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Unde.standing e.rlichia canis Infe.tions in Dogs of Costa Rica: He.atological Findings and Indicative.Clinical Signs

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Ope. Journal of Ve.e.inary Me.icine 2016年第11期6卷 163-175页

作者： Ale.ande. V. Barrante.-Gonzále. Ana E. Jiménez-Rocha Juan José Rome.o-Zuñiga Gaby Dolz Programa de.Inve.tigación e. Me.icina Poblacional Escuela de Medicina Veterinaria Universidad Nacional Heredia Costa Rica Laboratorio de.Parasitología Escuela de Medicina Veterinaria Universidad Nacional Heredia Costa Rica

Background: A cross-se.tional study combining diffe.e.t se.ological and mole.ular te.hnique. for the.de.e.tion of e.rlichia canis in dogs was carrie. out to de.e.mine.he.opathological findings and sugge.tive.clinical signs associate. with acute. subclinical and chronic infe.tions in the.dog population of Costa Rica. Obje.tive.: The.pre.e.t study de.cribe. and analyze., in a more.re.re.e.tative.sampling frame. the.clinical and he.atological pre.e.tation of e. canis infe.tion in dogs of Costa Rica in all its clinical stage.. Me.hods: A de.criptive.analysis of the.clinical signs was pe.forme. from a 441-dog sample. Se.ological and mole.ular te.hnique. for the.de.e.tion of e.rlichia canis in dogs we.e.applie.. One.and two-way ANOVA we.e.carrie. out to de.e.mine.the.e.fe.t of the.infe.tion status on the.he.atological parame.e.s. Re.ults: A total of 0.7% (3/407) dogs we.e.found with acute.(se.one.ative.but PCR positive., 29.7% (121/407) with subclinical (se.opositive.and PCR ne.ative., and 2.5% (10/407) with chronic (se.opositive.and PCR positive. e. canis infe.tions. Significant he.opathological findings we.e.de.e.mine. in dogs with acute.(thrombocytosis), subclinical and chronic (ane.ia, thrombocytope.ia, le.kope.ia) e. canis infe.tions. Conclusions: Future.studie. must de.e.mine.if dogs with subclinical e. canis infe.tions e.iminate. the.age.t without any me.ication, or if the. continue.to be.pe.siste.tly infe.te., and will de.e.op the.chronic dise.se.at some.point in the.r live..

关键词： e.rlichiosis e.ide.iology He.atopathology Infe.tious Dise.se Clinical Pathology

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Wate. yie.d and biomass production for on a e.calypt-dominate. Me.ite.rane.n catchme.t unde. diffe.e.t climate.sce.arios

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林业研究:英文版 2023年第5期34卷 1263-1278页

作者： Joao rocha ana Quinte.a Dalila Se.pa Jan Jacob Ke.ze. Sérgio Fabre. RAIZ-Fore.t and Pape. Re.e.rch Institute Quinta de S.FranciscoRua JoséEstevao(EN 230-1)3800–783 EixoAveiroPortugal De.artme.t of e.vironme.t and Planning Centre of Environmental and Marine Studies(CESAM)University of AveiroCampus Universitário de Santiago3810–193 AveiroPortugal

Worldwide.fore.ts are.vital in the.re.ulation of the.wate. cycle.re.ulation and in wate. balance.allocation.Knowle.ge.of e.ohydrological re.ponse. of production fore.ts is e.se.tial to support manage.e.t strate.ie.,e.pe.ially whe.e.wate. is alre.dy scarce.Shifting climatological patte.ns are.e.pe.te. to impact the.mopluviome.ric re.ime.,wate. cycle.compone.ts,hydrological re.ponse.,and plant physiology,e.apotranspiration rate.,crop productivity and land manage.e.t ope.ations.This work(1)asse.se. the.impacts of diffe.e.t pre.icte. climate.conditions on wate. yie.d;(2)infe.re. the.impacts of climate.change.on biomass production on e.calypt-to-e.calypt succe. sion.To this e.d,the.wide.y acce.te. Soil and Wate. Asse.sme.t Tool(SWAT)was run with the.RCA,HIRHAM5 and RACMO climate.mode.s for two e.ission sce.arios(RCP 4.5 and8.5).Thre. 12-ye.r pe.iods we.e.conside.e. to simulate.tre. growth unde. coppice.re.ime.The.re.ults re.e.le. an ove.all re.uction in stre.mflow and wate. yie.d in the.catchme.t in line.with the.proje.te. re.uction in total annual pre.ipitation.More.ve.,HIRHAM5 and RACMO mode.s fore.ast a slight shift in se.sonal stre.mflow of up to 2 months(for2024-2048)in line.with the.proje.te. incre.se.in pre.ipitation from May to Se.te.be..For biomass production,the.e.tre.e.climate.mode.(RCA)and se.e.e.e.is sion sce.ario(RCP 8.5)pre.icte. a de.re.se.up to 46%.Howe.e.,in the.le.s e.tre.e.and more.corre.ate.(with actual catchme.t climate.conditions)climate.mode.s(RACMO and HIRHAM5)and in the.le.s e.tre.e.e.ission sce.ario(RCP 4.5),biomass production incre.se.(up to 20%),and the.growth cycle.was slightly re.uce..SWAT was prove. to be.a valuable.tool to asse.s climate.change.impacts on a e.calypt-dominate. catchme.t and is a suitable.de.ision-support tool for fore.t manage.s.

关键词： Climate.sce.arios Fore.te. catchme.ts Fore.t e.ohydrological mode.ling e.calypt biomass production SWAT mode.

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Comparison of grain prote.n profile. of Brazilian cowpe. (Vigna unguiculata) cultivars base. on principal compone.t analysis

Food Production, Processing and Nutrition

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Food Production, Proce.sing and Nutrition 2022年第1期4卷 172-182页

作者： Tuany Camila Honaise. Gabrie.a Barbosa Rossi Maurisrae. de.Moura rocha ana Carolina Maisonnave.Arisi Food Scie.ce.and Te.hnology De.artme.t CAL CCA UFSCFederal University of Santa CatarinaRod.Admar GonzagaFlorianópolisSanta Catarina134688034-001Brazil e.brapa Me.o-Norte Caixa Postal 001TeresinaPiauí64008-780Brazil

This study aims to compare.the.grain prote.n profile.of four Brazilian cowpe. cultivars (BRS Aracê, BRS Itaim, BRS Paje., and BRS Xique.ique. by two-dime.sional e.e.trophore.is (2-De. and principal compone.t analysis (PCA). 2-De.e.ficie.tly se.arate.cowpe. prote.n profile., showing high homoge.e.ty among the.four cultivars. In addition, the.principal compone.t analysis indicate. that the.e.is a diffe.e.ce.in abundance.of prote.ns among the.cultivars. The.cultivars BRS Aracê and BRS Xique.ique. both biofortifie. in iron and zinc, we.e.se.arate. from the.cultivars BRS Itaim and BRS Paje.. The.e.re.ults de.onstrate.that prote.n profile. can be.use. to discriminate.cowpe. varie.ie..

关键词： Vigna 2-De PCA Le.ume.

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Risk Factors and Ge.de. Diffe.e.ce. for De.re.sion in Chile.n Olde. Adults:A Cross-Se.tional analysis from the.National He.lth Surve. 2016–2017

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Inte.national Journal of Me.tal He.lth Promotion 2022年第5期24卷 679-697页

作者： Gabrie.a Nazar Carlos-María Alcove. Ye.y Concha-Ciste.nas Igor Cigarroa Xime.a Díaz-Martínez Marie.a Gatica-Saave.ra Fabián Lanuza ana María Le.va-Ordónez María Ade.a Martínez-Sanguine.ti Mique. Martore.l Fanny Pe.e.mann-rocha Claudia Troncoso-Pantoja Carlos Ce.is-Morale. De.artame.to de.Psicología Facultad de Ciencias SocialesUniversidad de ConcepciónConcepciónChile Ce.tro de.Vida Saludable Universidad de ConcepciónConcepciónChile De.artame.to de.Psicología Facultad de Ciencias de la SaludUniversidad Rey Juan CarlosMadridEspaña Pe.agogía e. e.ucación Física Facultad de EducaciónUniversidad AutónomaTalcaChile e.cue.a de.Kine.iología Facultad de SaludUniversidad Santo TomásLosÁngelesChile Grupo de.Inve.tigación Calidad de.Vida Departamento de Ciencias de la EducaciónUniversidad del BiobíoChillánChile De.to de.Psiquiatría y Salud Me.tal Facultad de MedicinaUniversidad de ConcepciónConcepciónChile Ce.tro de.e.ide.iología Cardiovascular y Nutricional(e.ICYN) Facultad de MedicinaUniversidad de La FronteraTemucoChile Biomarke.s and Nutrime.abolomics Laboratory Department of NutritionFood Sciences and GastronomyFood Technology Reference Net(XIA)Nutrition and Food Safety Research Institute(INSA)Faculty of Pharmacy and Food SciencesUniversity of BarcelonaBarcelona08028Spain Instituto de.anatomía Histología y PatologíaFacultad de MedicinaUniversidad Austral de ChileValdiviaChile Instituto de.Farmacia Facultad de CienciasUniversidad Austral de ChileValdiviaChile De.artame.to de.Nutrición y Die.ética Facultad de Farmacia.Universidad de ConcepciónConcepciónChile Facultad de.Me.icina Universidad Diego PortalesSantiagoChile BHF Glasgow Cardiovascular Re.e.rch Ce.tre Institute of Cardiovascular and Medical SciencesUniversity of GlasgowGlasgowUK Ce.tro de.Inve.tigación e. e.ucación y De.arrollo(CIe.e.UCSC).De.artame.to de.Salud Pública Facultad de MedicinaUniversidad Católica de la Santísima ConcepciónConcepciónChile Laboratorio de.Re.dimie.to Humano Grupo de Estudio en EducaciónActividad Física y Salud(GEEAFyS)Universidad Católica del MauleTalcaChile

De.re.sive.disorde.s are.re.ognize. as one.of the.most common me.tal he.lth conditions across diffe.e.t age.groups.Howe.e.,the.risk factors associate. with de.re.sion among olde. pe.ple.from low-and middle.income.countrie. re.ains uncle.r.This study aims to ide.tify socio-de.ographic,he.lth and psychosocial-re.ate. factors associate. with de.re.sion in Chile.n olde. adults.A cross-se.tional study was carrie. out in a re.re.e.tative.sample.of 1,765 adults age.≥60 ye.rs participants from the.Chile.n National He.lth Surve. 2016–2017.De.re.-sion was asse.se. with the.Composite.Inte.national Diagnostic Inte.vie.(CIDI-SF).Associations be.we.n the.e.posure.variable. and de.re.sion we.e.inve.tigate. using Poisson re.re.sion analyse..The.mainﬁndings indi-cate. that wome. showe. highe. like.ihood of de.re.sion than me.(Pre.ale.ce.Ratio(PR)=2.6[95%CI:1.40;4.89]).An incre.se. like.ihood of de.re.sion was found in olde. adults with chronic pain,multimorbidity(≥2 dise.se.),pre.ious diagnose.of de.re.sion,high pe.ce.tion of stre.s,ﬁnancial stre.s,and difﬁcultie. for social par-ticipation.In wome.,highe. like.ihood of de.re.sion was found for those.with the.frailty phe.otype.PR:8.53[95%CI:1.68;43.32]),rhe.matoid arthritis(PR:2.41[95%CI:1.34;4.34]),insomnia(PR:2.99[95%CI:1.74;5.12])and low se.f-rate. we.l-be.ng(PR:4.94[95%CI:2.26;10.79]).Me. who we.e.divorce.(PR:7.10[95%CI:1.44;34.90])or widowe.(PR:10.83[95%CI:3.71;31.58]),obe.e.PR:5.08[95%CI:1.48;17.42])and who had asthma(PR:7.60[95%CI:2.31;24.99])we.e.associate. with highe. odds of de.re.sion.The.curre.tﬁndings may have.clinical implications for the.e.rly ide.tiﬁcation of olde. adults more.susce.tible.to de.re.sion and also sugge.t the.ne.d to imple.e.t cultural and age.se.sitive.strate.ie. to promote.me.tal he.lth in late.life.

关键词： De.re.sion olde. adults aging late.life.de.re.sion risk factors

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Ne.roinflammation and oxidative.stre.s act in conce.t to promote.ne.rode.e.e.ation in the.diabe.ic re.ina and optic ne.ve.gale.tin-3 participation

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Ne.ral Re.e.e.ation Re.e.rch 2020年第4期15卷 625-635页

作者： He.rique.rocha Me.donca Raul Carpi-Santos Karin da Costa Calaza ana Maria Blanco Martinez Laboratorio de.Ne.rode.e.e.acao e.Re.aro Departamento de PatologiaPrograma de Pos-graduacao em Anatomia PatologicaFaculdade de MedicinaHospital Universitrio Clementino Fraga FilhoFederal University of Rio de JaneiroRio de JaneiroBrazil Polo Unive.sitario Macae Unidade Integrada de Pesquisa em Produtos Bioativos e BiocienciasFederal University of Rio de JaneiroMacaeBrazil Laboratorio Inte.rado de.Morfologia Instituto de Biodiversidade e SustentabilidadeNucleo de Pesquisas Ecologicas de MacaeFederal University of Rio de JaneiroMacaeBrazil Laboratorio de.Ne.robiologia Ce.ular Instituto de Ciencias BiomedicasCentro de Ciencias da SaudeFederal University of Rio de JaneiroRio de JaneiroBrazil Laboratorio de.Ne.robiologia da Re.ina Departamento de NeurobiologiaPrograma de Pos-Graduacao em NeurocienciasFluminense Federal UniversityNiteroiBrazil

Diabe.e. is a life.ong dise.se.characte.ize. by glucose.me.abolic imbalance.in which low insulin le.e.s or impaire. insulin signaling le.d to hype.glyce.ic state.Within 20 ye.rs of diabe.e. progre.sion,95%of patie.ts will have.diabe.ic re.inopathy,the.le.ding cause.of visual de.e.ts in working-age.pe.ple.worldwide.Although diabe.e. is conside.e. a microvascular dise.se.re.e.t studie. have.shown that ne.rode.e.e.ation pre.e.e. vascular change. within the.diabe.ic visual syste.,albe.t its me.hanisms are.still unde. inve.tigation.Ne.roinflammation and oxidative.stre.s are.intrinsically re.ate. phe.ome.a,since.macrophage.microglia and astrocyte. are.the.main source. of re.ctive.oxyge. spe.ie. during ce.tral ne.vous syste. chronic de.e.e.ative.dise.se.,and both pathological proce.se. are.incre.se. in the.visual syste. during diabe.e..The.pre.e.t re.ie. will focus on re.e.t findings of the.contribution of oxidative.stre.s de.ive. from ne.roinflammation in the.e.rly ne.rode.e.e.ative.aspe.ts of the.diabe.ic visual syste. and the.r re.ationship with gale.tin-3.

关键词： diabe.e. diabe.ic re.inopathy gale.tin-3 ne.rode.e.e.ation ne.roinflammation optic ne.ve.oxidative.stre.s re.ina

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Dynamics of air transport ne.works：A re.ie. from a comple. syste.s pe.spe.tive

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Chine.e.Journal of Ae.onautics 2017年第2期30卷 469-478页

作者： Luis e.C.rocha De.artme.t of Public He.lth Scie.ce. Karolinska Institutet Stockholm 17177 Sweden De.artme.t of Mathe.atics University of Namur 5000 Belgium

Air transport syste.s are.highly dynamic at te.poral scale. from minute. to ye.rs.This dynamic be.avior not only characte.ize. the.e.olution of the.syste. but also affe.t the.syste.＇s functioning.Unde.standing the.e.olutionary me.hanisms is thus fundame.tal in orde. to be.te. de.ign optimal air transport ne.works that be.e.its companie.,passe.ge.s and the.e.vironme.t.In this re.ie.,we.brie.ly pre.e.t and discuss the.state.of-the.art on time.e.olving air transport ne.works.We.distinguish the.structural analysis of se.ue.ce. of ne.work snapshots,ide.l for long-te.m ne.work e.olution（e.***.annual e.olution）,and te.poral paths,pre.e.re. for short-te.m dynamics（e.***.hourly e.olution）.We.e.phasize.that most pre.ious re.e.rch focuse. on the.first mode.ing approach（i.***.long-te.m） whe.e.s only a fe. studie. look at high-re.olution te.poral paths.We.conclude.the.re.ie. highlighting that much re.e.rch re.ains to be.done.both to apply alre.dy available.me.hods and to de.e.op ne. me.sure. for te.poral paths on air transport ne.works.In particular,we.ide.tify that the.study of de.ays,ne.work re.ilie.ce.and optimization of re.ource.（aircraft and cre.） are.critical topics.

关键词： Air transport Airport ne.work Comple. ne.work Dynamic ne.work Te.poral ne.work

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The.road to sustainable.use.and waste.manage.e.t of plastics in Portugal

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Frontie.s of e.vironme.tal Scie.ce.& e.gine.ring 2022年第1期16卷 91-106页

作者： Joana C.Prata ana LPatrício Silva Armando CDuarte.Te.e.a rocha-Santos Ce.tre.for e.vironme.tal and Marine.Studie.(Ce.AM)&De.artme.t of Che.istry University of Aveiro3810-193 AveiroPortugal Ce.tre.for e.vironme.tal and Marine.Studie.(Ce.AM)&De.artme.t of Biology University of Aveiro3810-193 AveiroPortugal

As a e.rope.n Union(e.)me.be.,Portugal must comply with re.uctions in plastic waste.In Portugal,the.330 ite.s/100 m of be.ch litte.,comprising up to 3.9 million pie.e. and of which 88%is plastic,is highe. than the.e. me.ian(149 ite.s/100 m)and must be.re.uce. to 20 ite.s/100 m(94%).Inte.rative.me.sure. are.ne.de. to re.uce.litte.ing and improve.plastics’use.and disposal unde. the.circular e.onomy.Of this 414 kt of plastic packaging waste.163 kt we.e.de.lare. plastic packaging,140 kt subje.te. to re.ycling,and 94 kt to e.e.gy re.ove.y.The.curre.t re.ycling rate.of plastic packaging(34%)should be.improve. to re.ch e. re.ycling ave.age.(42%)and goals and to provide.wide.pre.d be.e.its,conside.ing re.e.ue. of 167€/t.As a ne. importe. of waste.Portugal could be.e.it from the.valorization of importe. waste.Be.ide. incre.se. re.ycling,pyrolysis and gasification could provide.short-te.m alte.native. for producing value.adde. substance. from plastic waste.such as hydroge.,consiste.t with the.National Plan of Hydroge. and improving ongoing re.ulations on single.use.plastics.This manuscript provide. an inte.rative.vie. of plastics in Portugal,from use.to disposal,providing spe.ific re.omme.dations unde. the.circular e.onomy.

关键词： Single.use.plastics Plastic packaging Plastic waste Waste.manage.e.t Waste.shipme.t Lightwe.ght plastic bags

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Past,pre.e.t and future.of pre.e.ving and re.toring function in the.visual syste.:re.oving gale.tin-3 as a promising tre.tme.t

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Ne.ral Re.e.e.ation Re.e.rch 2017年第1期12卷 58-59页

作者： Silmara de.Lima He.rique.rocha Me.donca Camila Olive.ra Goulart ana M.Blanco Martinez Laboratorie. for Ne.roscie.ce.Re.e.rch in Ne.rosurge.y and F.M.Kirby Ne.robiology Ce.te. Children's Hospital BostonDepartmentsof Surgery and Ophthalmology and Program in NeuroscienceHarvard Medical SchoolBostonMAUSA Laboratorio de.Ne.rode.e.e.acao e.Re.aro-De.artame.to de.Patologia-Faculdade.de.Me.icina-HUCFF-UFRJ-Rio de.Jane.ro-RJ Brazil Polo Unive.sitairio Macae UFRJMacaeRJBrazil

Gre.t advance. in re.inal ganglion ce.ls survival（RGCs）,optic ne.ve.pre.e.vation and re.e.e.ation have.be.n made.in the.past 15ye.rs.Nowadays,we.know that RGCs are.capable.of re.e.e.ating the.full le.gth of the.opti... 详细信息

关键词： RGCs pre.e.ving re.e.e.ation pre.e.vation gale.tin re.oving optic capable.ganglion microglia

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Pe.toxifylline.e.hance. the.prote.tive.e.fe.ts of hype.tonic saline.solution on live. ische.ia re.e.fusion injury through inhibition of oxidative.stre.s

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He.atobiliary & Pancre.tic Dise.se. Inte.national 2015年第2期14卷 194-200页

作者： Vinicius rocha-Santos e.te.a RR Figue.ra Joe. A rocha-Filho ana MM Coe.ho Rafae. Sorae. Pinhe.ro Te.e.foro Bacche.la Marce. CC Machado Luiz AC D'Albuque.que De.artme.t of Gastroe.te.ology Laboratory of Medical Investigations LIM37 Discipline of Liver and Gastrointestinal Transplantation Hospital das Clinicas University of Sao Paulo School of Medicine Discipline.of Ane.the.iology Hospital das Clinicas University of Sao Paulo School of Medicine De.artme.t of Gastroe.te.ology Laboratory of Medical Investigations LIM37 Discipline of Liver and Gastrointestina Hospital das Clinicas University of Sao Paulo School of Medicinel Transplantation

BACKGROUND：Live. ische.ia re.e.fusion（IR）injury trigge.s a syste.ic inflammatory re.ponse.and is the.main cause.of organ dysfunction and adve.se.postope.ative.outcome. afte. live. surge.y.Pe.toxifylline.PTX）and hype.tonic saline.solution（HTS）have.be.n ide.tifie. to have.be.e.icial e.fe.ts against IR injury.This study aime. to inve.tigate.if the.addition of PTX to HTS is supe.ior to HTS alone.for the.pre.e.tion of live. IR injury.Me.HODS： Male.Wistar rats we.e.allocate. into thre. groups. Control rats unde.we.t 60 minute. of partial live. ische.ia, HTS rats we.e.tre.te. with 0.4 mL/kg of intrave.ous 7.5% NaCl 15 minute. be.ore.re.e.fusion, and HPTX group we.e.tre.te. with 7.5% NaC1 plus 25 mg/kg of PTX 15 minute. be.ore.re.e.fusion. Sample. we.e.colle.te. afte. re.e.fusion for de.e.mination of ALT, AST, TNF-α, IL-6, IL-10, mitochondrial re.piration, lipid pe.oxidation, pulmonary pe.me.bility and mye.ope.oxidase. Re.ULTS： HPTX significantly de.re.se. TNF-α 30 minute. afte. re.e.fusion. HPTX and HTS significantly de.re.se. ALT,AST, IL-6, mitochondrial dysfunction and pulmonary mye.o- pe.oxidase.4 hours afte. re.e.fusion. Compare. with HTS only, HPTX significantly de.re.se. he.atic oxidative.stre.s 4 hours afte. re.e.fusion and pulmonary pe.me.bility 4 and 12 hours afte. re.e.fusion. CONCLUSION： This study showe. that PTX adde. the.be.e.icial e.fe.ts of HTS on live. IR injury through de.re.se. of he.atic oxidative.stre.s and pulmonary pe.me.bility.

关键词： pe.toxifylline hype.tonic saline.solution he.atic oxidative.stre.s ische.ia re.e.fusion injury pulmonary pe.me.bility

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Re.in angiote.sin syste. in live. dise.se.: Frie.d or foe.

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World Journal of Gastroe.te.ology 2017年第19期23卷 3396-3406页

作者： ana Cristina Simoe. e.Silva Aline.S Miranda Natália P rocha Antonio L Te.xe.ra De.artme.t of Pe.iatrics Faculty of MedicineFederal University of Minas Gerais Inte.disciplinary Laboratory of Me.ical Inve.tigation Faculty of MedicineUFMG Laboratory of Ne.robiology Department of MorphologyInstitute of Biological SciencesUFMG Ne.ropsychiatry Program Department of Psychiatry and Behavioral SciencesMcGovern Medical SchoolUniversity of Texas Health Science Center at Houston

In the.last thre. de.ade.,the.unde.standing of the.re.in angiote.sin syste.(RAS)has be.n change. by the.discove.ie. of functional local syste.s,nove. biologically active.pe.tide.,additional spe.ific re.e.tors,alte.native.pathways of angiote.sin(Ang)?Ⅱ?ge.e.ation,and ne. role. for e.zyme. and pre.ursor compone.ts othe. than those.in Ang?Ⅱ?synthe.is.In this re.ard,the.discove.y that Ang-(1-7)oppose. the.pre.sor,prolife.ative.pro-fibrotic,and pro-inflammatory e.fe.ts me.iate. by Ang?Ⅱ?has contribute. to the.re.lization that the.RAS is compose. of two axe..The.first axis consists of the.angiote.sin-conve.ting e.zyme.ACe.,with Ang?Ⅱ?as the.e.d product,and the.angiote.sin type.1(AT1)re.e.tor as the.main e.fe.tor me.iating the.biological actions of Ang?Ⅱ.The.se.ond axis re.ults from ACe.-me.iate. hydrolysis of Ang?Ⅱ,le.ding to the.production of Ang-(1-7),with the.Mas re.e.tor as the.main e.fe.tor conve.ing the.vasodilatory,antiprolife.ative.anti-fibrotic,and anti-inflammatory e.fe.ts of Ang-(1-7).e.pe.ime.tal and clinical studie. have.shown that both axe. of the.RAS may take.part in the.pathoge.e.is of live. dise.se..In this manuscript,we.summarize.the.curre.t e.ide.ce.re.arding the.role.of RAS in he.atic cirrhosis and its complications,including he.odynamic change. and he.atore.al syndrome.The.the.ape.tic pote.tial of the.modulation of RAS mole.ule. in live. dise.se. is also discusse..

关键词： Re.in angiote.sin syste. Angiote.sin Ⅱ Angiote.sin-(1-7) He.atic cirrhosis Live. fibrosis He.atore.al syndrome

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