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Relative peripheral refraction across 4 meridians after orthokeratology and LASIK surgery

Eye and Vision 2018年第1期5卷 118-125页

作者： António Queirós ana amorim-de-sousa Daniela Lopes-Ferreira César Villa-Collar Ángel Ramón Gutiérrez JoséManuel González-Méijome Clinical&Experimental Optometry Research Lab-CEORLab Center of Physics(Optometry)University of MinhoBragaPortugal department of Optics and Optometry European University of MadridMadridSpain. department of Ophthalmology University of MurciaMurciaSpain

Background:To characterize the axial and off-axis refraction across four meridians of the retina in myopic eyes before and after Orthokeratology(OK)and LASIK ***:Sixty right eyes with a spherical equivalent(M)between−0.75 to−5.25 D(cylinderderwent LASIK(n=26)or OK(n=34)to treat *** and off-axis refraction were measured with an open-field autorefractometer before and after stabilized ***-axis measurements were obtained for the horizontal(35°nasal and temporal retina)and vertical(15°superior and inferior retina)meridians,and for two oblique directions(45–225°and 135–315°)up to 20°of *** refractive profile was addressed as relative peripheral refractive error(RPRE).Results:OK and LASIK post-treatment results showed an increase of myopic relative refraction at several eccentric *** the four meridians evaluated,the M component of the pre-treatment RPRE values was not statistically different(p>0.05)from the post-treatment RPRE within 30°and 20°of the central visual field after LASIK and OK,*** results demonstrated that the treatment zone warrants an optimal central field of ***:The present study gives an overview of RPRE after refractive corneal reshaping treatments(OK and LASIK)across vertical,horizontal and two oblique meridians *** allows a 3D representation of RPRE at the retina and shows that the myopic shift induced by both treatments is more relevant in horizontal directions.

关键词： LASIK surgery Orthokeratology Peripheral refraction Myopia progression

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Treatment of spinal cord injury with biomaterials and stem cell therapy in non-human primates and humans

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Neural Regeneration Research 2025年第2期20卷 343-353页

作者： ana Milena Silva Olaya Fernanda Martins Almeida ana Maria Blanco Martinez Suelen Adriani Marques PhD Program in Pathological anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Biomedical Science Institute Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in Pathological anatomy(PPGAP/UFRJ) Department of Neurobiology/Institute of BiologyCampus do GragoatáNiteróiRio de JaneiroBrazil

Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical ***,in the search for more effective treatments than those already applied for years,which are not entirely efficient,researches have been able to demonstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord *** of these strategies has been developed and meticulously evaluated in several animal models with the aim of analyzing the potential of interventions for neuronal repair and,consequently,boosting functional *** the majority of experimental research has been conducted in rodents,there is increasing recognition of the importance,and need,of evaluating the safety and efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in *** article is a literature review from databases(PubMed,Science Direct,Elsevier,Scielo,Redalyc,Cochrane,and NCBI)from 10 years ago to date,using keywords(spinal cord injury,cell therapy,non-human primates,humans,and bioengineering in spinal cord injury).From 110 retrieved articles,after two selection rounds based on inclusion and exclusion criteria,21 articles were ***,this review arises from the need to recognize the experimental therapeutic advances applied in non-human primates and even humans,aimed at deepening these strategies and identifying the advantages and influence of the results on extrapolation for clinical applicability in humans.

关键词： bioengineering biomaterials cell therapy humans non-human primates spinal cord injury stem cell therapy

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High aluminum concentration and initial establishment of Handroanthus impetiginosus : clues about an Al non-resistant species in Brazilian Cerrado

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Journal of Forestry Research 2020年第6期31卷 2075-2082页

作者： Ane Marcela das Chagas Mendon ca Jean Marcel sousa Lira ana Luiza de Oliveira Vilela Daniel amorim Vieira Nayara Cristina de Melo Joao Paulo Rodrigues Alves delfi no Barbosa Programa de Pós-Graduacao em Fisiologia Vegetal Departamento de BiologiaUniversidade Federal de LavrasLavrasMG 37200-000Brazil Programa de Pós-Graduacao em Ciências Ambientais Instituto de Ciências ExatasUniversidade Federal de AlfenasAlfenasMG 37130-001Brazil Programa de Pós-Graduacao em Fitotecnia Departamento de AgriculturaUniversidade Federal de LavrasLavrasMG 37200-000Brazil Instituto Federal de Educacao Ciência e Tecnologia do Pará BelémPA 66093-020Brazil

Cerrado soils are acidic and nutrient-poor,with high content of solubilized Al 3+.Plants growing in these conditions may display adaptations to cope with high aluminum concentrations especially during early developmental *** investigated leaf nutritional status,and photosynthetic and growth characteristics during the initial establishment of Handroanthus impetiginosus(*** Dc.)Mattos,a secondary tree species distributed in the Brazilian *** goal was to understand leaf-level traits related to diff erent aluminum *** plants were cultivated in four diff erent aluminum sulfate concentrations:0,1,2,and 4 mM Al,for 40 *** performed analyses of growth,leaf gas exchange,chloroplast pigment content,and leaf mineral *** observed a linear increase of Al leaf content as a function of Al concentration in the nutrient *** grown in 1 mM Al showed a remarkable increase of K leaf content,net photosynthesis,stomatal conductance,and transpiration,while in 4 mM Al there were reductions of N,P,and K contents,gas exchange characteristics,and *** did not have mechanisms of avoidance,compartmentalization,or resistance to high Al ***,this species showed a hormetic response,with low Al concentrations stimulating and high Al concentrations inhibiting plant responses.

关键词： Hormesis Low Al concentration Al toxicity Cerrado species Carbon assimilation

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Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-Núñez María Fernanda González ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and Notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

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SARS-CoV-2 and hearing:An audiometric analysis of COVID-19 hospitalized patients

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Journal of Otology 2021年第3期16卷 158-164页

作者： Francisco Alves de sousa Rodrigo Pinto Costa Sandra Xará ana Nóbrega Pinto Cecília Almeida e sousa Centro Hospitalar Universitario do Porto Serviço de Otorrinolaringologia e Cirurgia da Cabeça e Pescoço(Otorhinolaryngology and Head&Neck surgery Department)Largo Prof.Abel Salazar4099-001PortoPortugal Unidade de Saúde Familiar Garcia de Orta ACeS Porto OcidentalMedicina Geral e Familiar(Family Medicine)R.Pinho Leal 294150-620PortoPortugal Centro Hospitalar Universitario do Porto Serviço de Doenças Infeciosas(Infectious Diseases Department)Largo Prof.Abel Salazar4099-001PortoPortugal

Purpose COVID-19 associated hearing loss is still an ongoing matter of *** original studies exist on audiological effects of SARS-CoV-2 infection in hospitalized *** main objective was to determine whether SARS-CoV-2 may affect auditory function in clinically ill COVID-19 *** and methods COVID-19 patients with moderate-severe disease and without prior history of hearing abnormalities were enrolled from a tertiary referral center,and matched with *** performed an audiometric evaluation,and thresholds were *** 120 ears from 60 patients were *** with COVID-19 showed worse mean auditory thresholds starting from 1000 Hz through higher frequencies,when compared to controls(1000 Hz:18.52±5.49 dB HL in controls vs 25.36±6.79 dB HL in COVID-19,pders such as age,gender and various comorbidities(pderate-severe *** are in line with the previous suggested effects of COVID-19 on auditory *** study is expected to encourage further research on this topic.

关键词： SARS-CoV-2 COVID-19 Coronavirus Audiometry Hearing

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Evidences on adaptive mechanisms for cardiorespiratory diseases regarding extreme temperatures and air pollution:A comparative systematic review

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Geography and Sustainability 2021年第3期2卷 182-194页

作者： Helena Madureira Maria Pacheco Carlos sousa ana Monteiro Francesca de’-Donato Manuela de-Sario department of Geography University of PortoCEGOTPorto 4150-564Portugal Faculty of Arts and Humanities University of PortoPorto 4150-564Portugal department of Geography University of PortoCEGOTCITTAPorto 4150-564Portugal department of Epidemiology Lazio Regional Health ServiceRome 00147Italy

The negative cardiorespiratory health outcomes due to extreme temperatures and air pollution are widely stud-ied,but knowledge about the effectiveness of the implementation of adaptive mechanisms remains *** objective of this paper is to explore the evidence of adaptive mechanisms for cardiorespiratory diseases regard-ing extreme temperatures and air pollution by comparing the results of two systematic literature review(SLR)processes sharing the same initial research question but led by two research groups with different academic back-grounds working in the same multidisciplinary *** start by presenting the methodological procedures and the results of the SLR triggered by the research group mainly composed by researchers with a background in ge-ography(named geographical strategy).We then compare these results with those achieved in the SLR led by the research group with a background in epidemiology(named epidemiological strategy).Both SLR were developed under the EU Horizon 2020 Project“EXHAUSTION”.The results showed:1)the lack of evidence regarding the effectiveness of adaptation measures,namely due to the limited number of studies about the topic,the prepon-derance of studies dedicated to heat extremes or the unbalance between different adaptation measures;2)that the choice of search terms in the geographical strategy,despite being more comprehensive at first sight,ended up retrieving less results,but it brought new studies that can complement the results of the epidemiological ***,it is suggested that to strengthen the empirical evidence of the effectiveness of adaptation measures,powerful multidisciplinary teams should work together in the preparation of SLR in topics of great complexity,such as the one presented in this paper.

关键词： Cardiopulmonary diseases Extreme temperatures Air pollution Adaptation Planning Systematic literature review(SLR)

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Post-mortem Microstructural Study of Aluminous Refractory Brick Used in Channels of Blast Furnaces

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China's Refractories 2023年第1期32卷 40-43页

作者： ana Valéria de sousa COSTA Belmira Benedita de LIMA-KUHN Antonio Renato BIGANSOLLI department of Chemical Engineering Technology InstituteFederal Rural University of Rio de JaneiroSeropédica 23851-970Brazil

Aluminous refractory materials with high alumina contents are widely used in the steel industry,and the higher the alumina content,the higher the working *** such as high refractoriness and thermal shock resistance lead these refractory materials to be used as channel linings of blast furnaces,where they are exposed to the attack by slag,molten steel,working cycles and sudden temperature changes between 25℃(room temperature)and 1520℃(the temperature of molten pig iron).In this work,microstructural changes in post-mortem aluminous refractory bricks were investigated by apparent porosity,X-ray diffraction analysis(XRD),Fourier transform infrared spectroscopy(FTIR),scanning electron microscopy,and X-ray dispersion energy spectrometry(SEM/EDS).The results showed an increase in the apparent porosity and the bulk density and the presence of the phases mullite,sillimanite,alumina,and quartz in the post-mortem *** and magnesium were not detected in the microstructure of the post-mortem brick,indicating that slags did not corrode these refractory ***,the microstructural changes that occurred in the post-mortem bricks must be due to thermal *** the X-ray diffraction(XRD)test,mullite,sillimanite,quartz,andα-alumina phases were *** results indicate that the aluminous refractory was obtained from *** infrared spectroscopy(FTIR)it was possible to identify the vibration bands referring to the Si-O and Al-O *** increase in the porosity is a result of cracks caused by work cycles at high temperatures and the temperature gradient to which the refractory was subjected during *** the micrograph it was possible to identify the presence of acicular *** absence of magnesium and calcium in the microanalysis results by energy dispersed X-ray spectrometry(EDS)indicates that there was no infiltration by slag or liquid *** results indicate that the microstructural changes that occurred in t

关键词： aluminous refractories steel industry microstructural blast furnace

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Mindfulness interventions during pregnancy:A narrative review

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Journal of Integrative Medicine 2020年第6期18卷 470-477页

作者： Leandro Lucena Cristina Frange ana Claudia amorim Pinto Monica Levy Andersen Sergio Tufik Helena Hachul department of Psychobiology Universidade Federal de Sao Paulo(UNIFESP)Sao Paulo 04023062Brazil department of Neurology and Neurosurgery Universidade Federal de Sao Paulo(UNIFESP)Sao Paulo 04039002Brazil department of Gynecology Universidade Federal de Sao Paulo(UNIFESP)Sao Paulo 04024002Brazil

Pregnancy is a period of major transformations in a woman’s life;increased stress,and mood and sleep disorders are *** review evaluates mindfulness interventions during pregnancy and their ability to help manage stress,anxiety,depression,emotional regulation,level of mindfulness and sleep quality.A search of English language scientific literature relevant to mindfulness interventions for pregnant women was conducted using PubMed,Scopus and Web of Science,without restriction on publication *** criteria were randomized clinical trials with pregnant women,using mindfulness as an intervention for at least three weeks,in one of our main areas of interest,and using only validated scales to measure *** hundred and thirty studies were identified in our searches of research databases,and thirteen were included in our *** found a large diversity of mindfulness programs,heterogeneity among the instruments used to evaluate outcomes,and inconsistency in the gestational periods used in the *** interventions were beneficial for stress,anxiety and *** was also effective when applied in pregnant women with a history of depression or experiencing *** emotional regulation and the level of mindfulness,there were signs of improvement,but more studies are *** of the studies evaluated sleep *** review provides information about current mindfulness programs,an overview of the effects of mindfulness interventions,a description of the measurements used so far,and recommendations for developing highquality mindfulness protocols for pregnant women.

关键词： Mindfulness Pregnancy Anxiety Stress depression Sleep

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Rare complication of percutaneous endoscopic gastrostomy: Ostomy metastasis of esophageal carcinoma

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World Journal of Gastrointestinal Oncology 2013年第11期5卷 204-206页

作者： ana Lúcia sousa Diamantino sousa Francisco Velasco Francisco Aucena ana Lopes Horácio Guerreiro department of Gastroenterology Hospital de Faro E.P.E. department of Internal Medicine Hospital de Faro E.P.E.

The authors present the case of a 55-year-old male with a stage Ⅲ(T4N1M0) squamous-cell esophageal carcinoma, who underwent percutaneous endoscopic gastrostomy(PEG). The pull method of tube placement was used. Five months after the procedure, the patient was referred to the hospital with a hard palpable tumour at the ostomy site. The hystologic exam revealed an abdominal wall metastasis of the esophageal cancer. The authors present this case because of the rarity of metastasis in ostomy after placement of PEG in patients with tumours located in the head and neck. In this particular context and judging by the rarity of situation, the clinical impact of this phenomenom is limited. Nevertheless, metastasis in ostomy site could be prevented by the push method, laparoscopy or laparotomy.

关键词： Enteral nutrition Gastrostomy Esophageal neoplasms Neoplasm metastasis Ostomy

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Implementation of a High-Risk Outpatient Clinic for Children with Complex Congenital Heart Disease in a Reference Service in Brazil

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Congenital Heart Disease 2023年第6期18卷 649-656页

作者： Gustavo Foronda Vanessa Ferreira amorim de Melo Claudia Regina Pinheiro de Castro Grau Ingrid Magatti Piva Glaucia Maria Penha Tavares ana Cristina Sayuri Tanaka Nana Miura department of Pediatric Cardiology and Adult Congenital Heart Diseases Heart Institute of the University of São PauloSão PauloBrazil Foronda Clinic São PauloBrazil Institute of Orthopedics and Traumatology University of São PauloSão PauloBrazil department of Echocardiography Heart Institute of the University of São PauloSão PauloBrazil

Background:Children with congenital heart disease(CHD),even after surgical approaches,and especially those who undergo staged procedures in theﬁrst months of life,remain vulnerable to readmissions and complications,requiring very close monitoring and differentiated intervention ***:descriptive and exploratory study,of the experience report type,which presents the process of building the high-risk outpatient clinic for complex congenital heart diseases(AAR)at the Instituto do Coração(InCor).Results:Report of the path taken to structure the AAR,demonstrating the organization,interface with the multidisciplinary team,admission and discharge criteria,training,and patient proﬁ*** theseﬁve years of care,275 patients were treated,59.65%with biventricular interstage physiology,followed by univentricular interstage physiology(34.55%),residual defects after surgical procedures(3.63%),tumors with risk of mechanical obstruction(1.45%)and patients with an intrauterine approach(0.72%).The signiﬁcant number of critical patients who were successfully discharged from hospital(44.72%),the low mortality rate due to sudden deaths at home and the high adherence to follow-up cor-roborate the impact of this specialized ***:despite the limitations of the study,this experi-ence report showed that with few resources,there is the possibility of organizing an AAR with differentiated care,with the objective of early detection and treatment of residual injuries,identiﬁcation of early interventions,edu-cation of parents for follow-up of their children,resulting in individualized treatment,promoting a better quality of life for this population.

关键词： Congenital heart defects ambulatory care heart defects

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