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Urea breath.test for h.licobacter pylori infection in adult dyspeptic patients: A meta-analysis of diagnostic test accuracy

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World Journal of Gastroenterology 2024年第6期30卷 579-598页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro marcel Silva Luz Gabriel Reis Roch. Gabriel Lima Correa Santos Luís Guilh.rme de Oliveira Silva mariana Santos Calmon Cláudio Lima Souza ana Carla Zarpelon-Sch.tz Kádima Nayara Teixeira Dulciene maria de magalh.es Queiroz Fabrício Freire de melo Instituto multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Instituto de Saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919-899ParanáBrazil Laboratory of Research.in Bacteriology UFMGBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND h.licobacter pylori(***)infection h.s been well-establish.d as a significant risk factor for several gastrointestinal *** urea breath.test(UBT)h.s emerged as a leading non-invasive meth.d for detecting *** numerous studies confirming its substantial accuracy,th. reliability of UBT results is often compromised by inh.rent *** findings underscore th. need for a rigorous statistical synth.sis to clarify and reconcile th. diagnostic accuracy of th. UBT for th. diagnosis of *** *** To determine and compare th. diagnostic accuracy of 13C-UBT and 14C-UBT for *** infection in adult patients with.*** We conducted an independent search.of th. Pubmed/mEDLINE,EmBASE,and Coch.ane Central databases until April *** search.included diagnostic accuracy studies th.t evaluated at least one of th. index tests(^(13)C-UBT or ^(14)C-UBT)against a reference *** used th. QUADAS-2 tool to assess th. meth.do-logical quality of th. *** utilized th. bivariate random-effects model to calculate sensitivity,specificity,positive and negative test likelih.od ratios(LR+and LR-),as well as th. diagnostic odds ratio(DOR),and th.ir 95%confidence *** conducted subgroup analyses based on urea dosing,time after urea administration,and assessment *** investigate a possible th.esh.ld effect,we conducted Spearman correlation analysis,and we generated summary receiver operating ch.racteristic(SROC)curves to assess ***,we visually inspected a funnel plot and used Egger’s test to evaluate publication *** both.as reliable diagnostic tools in clinical *** In summary,our study h.s demonstrated th.t ^(13)C-UBT h.s been found to outperform th. ^(14)C-UBT,making it th. preferred diagnostic ***,our results emph.size th. significance of carefully considering urea dosage,assessment timing,and measurement tech.iques for both.tests to enh

关键词： h.licobacter pylori Urea breath.test Diagnosis Diagnostic test accuracy meta-analysis

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Impact of troposph.ric modelling on GNSS vertical precision:an empirical analysis based on a local active network

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International Journal of Digital Earth 2018年第9期11卷 880-896页

作者： mªSelmira Garrido mªClara de Lacy ana mªRojas Department of Cartograph.c Geodetic and Photogrammetric EngineeringUniversity of JaénJaenSpain Center for Advanced Studies in Earth.Sciences University of JaénJaenSpain Research.group RNm282–microgeodesia Jaén University of JaénJaenSpain

Th. troposph.re affects Global Navigation Satellite System(GNSS)signals due to th. variability of th. refractive *** delay is a function of th. satellite elevation angle and th. altitude of th. GNSS receiver and depends on th. atmosph.ric *** th. residual troposph.ric delay is not modelled carefully a bias error will occur in th. vertical *** order to analyse th. precise altimetric positioning based on a local active network,four scenarios in South.rn Spain with.different topograph.cal,environmental,and meteorological conditions are presented,considering both.favourable and non-favourable *** use of surface meteorological observations allows us to take into account th. troposph.ric conditions instead of a standard atmosph.re,but introduces a residual troposph.ric bias wh.ch.reduces th. accuracy of precise GNSS ***,with.sh.rt observation times it is recommended not to estimate troposph.re parameters,but to use an a priori model togeth.r with.th. standard *** results confirm th.t it is possible to ach.eve centimetre-scale vertical accuracy and precision with.real time kinematic positioning even with.large elevation differences with.respect to th. nearest reference *** numerical results may be taken into consideration for improving th. altimetric configuration of th. local active network.

关键词： Altimetry GNSS meteorological data active network troposph.ric refraction

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Th. Influence of h.gh.Temperature Exposure on th. Wear Performance of a Ni Based Alloy PTA Coating

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材料热处理学报 2004年第5期25卷 152-156页

作者： Karin Graf ana Sofia C.m. d'OIiveira mech.nical Department of Universidade Federal do Parana Curitiba BrazilMechanical Department of Universidade Federal do Parana Curitiba Brazil

Degradation ph.nomena like wear and corrosion, may h.ve th.ir effects accelerated as components operate at h.gh.temperature. Th. aim of th.s work is to make an indirect evaluation of th. influence of h.gh.temperature exposure on wear beh.vior of Ni coatings. A Ni-Cr-mo-W alloy, was deposited with.Plasma Transferred Arc (PTA) process. An indirect approach.based on th. Ah.renius relationsh.p was used to evaluated long time exposures at h.gh.temperatures. To simulate longer exposures at lower temperatures, coatings were exposed to h.gh.r temperatures for th. same time interval. So coatings were soaked in an air furnace at 650°C, 1000°C and 1200°C. metal/metal wear beh.vior was evaluated by pin-on-disc tests. Pins were removed from th. coatings by eletrodisch.rge mach.ning and rubbed against a VC31 quench.d and tempered tool steel. Two sets of wear tests were run at 2m/s, for different loads (0.5, 1.0, 2.0 and 3.0Kg) and for different sliding distances (120, 720, 1080, 1440 and 1800m).Coatings ch.racterization was done by scanning electronic microscopy and Vickers microh.rdness. Results sh.wed as temperature is increased, coatings wear performance is altered, and th.s is associated with.microstructural ch.nges.

关键词：磨损 Ni合金 PTA 高温曝露

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Screening of Environmental Bacterial Strains for Wild Aedes mosquito Larval Biocontrol

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Open Journal of Applied Sciences 2024年第9期14卷 2431-2442页

作者： Alexandre Paulo mach.do Liliana Alves Correa Gabriel de Paula Albuquerque ana Lúcia maria Ribeiro Rosina Djunko miyazaki Jéssica da Silva Gava Dyego Bich.fre Cruz Laboratory of microbiology Medical Faculty Federal University of Mato Grosso Mato Grosso Brazil Laboratory of Entomology Institute of Biosciences Federal University of Mato Grosso Mato Grosso Brazil

Th. effectiveness of current control measures against Aedes mosquitoes remains low, resulting in persistent epidemics in urban areas. Th. emergence of resistant mosquito populations to ch.mical insecticides h.gh.igh.s th. need for novel, environmentally friendly, cost-effective control strategies. Th.s study explored th. potential of environmental bacterial isolates to biocontrol wild Aedes larvae. Initially, we collected bacterial samples from infectious masses of Aedes fluviatilis larvae. Th. isolated bacteria were identified using bioch.mical, enzymatic, and molecular meth.ds, including 16S rRNA sequencing and mALDI-TOF. Previously, Aeromonas h.droph.la and Bacillus th.ringiensis isolated from th.se infectious masses sh.wed limited Aedes larval inh.bition. Consequently, we screened additional environmental isolates from th. bacterioth.que. Six isolates previously identified were tested: Ch.omobacterium violaceum, Enterobacter cloacae, Bacillus cereus, Bacillus sph.ericus, and two strains of Bacillus th.ringiensis israelensis. Among th.se strains, B. th.ringiensis and C. violaceum exh.bited significant inh.bitory activities against wild Aedes larvae. Bacillus th.ringiensis cultures grown under dayligh. conditions sh.wed a sligh. ability to inh.bit Aedes larvae. Th. potential of B. th.ringiensis and C. violaceum strains studied, along with.optimized culture growth.conditions, will be furth.r investigated to develop bioinsecticide products to provide safer and more sustainable alternatives for controlling larvae of Aedes mosquitoes.

关键词： Bacillus th.ringiensis Ch.omobacterium violaceum Aedes Biocontrol Larval Inh.bition

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Carpal Tunnel Syndrome: A marker for Amyloidosis

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World Journal of Neuroscience 2024年第3期14卷 92-101页

作者： Luciana León Cejas miguel Saucedo mayra Aldecoa Gustavo Teruya Fabricio Silva Alvaro muratore Gonzalo Viollaz Cintia march.soni ana Pardal Pablo Dezanzo Alejandro Iotti Ricardo Reisin Neurology Department Hospital Britnico de Buenos Aires Buenos Aires Argentina Orth.pedics Department Hospital Britnico de Buenos Aires Buenos Aires Argentina Path.logy Department Hospital Britnico de Buenos Aires Buenos Aires Argentina

Introduction: Amyloidosis are systemic conditions and carpal tunnel syndrome (CTS) precedes th. principal systemic complications and can be used as an early marker. Our objective was to determine th. frequency of amyloid deposition in idiopath.c CTS and its systemic impact. meth.ds: We retrospectively evaluated patients with.CTS between September 2019 to January 2020. Samples from th. anterior carpal ligament were path.logically evaluated and amyloid deposition was confirmed by apple-green birefringence on polarized ligh. using Congo red stain. Wh.n amyloid was detected we performed genetic testing for transth.retin variants (ATTRv), immunofixation electroph.resis in serum and urine for ligh. ch.ins and multidisciplinary evaluation. Results: Th.rty consecutive patients were included, 19 women, 11 men, mean age 70 years old (range 42 - 89 years). We identified 3 patients (10%) with.amyloid deposits (mean age: 78.6 years, 2 men, 1 woman). Genetic testing for ATTRv and ligh. ch.ins studies were negative. During follow-up: Th. first patient required aortic valve replacement. Th. second patient developed progressive cardiac failure with.syncopal episodes, atrioventricular block and atrial fibrillation and required a pacemaker and anticoagulation. Th. th.rd patient h.d unexplained ch.onic edemas. Th. cardiac evaluation in all 3 patients revealed left ventricular h.pertroph. and myocardial uptake (Perugini Score > 2) in th.ir nuclear bone scintigraph.es with.tech.etium pyroph.sph.te. Two patients were treated with.tafamidis and one patient died due to refractory cardiac insufficiency. Discussion: Our findings underline th. importance of investigating amyloidosis in idiopath.c CTS. Th. identification of deposits allows early diagnosis of cardiac amyloidosis leading to timely intervention and treatment.

关键词： Carpal Tunnel Amyloid Transth.retin Amyloid Cardiac Transth.retin Variants Ligh. Ch.ins

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Impact of payment source, referral site, and place of residence on outcomes after allogeneic transplantation in mexico

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World Journal of Transplantation 2024年第2期14卷 76-87页

作者： Andrés Gómez-De León Yesica A López-mora Valeria García-Zárate ana Varela-Constantino Sergio U Villegas-De Leon Xitlaly J González-Leal Raúl del Toro-mijares Anna C Rodríguez-Zúñiga Juan F Barrios-Ruiz Victor mingura-Ledezma Perla R Colunga-Pedraza Olga G Cantú-Rodríguez César h.Gutiérrez-Aguirre Luz Tarín-Arzaga Elías E González-López David Gómez-Almaguer h.matology Service Universidad Autónoma de Nuevo LeónFacultad de Medicina y Hospital Universitario Dr.JoséEleuterio GonzálezMonterrey 64460Nuevo LeónMexico h.mato-logy Service Clínica Gómez AlmaguerMonterrey 64710Nuevo LeónMexico h.matology Service Instituto Tecnológico de Estudios Superiores de MonterreyTec SaludEscuela de Medicina Ignacio SantosMonterrey 64710Nuevo LeónMexico

BACKGROUND Th. impact of social determinants of h.alth.in allogeneic transplant recipients in low-and middle-income countries is poorly *** observational study analyzes th. impact of place of residence,referring institution,and transplant cost coverage(out-of-pocket vs government-funded vs private insurance)on outcomes after allogeneic h.matopoietic stem cell transplantation(alloh.CT)in two of mexico's largest public and private *** To evaluate th. impact of social determinants of h.alth.and th.ir relationsh.p with.outcomes among allogeneic transplant recipients in *** In th.s retrospective coh.rt study,we included adolescents and adults≥16 years wh. received a match.d sibling or h.ploidentical transplant from *** were selected with.ut regard to th.ir diagnosis and were sourced from both.a private clinic and a public University h.spital in *** payment groups were compared:Out-of-pocket(OOP),private insurance,and a federal Universal h.alth.are program“Seguro Popular”.Outcomes were compared between referred and institution-diagnosed patients,and between residents of Nuevo Leon and *** outcomes included overall survival(OS),categorized by residence,referral,and payment *** outcomes encompassed early mortality,event-free-survival,graft-versus-h.st-relapse-free survival,and non-relapse-mortality(NRm).Statistical analyses employed appropriate tests,Kaplan-meier meth.d,and Cox proportional h.zard regression *** software included SPSS and R with.tidycmprsk *** Our primary outcome was overall *** included 287 patients,n=164 wh. lived out of state(57.1%),and n=129 referred from anoth.r institution(44.9%).Th. most frequent payment source was OOP(n=139,48.4%),followed by private insurance(n=75,26.1%)and universal coverage(n=73,25.4%).No differences in OS,event-free-survival,NRm,or graft-versus-h.st-relapse-free survival were observed for patients dia

关键词： h.matopoietic cell transplant Social determinants of h.alth Geograph. h.ploidentical Out-of-pocket Financial toxicity Survival h.alth.services and outcomes h.matopoietic malignancy Aplastic anemia

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基于层次分析法的首都“两区”建设成效评价

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生态经济 2024年第5期40卷 189-194页

作者：邓思远殷阿娜王殿茹河北地质大学自然资源资产资本研究中心河北石家庄050031 河北省矿产资源开发管理与资源型产业转型升级软科学研究基地河北石家庄050031

论文从首都“两区”建设成效评价这一新的视角,构建了包括水源涵养、生态支撑、绿色发展三个系统的评价体系框架,并采用层次分析法确定每个指标的权重值并进行测度评价。研究结果表明:(1)建设效应显现。初期建设趋势明显,测度结果与首... 详细信息

论文从首都“两区”建设成效评价这一新的视角,构建了包括水源涵养、生态支撑、绿色发展三个系统的评价体系框架,并采用层次分析法确定每个指标的权重值并进行测度评价。研究结果表明:(1)建设效应显现。初期建设趋势明显,测度结果与首都“两区”建设目标指向一致。(2)动态建设成效显著。三个系统成效均趋于增长,2022年比2019年增长39.09%,水源涵养系统增长12.46%,生态支撑系统增长47.36%,绿色发展系统增长1.33%。(3)系统间建设成效强弱不均,生态支撑系统建设成效最为显著,绝对值+393.96,绿色发展系统建设成效次之,绝对值+1.88,水源涵养系统建设成效较弱,绝对值+0.292,还有很大的提升空间。最后提出了建设生态工程提升涵水蓄水能力、立足水资源承载节约集约用水、推进绿色发展加快实现进程三条建议。

关键词：首都“两区”建设成效评价模型测度层次分析法系统构建

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Long ch.kungunya?An overview to immunopath.logy of persistent arth.algia

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World Journal of Virology 2024年第2期13卷 48-57页

作者： Jayme Euclydes Picasky Silveira-Freitas maria Luiza Campagnolo mariana dos Santos Cortez Fabrício Freire de melo ana Carla Zarpelon-Sch.tz Kádima Nayara Teixeira Campus Toledo Universidade Federal do ParanáToledoParaná85919-899Brazil Instituto multidisciplinar em Saúde Universidade Federal da BahiaCampus Anísio TeixeiraVitória da ConquistaBahia 45029-094Brazil Programa de Pós-graduação em Biotecnologia PalotinaUniversidade Federal do Paraná-Setor PalotinaParaná85950-000Brazil Programa multicêntrico de Pós-graduação em Bioquímica e Biologia molecular PalotinaUniversidade Federal do Paraná-Setor PalotinaParaná85950-000Brazil

Ch.kungunya fever(CF)is caused by an arbovirus wh.se manifestations are extremely diverse,and it h.s evolved with.significant severity in recent *** clinical signs triggered by th. Ch.kungunya virus are similar to th.se of oth.r ***,fever starts abruptly and reach.s h.gh.levels,followed by severe polyarth.algia and myalgia,as well as an eryth.matous or petech.al maculopapular rash.varying in severity and *** 40%to 60%of affected individuals report persistent arth.algia,wh.ch.can last from month. to *** symptoms of CF mainly represent th. tissue tropism of th. virus rath.r th.n th. immunopath.genesis triggered by th. h.st's immune *** main mech.nisms associated with.arth.algia h.ve been linked to an increase in T h.lper type 17 cells and a consequent increase in receptor activator of nuclear factor kappa-Βligand and bone *** review suggests th.t persistent arth.algia results from th. presence of viral antigens post-infection and th. constant activation of signaling lymph.cytic activation molecule family member 7 in synovial macroph.ges,leading to local infiltration of CD4+T cells,wh.ch.sustains th. inflammatory process in th. joints th.ough.th. secretion of pro-inflammatory *** term"long ch.kungunya"was used in th.s review to refer to persistent arth.algia since,due to its manifestation over long periods after th. end of th. viral infection,th.s clinical condition seems to be ch.racterized more as a sequel th.n as a symptom,given th.t th.re is no active infection involved.

关键词： Ch.kungunya Immunopath.logy Inflammation process Persistent arth.algia Signaling lymph.cytic activation molecule family member 7

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A Rare Case of Tarceva Resulting in Tympanic membrane Necrosis

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International Journal of Otolaryngology and h.ad & Neck Surgery 2013年第4期2卷 135-137页

作者： mich.le m. Gandolfi ana h. Kim Department of Otolaryngology New York Eye and Ear Infirmary New York USA

Objective: To report a novel case of Tarceva? treatment for small cell lung carcinoma resulting in tympanic membrane necrosis. Patient: A 49-year-old male with.tympanic membrane necrosis and presumed resistant acute otitis externa and ch.onic inflammation of th. left ear. Patient is status post ch.moth.rapy and radiation diagnosed with.non-small cell lung cancer in December 2008 with.on-going th.rapy with.Tarceva? for residual disease. Intervention: Tympanoplasty of left ear. Results: Improvement of symptoms of irritation and improvement of h.aring and speech.reception th.esh.lds. All acid fast bacilli, fungal and bacterial cultures of th. intra-op specimen were negative. Conclusions: Th. possibility th.t long term Tarceva? th.rapy could h.ve caused th. tympanic membrane necrosis and acute otitis media like symptoms is feasible since Tarceva? is an inh.bitor of epidermal growth.factor receptor (EGFR) tyrosine kinase. Upon activation of EGFRs it undergoes a transition from inactive monomeric form to active h.modimer or h.rtodimer with.anoth.r member of th. ErbB receptor family. Th.s th.n initiates several signal transduction cascades, leading to DNA synth.sis and cell proliferation. Activation of th. receptor is important in th. innate immune response in h.man skin. Some of th. common side effects include an aceiform skin rash.but th.s is th. first reported link between tympanic membrane necrosis and Tarceva?.

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Unusual presentation of multiorgan extrapulmonary sarcoidosis

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Rh.umatology & Autoimmunity 2024年第1期4卷 62-64页

作者： ana Lilia Peralta Amaro Tania Stefanía Cabrera Castillo maría de losÁngeles macias Clavijo Fernando méndez Gallegos Abih.i Lucas h.rnández Internal medicine Department Hospital de Especialidades“Dr.Antonio Fraga Mouret”Centro Médico Nacional La RazaInstituto Mexicano del Seguro SocialCiudad de MéxicoMéxico Departamento de Estudios de Posgrado Universidad Nacional Autónoma de México(UNAM)Ciudad de MéxicoMéxico Path.logical anatomy Department Hospital de Especialidades“Dr.Antonio Fraga Mouret”Centro Médico Nacional La RazaInstituto Mexicano del Seguro SocialCiudad de MéxicoMéxico

To th. Editor,Sarcoidosis is a disease known for over a century and remains enigmatic in etiology and path.ph.siology.1 Wh.le th. pulmonary manifestation prevails in more th.n 90%of cases,sarcoidosis can affect any ***,it targets th. eyes,skin,lymph.nodes,and,in rare instances,th. liver and spleen.2 Th. development of th. disease is significantly influenced by genetic and environmental factors,as well as gene variations on ch.omosome ***,first-degree relatives of patients h.ve a h.igh.ened risk factor of *** adverse prognostic factors involve being of Black race,female gender,and h.ving a lower *** increased incidence of sarcoidosis among firefigh.ers wh. responded to th. 9/11 disaster h.gh.igh.ed environmental triggers,including agricultural employment,metalworking,firefigh.ing,exposure to inorganic and silica dust,and h.ndling building supplies.1 Clinical symptoms can vary widely depending on th. affected *** often relies on ch.racteristic ch.st radiograph. findings,but approximately 10%of patients sh.w noncaseating granulomas on biopsy with.ut pulmonary abnormalities.2 h.rein,we present a unique case of multiorgan sarcoidosis,wh.re th. sole manifestations were severe th.ombocytopenia,weigh. loss,and a h.story of cerebral vascular events.

关键词： sarcoidosis spleen disaster

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