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Treatment of spinal cord injury with biomaterials and stem cell therapy in non-human primates and humans

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Neural Regeneration Research 2025年第2期20卷 343-353页

作者： ana Milena Silva Olaya Fernanda Martins Almeida ana Maria Blanco Martinez Suelen Adriani Marques PhD Program in Pathological anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Biomedical Science Institute Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological anatomy(PPGAP/UFRJ) Department of Neurobiology/Institute of BiologyCampus do GragoatáNiteróiRio de JaneiroBrazil

Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical ***,in the search for more effective treatments than those already applied for years,which are not entirely efficient,researches have been able to demonstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord *** of these strategies has been developed and meticulously evaluated in several animal models with the aim of analyzing the potential of interventions for neuronal repair and,consequently,boosting functional *** the majority of experimental research has been conducted in rodents,there is increasing recognition of the importance,and need,of evaluating the safety and efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in *** article is a literature review from databases(PubMed,Science Direct,Elsevier,Scielo,Redalyc,Cochrane,and NCBI)from 10 years ago to date,using keywords(spinal cord injury,cell therapy,non-human primates,humans,and bioengineering in spinal cord injury).From 110 retrieved articles,after two selection rounds based on inclusion and exclusion criteria,21 articles were ***,this review arises from the need to recognize the experimental therapeutic advances applied in non-human primates and even humans,aimed at deepening these strategies and identifying the advantages and influence of the results on extrapolation for clinical applicability in humans.

关键词： bioengineering biomaterials cell therapy humans non-human primates spinal cord injury stem cell therapy

Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-Núñez María Fernanda González ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and Notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

Oil recovery tests with ionic liquids: A review and evaluation of 1-decyl-3-methylimidazolium triflate

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Petroleum Science 2022年第4期19卷 1877-1887页

作者： alba Somoza Alberto Arce ana Soto CRETUS Department of Chemical EngineeringUniversidade de Santiago de CompostelaE-15782Santiago de CompostelaSpain School of Engineering Universidade de A CorunaE-15403FerrolSpain

The main advantages of the use of ionic liquids in enhanced oil recovery are their tunability and stability in harsh environmental conditions. In this work, a comprehensive review of ionic liquids proposed to improve current chemical oil recovery methods has been presented, focusing on core flooding experiments. With an almost infinite number of possible ionic liquids, the amount of experiments carried out up to now has been very limited. However, results are promising, with additional recovery after secondary flooding of up to 32% of the original oil in place. Most formulations with ionic liquids have been proposed for sandstone reservoirs, the number of studies with carbonate cores being very scarce. The possibilities of a new room temperature surface active ionic liquid, 1-decyl-3-methylimidazolium triflate,for this application were analyzed. It was shown that it is able to drastically reduce the water/oil interfacial tension. An optimized formulation was proposed for carbonate reservoirs. After secondary flooding with brine, an additional recovery of 10.5% of original oil in place was achieved at room conditions. A combination of the proposed method followed by a polymer flooding step with polyacrylamide led to a lesser but still significant recovery, reducing the costs associated to the ionic liquid.

关键词： Enhanced oil recovery(EOR) Ionic liquids Core flooding Interfacial tension 1-Decyl-3-methylimidazolium triflate

Nanofluid based on 1-dodecylpyridinium chloride for enhanced oil recovery

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Petroleum Science 2023年第1期20卷 600-610页

作者： Akram Al-Asadi alba Somoza Alberto Arce Eva Rodil ana Soto CRETUS.Department of Chemical Engineering Universidade de Santiago de CompostelaE-15782Santiago de CompostelaSpain Chemical and Petrochemical Techniques Eng.Department Basra Engineering Technical CollegeSothern Technical UniversityMinistry of Higher Education and Scientific ResearchIraq School of Engineering Universidade de A CorunaE-15403FerrolSpain

The use of nanoparticles is considered promising for enhanced oil recovery(EOR),especially when they are combined with ***,the combination of nano-sized material with surface-active ionic liquids(SAILs)is an unexplored EOR *** this work,the advantages of mixing Al2O3 nanoparticles with the SAIL 1-dodecylpyridinium chloride were *** nanofluids in brine could only be achieved using the polymer polyvinylpyrrolidone(PVP)as a stabilizing *** was found that the addition of nanoparticles(and PVP)to the surfactant formulation helped to:slightly increase its viscosity,enhance its water-oil interfacial tension(IFT)reduction capacity,and reduce the adsorption on carbonate rocks(adsorption on sandstone was found to be excessive).IFT was selected as target property to minimize for the design of EOR *** flooding tests were carried out with surfactant(0.5 wt%[C_(12)py]Cl),surfactant-polymer(0.5 wt%[C_(12)py]Cl,1.0 wt%PVP)and nanofluid(0.05 wt%Al_(2)O_(3),1.0 wt%PVP,0.5 wt%[C12py]Cl)formulations in brine(0.5 wt%NaCl).Additional oil recoveries of 3.4%,7.4%and 12.0%OOIP were achieved,respectively,the nanofluid formulation being the most promising for the ***,it was found capable of changing the wettability of carbonate rocks from oilwet to *** significance of this work lies in showing the new possibilities resulting from the combination of SAILs and nanoparticles for EOR,specifically the combination of[C_(12)py]Cl with Al_(2)O_(3).

关键词： Nanofluid Viscosity Interfacial tension Adsorption Wettability EOR

Modeling the impact of surveillance activities combined with physical distancing interventions on COVID-19 epidemics at a local level

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Infectious Disease Modelling 2022年第4期7卷 811-822页

作者： Guan-Jhou Chen John RBPalmer Frederic Bartumeus ana alba-Casals College of Medicine National Taiwan UniversityTaipeiTaiwan Min-Sheng General Hospital TaoyuanTaiwan Department of Political and Social Sciences Universitat Pompeu FabraBarcelonaSpain Centre d’Estudis Avançats de Blanes(CEAB-CSIC) Blanes17300Spain Centre de Recerca Ecológica i Aplicacions Forestals(CREAF) Cerdanyola del Vallès08193Spain InstituciòCatalana de Recerca i Estudis Avançats(ICREA) Barcelona08010Spain Centre de Recerca en Sanitat Animal(CReSA) Institut de Recerca i Tecnologia AgroalimentàriesSpain

Physical distancing and contact tracing are two key components in controlling the COVID-19 *** their interaction at local level is important for *** propose a flexible modeling framework to assess the effect of combining contact tracing with different physical distancing *** scenario tree analyses,we compute the probability of COVID-19 detection using passive surveillance,with and without contact tracing,in metropolitan *** estimates of detection probability and the frequency of daily social contacts are fitted into an age-structured susceptible-exposed-infectious-recovered compartmental model to simulate the epidemics considering different physical distancing scenarios over a period of 26 *** the original Wuhan strain,the probability of detecting an infected individual without implementing physical distancing would have been 0.465,0.515,0.617,and 0.665 in designated age groups(0e14,15e49,50e64,and>65),*** the physical distancing measures were reinforced and the disease circulation decreased,the interaction between the two interventions resulted in a reduction of the detection probabilities;however,despite this reduction,active contact tracing and isolation remained an effective supplement to physical *** we relied solely on passive surveillance for diagnosing COVID-19,the model required a minimal 50%(95%credible interval,39e69%)reduction of daily social contacts to keep the infected population under 5%,as compared to the 36%(95%credible interval,22e56%)reduction with contact tracing *** simulation with the B.1.1.7 and B.1.167.2 strains shows similar *** simulations showed that a functioning contact tracing program would reduce the need for physical distancing and mitigate the COVID-19 epidemics.

关键词： SARS-CoV-2 Physical distancing Social mixing pattern Contact tracing Scenario tree analysis

Ambient Air Particulate PM2.5 Concentrations and Identification of Source Categories at Chihuahua, Mexico

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Journal of Environmental Science and Engineering(A) 2013年第3期2卷 147-154页

作者： ana canseco-Lajas Ramon Gomez Vargas Alfredo Campos-Trujillo Department of Environment and Energy Advanced Materials Research Center Chihuahua 31109 Mexieo

Suspended particles in the air are pollutants formed by diverse materials and sizes. As determined in multiple studies, particulate matter equal to or less than 2.5 μrn also called breathable fraction is the one that penetrates the inferior respiratory system. The present study shows the results of a sampling campaign of particulate matter PM25 through 12 months at 3 sites： C33 （Clinic 33）, CIM （CIMAV） and A VA （Avalos） at Chihuahua, Mexico. The aim of this study was to determine the temporary concentrations of PM25, the concentration of metallic elements： Al, As, Co, Cu, Sb, Se, Fe, Mg, Mn, Ni, Pb and Zn, as well as their possible sources. The three sites had the same trend in the time, where in autumn and winter the higher concentrations were found. The yearly averages on sites C33, CIM, and AVA were 9.91, 12.74 and 21.67 μg·m^-3, respectively, finding that AVA site overpasses the standard of 15 μg·m^-3. The application of factor analysis to the data allowed to identify four source categories： crustal, related with Al-Co-Fe-Mg-Mn, vehicular, related with： As-Cu-Sb-Se; mixed, related with： As-Cu-Sb-Se-Pb-Zn and industrial related with Ni-Pb.

关键词： PM25 trace metallic elements factor analysis source categories.

Parkinson’s disease and diabetes mellitus: common mechanisms and treatment repurposing

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Neural Regeneration Research 2022年第8期17卷 1652-1658页

作者： Carmen M.Labandeira Arturo Fraga-Bau David Arias Ron Elena Alvarez-Rodriguez Pablo Vicente-alba Javier Lago-Garma ana I.Rodriguez-Perez Department of Clinical Neurology Hospital Alvaro CunqueiroUniversity Hospital ComplexVigoSpain Laboratory of Cellular and Molecular Neurobiology of Parkinson’s Disease Research Center for Molecular Medicine and Chronic Diseases(CIMUS)IDISUniversity of Santiago de CompostelaSantiago de CompostelaSpain Department of Clinical Oncology University Hospital ComplexOurenseSpain Department of Endocrinology Hospital MeixoeiroUniversity Hospital ComplexVigoSpain Networking Research Center on Neurodegenerative Diseases(CiberNed) MadridSpain

In the last decade,attention has become greater to the relationship between neurodegeneration and abnormal insulin signaling in the central nervous system,as insulin in the brain is implicated in neuronal survival,plasticity,oxidative stress and *** mellitus and Parkinson’s disease are both aging-associated diseases that are turning into epidemics *** mellitus and insulin resistance not only increase the possibility of developing Parkinson’s disease but can also determine the prognosis and progression of Parkinsonian ***,there are no available curative or disease modifying treatments for Parkinson’s disease,but the role of insulin and antidiabetic medications in neurodegeneration opens a door to treatment repurposing to fight against Parkinson’s disease,both in diabetic and nondiabetic Parkinsonian ***,it is essential to comprehend how a frequent and treatable disease such as diabetes can influence the progression of neurodegeneration in a challenging disease such as Parkinson’s ***,we review the present evidence on the connection between Parkinson’s disease and diabetes and the consequential implications of the existing antidiabetic molecules in the severity and development of Parkinsonism,with a particular focus on glucagon-like peptide-1 receptor agonists.

关键词： antidiabetic diabetes mellitus dopamine exenatide glucagon-like peptide-1 insulin neurodegeneration neuroinflammation Parkinson’s disease repurposing

The growth and production modeling of individual trees of Eucalyptus urophylla plantations

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Journal of Forestry Research 2020年第5期31卷 1663-1672页

作者： Joao Victor Nobre Carrijo ana Beatriz de Freitas Ferreira Marcela Costa Ferreira Mario Cesar de Aguiar Eder Pereira Miguel Eraldo Aparecido Trondoli Matricardi alba Valeria Rezende Department of Forestry Faculty of TechnologyUniversity of Brası´liaBrası´lia 70910-900Brazil

Individual tree models(ITMs)are classified as growth and production models for projecting current and future forest *** are more complex than other growth and production models,show a higher level of detail and,consequently,produce a better modeling ***,the accuracy and efficiency of ITMs have not been properly assessed to *** this study,we estimated the growth in height,diameter,and individual tree volume of a Eucalyptus urophylla plantation by applying an *** used a continuing forest inventory dataset in which 1554 individual trees within 29 permanent plots were measured in the field over a 6-year period(24 to 72 months).Each individual tree volume was estimated for future tree *** achieve this,we adjusted the model to predict the height and diameter growth,and the probability of mortality as a function of the competition *** ITM accuracy was assessed based on the analysis of variance results and,subsequently,the multiple mean comparison test at the 5%significance *** tree volumes predicted by the ITM for the forest stand aged 72 months,beginning at ages 24,36,48,and 60 months,were compared to the field measured tree volume acquired from the 72-month forest inventory that was used as the reference *** and observed tree volumes were similar when the estimation was based on the 48-month forest *** results might help to reduce financial costs of forest inventory because the ITM produces accurate future predictions of forest stand *** estimated ITM for Eucalyptus plantations using measurement intervals up to 2 years is recommended because it significantly reduced the projected volume discrepancy compared to the field measurements.

关键词： Competition index Forest production Forest site Simulation models Tree mortality

The Convex-Set Algebra and Intersection Theory on the Toric Riemann–Zariski Space

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Acta Mathematica Sinica,English Series 2022年第3期38卷 465-486页

作者： ana María BOTERO Institut Für Mathematik Universität RegensburgUniversitätsstr.3193053RegensbergGermany

In previous work of the author,a top intersection product of toric b-divisors on a smooth complete toric variety is *** is shown that a nef toric b-divisor corresponds to a convex set and that its top inetersection number equals the volume of this convex *** goal of this article is to extend this result and define an intersection product of sufficiently positive toric b-classes of arbitrary *** this,we extend the polytope algebra of McMullen to the so called convex-set algebra and we show that it embeds in the toric b-Chow *** this way,the convex-set algebra can be viewed as a ring for an intersection theory for sufficiently positive toric *** an application,we show that some Hodge type inequalities are satisfied for the convex set algebra.

关键词： Convex geometry intersection theory toric varieties b-Chow groups Riemann–Zariski spaces