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The Influence of Sound Deprivation on Audiologic Outcomes after Cochlear Implantation

International Journal of clinical Medicine 2018年第1期9卷 28-38页

作者： Maria Stella Arantes do Amaral ana cláudia mirandola barbosa reis Henrique F. Pauna Sarah C. Bernal Eduardo T. Massuda Miguel Angelo Hyppolito Department of Ophthalmology Otorhinolaryngology Head and Neck Surgery Ribeir&atilde o Preto Medical School University of S&atilde o Paulo (FMRP-USP) Ribeir&atilde o Preto S&atilde o Paulo Brazil

The cochlear implant is a prosthesis that is capable to replace listening capability among patients with sensorineural hearing loss. Many studies suggest a negative relationship among duration of sound deprivation and audiometric gain (by means of speech perception test) after cochlear implantation. We evaluated surgical and audiologic results among post-lingual deafened adults, in different times of sound deprivation, and correlated with social isolation, presence of vertigo or tinnitus, and the speech therapy yield, between pre- and post-operative stages. A retrospective study was conducted on patients with post-lingual hearing loss, aged over 18 years old who underwent cochlear implant surgery in a public hospital from 2004 to 2014. Audiological, socio-demographic questionnaire, and manifestations of vertigo and tinnitus, during pre- and post-operative stages, were compared and correlating to the different periods of sound deprivation. Two groups were studied. The group A was composed of 38 participants (14 male and 24 female) with sound deprivation of less than 10 years;and group B was composed of 17 participants (8 male and 9 female) with sound deprivation longer than 10 years. We found no differences regarding age, sex, duration of sound deprivation, mean pure-tone audiometric results (pre- and post-surgery), and speech perception tests (pre-operatively). After one year of the surgery, we observed a significant difference between both groups, with a better performance to group A. The results of speech perception test, after cochlear implantation in group B, were worse than the results obtained in group A, although these correlations are not determinant whether to perform cochlear implant surgery or not.

关键词： Audiometry Cochlear Implantation Sensorineural Hearing Loss Sound Deprivation Deafness

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Cochlear Implant in a Patient with Arnold-Chiari Syndrome

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Case Reports in clinical Medicine 2018年第2期7卷 162-167页

作者： Maria Stella Arantes do Amaral Daniela Soares Fonseca Antonio Carlos dos Santos Henrique Furlan Pauna Eduardo T. Massuda ana cláudia mirandola barbosa reis Miguel Angelo Hyppolito Department of Ophthalmology Otorhinolaryngology Head and Neck Surgery Ribeir&#227 o Preto Medical School University of S&#227 o Paulo S&#227 o Paulo Brazil Postgraduate Program in Oftalmology Otorrhinolaryngology and Head and Neck Surgery of the FMRP/USP-Medical Sciences Department of Ophthalmology Otorhinolaryngology Head and Neck Surgery Ribeir&#227 o Preto Medical School University of S&#227 o Paulo S&#227 o Paulo Brazil Department of clinical Medicine (Center of Image Sciences and Medical Physics) Ribeir&#227 o Preto Medical School University of S&#227 o Paulo S&#227 o Paulo Brazil Department of Health Sciences RCS—Ribeir&#227 o Preto Medical School University of S&#227 o Paulo S&#227 o Paulo Brazil

Objective: To verify the efficacy of cochlear implantation in a patient with Arnold-Chiari syndrome. Design: Review of a medical chart from a patient with Arnold-Chiari syndrome that underwent to cochlear implant surgery. Case report: A 6 year-old female, with meningomyelocele and congenital hydrocephalus, deaf in the past 3 years, after meningitis. At that time, she used oral language with adequate speech development. Tone audiometry revealed bilateral profound sensorineural hearing loss. The MRI was compatible with the Arnold-Chiari syndrome. Cochlear implantation was performed on the left ear with MED-EL? Implant (model SONATATi100). Currently, the child is 12 year-old, performs speech therapy three times a week, with good hearing and language development. Conclusion: Despite the presence of Arnold-Chiari syndrome (Chiari type II) with neurological disorders and with ventriculoperitoneal shunt, patient had good hearing results after cochlear implant surgery.

关键词： Audiometry Cochlear Implant Sensorineural Hearing Loss Arnold-Chiari Syndrome Deafness Central Nervous System Malformation

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Urea breath test for Helicobacter pylori infection in adult dyspeptic patients: A meta-analysis of diagnostic test accuracy

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World Journal of Gastroenterology 2024年第6期30卷 579-598页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Marcel Silva Luz Gabriel reis Rocha Gabriel Lima Correa Santos Luís Guilherme de Oliveira Silva Mariana Santos Calmon cláudio Lima Souza ana Carla Zarpelon-Schutz Kádima Nayara Teixeira Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Instituto de Saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919-899ParanáBrazil Laboratory of Research in Bacteriology UFMGBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Helicobacter pylori(***)infection has been well-established as a significant risk factor for several gastrointestinal *** urea breath test(UBT)has emerged as a leading non-invasive method for detecting *** numerous studies confirming its substantial accuracy,the reliability of UBT results is often compromised by inherent *** findings underscore the need for a rigorous statistical synthesis to clarify and reconcile the diagnostic accuracy of the UBT for the diagnosis of *** *** To determine and compare the diagnostic accuracy of 13C-UBT and 14C-UBT for *** infection in adult patients with *** We conducted an independent search of the PubMed/MEDLINE,EMBASE,and Cochrane Central databases until April *** search included diagnostic accuracy studies that evaluated at least one of the index tests(^(13)C-UBT or ^(14)C-UBT)against a reference *** used the QUADAS-2 tool to assess the methodo-logical quality of the *** utilized the bivariate random-effects model to calculate sensitivity,specificity,positive and negative test likelihood ratios(LR+and LR-),as well as the diagnostic odds ratio(DOR),and their 95%confidence *** conducted subgroup analyses based on urea dosing,time after urea administration,and assessment *** investigate a possible threshold effect,we conducted Spearman correlation analysis,and we generated summary receiver operating characteristic(SROC)curves to assess ***,we visually inspected a funnel plot and used Egger’s test to evaluate publication *** both as reliable diagnostic tools in clinical *** In summary,our study has demonstrated that ^(13)C-UBT has been found to outperform the ^(14)C-UBT,making it the preferred diagnostic ***,our results emphasize the significance of carefully considering urea dosage,assessment timing,and measurement techniques for both tests to enh

关键词： Helicobacter pylori Urea breath test Diagnosis Diagnostic test accuracy Meta-analysis

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Design multifunctional Mg–Zr coatings regulating Mg alloy bioabsorption

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Journal of Magnesium and Alloys 2024年第4期12卷 1461-1478页

作者： Zohra Benzarti Sandesh Itani JoséDavid Castro Sandra Carvalho ana Sofia Ramos University of Coimbra CEMMPREARISEDepartment of Mechanical EngineeringRua Luís Reis Santos3030-788CoimbraPortugal Laboratory of Multifunctional Materials and Applications(LaMMA) Department of PhysicsFaculty of Sciences of SfaxUniversity of SfaxSoukra Road km 3.5B.P.1171Sfax3000Tunisia

Magnesium(Mg)alloys are widely used for temporary bone implants due to their favorable biodegradability,cytocompatibility,hemocompatibility,and close mechanical properties to ***,rapid degradation and inadequate strength limit their *** overcome this,the direct current magnetron sputtering technique is employed for surface coating in Mg-based alloys using various zirconium(Zr)*** approach presents a promising strategy for simultaneously improving corrosion resistance,maintaining biocompatibility,and enhancing strength without compromising *** leveraging Mg’s inherent biodegradability,it has the potential to minimize the need for secondary surgeries,thereby reducing costs and *** paper is a systematic study aimed at understanding the corrosion mechanisms of Mg–Zr coatings,denoted Mg-xZr(x=0–5 at.%).Zr-doped coatings exhibited columnar growth leading to denser and refined structures with increasing Zr *** analysis confirmed the presence of the Mg(00.2)basal plane,shifting towards higher angles(1.15°)with 5 at.%Zr doping due to lattice parameter changes(i.e.,decrease and increase of“c”and“a”lattice parameters,respectively).Mg–Zr coatings exhibited“liquidphilic”behavior,while Young’s modulus retained a steady value around 80 GPa across all ***,the hardness has significantly improved across all samples’coating,reaching the highest value of(2.2±0.3)GPa for 5 at.%*** testing in simulated body fluid(SBF)at 37℃ revealed a significant enhancement in corrosion resistance for Mg–Zr coatings containing 1.0–3.4 at.%*** with the 5 at.%Zr coating which exhibited a corrosion rate of 32 mm/year,these coatings displayed lower corrosion rates,ranging from 1 to 12 mm/*** synergistic enhancement in mechanical properties and corrosion resistance,achieved with 2.0–3.4 at.%Zr,suggests potential ability for reducing stress shielding and controlled degradation performance,and consequentl

关键词： Mg-Zr coatings Magnetron sputtering Nanoindentation Corrosion resistance Bone implants

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An Outlook on Implantable Biosensors for Personalized Medicine

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Engineering 2021年第12期7卷 1696-1699页

作者： Rita Rebelo ana Isabel barbosa Vitor M.Correlo Rui L.reis Research Institute on Biomaterials Biodegradablesand BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineBarcoGuimarães 4805-017Portugal ICVS/3B’s-PT Government-Associated Laboratory BragaGuimarães 4710-057Portugal

Biosensors are a fast-growing field,as they have been shown to be very helpful in our daily life,playing roles in industries such as agriculture,food safety,homeland security,bioprocessing,environmental monitoring,and industrial *** these,the application of biosensing in medicine and biomedical engineering may have the highest potential for growth and for affecting human quality of life in the near *** potential is driven by the need for new and improved devices and technologies with improved sensitivity,specificity,reliability,and biocompatibility.

关键词： Outlook specificity playing

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Impact of Drug-Drug Interaction between CDK4/6 Inhibitors and Proton Pump Inhibitors on Survival Outcomes in the Treatment of Metastatic Breast Cancer—Real World Data from a Portuguese Center

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Journal of Cancer Therapy 2022年第5期13卷 266-274页

作者： Joana reis Inês Costa Mariana Costa ana Valente Catarina Almeida Marta Freitas cláudia Caeiro Catarina Fernandes Nuno Tavares Miguel barbosa Centro Hospitalar SÃ O JOÃ O E.P.E. Porto Portugal

Introduction: Proton pump inhibitors (PPi) are widely prescribed, including in patients undergoing treatment for advanced breast cancer (ABC). Due to the pharmacokinetic characteristics of the CDK4/6 inhibitor (Ci) palbociclib a drug interaction with PPi was hypothesized. It was shown in a retrospective study that this association was an independent predictive factor for worse progression-free survival (PFS). Objective: To verify the impact of concomitant administration of PPi with Ci on overall survival (OS) and PFS. Material and Methods: This is a retrospective cohort study of patients treated with Ci for HR+HER2-ABC in the period from Feb/2017 to Aug/2020. SPSS software was used for data processing. Univariate analysis was done by the Kaplan-Meier method and log-rank test, and multivariate analysis by COX regression. P-value cluded. The median age at diagnosis of ABC was 56 years (25 - 75). Treatment with Ci was 1st line for ABC in 68.8%. Choice of Ci was palbociclib in 73.8% (n = 59) and ribociclib in 26.3% (n = 21). The hormone partner was a nonsteroidal aromatase inhibitor in 45.0%, and fulvestrant in 55.0% of cases. 37.5% of patients were on PPi, and 70.0% of them were during the entire treatment (23.3% omeprazole, 73.4% pantoprazole, 3.3% others). Patients taking concomitant PPi and Ci had lower OS (OS-3 years 42.6% vs. 63.4%, p = 0.254) and PFS (PFS med 15 m. vs. 21 m., p = 0.733), although with no statistically significant difference. Discussion: In the sample, there was a numerical difference, without the statistical significance in the use of PPi in the survival of patients under Ci. This difference could be more evident with a longer follow-up and a larger sample size. This study intends to alert to the growing importance of checking for drug interactions. Polymedication, advanced age and the presence of several comorbidities are real problems in patients with ABC. Conclusion: Real-world dat

关键词： Drug Interaction Survival Impact Advanced Breast Cancer CDK4/6 Inhibitors Proton Pump Inhibitors

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Changes in social emotion recognition following traumatic frontal lobe injury

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Neural Regeneration Research 2012年第2期7卷 101-108页

作者： ana Teresa Martins Luis Faísca Francisco Esteves cláudia Simo Mariline Gomes Justo Angélica Muresan Alexandra reis Department of Psychology University of Algarve Lisbon Universitary Institute

Changes in social and emotional behaviour have been consistently observed in patients with traumatic brain injury. These changes are associated with emotion recognition deficits which represent one of the major barriers to a successful familiar and social reintegration. In the present study, 32 patients with traumatic brain injury, involving the frontal lobe, and 41 age- and education-matched healthy controls were analyzed. A Go/No-Go task was designed, where each participant had to recognize faces representing three social emotions （arrogance, guilt and jealousy）. Results suggested that ability to recognize two social emotions （arrogance and jealousy） was significantly reduced in patients with traumatic brain injury, indicating frontal lesion can reduce emotion recognition ability. In addition, the analysis of the results for hemispheric lesion location （right, left or bilateral） suggested the bilateral lesion sub-group showed a lower accuracy on all social emotions.

关键词： traumatic brain injury facial emotion recognition social emotions

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Long Latency Auditory Potential(P300)Outcomes in a Patient with Vestibular Schwannoma after Cochlear Implant Surgery

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Case Reports in clinical Medicine 2018年第5期7卷 343-348页

作者： Maria Stella Arantes do Amaral Victor Goiris Calderaro Henrique Furlan Pauna Eduardo Tanaka Massuda ana claudia mirandola barbosa reis Miguel Angelo Hyppolito Department of Ophthalmology OtorhinolaryngologyHead and Neck SurgeryRibeirao Preto Medical SchoolUniversity of Sao PauloRibeirao PretoSao PauloBrazil Postgraduate Program at the Department of Ophthalmology OtorhinolaryngologyHead and Neck SurgeryRibeirao Preto Medical SchoolUniversity of Sao PauloRibeirao PretoSao PauloBrazil Department of Health Sciences—RCS—Ribeirao Preto Medical School University of Sao PauloRibeirao PretoSao PauloBrazil Postgraduate Program at the Department of Health Sciences—RCS—Ribeirao Preto Medical School University of Sao PauloRibeirao PretoSao PauloBrazil

Background: Neurofibromatosis type 2 (NF2) is a rare syndrome and it is usually presented with bilateral vestibular schwannomas (VS), multiple meningiomas, and other types of tumors associated to peripheral nerves. Hearing loss is one of its leading manifestations, and surgery for removal of the tumor is often required. Cochlear implant (CI) surgery is an option for auditory rehabilitation and long latency auditory potentials (P300) are becoming a very useful tool to assess hearing outcomes. Objective: To verify the presence of P300 waves during auditory and cortical function assessment in a patient submitted to VS removal and CI surgery. Design: Retrospective chart review. Case Report: A 62 years old male patient, presented at the clinic with a bilateral severe to profound hearing loss, worst at the right side. MRI scan revealed bilateral expansive tumor within the internal auditory canal expanding to cerebellopontine angle, suggestive of VS. Tumor was removed at the right side, and CI surgery was indicated for the left ear. P300 tests were performed pre-operatively, at the moment of activation, and 6 months post-operatively. After CI activation, P300 waves appeared, and presented reduced latency and increased amplitude after 6 months of CI use. Conclusion: P300 waves appear to be dependent on the auditory stimulus to be generated, showing that it can be a useful tool to estimate improvement in cortical cognitive function after restoring hearing through CI surgery after VS removal.

关键词： Audiometry Cochlear Implant Sensorineural Hearing Loss Deafness Schwannoma

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How do greenhouse gas emissions vary with biofertilizer type and soil temperature and moisture in a tropical grassland?

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Pedosphere 2020年第5期30卷 607-617页

作者： Abmael da Silva CARDOSO Juliana Bega JUNQUEIRA Ricardo Andrade reis ana claudia RUGGIERIAnimal Science Departament College of Agricultural and Veterinarian SciencesSao Paulo State UniversityJaboticabal 14884-900(Brazil) Kenji Agricultural and Environmental Consultancy Ribeirdo Preto 14010-079(Brazil)

Greenhouse gases are known to play an important role in global *** this study,we determined the effects of selected soil and climate variables on nitrous oxide(N2O),methane(CH4),and carbon dioxide(CO2)emissions from a tropical grassland fertilized with chicken slurry,swine slurry,cattle slurry,and cattle *** N2O emissions did not differ between treatments and varied from 29.26 to 32.85 mg N m^-***,cumulative CH4 emissions were not significantly different among the treatments and ranged from 6.34 to 57.73 mg CH4 m^-*** and compost application induced CO2 emissions that were significantly different from those in the control *** CH4 conversion factors measured were 0.21%,1.39%,4.39%,and 5.07%for cattle compost,chicken slurry,swine slurry,and cattle slurry,respectively,differing from the recommendations of the Intergovernmental Panel on climate Change(IPCC).The fraction of added Nemitted as N2O was 0.39%,which was lower than the IPCC default value of 2%.Our findings suggest that N2O emissions could be mitigated by replacing synthetic fertilizer sources with either biofertilizer or *** results indicate the following:N2O emission was mainly controlled by soil temperature,followed by soil moisture and then soil NH^"content;CH4 fluxes were mainly controlled by soil moisture and chamber headspace temperature;and CO2 fluxes were mainly controlled by chamber headspace temperature and soil moisture.

关键词： emission factor methane conversion factor methane oxidation methane production capacity slurry fertilizer soil moisture

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^(222)Rn calibration procedure for water analyses by liquid scintillation counting

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辐射探测技术与方法(英文) 2023年第2期7卷 311-319页

作者： ana Rita Gomes Sérgio Dias anabela Mourato Joao Abrantes Mário reis Laboratório de Protecao e Seguranca Radiológica Instituto Superior TécnicoUniversidade de LisboaEstrada Nacional 10km 13972695‑066 Bobadela LRSPortugal Laboratórios de Massa e Massa Volúmica de Sólidos Instituto Portugues da QualidadeRua António Giao22829‑513 CaparicaPortugal Centro de Ciências e Tecnologias Nucleares Instituto Superior TécnicoUniversidade de LisboaEstrada Nacional 10km 13972695‑066 Bobadela LRSPortugal

Purpose Among the several methods to measure ^(222)Rn in water,the liquid scintillation counting(LSC)technique is one of the most sensitive and widely used when analysing non-saline waters by liquid extraction,providing excellent accuracy,precision and low-level detection *** using the liquid scintillation counter Tri-Carb 3170 TR/SL(Perkin-Elmer)it is not possible to make an automatic determination of the alpha/beta discrimination parameter,being necessary to evaluate the pulse decay discriminator(PDD)value manually to the ^(222)Rn *** this work,we describe the steps to perform the calibration of that type of *** The method consists in the preparation of standard samples from a ^(226)Ra certified standard solution and the adjustment of the PDD value by hand until the percentage of alpha events reaches a plateau of a near-constant fraction of total *** process consists in taking several measures between PDD 80 and 200 with 15 min counting time *** the plateau,the alpha/beta ratio was used to determine the plateau final range as well as the optimum PDD *** that,the calibration standards and blanks were measured and the region of interest(ROI)was established by finding the maximum value for the figure of merit(FOM)in the upper and lower *** The optimal PDD value of 148 was established by the alpha/beta ratio,and after that,it was possible to measure ^(226)Ra standards to perform the *** efficiency of(9.758±0.035)×1^(0-1) was *** routine measurements,a detection limit of about 0.50 Bq L^(-1) is achieved for a 120 min counting *** evaluate the uncertainty budget,the uncertainties of the net count rate,the efficiency,the sample amount and the decay correction factor were *** A method was developed for the calibration of LSC Tri-Carb 3170 TR/SL with the optimization of the PDD using a ^(226)Ra standard *** acquisition to obtain the plot of the variation

关键词： Radon Waters Pulse decay discriminator Liquid scintillation counting Calibration

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