antigens,the E2 subunits of mitochondrial 2-oxo-acid dehydrogenase enzymes,chiefly pyruvate dehydrogenase(PDC-E2).The disease results from a combination of genetic and environmental risk *** predisposition is indicated by the higher familial incidence of the disease particularly among siblings and the high concordance rate among monozygotic *** triggering events appear crucial to disrupt a pre-existing unstable immune tolerance of genetic origin allowing,after a long latency,the emergence of clinical *** mimetopes of the vulnerable epitope of the PDC-E2 autoantigen can be derived from microbes that utilize the PDC enzyme or,alternatively,environmental xenobiotics/chemical compounds that modify the structure of native proteins to make them immunogenic.A further alternative as a source of antigen is PDC-E2 derived from apoptotic *** the effector phase the biliary ductular cell,by reason of itsproclivity to express the antigen PDC-E2 in the course of apoptosis,undergoes a multilineage immune attack comprised of CD4+ and CD8+ T cells and *** this article,we critically review the available evidence on etiopathogenesis of PBC and present interpretations of complex data,new developments and theories,and nominate directions for future research.

关键词： Autoantibodies Autoreactive T cells 2-oxoacid dehydrogenase Biliary epithelial cells Primary biliary cirrhosis

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Immunomodulatory biomaterial-based wound dressings advance the healing of chronic wounds via regulating macrophage behavior

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Regenerative Biomaterials 2022年第1期9卷 1131-1142页

作者： ana Beatriz Sousa Artur P.Águas mário A.Barbosa Judite N.Barbosa i3S—Instituto de Inovaçäo e Investigaçäo em Saúde Universidade do PortoRua Alfredo Allen2084200-125 PortoPortugal INEB—Instituto de Engenharia Biomédica Rua Alfredo Allen2084200-125 PortoPortugal ICBAS—Instituto de Ciências Biomédicas Abel Salazar Universidade do PortoRua de Jorge Viterbo Ferreira2284050-313 PortoPortugal UmIB—Unit for multidisciplinary Biomedical Research of ICBAS—Instituto de Ciências Biomédicas de Abel Salazar Universidade do PortoRua de Jorge Viterbo Ferreira2284050-313 PortoPortugal

Successful wound healing is a process that has three overlying phases:inflammatory,proliferative and *** wounds are characterized by a perpetuated inflammation that inhibits the proliferative and remodeling phases and impairs the wound *** are key modulators of the wound healing ***,they are responsible for the wound cleaning and for the phagocytosis of pathogens and afterwards they lead to the resolution of the inflammatory response and they express growth factors important for angiogenesis and cytokines and growth factors needed for cell proliferation and deposition of extracellular *** phenotype of the macrophage changes gradually throughout the healing process from the initial m1 pro-inflammatory phenotype characteristic of the acute response to the m2 pro-regenerative phenotype that allows an accurate tissue *** chronic wounds,m1 pro-inflammatory macrophages persist and impair tissue *** such,immunomodulatory biomaterials arise as promising solutions to accelerate the wound healing *** this review,we discuss the importance of macrophages and their polarization throughout the different phases of wound healing;macrophage dysfunction in chronic wounds and the use of immunomodulatory biomaterials to overcome the critical problem of chronic wounds-the continued inflammatory phase that impairs healing.

关键词： wound healing chronic wounds macrophage immunomodulatory biomaterials

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Development of an inflatable solar dryer for improved postharvest handling of paddy rice in humid climates

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International Journal of Agricultural and Biological Engineering 2017年第3期10卷 269-282页

作者： ana Salvatierra-Rojas marcus Nagle martin Gummert Tom de Bruin Joachim müller Institute of Agricultural Engineering Tropics and Subtropics GroupUniversität HohenheimGarbenstrasse 9Stuttgart 70599Germany Postharvest Development Program International Rice Research Institute(IRRI)Los Baños 4031Philippines GrainPro Philippines Inc. Subic Bay 2222Philippines

Rice is the staple food for more than three billion people *** considerable progress has been made with respect to improved breeds and production practices,losses during postharvest handling remain *** and storage of paddy are two key stages where management can be *** rice,grain moisture content of 14%prevents microbiological activity,while a level of about 12%minimizes quality losses over prolonged storage *** to the need for simple and economical technologies,an inflatable solar dryer(ISD)was developed based on adaptations of the Hohenheim-type solar tunnel *** form a drying tunnel,transparent polyethylene(PE)film attaches by zipper to a reinforced black polyvinyl chloride(PVC)*** reduce heat loss,a flexible multilayer floor was used along the drying *** tunnel does not need a substructure as it is stabilized adequately from pressure created by two axial flow *** experiments,paddy was spread on the floor and mixed with a special roller *** ISD has been evaluated for paddy in the Philippines during both rainy and dry seasons and was subsequently *** drying and shade drying were carried out in parallel for comparison and product was evaluated for moisture content and quality in terms of milling recovery and head rice *** content was reduced from 23%to 14%within 26-52 h of continuous operation during the rainy season and 16%to 14%within 4-26 h of drying during the dry *** both seasons,the final moisture content of 12%was reached after prolonged drying *** was not found to be affected with respect to drying *** ISD showed advantages over sun drying,despite longer drying periods.

关键词： paddy rice postharvest handling solar dryer mobile dryer collapsible dryer Philippines

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Bioguided isolation of antimicrobial polyphenols from Cuspidaria convoluta leaves and their synergistic effect with antibiotics

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Asian Pacific Journal of Tropical Biomedicine 2019年第10期9卷 434-442页

作者： Carola A.Torres mario A.Sturla ana m.Romero maría A.Judis Department of Basic and Applied Sciences Microbiology LaboratoryUniversidad Nacional del Chaco AustralComandante Fernández 755Presidencia Roque Sáenz PenaChacoArgentina Consejo Nacional de Investigaciones Científicas y Técnicas Buenos AiresArgentina Department of Basic and Applied Sciences Laboratory of Organic ChemistryUniversidad Nacional del Chaco AustralArgentina Department of Basic and Applied Sciences Food Industry LaboratoryUniversidad Nacional del Chaco AustralArgentina

Objective:To identify and isolate phenolic compounds from Cuspidaria convoluta,and to evaluate their antibacterial activity and synergistic effect with ***:The crude extract was prepared by maceration with methanol(5%).The dry extract was suspended in water and fractionated *** most active extract was selected by its antibacterial activity and its total phenol content was determined by spectrophotometry and by HPLC-mS/*** fractions of the most active extract were separated by column chromatography and evaluated by *** compounds were *** inhibitory concentration(mIC)of these compounds was determined by microdilution broth method,and synergism with antibiotics(ampicillin,gentamicin and oxacillin)was tested by checkerboard and time-kill ***:Coumaric acid,catechin/epicatechin,and luteolin were purified and identified from the *** was an increase in the antibacterial activity of antibiotics when they were combined with these *** combination of luteolin and ampicillin had the most potent antibacterial *** mICs of oxacillin for each of methicillin-resistant Staphylococcus aureus strains were reduced between 4 and 8-fold when these strains were coincubated with sub-mIC(≤?mIC)levels of these compounds,demonstrating that the combination had synergistic effect for all ***:Cuspidaria convoluta contains important pharmacologically active substances that can be used to improve antibiotic efficacy.

关键词： Luteolin Ampicillin mIC reduction Antimicrobial agents

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