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PM_(2.5) chemical composition and health risks by inhalation near a chemical complex

Journal of Environmental Sciences 2023年第2期124卷 860-874页

作者： Celia Alves Margarita Evtyugina Estela Vicente ana Vicente Ismael Casotti Rienda ana Sanchez de la Campa Mario Tome Iola Duarte Department of Environment Centre for Environmental and Marine Studies(CESAM)University of Aveiro3810-193 AveiroPortugal Associate Unit CSIC-University of Huelva“Atmospheric Pollution” Centre for Research in Sustainable Chemistry-CIQSOUniversity of HuelvaE21071 HuelvaSpain Department of Mining MechanicEnergetic and Construction EngineeringETSIUniversity of Huelva21071 HuelvaSpain PROMETHEUS School of Technology and Management(ESTG)Polytechnic Institute of Viana do Castelo4900-348 Viana do CasteloPortugal Department of Chemistry CICECO-Aveiro Institute of MaterialsUniversity of Aveiro3810-193 AveiroPortugal

Particulate matter(PM_(2.5))samples were collected in the vicinity of an industrial chemical pole and analysed for organic and elemental carbon(OC and EC),47 trace elements and around 150 organic *** average,OC and EC accounted for 25.2% and 11.4% of the PM_(2.5) mass,*** compounds comprised polycyclic aromatic hydrocarbons(PAHs),alkylated PAHs,anhydrosugars,phenolics,aromatic ketones,glycerol derivatives,aliphatic alcohols,sterols,and carboxyl groups,including aromatic,carboxylic and dicarboxylic *** factors>100 were obtained for Pb,Cd,Zn,Cu,Sn,B,Se,Bi,Sb and Mo,showing the contribution of industrial emissions and nearby major *** component analysis revealed that vehicle,industrial and biomass burning emissions accounted for 66%,11% and 9%,respectively,of the total PM_(2.5)-bound *** of the detected organic constituents are likely associated with plasticiser ingredients and thermal stabilisers used in the manufacture of PVC and other plastics in the industrial *** products of both anthropogenic(e.g.,toluene)and biogenic(e.g.,isoprene and pinenes)precursors were also *** was estimated that biomass burning accounted for 13.8%of the PM_(2.5) concentrations and that secondary OC represented 37.6% of the total *** lifetime cancer risk from inhalation exposure to PM_(2.5)-bound PAHs was found to be negligible,but it exceeded the threshold of 10−6 for metal(loi)s,mainly due to Cr and As.

关键词： PM_(2.5) OC/EC Organic speciation Trace elements Cancer and non-cancer risks

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Second-look surgery plus hyperthermic intraperitoneal chemotherapy for patients with colorectal cancer at high risk of peritoneal carcinomatosis:Does it really save lives?

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World Journal of gastroenterology 2017年第3期23卷 377-381页

作者： Delia Cortes-guiral Dominique elias Pedro Antonio Cascales-Campos Alfredo Badía Yébenes Ismael guijo Castellano ana Isabel León Carbonero JoséIgnacio Martín Valadés Jesus garcia-Foncillas Damian garcia-Olmo Department of general Surgery(Peritoneal Surface Surgical Oncolongy) Fundación Jiménez Díaz Hospital28050 MadridSpain Department of Surgical Oncology Institut Gustave Roussy94805 VillejuifCédexFrance Department of general Surgery(Peritoneal Surface Surgical Oncolongy) Virgen de la Arrixaca30120 MurciaSpain Department of Medical Oncology Fundación Jiménez Díaz Hospital28050 MadridSpain

The treatment of peritoneal carcinomatosis (PC) of colorectal origin with cytoreductive surgery(CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has a 5-year recurrence-free or cure rate of at least 16%, so it is no longer labeled as a fatal disease, and offers prolonged survival for patients with a low peritoneal carcinomatosis index. Metachronous PC of colorectal origin is so predictable that there is a model which has been used to successfully determine the individual risk of each patient. Patients at risk are clearly identified; those with the highest risk have small peritoneal nodules present in the first surgery (70% probability of developing PC), ovarian metastases(60%), perforated tumor onset or intraoperative tumor rupture(50%). Current clinical, biological and imaging techniques still lack sufficient sensitivity to diagnose PC in its initial stages, when CRS plus HIPEC has a greater impact and a higher cure rate. Second-look surgery with HIPEC or prophylactic HIPEC at the time of the first intervention have been proposed as means of preventing and/or anticipating clinical or radiological relapse in at-risk patients. Both techniques have shown a significant decrease in peritoneal relapses and should be considered essential weapons in the management of colorectal cancer.

关键词： Second-look surgery High-risk patients Peritoneal carcinomatosis Hyperthermic intraperitoneal chemotherapy Colo-rectal cancer

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graphene electronic fibres with touch-sensing and lightemitting functionalities for smart textiles

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npj Flexible Electronics 2018年第1期2卷 231-236页

作者： elias Torres Alonso Daniela P.Rodrigues Mukond Khetani Dong-Wook Shin Adolfo De Sanctis Hugo Joulie Isabel de Schrijver Anna Baldycheva Helena Alves ana I.S.Neves Saverio Russo Monica F.Craciun Centre for graphene Science College of EngineeringMathematics and Physical SciencesUniversity of ExeterEX44QL ExeterUnited Kingdom Department of Physics and CICECO University of Aveiro3819-130 AveiroPortugal Centexbel Technologiepark-Zwijnaarde 79052 GhentBelgium Department of Physics Instituto Superior TécnicoUniversity of LisbonAv.Rovisco Pais 11040-001 LisbonPortugal

The true integration of electronics into textiles requires the fabrication of devices directly on the fibre itself using high-performance materials that allow seamless incorporation into *** electronics and opto-electronics,attained by intertwined fibres with complementary functions are the emerging and most ambitious technological and scientific *** we demonstrate graphene-enabled functional devices directly fabricated on textile fibres and attained by weaving graphene electronic fibres in a *** touch-sensors and light-emitting devices were produced using a roll-to-roll-compatible patterning technique,opening new avenues for woven textile ***,the demonstration of fabric-enabled pixels for displays and position sensitive functions is a gateway for novel electronic skin,wearable electronic and smart textile applications.

关键词： textiles smart functional

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Towards efficient strain engineering of 2D materials:A four-points bending approach for compressive strain

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Nano Research 2024年第6期17卷 5317-5325页

作者： Hao Li Félix Carrascoso ana Borrás gloria P.Moreno Francisco J.Aparicio Ángel Barranco Andrés Castellanos gómez Campus de Cantoblanco Instituto de Ciencia de Materiales de MadridC.Sor Juana Inés de la Cruz328049 MadridSpain Nanotechnology on Surfaces and Plasma Lab Instituto de Ciencia de Materiales de Sevilla(CSIC-Universidad de Sevilla).C/Americo Vespucio 49E-41092 SevilleSpain Departamento de Física Aplicada I Escuela Politécnica SuperiorUniversidad de Sevillac/Virgen deÁfrica 7E-41011 SevilleSpain

Strain engineering,as a powerful strategy to tune the optical and electrical properties of two-dimensional(2D)materials by deforming their crystal lattice,has attracted significant interest in recent years.2D materials can sustain ultra-high strains,even up to 10%,due to the lack of dangling bonds on their surface,making them ideal brittle *** remarkable mechanical resilience,together with a strong strain-tunable band structure,endows 2D materials with a broad optical and electrical response upon ***,strain engineering based on 2D materials is restricted by their nanoscale and strain quantification *** this study,we have modified a homebuilt three-points bending apparatus to transform it into a four-points bending apparatus that allows for the application of both compressive and tensile strains on 2D *** approach allows for the efficient and reproducible construction of a strain system and minimizes the buckling effect caused by the van der Waals interaction by adamantane encapsulation *** results demonstrate the feasibility of introducing compressive strain on 2D materials and the potential for tuning their optical and physical properties through this approach.

关键词： uniaxial compressive strain polymer encapsulation differential reflectance spectroscopy exciton tunability

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An MAP Kinase Cascade Downstream of RgF/gLV Peptides and Their RgI Receptors Regulates Root Development

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Molecular Plant 2020年第11期13卷 1542-1544页

作者： ana I.Fernandez Tom Beeckman Department of Plant Biotechnology and Bioinformatics Ghent UniversityGhentBelgium VIB Center for Plant Systems Biology GhentBelgium

Plant developmental processes require active cell-cell *** peptides are now recognized as major players involved in many plant developmental and immunity ***,the cognate receptors for many signaling peptides have also been *** we are starting to gain insights into some of the molecular components,the downstream pathway after ligand perception is in most cases unknown(Oh et al.,2018).

关键词： starting insight hough

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Doxycycline induces bone repair and changes in Wnt signalling

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International Journal of Oral Science 2017年第3期9卷 158-166页

作者： kátia do nascimento gomes ana paula negreiros nunes alves paula góes pinheiro dutra glauce socorro de barros viana faculty of dentistry pharmacy and nursingfederal university of cearáFortalezaBrazil faculty of medicine federal university of cearáFortaleza Brazil

Doxycycline （DOX） exhibits anti-inflammatory and MMP inhibitory properties. The objectives of this study were to evaluate the effects of DOX on alveolar bone repair. Controls （CTL） and DOX-treated （10 and 25 mg. kg- 1） molars were extracted, and rats were killed 7 or 14 days later. The maxillae were processed and subjected to histological and immunohistochemical assays. Hematoxylin-eosin staining （7th day） revealed inflammation in the CTL group that was partly reversed after DOX treatment. On the 14th day, the CTL group exhibited bone neoformation, conjunctive tissue, re-epithelization and the absence of inflammatory infiltrate. DOX-treated groups exhibited complete re-epithelization, tissue remodelling and almost no inflammation. Picrosirius red staining in the DOXlO group （7th and 14th days） revealed an increased percentage of type I and III collagen fibres compared with the CTL and DOX25 groups. The DOXlO and DOX25 groups exhibited increases in osteoblasts on the 7th and 14th days. However, there were fewer osteoclasts in the DOXlO and DOX25 groups on the 7th and 14th days. Wnt-lOb- immunopositive cells increased by 130% and 150% on the 7th and 14th days, respectively, in DOX-treated groups compared with the CTL group. On the 7th day, Dickkopf （Dkk）-I immunostaining was decreased by 63% and 46% in the DOXlO and DOX25 groups, respectively. On the 14th day, 69% and 42% decreases in immunopositive cells were observed in the DOXlO and DOX25 groups, respectively, compared with the CTL group. By increasing osteoblasts, decreasing osteoclasts, activating Wnt lOb and neutralising Dkk, DOX is a potential candidate for bone repair in periodontal diseases.

关键词： alveolar bone loss bone diseases bone repair doxycycline Dickkopf-1 immunohistochemistry Wnt-lOb

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Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells

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World Journal of gastroenterology 2006年第36期12卷 5834-5845页

作者： Raquel Taléns-Visconti ana Bonora Ramiro Jover Vicente Mirabet Francisco Carbonell José Vicente Castell María José gómez-Lechón Unidad de Hepatología Experimental Centro de Investigación Hospital La Fe Valencia Spain Departamento de Bioquímica y Biología Molecular Universidad de Valencia Valencia Spain. Unidad de Hepatología Experimental Centro de Investigación Hospital La Fe Valencia Spain Centro de Transfusión de la Comunidad Valenciana Generalidad ValencianaValencia Spain Unidad de Hepatología Experimental Centro de Investigación Hospital La Fe Valencia.Spain. Departamento de Bioquímica y Biología Molecular Universidad de Valencia Valencia Spain Unidad de Hepatología Experi-mental Centro de Investigación Hospital La Fe Valencia Spain

AIM： To investigate and compare the hepatogenic transdifferentiation of adipose tissue-derived stem cells （ADSC） and bone marrow-derived mesenchymal stem cells （BMSC） in vitro. Transdifferentiation of BMSC into hepatic cells in vivo has been described. Adipose tissue represents an accessible source of ADSC, with similar characteristics to BMSC. METHODS： BMSCs were obtained from patients undergoing total hip arthroplasty and ADSC from human adipose tissue obtained from lipectomy. Cells were grown in medium containing 15% human serum. Cultures were serum deprived for 2 d before cultivating under similar pro-hepatogenic conditions to those of liver development using a 2-step protocol with sequential addition of growth factors, cytokines and hormones. Hepatic differentiation was RT-PCR-assessed and liver-marker genes were immunohistochemically ***： BMSC and ADSC exhibited a fibroblastic morphology that changed to a polygonal shape when cells differentiated. Expression of stem cell marker Thyl decreased in differentiated ADSC and BMSC. However, the expression of the hepatic markers, albumin and CYPs increased to a similar extent in differentiated BMSC and ADSC. Hepatic gene activation could be attributed to increased liver-enriched transcription factors （C/EBPβ and HNF4α）, as demonstrated by adenoviral expression ***： Mesenchymal stem cells can be induced to hepatogenic transdifferentiation in vitro. ADSCs have a similar hepatogenic differentiation potential to BMSC, but a longer culture period and higher proliferation capacity. Therefore, adipose tissue may be an ideal source of large amounts of autologous stem cells, and may become an alternative for hepatocyte regeneration, liver cell transplantation or preclinical drug testing.

关键词： Mesenchymal stem cells Bone marrow Adipose tissue Transdifferentiation Hepatic lineage Liver cell transplantation.

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Targeting the premetastatic niche:epigenetic therapies in the spotlight

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1871-1872页

作者： Vivien Low John Blenis ana P.gomes Meyer Cancer Center Weill Cornell MedicineNew YorkNYUSA Department of Pharmacology Weill Cornell MedicineNew YorkNYUSA

The treatment of metastatic cancers remains a challenge in the clinic,with recurrences persisting at high rates even after surgical resection of primary *** the perseverance of circulating tumor cells after resection,this phenomenon is abetted by the formation of the premetastatic niche(PMN),a distant environment ripe for the colonization of new metastases,which is conditioned by factors and extracellular vesicles secreted by the primary *** their recent paper,Lu et *** how such PMNs in the lung can be disrupted by low-dose adjuvant epigenetic therapy,and propose a novel therapeutic avenue to supplement tumor resection.

关键词： metastatic epigenetic al

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Parkinson's disease, heart disease and propolis consumption

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Journal of Integrative Medicine 2021年第5期19卷 467-468页

作者： Fulvio A.Scorza Antonio-Carlos g.de Almeida Carla A.Scorza ana C.Fiorini Josef Finsterer Disciplina de Neurociência Escola Paulista de MedicinaUniversidade Federal de Sao Paulo(EPM/UNIFESP)Sao PauloSP 04021-001Brazil Centro de Neurociências e Saúde da Mulher Escola Paulista de MedicinaUniversidade Federal de Sao Paulo(EPM/UNIFESP)Sao PauloSP04021-001Brazil Departamento de Engenharia de Biossistemas Universidade Federal de Sao Joao del-Rei(UFSJ)Sao Joao del-ReiMG36307-352Brazil Departamento de Fonoaudiologia Escola Paulista de MedicinaUniversidade Federal de Sao Paulo(EPM/UNIFESP)Sao PauloSP04021-001Brazil Brazil-Programa de Estudos Pós-graduado em Fonoaudiologia Pontifícia Universidade Católica de Sao Paulo(PUC-SP)Sao PauloSP04021-001Brazil Klinikum Landstrasse Messerli InstituteVienna 1210Austria

It is reported that neurodegeneration is a process that is implicated in both neuropharmacological disorders and brain aging [1].Research has shown that natural products have a wide range of pharmacological and biolog... 详细信息

关键词： Parkinson’s disease heart disease and propolis consumption

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VAMP2 is implicated in the secretion of antibodies by human plasma cells and can be replaced by other synaptobrevins

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Cellular & Molecular Immunology 2018年第4期15卷 353-366页

作者： Laura gómez-Jaramillo Raquel Romero-garcía gema Jiménez-gómez Lisa Riegle ana Belén Ramos-Amaya JoséAntonio Brieva Marie Kelly-Worden Antonio Campos-Caro Unidad de Investigación Hospital Universitario Puerta del MarCádizSpain Department of Biology Ball State UniversityMuncieINUSA

The production and secretion of antibodies by human plasma cells(PCs)are two essential processes of humoral *** secretion process relies on a group of proteins known as soluble N-ethylmaleimide-sensitive factor attachment protein receptors(SNAREs),which are located in the plasma membrane(t-SNAREs)and in the antibody-carrying vesicle membrane(v-SNARE),and mediate the fusion of both *** have previously shown that SNAP23 and STX4 are the t-SNAREs responsible for antibody ***,using human PCs and antibody-secreting cell lines,we studied and characterized the expression and subcellular distribution of vesicle associated membrane protein(VAMP)isoforms,demonstrating that all isoforms(with the exception of VAMP1)are expressed by the referenced ***,the functional role in antibody secretion of each expressed VAMP isoform was tested using *** results show that VAMP2 may be the v-SNARE involved in vesicular antibody *** further support this conclusion,we used tetanus toxin light chain to cleave VAMP2,conducted experiments to verify co-localization of VAMP2 in antibody-carrying vesicles,and demonstrated the coimmunoprecipitation of VAMP2 with STX4 and SNAP23 and the in situ interaction of VAMP2 with *** together,these findings implicate VAMP2 as the main VAMP isoform functionally involved in antibody secretion.

关键词： exocytosis human immunoglobulin plasma cells VAMP proteins

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