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Tibolone Reverses NAfLD in Ovariectomised Rats by Reducing Adiposity and Insulin Resistance

Journal of Pharmacy and Pharmacology 2019年第4期7卷 148-164页

作者： Lilian Brites Campos-Shimada Eduardo Hideo Gilglioni Danielle Aparecida Munhos Hermoso ana Julia dos Reis Buzzo Rosangela fernandes Garcia Elismari Rizato Martins-Maciel Emy Luiza Ishii-Iwamoto Clairce Luzia Salgueiro-Pagadigorria Laboratory of Experimental Steatosis Department of BiochemistryState University of MaringáMaringá87020900Brazil Department of Physiological Sciences State University of MaringáMaringá87020900Brazil Department of Biomedicine Centro Universitario IntegradoCampo Mourao 87300970Brazil

This study aimed to investigate the effects of tibolone,a synthetic steroid,on several metabolic dysfunctions induced by oestrogen deficiency,in ***(OVX)rats were used as animal model of postmenopausal metabolic *** OVX rats were treated with daily doses of tibolone(0.16 mg/kg)and the results were compared with control(sham-operated)and OVX untreated *** reduced the adiposity and the visceral adipocyte size in OVX *** insulin sensitivity was also improved,and a decrease in the activity of the adipose tissue hormone-sensitive lipase enzyme was *** lower lipolysis by visceral adipocytes,associated with the recovery of peroxisomalβ-oxidation by tibolone may have contributed to the reversion of NAfLD in treated OVX *** reduction of liver lipid contents resulted in a general improvement in the liver redox *** addition,tibolone reduced the mitochondrial ROS generation and restored the activity of glucose-6-phosphate *** also exerted antioxidant effects on inguinal adipose *** exerted several beneficial effects on cellular and metabolic dysfunctions induced by ovariectomy in *** important mode of action of tibolone was the reduction of the visceral adipocyte size,corroborating the relationship between this one and the development and progression of several comorbidities associated with metabolic syndrome.

关键词： Tibolone ovariectomy hepatic steatosis obesity oxidativestress

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Clinical and Technological Dependence Characteristics on a Series of Brazilian Cases with Infantile Onset Pompe Disease in Enzyme Replacement Therapy

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Open Journal of Clinical Diagnostics 2019年第1期9卷 16-32页

作者： Paula De Almeida Thomazinho Eliana Pelissari Regina Celia Beltrao Duarte Carolina fishinger Moura De Souza Heloise Helena Siqueira Borges Maria Da Gloria Cruvinel Horta Liane De Rosso Giuliani ana Maria Martins Lilian Stewart Dafne Dain Gandelman Horovitz Juan Clinton Llerena Motor Physical Therapy Unit Fernandes Figueira National Institute/FIOCRUZRio de JaneiroBrazil Clinical Medical Unit Dr.Jeser Amarante Faria Children’s HospitalJoinvilleBrazil Pediatric Neurology Unit Santa Casa de Misericordia do Para FoundationBelemBrazil Sciences Medical Genetics Unit Service of Information on Inborn Errors of MetabolismHospital de Clínicas de Porto AlegrePorto AlegreBrazil Clinical Medical Unit University of Cuiaba UNICCuiabaBrazil Santa Casa de Belo Horizonte Belo HorizonteBrazil Genetics Unit Federal University of Mato Grosso do SulCampo GrandeBrazil Inborn Errors of Metabolism and Genetics Unit Federal University of São PauloUNIFESPSão PauloBrazil Pediatric Intensive Care Unit State Institute of Cardiology of Rio de JaneiroIECACRio de JaneiroBrazil 1 Medical Genetics Unit Fernandes Figueira National Institute of WomenChildren and Adolescent Health/FIOCRUZRio de JaneiroBrasil

Pompe disease (PD) is a rare inborn error of metabolism due to an abnormal acid alpha-glucosidase (GAA) activity that comprises glycogen breakdown mainly in the lysosomes. Since the introduction of enzyme replacement therapy (ERT), with recombinant human GAA for the early onset PD patient, a relevant field of clinical research due to the benefits regarding survival rate has been widely documented worldwide. Objective: To describe the clinical characteristics and the ERT effects in a series of Brazilian patients with infantile onset PD (IOPD) under ERT. Methods: Brazilian patients diagnosed with IOPD under ERT were recruited through their physicians participating in the International Pompe Disease Registry from 2009 to 2017. Data were collected by an online survey. Results: 10 IOPD patients were identified through the survey with a death rate of 30% and technology dependency rate reported as 80% (motor, respiratory or nutritional fields) of the patients. After the third year of ERT, motor disabilities were lost in 50% of ambulated patients. The overall characteristics were similar to international studies. Conclusion: Despite ERT benefits in cardiac involvement, motor disabilities seem to be much more compromised in IOPD patients, with high technology dependence, especially after three years of age.

关键词： Motor Development Child Disability Glycogen Storage Disease Type II Enzyme Replacement Therapy

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Punica granatum Leaf Lipophilic fraction favours Mortality by Attenuating Inflammation in Mice with Polymicrobial Sepsis

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Journal of Pharmacy and Pharmacology 2019年第7期7卷 355-367页

作者： Nagila Caroline fialho Sousa Isabella fernandes da Silva figueiredo Mizael Calacio de Araujo Elaine Pereira de Andrade Thais Costa Alves Bruna Letícia Rosa da Silva Domingos Magno Santos Pereira Saulo Josefigueiredo Mendes Joao francisco Silva Rodrigues Jaqueline Pessoa Pontes Simone Aparecida Teixeira AndreAlvares Marques Vale Marcus Vinicius Dias-Souza Lidio Goncalves Lima-Neto Vera Lucia dos Santos ana Paula Azevedo-Santos Marcelo Nicolas Muscara Valerio Monteiro-Neto Andrea de Souza Monteiro Luis Claudio Nascimento da Silva Elizabeth Soares fernandes Programa de Pos-graduacao Universidade CEUMARua JosueMontellon°1RenascencaSao LuisMA 65075-120Brazil Departamento de farmacologia Universidade de Sao PauloAv.Prof.Lineu Prestesn°1524Sala 326ButantanSao PauloSP 05508-900Brazil Programa de Pos-graduacao em Ciências em Saude Universidade Federal do MaranhaoAvenida dos Portuguesesn°1966BacangaSao LuisMA 65080-805Brazil Departamento de Microbiologia Universidade Federal de Minas GeraisAv.Antonio Carlosn°6627PampulhaBelo HorizonteMG 31270-901Brazil Departamento de Patologia Universidade Federal do MaranhaoAvenida dos Portuguesesn°1966BacangaSao LuísMA 65080-805Brazil

Punica granatum *** known antimicrobial and anti-inflammatory *** of different parts of this plant have been commonly used in the folk medicine to prevent and treat infections;and studies have supported the use of *** extracts for this ***,little is known of the effects of ***-derived fractions in severe infectious diseases such as ***,we investigated the actions of the hexane fraction(Hf),rich in lipophilic compounds,obtained from the leaves of this plant,in a murine model of polymicrobial *** pre-treatment with Hf increased mortality in septic *** same animals presented with lower levels of interleukin-6,nitric oxide and hydrogen peroxide in their peritoneal lavage samples than vehicle *** also increased polymorphonuclear cell accumulation in to the peritoneum of mice with ***-derived nitric oxide upon lipopolysaccharide stimuli was markedly reduced by incubation with ***,triterpenes,phytosterols,vitamin E and ascorbyl palmitate were detected in the *** results indicate that *** leaf lipophilic fractions may worsen sepsis *** effect may be associated with its bioactive compounds which act synergistically or not,increasing sepsis mortality in vivo.

关键词： P.granatum infection inflammation

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