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Polyethylene glycol 35 ameliorates pancreatic inflammatory response in cerulein-induced acute pancreatitis in rats

World Journal of Gastroenterology 2020年第39期26卷 5970-5982页

作者： ana ferrero-andrés Arnau Panisello-Roselló Joan Roselló-Catafau Emma Folch-Puy Experimental Pathology Department Institut d'Investigacions Biomèdiques de Barcelona-Consejo Superior de Investigaciones científicasBarcelona 08036CataloniaSpain Experimental Pathology Department Institut d'Investigacions Biomèdiques de Barcelona-Consejo Superior de Investigaciones científicasCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y DigestivasInstitut d'Investigacions Biomèdiques August Pi i SunyerBarcelona 08036CataloniaSpain

BACKGROUND Acute pancreatitis(AP)is a sudden inflammatory process of the pancreas that may also involve surrounding tissues and/or remote *** and parenchymal cell death are common pathological features of this condition and determinants of disease *** glycols(PEGs)are nonimmunogenic,non-toxic water-soluble polymers widely used in biological,chemical,clinical and pharmaceutical *** To evaluate the protective effect of a 35-kDa molecular weight PEG(PEG35)on the pancreatic damage associated to cerulein-induced acute pancreatitis in vivo and in *** Wistar rats were assigned at random to a control group,a cerulein–induced AP group and a PEG35 treatment *** was induced by five hourly intraperitoneal injections of cerulein(50μg/kg/bw),while the control animals received saline ***35 was administered intraperitoneally 10 minutes before each cerulein injection in a dose of 10 mg/*** AP induction,samples of pancreatic tissue and blood were collected for ***42J pancreatic acinar cells were treated with increasing concentrations of PEG35 prior to exposure with tumor necrosis factorα(TNFα),staurosporine or *** severity of AP was determined on the basis of plasma levels of lipase,lactate dehydrogenase activity,pancreatic edema and histological *** evaluate the extent of the inflammatory response,the gene expression of inflammation-associated markers was determined in the pancreas and in AR42J-treated ***-induced cell death was also measured in models of in vivo and in vitro pancreatic *** Administration of PEG35 significantly improved pancreatic damage through reduction on lipase levels and tissue edema in cerulein-induced AP *** increased associated inflammatory response caused by cerulein administration was attenuated by a decrease in the gene expression of inflammation-related cytokines and inducible nitric oxide synthase enzyme in the *** contr

关键词： Acute pancreatitis Inflammation Polyethylene glycols Cytokines AR42J cells Cell death

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Prognostic value of increased carbohydrate antigen in patients with heart failure

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World Journal of Cardiology 2014年第4期6卷 205-212页

作者： ana B Méndez Jordi Ordonez-Llanos andreu ferrero Mariana Noguero Teresa Mir Josefina Mora Antoni Bayes-Genis sònia Mirabet Juan Cinca Eulàlia Roig Cardiology Department Hospital de la Santa Creu i Sant PauInstitut de Recerca Biomèdica Sant Pau and Universitat Autònoma Biochemistry Department Hospital de la Santa Creu i Sant PauInstitut de Recerca Biomèdica Sant Pau and Universitat Autònoma Cardiology Department Hospital Germans Trias I Pujol

AIM:To study the prognostic value of carbohydrateantigen 125(CA125) and whether it adds prognostic information to N-terminal pro-brain natriuretic peptide(NT-proBNP) in stable heart failure(HF) ***:The predictive value of CA125 was retrospectively assessed in 156 patients with stable HF remitted to the outpatient HF unit for monitoring from 2009 to *** were included in the study if they had a previous documented episode of HF and received HF ***125 and NT-proBNP concentrations were *** independent association between NT-proBNP or CA125 and mortality was assessed with Cox regression analysis,and their combined predictive ability was tested by the integrated discrimination improvement(IDI) ***:The mean age of the 156 patients was 72 ± 12 *** follow-up(17 ± 8 mo),27 patients died,1 received an urgent heart transplantation and 106 required hospitalization for *** CA125 values were correlated with outcomes:58 ± 85 KU/L if hospitalized vs 34 ± 61 KU/L if not(P se who died or needed urgent heart transplantation vs 45 ± 78 KU/L in survivors(P sting for propensity scores,the highest risk was observed when both biomarkers were elevated vs not elevated(HR = 8.95,95%CI:3.11-25.73; P s elevated vs not elevated(HR = 4.15,95%CI:1.41-12.24; P s added to the clinical model with NT-proBNP,a 4%(P s ***:CA125 > 60 KU/L identified patients in stable HF with poor *** CA125 level adds prognostic value to NT-proBNP level in predicting HF outcomes.

关键词： Heart failure Prognosis Carbohydrate antigen 125 Brain natriuretic peptides survival

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standardized semi-Quantitative Evaluation of [123I]FP-CIT sPECT in a Multicenter study

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Advances in Molecular Imaging 2013年第4期3卷 55-60页

作者： andrea skanjeti Giancarlo Castellano Baldassarre Elia Francesca Dazzara Michela Zotta Gabriela Mariam Delgado Yabar Matteo Manfredi Marco Iudicello Maurizio Zibetti Patrizia ferrero Paola Filippi Riccardo Emanuele Pellerito Valerio Podio Neurology 1 San Luigi Gonzaga Hospital Orbassano Italy Neurology 2 San Giovanni Battista Hospital University of Turin Turin Italy Neurology 4 San Giovanni Battista Hospital University of Turin Turin Italy Neurology Maria Vittoria Hospital Turin Italy Nuclear Medicine Unit San Giovanni Battista Hospital University of Turin Turin Italy Nuclear Medicine Unit San Luigi Gonzaga Hospital University of Turin Orbassano Italy Nuclear Medicine Unit San Luigi Gonzaga Hospital University of Turin Orbassano Italy Medical science Department University A. Avogadro Novara Italy Nuclear Medicine Unit Umberto I Hospital Turin Italy

To the best of our knowledge no multicenter studies have been published using standardized semi-quantitative evaluation of [123I]FP-CIT scan (DAT-sPECT). The aims of this study were: 1) to cross-compare semi-quantitative software-assisted evaluations of DAT-sPECTs performed in three centers with different equipments;2) to assess the accuracy of semi-quantitative evaluations of DAT-sPECT and 3) to identify the threshold with the best accuracy, sensitivity and specificity in a patient population with suspected parkinsonian syndrome. Materials and Methods: Two hundred twenty patients (mean age at the time of sPECT acquisition, 67.4 ± 9.5 yy) acquired in three centers (Ospedale san Luigi Gonzaga;Ospedale san Giovanni Battista Molinette;Ospedale Mauriziano Umberto I) were included. All of them underwent DAT-sPECT from January 2006 to July 2010. All exams were analyzed with the freely available software BAsGAN and semi-quantitative data were used to predict disease. In particular, analyses were based on the values from the most deteriorated putamen and caudate, normalized for age and corrected for equipment. ROC analysis was performed and area under the curve (AUC) was estimated. Results: analysis showed high AUCs (0.898, 0.864, 0.900 and 0.891 for each center and for the multicenter setting, respectively) confirming the very good accuracies reached. The best cut-off were 0.72 and 0.82 for putamen and caudate respectively. These thresholds allowed sensitivities and specificities in each center and in the multicenter setting of 76% and 96%, 91% and 82%, 93% and 90%, 86% and 89% respectively. No significant differences were observed between sensibility and specificity in each center. Conclusion: A unique threshold useful for all centers with high and similar sensitivities and specificities is possible after correction for age and equipments. The high accuracy reached in this multicenter trial by the semi-quantitative analysis seems similar to accuracies from qualitative ana

关键词： Movement Disorder Parkinson Disease [123I]FP-CIT-sPECT semi-Quantitative Evaluation Multicenter study

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