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Prevalence of sarcopenia using different methods in patients with non-alcoholic fatty liver disease

World Journal of Hepatology 2022年第8期14卷 1643-1651页

作者： Naiade Silveira Almeida Raquel Rocha Claudineia Almeida de Souza ana carolina Sirelli da Cruz Bruna dos Reis Ribeiro Luiza Valois Vieira Carla Daltro Rafael Silva Manoel Sarno Helma Pinchemel Cotrim Programa de Pós-Graduação em Medicina e Saúde Universidade Federal da BahiaSalvador 40110-060BABrazil Departamento de Ciência da Nutrição Escola de NutriçãoUniversidade Federal da BahiaSalvador 40110-060Brazil Caliper Clínica e Escola de Imagem Salvador 41810-012Brazil

BACKGROUND Sarcopenia is a clinical condition associated with several liver diseases and it includes non-alcoholic fatty liver disease(NAFLD)in its broad spectrum as steatosis,steatohepatitis and ***,the criteria to define sarcopenia are diverse,and even those established in consensus have been discussed regarding their performance in making an accurate *** To evaluate the prevalence of sarcopenia,using different methods,in patients with NAFLD,and its association with clinical-anthropometric *** This was an observational study of outpatients with *** was defined by the European Working Group Consensus on Sarcopenia in Older People of 2010(EWGSOP1)and 2018(EWGSOP2).The skeletal muscle index was used to estimate muscle mass,handgrip strength was assessed using the dynamometer and physical performance by walking a distance of four meters at usual walking *** non-invasive fibrosis scores,fibrosis-4(FIB-4)index and Aspartate aminotransferase to platelet ratio index(APRI),were used to assess the absence and presence of *** Fifty-seven individuals with NAFLD were evaluated,the mean age(SD)was 52.7(11.3)years and 75.4%were *** assessed by FIB-4 and APRI was observed in 3.7%and 16.6%of patients with NAFLD,*** diagnosis of sarcopenia was identified only by EWGSOP1 in 3.5%of NAFLD patients,and the prevalence of probable/pre-sarcopenia was higher using the EWGSOP2 consensus at 26.3%,when compared to 1.8%with *** defined by EWGSOP1,was associated with grade I steatosis,but without overweight(P0.05).EWGSOP2 showed a greater number of patients with probable sarcopenia,and who were overweight(12(80.0%)),with a higher degree of steatosis[11(73.3%)and presence of fibrosis(1(6.7%),FIB-4 and 3(20.0%),APRI]compared to EWGSOP1[1(100%),0(0.0%),0(0.0%),FIB-4 and 0(0.0%),APRI,respectively].CONCLUSION The presen

关键词： Non-alcoholic fatty liver disease Sarcopenia Muscle strength Physical performance Liver fibrosis

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Co-expression of HBZ,TAX and FOXp3 and HTLV-1-associated myelopathy/tropical spastic paraparesis development in HTLV-1-infected individuals:A systematic review

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Asian Pacific Journal of Tropical Medicine 2021年第8期14卷 333-340页

作者： ana carolina Marinho Monteiro Lima Greice carolina Santos da Silva Fernanda Khouri Barreto Filipe Ferreira de Almeida Rego Luana Leandro Gois Luciane Amorim Santos Catholic University of Salvador SalvadorBahiaBrazil Multidisciplinary Institute in Health Federal University of BahiaVitoria da ConquistaBahiaBrazil Bahia School of Medicine and Public Health SalvadorBahiaBrazil Postgraduate Program in Health Sciences Faculty of Medicine of BahiaFederal University of BahiaSalvadorBahiaBrazil

Human T-cell lymphotropic virus type 1(HTLV-1)is associated with the development of HTLV-1-associated myelopathy/tropical spastic paraparesis(HAM/TSP).It has been reported that the HTLV-1 proteins(specifically TAX and HBZ)can modulate FOXp3,resulting in an immune imbalance that can favor the progression of HAM/*** review aims to summarize the literature in order to clarify the relationship between the expression of HTLV-1 m RNAs and/or viral proteins(TAX and HBZ)with the expression of mRNA and/or protein FOXp3 and their correlation with HAM/TSP *** systematic review was conducted according to the recommendations of the Preferred Reporting Items for Systematic Reviews and *** search strategy was performed on the Medical Literature analysis and Retrieval System Online and Latin American and Caribbean Literature in Health Sciences Platform using subject *** screening,six articles were included in this *** studies suggested that TAX and HBZ have a directly proportional correlation with FOXp3 in individuals with HAM/TSP,which also presented an increased expression of FOXp3 compared to asymptomatic controls and/or healthy *** systematic review indicates that TAX and HBZ can interact with FOXp3 and that interaction may influence HAM/TSP development.

关键词： HTLV-1 HTLV-1-associated myelopathy/tropical spastic paraparesis(HAM/TSP) FOXp3 HBZ TAX

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阿塞洛米塔尔图巴朗钢铁集团火花发射光谱法优化氮的分析

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冶金分析 2012年第7期32卷 25-31页

作者： FAGUNDES Laura DIEGUEZ ana carolina 阿塞洛米塔尔图巴朗钢铁集团

近年来,钢铁行业需求量快速上升,竞争也变得更加激烈。为了得到性能可靠的产品,钢铁车间在生产工艺方面需要进一步严格控制好产品的生产规格。在这种背景下,为了严格控制好生产工艺的密封性并保证产品所期望的特性(尤其是其韧性和机械... 详细信息

近年来,钢铁行业需求量快速上升,竞争也变得更加激烈。为了得到性能可靠的产品,钢铁车间在生产工艺方面需要进一步严格控制好产品的生产规格。在这种背景下,为了严格控制好生产工艺的密封性并保证产品所期望的特性(尤其是其韧性和机械加工性方面),精确地进行氮的分析必不可少。在过去几年中,经典燃烧技术(CC)已广泛应用于鉴定钢中的碳、硫和氮元素。而火花发射法因其性能改进、耗材成本(燃烧技术方面)降低以及在分析时间缩短等方面的优势,也在氮分析方面得到了应用,并且应用越来越广泛。本项研究的目的在于通过火花发射光谱仪(OES)对氮分析进行优化。研究是在巴西塞拉的阿塞洛米塔尔图巴朗钢铁集团的化学分析实验室进行,利用DMAIC方法学(一种用于改进生产工艺质量的研究方法)[1],对潜在的影响因素(包括漂移、样品和周期)进行了分析,并确定和优化了影响氮分析精度的根本原因。在实施该计划后,对结果的精度(基于内标物的标准偏差)和准确性(通过与OE认证的参考物质和力可交叉核验结果进行比较)进行了评估。在本研究项目之前,通过光发射法测得的氮元素的标准偏差高达0.004 0%。阿塞洛米塔尔图巴朗钢铁集团利用光谱仪完成所有的研究计划后,试验表明,其测定标准偏差低达0.000 5%,充分展现了该技术的潜力。本研究对这一标准偏差进行了监测,频率为每周一次,监测期为3个月。结果发现,该标准偏差在0.000 3%到0.000 5%之间波动,表明稳定性较好。由此可见,火花发射光谱技术是氮分析的一种较有前途的方法。

关键词：光发射氮分析钢铁经典燃烧

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Nitric oxide plays a key role in the suppressive activity of tolerogenic dendritic cells

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Cellular & Molecular Immunology 2015年第3期12卷 384-386页

作者： Liana Verinaud Luidy Kazuo Issayama Fabio Zanucoli ana carolina de Carvalho Thiago alves da Costa Rosaria Di Gangi Amanda Pires Bonfanti Isadora Tassinari Ferreira Alexandre Leite Rodrigues de Oliveira Dagmar Ruth Stach Machado Rodolfo Thome Department of Structural and Functional Biology Institute of Biology University of Campinas SP Brazil

Tolerogenic dendritic cells （DCs） are widely studied for their possible use in the treatment of inflammatory disorders, such as autoimmune diseases. One of the obstacles for the use of this cell-based therapy is the characterization of drugs that are able to modulate DCs. We have previously shown that chloroquine （CQ）, an antimalarial agent, has the ability to modulate DCs towards a tolerogenic phenotype.1 These tolerogenic DCs are able to suppress the development of experimental autoimmune encephalomyelitis （EAE）, a T cell-driven mouse model of human multiple sclerosis. In addition, several studies have proposed that nitric oxide （NO） plays a major role in the dif- ferentiation of regulatory T cells （Tregs） and the suppression of Thl/Th17 cells.2＂3 However, little is known about the role of DC-derived NO in the modulation of inflammatory auto- immune responses. Thus, we aimed to evaluate whether NO plays a role in the tolerogenic activity of CQ-treated DCs （CQ- DCs）. We found that CQ induces DC production of NO and expression of indoleamine 2,3-dioxygenase （IDO）, as well as inducible nitric oxide syrtthase （iNOS）.

关键词： suppressive activity tolerogenic

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Antibacterial activity and inhibition against Staphylococcus aureus NorA efflux pump by ferulic acid and its esterified derivatives

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Asian Pacific Journal of Tropical Biomedicine 2021年第9期11卷 405-413页

作者： Patrícia gonçalves Pinheiro Gilvandete Maria Pinheiro Santiago Francisco Erivaldo Freitas da Silva ana carolina Justino de Araújo Cícera Rejane Tavares de Oliveira Priscilla Ramos Freitas Janaína Esmeraldo Rocha JoséBezerra de Araújo Neto Maria Milene Costa da Silva Saulo Relison Tintino Irwin Rose Alencar de Menezes Henrique Douglas Melo Coutinho JoséGalberto Martins da Costa Departamento de Química Biológica Programa de Pos-Graduação em Química BiológicaUniversidade Regional do Cariri–URCACrato–CEBrazil Programa de Pós-Graduação em Química Centro de CiênciasUniversidade Federal do Ceará–UFCFortaleza–CEBrazil

Objective:To evaluate the inhibitory activity of ferulic acid and four of its esterified derivatives(methyl,ethyl,propyl,and butyl)against resistance mechanisms in Staphylococcus aureus ***:Ferulic acid derivatives were obtained by esterification with methanol,ethanol,propanol,and butanol,and then characterized by hydrogen and carbon-13 nuclear magnetic resonance *** minimum inhibitory concentrations(MIC)of ferulic acid and its esterified derivatives,ethidium bromide,and norfloxacin were obtained using the microdilution test,while the efflux pump inhibition test was conducted by examining reduction in the MICs of norfloxacin and ethidium *** docking was also carried out using the Schrodinger Suite 2015 molecular modeling software.A three-dimensional model of NorA efflux pump was generated using *** best scoring model was used as a receptor for ligand-receptor ***:The methyl and butyl ester derivatives did not demonstrate significant antimicrobial ***,a significant synergic effect was evidenced when norfloxacin was combined with the ethyl and propyl esterified *** docking study demonstrated favorable energy of interaction between ferulate derivatives and NorA,and amino acid residues TYR57,TYR58,and LEU255 were present commonly in stabilizing all *** PCA analysis corroborated the docking hypothesis that the lipophilic character and hydrogen bond interactions were the most relevant characteristics involved with NorA *** pharmacokinetic parameters of ferulic acid derivatives showed good ADMET properties,demonstrating that they can be easily absorbed and have no effect or inhibit the cytochrome P450 enzyme complex,revealing their potential as drug ***:This study provides strong evidence that the molecular basis for this activity is potentially due to the NorA efflux pump.

关键词： Ferulic acid Esterified derivatives Efflux pump Staphylococcus aureus Resistance mechanisms

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Structural and nucleic acid binding properties of hepatitis delta virus small antigen

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World Journal of Virology 2017年第2期6卷 26-35页

作者： carolina alves Hong Cheng Joao Paulo Tavanez ana Casaca Severin Gudima Heinrich Roder Celso Cunha Global Health and Tropical Medicine GHTMInstituto de Higiene e Medicina Tropical IHMTUniversidade Nova de Lisboa Institute for Cancer Research Fox Chase Cancer Center Global Health and Tropical Medicine GHTM Instituto de Higiene e Medicina Tropical IHMT Universidade Nova de Lisboa Department of Microbiology Molecular Genetics and ImmunologyKansas University Medical Center

AIM To further characterize the structure and nucleic acid binding properties of the 195 amino acid small delta antigen, S-HDAg, a study was made of a truncated form of S-HDAg, comprising amino acids 61-195(?60HDAg), thus lacking the domain considered necessary for dimerization and higher order *** Circular dichroism, and nuclear magnetic resonance experiments were used to assess the structure of ?60HDAg. Nucleic acid binding properties were investigated by gel retardation assays. RESULTS Results showed that the truncated ?60HDAg protein is intrinsically disordered but compact, whereas the RNA binding domain, comprising residues 94-146, adopts a dynamic helical conformation. We also found that ?60HDAg fails to multimerize but still contains nucleic acid binding activity, indicating that multimerization is not essential for nucleic acid binding. Moreover, in agreement with what has been previously reported for full-length protein, no apparent specificity was found for the truncated protein regarding nucleic acid *** Taken together these results allowed concluding that ?60HDAg is intrinsically disordered but compact; ?60HDAg is not a multimer but is still capable of nucleic acid binding albeit without apparent specificity.

关键词： Hepatitis delta virus Delta antigen Nuclear magnetic resonance Circular dichroism Intrinsically disordered protein

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Obesity: Body Relief Surgeries before Bariatric Surgery for Risk Reduction

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Modern Plastic Surgery 2020年第3期10卷 31-37页

作者： José Humberto Cardoso Resende ana Letícia Pinto Guimarã es Brunna Abreu Perillo ana carolina Melo Maluf Laura Ribeiro da Costa Rafaella Cristina Gomes Bernardes Arthur Camargo Pires Thalles gonç alves Souza Menezes Murilo Calil alves Emídio Silva Falcã o Brasileiro UNIFAN Work Coordinator Aparecida de Goi&#226 nia Brazil UNIFAN Medicine Academics Aparecida de Goi&#226 nia Brazil UNIFAN Research Coordinator Aparecida de Goi&#226 nia Brazil

Depending on the treatment and weight of the breasts or abdomen, they may exceed volumes considered giant and morbidly obese. In these cases, and when the patient’s BMI is high above 40 kg/m2, the weight of the breasts or abdomen produces what we consider suffocation when the patient is placed in horizontal position on surgical tables, decreasing his respiratory capacity and increasing the difficulty in treating respiratory or embolic risks. An 8-kg breast on the patient’s chest prevents normal breathing. An abdomen with a volume of 30 kg causes difficulties in all senses, making the physiological expansion of the lungs impossible and even preventing surgical assistance to patients. These patients are almost always customers who sleep in the sitting position to breathe better. The gigantic extirpation of the surgical parts facilitates a better respiratory expansion reducing by a large percentage the risk of death, what we call body relief. This relief does not free the patient from bariatric surgery for a possible weight loss, which is vital for the proper functioning of the organs and decreasing arterial hypertension and diabetes.

关键词： Obesity Disease Surgery Bariatric Risk Hypertension and Diabetes

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Crambe (<i>Crambe abyssinica</i>) Cultivation under Different Levels of Fertilization with Nitrogen, Phosphorus and Potassium

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American Journal of Plant Sciences 2017年第9期8卷 2031-2039页

作者： ana carolina F. de Vasconcelos Lúcia Helena G. Chaves Josely Dantas Fernandes Gilvanise alves Tito Department of Agricultural Engineering Federal University of Campina Grande Paraiba State Brazil Department of Agroecology and Agropecuaria State University of Paraiba Paraiba State Brazil

The effects of fertilization on crambe are poorly understood;in this sense, this study aimed to evaluate the crambe growth under different levels of nitrogen (0, 40, 80, 120 kg·ha-1), phosphorus (0, 50, 100, 150 kg·ha-1), and potassium (0, 30, 60, 90 kg·ha-1) in a greenhouse. The height of the plants, the production of dried biomass and that of 1000 grains of crambe were evaluated. The height of the plants was impaired as a function of increasing doses of nitrogen. The interaction of nitrogen and phosphorus in the crambe crop increased the number of grains and dry shoot biomass. The growth and yield of the crop were not influenced by the use of potassium in mineral fertilization.

关键词： Biodiesel Semiarid Region Mineral Fertilization Crambe Growth

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Dry Matter Production and Nutritional Status of Sunflower Grown in Nutrient Solution under Macronutrient Omission

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Agricultural Sciences 2018年第11期9卷 1479-1486页

作者： Allan Nunes alves Felipe Guedes de Souza Lúcia Helena Garófalo Chaves ana carolina Feitosa de Vasconcelos Department of Agricultural Engineering Federal University of Campina Grande Campina Grande Brazil

The objective of this study was to evaluate the effect of omission of macronutrients on dry matter production and on the nutritional status of sunflower cv. BRS 122. The experiment was carried out in a greenhouse, in randomized blocks, with seven treatments corresponding to the Hoagland & Arnon standard solution (1950) and the individual omission of N, P, K, Ca, Mg and S, in three replicates. After 50 days of sowing, the dry matter and the nutritional status of the plants were evaluated. The omission of N, P, K, Ca, Mg and S limited the dry mass production of sunflower cv. BRS 122 in relation to the complete solution, besides causing nutritional imbalance due to the interaction between the nutrients. The omission of the macronutrients K, Ca, and Mg caused the higher imbalances in the plants, highlighting the elevated N contents in these treatments comparing to the complete solution.

关键词： Helianthus annuus Nutritional Diagnosis Omission of Nutrients

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Pulmonary Tuberculosis Associated with Socioeconomic Vulnerability and Ineffective Support Network: Case Report

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Journal of Biosciences and Medicines 2023年第5期11卷 151-157页

作者： Michele Paula dos Santos Gabriela Di Lorenzo Garcia Scherer carolina Hack alves Italo Trois Maestri carolina Boeira Soares Carlos Augusto Treviso Stella Duarte Pinto ana Paula Wagner Steinmetz Laura Gomes Boabaid de Barros Maria Eduarda Perobelli Buzetto Gabriel Lorentz Trein Guilherme Boeira Soares Aline Porto Brendda Pereira Gomes Fernanda Bercht Merten Luane Pereira Gomes Bárbara Adelmann de Lima Rafaela Siviero Caron-Lienert Miriam Viviane Baron School of Medicine Pontifical Catholic University of Rio Grande do Sul (PUCRS) Porto Alegre Brazil Course of Medicine Lutheran University of Brazil (ULBRA) Canoas Brazil School of Health and Life Sciences Pontifical Catholic University of Rio Grande do Sul (PUCRS) Porto Alegre Brazil Interdisciplinary Institute of Science and Health Education Porto Alegre Brazil

Tuberculosis is one of the 10 leading causes of death in the world. Its symptoms include fever, malaise, weakness, weight loss, chest pain, cough, expectoration, shortness of breath and sepsis, which is its most frequent complication. Due to these symptoms, many patients with tuberculosis require admission to the Intensive Care Unit, where they usually are placed on mechanical ventilation. Tuberculosis is more prevalent in the population in situations of social and economic vulnerability. The main factors that interfere with adherence to treatment and the prognosis of these patients are the patient’s support network and their socioeconomic status. We present the following report of a long-time smoker patient, with chronic kidney disease and previous treatment for tuberculosis, who was brought to the emergency room due to lowering of the sensorium, and was immediately placed on mechanical ventilation. The tests suggested sepsis with a respiratory focus, so a search for Alcohol-Acid-Resistant Bacillus was carried out, with a positive result. The patient was transferred to the Intensive Care Unit due to tachycardia and acute respiratory failure. The patient was a smoker with a high tobacco load, chronic kidney disease, in addition to precarious economic, educational and self-care conditions. This report shows that patients with tuberculosis and its complications can be stabilized through known pharmacological treatment. However, the most effective measure to interrupt the transmission of the disease remains the early diagnosis and the provision of adequate treatment, with guidelines aimed at the cessation of harmful habits, such as smoking.

关键词： Smoking Kidney Disease Sepsis Respiratory Failure

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