检索结果-南通市图书馆

Statins for age related macular degeneration: promising but unproven

Annals of Eye Science 2021年第4期6卷 26-30页

作者： Martin A.Mainster Ahmed Al-Janabi ana boris moreno andrade Gerardo Ledesma-Gil Department of Ophthalmology University of Kansas School of MedicinePrairie VillageKansasUSA Royal Glamorgan Hospital UK Retina Department Institute of OphthalmologyFundación Conde de ValencianaMexico CityMexico

Statins are used widely to treat hypercholesterolemia and atherosclerotic cardiovascular *** have inflammatory and immunomodulatory effects potentially useful for managing systemic autoimmune diseases such as rheumatoid arthritis,lupus erythematosus and multiple *** also have anti-oxidative and large-vessel endothelial supportive properties that occur independent of their lipid-lowering ***,statins can suppress macrophage and microglial activation responsible for initiating inflammatory cytokine *** than forty percent of adults aged 65 years or older use statins in the United States and Australia,a prevalence that increases with *** effects of statin usage on ophthalmic practice are probably *** disease and age-related macular degeneration(AMD)share common risk factors,consistent with the“vascular model”of AMD pathogenesis that implicates impaired choroidal circulation in Bruch’s membrane lipoprotein *** has a complex multifactorial pathogenesis involving oxidative stress,choroidal vascular dysfunction,dysregulated complement-cascade-mediated inflammation and pro-inflammatory and pro-angiogenic growth *** of these components are hypothetically amenable to the primary(cholesterol lowering)and secondary(anti-inflammatory,anti-oxidative,anti-vasculopathy)effects of statin *** studies have been promising,epidemiological trails have produced conflicting results and three prospective clinical trials have been inconclusive at demonstrating the value of statin therapy for delaying or preventing *** evidence to date has failed to prove conclusively that statins are beneficial for preventing or treating AMD.

关键词： Age-related macular degeneration(AMD) inflammation oxidative stress atherosclerosis statins

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：