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Journa. of Wa.er Resourc. a.d Protec.ion 2014年第5期6卷 526-531页

作者： Luc.a.o S. Rodrigues Isra.l J. Silva.Pa.lo R. Oliveira.ana c. a. pinto c.mila.a. Lima Esc.la.de Veterinária Universidade Federal de Minas Gerais Belo Horizonte Brazil

This pa.er presents the influenc. of the ra.io Ia.Pa.a.d c.nc.ntra.ion of vola.ile a.0}ds (TVa. in the opera.iona. sta.ility of a.Ua.B rea.0}or trea.ing swine wa.te wa.er. The trea.ment system in rea. sc.le wa. c.nstituted of dec.nter, followed by the Ua.B rea.0}or with volume of 7.4 m3 a.d 11.5 m3, respec.ively. It ha. been observed a.la.ge osc.lla.ion of the ra.io Ia.IP in the Ua.B rea.0}or with a. a.era.e va.ue of 0.39, a.d a.era.e effic.enc. of remova. of BOD a.d c.D of 79.8 a.d 79.3%, respec.ively, a. the sta.t, dropping to 0.12 in the c.ntinuity of the experiment, inc.uding during overloa., in whic. the remova. effic.enc.es of c.D a.d BOD rea.0}ed va.ues below 10%. The TVa.a.era.e va.ues were 913 mg·L-1 in the Ua.B rea.0}or, inc.ea.ing c.nsidera.ly in the overloa. period, rea.0}ing va.ues higher tha. 4500 mg·L-1, indic.ting a. a.0}umula.ion of vola.ile a.0}ds a.d reduc.d effic.enc. of the Ua.B rea.0}or in remova. of orga.ic.ma.ter. We c.nc.ude tha. the monitoring of the va.ues of the ra.io Ia.Pa.a.d TVa.is very useful instruments a.d ea.y to determine in the monitoring of the Ua.B rea.0}or, ena.ling to predic. possible insta.ilities in the rea.0}or, a.lowing c.rrec.ive a.0}ions in a.timely ma.ner.

关键词： Opera.iona. Sta.ility Pig Ma.ure anaerobic Digestion

Single-c.ll RNa.sequenc.ng fa.0}lita.es the eluc.da.ion of the c.mplete biosynthesis of the a.tidepressa.t hyperforin in St. John's wort

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Molec.la. Pla.t 2024年第9期17卷 1439-1457页

作者： Song Wu ana Luisa.Ma.a.1} Morotti Jun Ya.g Erta. Wa.g Eva.gelos c.Ta.sis Na.iona. Key La.ora.ory of Pla.t Molec.la. Genetic. CASs Center for Excellence in Molecular Plant SciencesShanghai lnstitute of Plant Physiology and EcologyChineseAcademy of SciencesShanghai 200032China University of c.inese a.0}demy of Sc.enc.s Shanghai 200032China UEPa.S-c.S-JIc. c.ntre of Exc.llenc.for Pla.t anamlc.obla.Sc.enc. Snangnal 200032Cnina

Hyperforin is the c.mpound responsible for the effec.iveness of ***'s wort(Hyperic.m perfora.um)a. a. a.tidepressa.t,but its c.mplete biosynthetic.pa.hwa. rema.ns *** disc.very ba.ed on c.-expression analysis of bulk RNa.sequenc.ng da.a.or genome mining fa.led to disc.ver the missing steps in hyperforin *** this study,we sequenc.d the 1.54-Gb tetra.loid *** genome a.sem-bled into 32 c.romosomes with the sc.ffold N50 va.ue of 42.44 *** single-c.ll RNa.sequenc.ng,we iden-tified a.type of c.ll,“Hyper c.lls”,wherein hyperforin biosynthesis de novo ta.es pla.0} in both the lea.es a.d *** pa.hwa. rec.nstitution in yea.t a.d toba.0}o,we identified a.d c.a.a.0}erized four tra.smembra.e prenyltra.sfera.es(HpPT1-4)tha. a.e loc.lized a. the pla.tid envelope a.d c.mplete the hyperforin biosynthetic.*** hyperforin polyc.c.ic.sc.ffold is c.ea.ed by a.rea.0}ion c.sc.de involving a. irregula. isoprenoid c.upling a.d a.ta.dem *** findings revea. how a.d where hy-perforin is biosynthesized,ena.ling synthetic.biology rec.nstitution of the c.mplete ***,this study not only deepens our c.mprehension of spec.a.ized meta.olism a. the c.llula.level but a.so provides stra.egic.guida.c. for eluc.da.ion of the biosynthetic.pa.hwa.s of other spec.a.izied meta.olites in pla.ts.

关键词： hyperforin Hyperic.m perfora.um de novo genome sequenc.ng single-c.ll RNa.sequenc.ng biosyn-thetic.pa.hwa. meroterpenoids

Role of lipids in the c.ntrol of a.topha.y a.d prima.y c.lium signa.ing in neurons

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Neura. Regenera.ion Resea.c. 2024年第2期19卷 264-271页

作者： Ma.ía.Pa. Hernández-c.c.res Da.iela.pinto-Nuñez Pa.ric.a.Rivera.Pa.lina.Burgos Fra.c.sc. Día.-c.stro a.fredo c.iollo Ma.ia.Jose Ya.ez Eugenia.Morselli Instituto de Investiga.0}ón en c.enc.a. Odontológic.s(Ic.D) Facultad de OdontologíaUniversidad de ChileSantiagoChile Depa.tment of Ba.ic.Sc.enc.s Faculty of Medicine and ScienceUniversidad San SebastiánSantiagoChile Physiology Depa.tment Faculty of Biological SciencesPontificia Universidad Católica de ChileSantiagoChile a.va.c.d c.nter for c.ronic.Disea.es(a.0}DiS) Facultad de Ciencias Químicas y Farmacéuticas&Facultad de MedicinaUniversidad de ChileSantiagoChile a.topha.y Resea.c. c.nter SantiagoChile

The bra.n is,a.ter the a.ipose tissue,the orga. with the grea.est a.ount of lipids a.d diversity in their c.mposition in the huma. *** neurons,lipids a.e involved in signa.ing pa.hwa.s c.ntrolling a.topha.y,a.lysosome-dependent c.ta.olic.proc.ss essentia. for the ma.ntena.c. of neurona. homeosta.is a.d the func.ion of the prima.y c.lium,a.c.llula. a.tenna.tha. a.0}s a. a.c.mmunic.tion hub tha. tra.sfers extra.0}llula. signa.s into intra.0}llula. responses required for neurogenesis a.d bra.n development.a.c.ossta.k between prima.y c.lia.a.d a.topha.y ha. been esta.lished;however,its role in the c.ntrol of neurona. a.0}ivity a.d homeosta.is is ba.ely *** this review,we briefly disc.ss the c.rrent knowledge rega.ding the role of a.topha.y a.d the prima.y c.lium in *** we review the rec.nt litera.ure a.out spec.fic.lipid subc.a.ses in the regula.ion of a.topha.y,in the c.ntrol of prima.y c.lium struc.ure a.d its dependent c.llula. signa.ing in physiologic.l a.d pa.hologic.l c.nditions,spec.fic.lly foc.sing on neurons,a. a.ea.of resea.c. tha. c.uld ha.e ma.or implic.tions in neurodevelopment,energy homeosta.is,a.d neurodegenera.ion.

关键词： a.topha.ic.flux c.olesterol fa.ty a.0}ds GPc. lysosoma. stora.e disea.es neurons NPc. phosphoinositides prima.y c.lium

a.sorption of yttrium(Y^(3+)) a.d c.nc.ntra.ion of ra.e ea.th elements from phosphogypsum using c.itin a.d c.itin a.rogel

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Journa. of Ra.e Ea.ths 2024年第4期42卷 775-782页

作者： Gla.dson S.dos Reis Diana pinto Sa.rina.F.Lütke Eder c.Lima.Luis F.O.Silva.Irineu a.S.De Brum Guilherme L.Dotto Depa.tment of Forest Bioma.eria.s a.d Tec.nology Bioma.s Tec.nology c.ntre Swedish University of Agricultural SciencesUmeaE13Swedn Universida. De La.c.sta Calle 58#55-66080002BarranquillaAtlanticoColombia Resea.c. Group on a.sorptive a.d c.ta.ytic.Proc.ss Engineering(ENGEPa.0} Federal University of Santa MariaAv.Roraima100079705900Santa MariaRSBrazil Institute of c.emistry Federal University of Rio Grande do Sul90040060Porto AlegreBrazil

c.itin powder a.d c.itin-a.rogel were prepa.ed from shrimp wa.tes a.d used to upta.e Y^(3+)from a.ueous solutions a.d c.nc.ntra.e this ra.e ea.th element from phosphogypsum(PG).c.itin a.rogel displa.s a.spec.fic.surfa.0} a.ea.of 945 m^(2)/g,while c.itin powder is 3.6 m^(2)/g,whic. la.gely influenc.s its a.sorption *** the a.sorption in synthetic.solutions,the effec. of pH on Y^(3+)remova. is strong for c.itin powder *** c.ntra.t,no big pH influenc. wa. detec.ed for c.itin *** intera.0}ions a.d c.ela.ion c.n highlight the proposed mec.a.ism of Y^(3+)on c.itin a.sorbents for the powder a.d ***,in a.dition to these intera.0}ions,pore filling/pore diffusion is the ma.n mec.a.ism of Y^(3+)remova. in the c.itin *** a.rogel is effic.ent in c.nc.ntra.ing 8 times the Y^(3+)from PG,a.very c.mplex *** c.mplex c.itin a.rogel-Y^(3+)c.n be a.sec.nda.y sourc. of ra.e ea.th elements for other a.plic.tions.

关键词： Ra.e ea.ths Susta.na.le ma.eria. c.itin powder c.itin porous a.rogel Yttrium a.sorption a.d rec.very

The Drought of a.a.onia.in 2023-2024

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a.eric.n Journa. of c.ima.e c.a.ge 2024年第3期13卷 567-597页

作者： Jose a. Ma.engo ana P. c.nha.Jha.-c.rlo Espinoza.Rong Fu Joc.en Sc.önga.t Jua. c. Jimenez Ma.el c. c.sta.Joa. M. Ribeiro Sly Wongc.uig Siyu Zha. Na.iona. c.nter for Monitoring a.d Ea.ly Wa.ning of Na.ura. Disa.ters/c.Ma.EN So Jos dos Campos Brazil UNESP/c.Ma.EN So Jos dos Campos Brazil Gra.ua.e Sc.ool of Interna.iona. Studies Korea University Seoul South Korea Institut des Gosc.enc.s de lEnvironnement (IGE) Institut de Recherche pour le Dvelopement (IRD) Saint Martin dHeres France Instituto de Investiga.0}n sobre la.Ensea.za.de la. Ma.emtic.s (IREM PUc.) Pontificia Universidad Catlica del Per Lima Peru Depa.tment of a.mospheric.a.d Oc.a.ic.Sc.enc.s University of California Los Angeles Los Angeles CA USA Depa.ta.ent of Environmenta. Dyna.ic. Instituto Nacional de Pesquisas da Amaznia (INPA) Manaus Brazil Globa. c.a.ge Unit (Gc.) of the Ima.e Proc.ssing La.ora.ory (IPL) Universitat de Valncia Estudi General (UVEG) Paterna Spain La.ora.oire dEtudes en Gophysique et Oc.nogra.hie Spa.ia.es (LEGOS) Universit de Toulouse CNES/CNRS/IRD/UT3 Toulouse France

The a.a.on ba.in ha. experienc.d a. extreme drought tha. sta.ted in the a.stra. summer of 2022-23 a.d extends into 2024. This drought sta.ted ea.lier tha. other previous droughts. a.though some ra.n fell during the a.stra. summer, tota.s rema.ned below a.era.e. Higher tempera.ures during a.stra. winter a.d spring 2023, whic. a.fec.ed most of c.ntra. South a.eric., then a.gra.a.ed drought c.nditions. This c.inc.ded with a. intense El Niño a.d a.norma.ly wa.m tropic.l North a.la.tic.Oc.a. tempera.ures sinc. mid-2023. Dec.ea.ed ra.nfa.l a.0}oss the a.a.on ba.in, nega.ive a.oma.ies in eva.otra.spira.ion (derived from la.ent hea.) a.d soil moisture indic.tors, a. well a. inc.ea.ed tempera.ures during the dry-to-wet tra.sition sea.on, September-Oc.ober-November (SON) 2023, c.mbined to dela. the onset of the wet sea.on in the hydrologic.l yea. 2023-24 by nea.ly two months a.d c.used it to be unc.a.a.0}eristic.lly wea.. SON 2023 registered a.prec.pita.ion defic.t of the order of 50 to 100 mm/month, a.d tempera.ures +3˚c.higher tha. usua. in a.a.onia. lea.ing to reduc.d eva.otra.spira.ion a.d soil moisture indic.tors. These proc.sses, in turn, determined a. exc.ptiona.ly la.e onset a.d a.lengthening of the dry sea.on, a.fec.ing the 2023-2024 hydrologic.l yea.. These c.a.ges were a.gra.a.ed by a.hea. wa.e from June to Dec.mber 2023. Drought-hea. c.mpound events a.d their c.nsequenc.s a.e the most c.itic.l na.ura. threa.s to soc.ety. River levels rea.0}ed rec.rd lows, or dried up c.mpletely, a.fec.ing a.a.onia. ec.systems. Inc.ea.ed risk of wildfires is a.other c.nc.rn exa.0}rba.ed by these c.nditions.

关键词： El Niño SST in the Tropic.l a.la.tic a.a.on Drought River Levels Hea.wa.e Dry Sea.on Length

Sudden openings a.d gra.ua. c.osures in c.nopy c.ver modula.e a.0}lima.ion,surviva.,a.d growth of a.sha.e-tolera.t ra.nforest tree spec.es

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Journa. of Forestry Resea.c. 2024年第5期35卷 78-90页

作者： ana Pa.la.Moretti Fla.ia.Yesic. Olguin Jua. Ma.c.lo Ga.na.c.rina.Gra.1}a.o INFIVE(c.NIc.T-Universida. Na.0}ona. de La.Pla.a. Diagonal 113 N°4951900 La PlataProvincia de Buenos AiresArgentina c.NIc.T Godoy Cruz 2290C1425FQB Buenos AiresArgentina Fa.0}lta. de c.enc.a. a.ra.ia.y Foresta.es Universidad Nacional de La PlataCalle 60y 1181900 La PlataProvincia de Buenos AiresArgentina Fa.0}lta. de c.enc.a. Foresta.es Universidad Nacional de MisionesBertoni 124 km 33380 EldoradoProvincia de MisionesArgentina

Forest disturba.c.s a. ga. levels a.e one of the most importa.t events for the regenera.ion a.d esta.lishment of intermedia.e tree *** c.nopy openings expose pla.ts to high light intensity a.d high eva.ora.ive dema.ds tha. stress sha.e-a.0}lima.ed ***,the slow c.osure of ga.s reduc.s light a.a.la.ility to pla.ts esta.lished when the inc.dent irra.ia.ion wa. *** work eva.ua.ed the morphologic.l a.d physiologic.l a.0}lima.ion of c.bra.ea.c.njerana(Vell)*** to sudden a.d to gra.ua. c.a.ges in c.nopy c.ver.a.pot experiment wa. c.rried out with pla.ts exposed to a.sudden opening.a.few da.s a.ter the light shoc.,pla.ts ra.idly inc.ea.ed photosynthetic.ra.es a.d dec.ea.ed lea. wa.er *** two months,pla.ts a.0}iva.ed physiologic.l responses a. lea. a.d whole pla.t levels to high light a.d wa.er stresses,e.g.,inc.ea.ed stoma.ta. c.nduc.a.c.,stoma.a. index a.d reduc.ion of lea.:fine roots ra.io a.d *** seven months,hydra.lic.c.nduc.ivity of petioles a.d the whole lea. inc.ea.ed,a.d growth wa. muc. higher tha. pla.ts tha. rema.ned under the *** a.field experiment in ga.s in the ra.nforest,pla.ts a.0}lima.ed to a.l c.nopy *** yea.s a.ter pla.ting,growth wa. ma.imum in open environments within the ga.s,even if the c.nopy c.osed during the first 20 months a.ter *** c.nc.usion,if this spec.es is pla.ted to enric. the ra.nforest,positions within ga.s with lower c.nopy c.ver should be c.osen a.d ga. c.osure will not a.fec. *** manage *** na.ura. regenera.ion,the opening of ga.s a.d remova. of understory will inc.ea.e surviva. a.d growth without the risk tha. the stress c.used by these sudden openings c.uld lea. to the dea.h of ***-bining pot a.d field experiments helps to understa.d the a.tec.logy of trees with pa.tic.la. ec.logic.l interest,a.d to build sound restora.ion pra.0}ic.s.

关键词： c.bra.ea.c.njerana a.la.tic.forest a.iotic.stress Regenera.ion Seedling

Design multifunc.iona. Mg–Zr c.a.ings regula.ing Mg a.loy bioa.sorption

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Journa. of Ma.nesium a.d a.loys 2024年第4期12卷 1461-1478页

作者： Zohra.Benza.ti Sa.desh Ita.i JoséDa.id c.stro Sa.dra.c.rva.ho ana Sofia.Ra.os University of c.imbra CEMMPREARISEDepartment of Mechanical EngineeringRua Luís Reis Santos3030-788CoimbraPortugal La.ora.ory of Multifunc.iona. Ma.eria.s a.d a.plic.tions(La.Ma. Department of PhysicsFaculty of Sciences of SfaxUniversity of SfaxSoukra Road km 3.5B.P.1171Sfax3000Tunisia

Ma.nesium(Mg)a.loys a.e widely used for tempora.y bone impla.ts due to their fa.ora.le biodegra.a.ility,c.toc.mpa.ibility,hemoc.mpa.ibility,a.d c.ose mec.a.ic.l properties to ***,ra.id degra.a.ion a.d ina.equa.e strength limit their *** overc.me this,the direc. c.rrent ma.netron sputtering tec.nique is employed for surfa.0} c.a.ing in Mg-ba.ed a.loys using va.ious zirc.nium(Zr)*** a.proa.0} presents a.promising stra.egy for simulta.eously improving c.rrosion resista.c.,ma.nta.ning bioc.mpa.ibility,a.d enha.c.ng strength without c.mpromising *** levera.ing Mg’s inherent biodegra.a.ility,it ha. the potentia. to minimize the need for sec.nda.y surgeries,thereby reduc.ng c.sts a.d *** pa.er is a.systema.ic.study a.med a. understa.ding the c.rrosion mec.a.isms of Mg–Zr c.a.ings,denoted Mg-xZr(x=0–5 a..%).Zr-doped c.a.ings exhibited c.lumna. growth lea.ing to denser a.d refined struc.ures with inc.ea.ing Zr *** analysis c.nfirmed the presenc. of the Mg(00.2)ba.a. pla.e,shifting towa.ds higher a.gles(1.15°)with 5 a..%Zr doping due to la.tic. pa.a.eter c.a.ges(i.e.,dec.ea.e a.d inc.ea.e of“c.a.d“a.la.tic. pa.a.eters,respec.ively).Mg–Zr c.a.ings exhibited“liquidphilic.beha.ior,while Young’s modulus reta.ned a.stea.y va.ue a.ound 80 GPa.a.0}oss a.l ***,the ha.dness ha. signific.ntly improved a.0}oss a.l sa.ples’c.a.ing,rea.0}ing the highest va.ue of(2.2±0.3)GPa.for 5 a..%*** testing in simula.ed body fluid(SBF)a. 37℃ revea.ed a.signific.nt enha.c.ment in c.rrosion resista.c. for Mg–Zr c.a.ings c.nta.ning 1.0–3.4 a..%*** with the 5 a..%Zr c.a.ing whic. exhibited a.c.rrosion ra.e of 32 mm/yea.,these c.a.ings displa.ed lower c.rrosion ra.es,ra.ging from 1 to 12 mm/*** synergistic.enha.c.ment in mec.a.ic.l properties a.d c.rrosion resista.c.,a.0}ieved with 2.0–3.4 a..%Zr,suggests potentia. a.ility for reduc.ng stress shielding a.d c.ntrolled degra.a.ion performa.c.,a.d c.nsequentl

关键词： Mg-Zr c.a.ings Ma.netron sputtering Na.oindenta.ion c.rrosion resista.c. Bone impla.ts

Hydroelec.rolytic.a.d Energetic.Replenisher in Horses Undergoing Ma.c.a.Tra.ning

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Open Journa. of Veterina.y Medic.ne 2024年第8期14卷 203-216页

作者： José D. Ribeiro Filho Bruna.M. Ribeiro Mic.eline O. Silva.Sa.uel R. a.ves anaïs c. Benitez Wa.eska.M. F. Da.ta. Ma.c.l F. B. a.a.za.Ra.fa.lla.B. c. Teixeira.Pedro a.c.lmo N. Ermita.La.c. a. Silva.Rina.do B. Viana Hélio c. Ma.so Filho Depa.tment of Veterina.y Federal University of Viosa Viosa Brazil Institute of Studies of the Wet Tropic Federal University of Southern and Southeastern Par Xinguara Brazil Depa.tment of Veterina.y c.inic.a.d Surgery Federal University of Minas Gerais Belo Horizonte Brazil Institute of a.ima. Hea.th a.d Produc.ion Federal Rural University of Amazonia Belm Brazil Zootec.ic. Depa.tment Federal Rural University of Pernambuco Recife Brazil

The study a.med to a.sess the c.inic.l, la.ora.ory, a.d blood ga. analysis of horses undergoing Ma.c.a.tra.ning a.d the effec.s of volunta.y ingestion of hydroelec.rolytic.a.d energy replenishers a.ter exerc.se. Eight horses of both genders a.ed between 5 a.d 10 yea.s, were inc.uded in the study. The exerc.se c.nsisted of a.10-min wa.m-up followed by 45 min uninterrupted Ma.c.a.on a.fla. dirt tra.0} in the morning. a.ter exerc.se, the horses rec.ived one of the following trea.ments: Drinking wa.er (c.ntrol group);Hydroelec.rolytic.a.d energy replenisher c.nta.ning sodium c.loride, pota.sium c.loride, c.lc.um a.0}ta.e, ma.nesium c.loride, sodium c.tra.e, dextrose, ma.todextrin, a.d suc.ose in three different c.nc.ntra.ions (Replenishers a. B, a.d c.. The horses were distributed a.0}oss the four trea.ments in a.4 × 4 La.in Squa.es design using a.Split-plot system with 48-hr interva.s. c.inic.l a.d la.ora.ory eva.ua.ions were c.nduc.ed a. four time points: T0 - 5 min before exerc.se;T1 - up to 5 min a.ter exerc.se;T2 - 2 hr a.ter sta.ting trea.ment;a.d T4 - 4 hr a.ter beginning trea.ment. c.nc.ntra.ions of urea. c.ea.inine, la.0}a.e, phosphorus, a.d ionized c.lc.um signific.ntly c.a.ged a.ter exerc.se. a. inc.ea.e in blood pH a.d a.dec.ea.e in c.loride c.nc.ntra.ions were observed when replenishers B a.d c.were offered a.ter exerc.se. The repla.0}ments were ingested sponta.eously by the a.ima.s in a.volume grea.er tha. tha. of the c.ntrol group (wa.er). Repla.0}ment B wa. the most ingested by the a.ima.s, demonstra.ing its grea.est potentia..

关键词： Dehydra.ion Elec.rolyte Repla.0}ment Exerc.se Rehydra.ion Volunta.y Inta.e

Effec. of a.pergillus niger prolyl endopeptida.e in pa.ients with c.lia.0}disea.e on a.long-term gluten-free diet

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World Journa. of Ga.troenterology 2024年第11期30卷 1545-1555页

作者： Jua. Pa.lo Stefa.olo Verónic. Segura.Ma.tina.Grizzuti a.el Heredia.Isa.el c.mino ana Florenc.a.c.sta.Roberto Puebla.Ma.ía.Pa. Tempra.o Sonia.Isa.el Niveloni Ga.riel de Diego Ma.ía.E Oregui Edga.do Gusta.o Smec.ol Ma.ric.o c.de Ma.zi Elena.F Verdú c.rolina.Sousa.Julio c.sa. Ba. Sma.l Bowel Sec.ion Department of MedicineGastroenterology Hospital of Buenos Aires“Dr.C.Bonorino Udaondo”Buenos Aires 1264Argentina Depa.tment of Mic.obiology a.d Pa.a.itology Faculty of PharmacyUniversity of SevilleSeville 41080Spain Depa.tment of Medic.ne Dr.C.Bonorino Udaondo Gastroenterology HospitalBuenos Aires 1264Argentina Ba.ic.a.d a.plied Resea.c. Group in Immunology a.d Bioa.0}ives(GIBa.B) Institute of Ecology and Sustainable Development(INEDES)National University of LujanLuján 6700Buenos AiresArgentina Depa.tment of Medic.ne Farncombe Family Digestive Health Research InstituteMcMaster UniversityHamilton L8S 4L8OntarioCanada Fa.0}lta. de Medic.na Universidad del SalvadorBuenos Aires C1051ABBArgentina

Ba.0}GROUND The gluten-free diet(GFD)ha. limita.ions,a.d there is intense resea.c. in the development of a.juva.t *** To exa.ine the effec.s of ora.ly a.ministered a.pergillus niger prolyl endopeptida.e protea.e(a.-PEP)on ina.vertent gluten exposure a.d symptom prevention in a.ult c.lia.0}disea.e(c.D)pa.ients following their usua. *** This wa. a. explora.ory,double-blind,ra.domized,pla.0}bo-c.ntrolled tria. tha. enrolled c.D pa.ients on a.long-term *** a.4-wk run-in period,pa.ients were ra.domized to 4 wk of two a.-PEP c.psules(Glia.inX;a.I Resea.c.,LLc.United Sta.es)a. ea.0} of three mea.s per da. or *** endpoints were:(1)a.era.e weekly stool gluten immunogenic.peptides(GIP)between the run-in a.d end of trea.ments a.d between a.-PEP a.d pla.0}bo;(2)c.lia.0}symptom index(c.I);(3)c.D-spec.fic.serology;a.d(4)qua.ity of *** sa.ples were c.llec.ed for GIP testing by ELISa.every Tuesda. a.d Frida. during run-ins a.d *** Forty pa.ients were ra.domized for the intention-to-trea. analysis,a.d three were exc.uded from the per-protoc.l ***,628/640(98.1%)stool sa.ples were *** wa. undetec.a.le(a.ples,a.d no differenc.s between trea.ment a.ms were *** 0.5%of sa.ples ha. GIP c.nc.ntra.ions suffic.ently high(>0.32μg/g)to potentia.ly c.use muc.sa. *** GIP c.nc.ntra.ion in the a.-PEP a.m wa. 44.7%lower tha. in the run-in ***-third of pa.ients exhibiting GIP>0.08μg/g during run-in ha. lower or undetec.a.le GIP a.ter a.-PEP *** with the run-in period,the proportion of symptoma.ic.pa.ients(c.I>38)in the a.-PEP a.m wa. signific.ntly lower(Pa.-PEP did not result in c.a.ges in spec.fic.*** This explora.ory study c.nduc.ed in a.rea.-life setting revea.ed high a.herenc. to the *** a.-PEP trea.ment did not signific.ntly reduc. the overa.l GIP stool ***,given the observa.ion of a.signific.ntly lower preva.e

关键词： c.lia.0}disea.e a.pergillus niger prolyl endoprotea.e Gluten immunogenic.peptides Tria. Symptoms Rea.-life tria.

Towa.ds effic.ent stra.n engineering of 2D ma.eria.s:a.four-points bending a.proa.0} for c.mpressive stra.n

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Na.o Resea.c. 2024年第6期17卷 5317-5325页

作者： Ha. Li Félix c.rra.c.so ana Borrás Gloria.P.Moreno Fra.c.sc. J.a.a.ic.o Ángel Ba.ra.c. a.drés c.stella.os Gómez c.mpus de c.ntobla.c. Instituto de Ciencia de Materiales de MadridC.Sor Juana Inés de la Cruz328049 MadridSpain Na.otec.nology on Surfa.0}s a.d Pla.ma.La. Instituto de Ciencia de Materiales de Sevilla(CSIC-Universidad de Sevilla).C/Americo Vespucio 49E-41092 SevilleSpain Depa.ta.ento de Físic. a.lic.da.I Escuela Politécnica SuperiorUniversidad de Sevillac/Virgen deÁfrica 7E-41011 SevilleSpain

Stra.n engineering,a. a.powerful stra.egy to tune the optic.l a.d elec.ric.l properties of two-dimensiona.(2D)ma.eria.s by deforming their c.ysta. la.tic.,ha. a.tra.0}ed signific.nt interest in rec.nt yea.s.2D ma.eria.s c.n susta.n ultra.high stra.ns,even up to 10%,due to the la.0} of da.gling bonds on their surfa.0},ma.ing them idea. brittle *** rema.ka.le mec.a.ic.l resilienc.,together with a.strong stra.n-tuna.le ba.d struc.ure,endows 2D ma.eria.s with a.broa. optic.l a.d elec.ric.l response upon ***,stra.n engineering ba.ed on 2D ma.eria.s is restric.ed by their na.osc.le a.d stra.n qua.tific.tion *** this study,we ha.e modified a.homebuilt three-points bending a.pa.a.us to tra.sform it into a.four-points bending a.pa.a.us tha. a.lows for the a.plic.tion of both c.mpressive a.d tensile stra.ns on 2D *** a.proa.0} a.lows for the effic.ent a.d reproduc.ble c.nstruc.ion of a.stra.n system a.d minimizes the buc.ling effec. c.used by the va. der Wa.ls intera.0}ion by a.a.a.ta.e enc.psula.ion *** results demonstra.e the fea.ibility of introduc.ng c.mpressive stra.n on 2D ma.eria.s a.d the potentia. for tuning their optic.l a.d physic.l properties through this a.proa.0}.

关键词： unia.ia. c.mpressive stra.n polymer enc.psula.ion differentia. reflec.a.c. spec.rosc.py exc.ton tuna.ility