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Neuropathic pain-like symptoms and pre-surgery radiographic severity contribute to patient satisfaction 4.8 years post-total joint replacement

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World Journal of Orthopedics 2017年第10期8卷 761-769页

作者： Sophie C Warner Helen Richardson Wendy Jenkins Thomas Kurien michael Doherty ana m valdes Academic Rheumatology University of NottinghamClinical Sciences BuildingNottingham City Hospital Department of Cardiovascular Sciences University of Leicester and National Institute for Health Res-earchLeicester Cardiovascular Biomedical Research Unit Arthritis Research UK Pain Centre Academic Division of Trauma and Orthopaedics Queens Medical Centre

AIm To investigate a comprehensive range of factors that contribute to long-term patient satisfaction post-total joint replacement(TJR) in people who had undergone knee or hip replacement for *** Participants(n = 1151) were recruited from Nottinghamshire post-total hip or knee replacement. Questionnaire assessment included medication use, the pain-DETECT questionnaire(PDQ) to assess neuropathic pain-like symptoms(NP) and TJR satisfaction measured on average 4.8 years post-TJR. Individual factors were tested for an association with post-TJR satisfaction, before incorporating all factors into a full model. Data reduction was carried out using LASSO and receiveroperator characteristic(ROC) curve analysis was used to quantify the contribution of variables to post-TJR *** After data reduction, the best fitting model for post-TJR satisfaction included various measures of pain, history of revision surgery, smoking, pre-surgical X-ray severity, WOmAC function scores and various comorbidities. ROC analysis of this model gave AUC = 0.83(95%CI: 0.80-0.85). PDQ scores were found to capture much of the variation in post-TJR satisfaction outcomes: AUC = 0.79(0.75-0.82). Pre-surgical radiographic severity was associated with higher post-TJR satisfaction: OR_(satisfied) = 2.06(95%CI: 1.15-3.69), P = *** These results highlight the importance of pre-surgical radiographic severity, post-TJR function, analgesic medication use and NP in terms of post-TJR satisfaction. The PDQ appears to be a useful tool in capturing factors that contribute to post-TJR satisfaction.

关键词： Osteoarthritis Patient satisfaction Total joint arthroplasty Neuropathic pain Surgery outcomes

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肠道微生物群在营养和健康中的作用

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英国医学杂志中文版 2021年第3期24卷 151-158页

作者： ana m valdes Jens Walter Eran Segal Tim D Spector 朱一丹(译) 武阳丰(校) School of medicine University of NottinghamCity HospitalNottingham NG51PBUK NIHR Nottingham Biomedical Research Centre NottinghamUK Department of Agricultural Foodand Nutritional Science and Department of Biological SciencesUniversity of AlbertaEdmontonCanada Department of Computer Science and Applied mathematics Weizmann Institute of ScienceRehovotIsrael Department of Twin Research and Genetic Epidemiology King′s College LondonLondonUK 北京大学临床研究所

ana m valdes及同事探讨了通过饮食和益生菌调节肠道微生物群的策略。微生物基因组(microbiome)是指在特定环境中微生物的基因组集合,而微生物群(microbiota)是指微生物自身组成的群落(译者注:国内文献通常将微生物群称为菌群,微生物基... 详细信息

ana m valdes及同事探讨了通过饮食和益生菌调节肠道微生物群的策略。微生物基因组(microbiome)是指在特定环境中微生物的基因组集合,而微生物群(microbiota)是指微生物自身组成的群落(译者注:国内文献通常将微生物群称为菌群,微生物基因组称为微生物组)(框图1)。约有100万亿微生物(大多数是细菌,也有病毒、真菌和原生动物)存在于人体胃肠道中1-2。

关键词：微生物群微生物组国内文献益生菌特定环境原生动物胃肠道

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Symmetry and Transitive Properties of monohedral f-triangulations of the Riemannian Sphere

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Acta mathematica Sinica,English Series 2009年第10期25卷 1609-1616页

作者： ana m.BREDA J.m.SIGARRETA Department of mathematics University of Aveiro Facultad de matematicas Universidad Autonoma de Guerrero

Here we give the complete description of the symmetry group and transitive properties of the set of all of monohedral triangulations of the Riemannian sphere by f-tilings. We shall also show that each monohedral f-tiling of the Riemannian sphere can be seen, up to a spherical isometry, as the singular set of a spherical isometric folding.

关键词： isometric folding monohedral tiling graphs combinatoric

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Bendable tube-shaped supercapacitor based on reduced graphene oxide and Prussian blue coated carbon fiber yarns for energy storage

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Journal of Energy Chemistry 2018年第3期27卷 866-873页

作者： mohd.Khalid ana m.B.Honorato Department of macromolecular Science and Engineering Case Western Reserve University

Carbon fiber yarns（CFY） are promising as a new type of flexible building blocks for the construction of flexible architectures for the energy storage applications. The main hurdle with CFY is how to make them high energy and power capable by using economically and environmentally viable materials. Here,we report reduced graphene oxide（r GO） and Prussian blue（PB） coated CFY, derived from a facile electrochemical process at room temperature for supercapacitor electrodes. The PB coated CFY and r GO coated CFY electrodes exhibit the excellent gravimetric capacitance of 339 F/g and 160.2 F/g, respectively, in aqueous KCl electrolyte in three-electrode cell configuration. When we coupled these electrodes inside the flexible plastic tube and separated by the electrolyte wet filter paper in order to construct flexible architecture, the resulting device delivers excellent specific energy of 52.1 Wh/kg and 26.5 Wh/kg with offering specific power of 3100 W/kg and 14400 W/kg respectively, under a wide operating potential of1.8 V with excellent rate capability. The device shows high tolerance towards bending, and retained its efficiency to the capacitance after being bent at an angle of 360° for 200 bending cycles.

关键词： Carbon fiber yarns Bendable supercapacitor Energy density Power density

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Impact of tropospheric modelling on GNSS vertical precision:an empirical analysis based on a local active network

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International Journal of Digital Earth 2018年第9期11卷 880-896页

作者： mªSelmira Garrido mªClara de Lacy ana mªRojas Department of Cartographic Geodetic and Photogrammetric EngineeringUniversity of JaénJaenSpain Center for Advanced Studies in Earth Sciences University of JaénJaenSpain Research group RNm282–microgeodesia Jaén University of JaénJaenSpain

The troposphere affects Global Navigation Satellite System(GNSS)signals due to the variability of the refractive *** delay is a function of the satellite elevation angle and the altitude of the GNSS receiver and depends on the atmospheric *** the residual tropospheric delay is not modelled carefully a bias error will occur in the vertical *** order to analyse the precise altimetric positioning based on a local active network,four scenarios in Southern Spain with different topographical,environmental,and meteorological conditions are presented,considering both favourable and non-favourable *** use of surface meteorological observations allows us to take into account the tropospheric conditions instead of a standard atmosphere,but introduces a residual tropospheric bias which reduces the accuracy of precise GNSS ***,with short observation times it is recommended not to estimate troposphere parameters,but to use an a priori model together with the standard *** results confirm that it is possible to achieve centimetre-scale vertical accuracy and precision with real time kinematic positioning even with large elevation differences with respect to the nearest reference *** numerical results may be taken into consideration for improving the altimetric configuration of the local active network.

关键词： Altimetry GNSS meteorological data active network tropospheric refraction

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Hydroxytyrosol and Parkinson's disease:protective actions against alpha-synuclein toxicity

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Neural Regeneration Research 2024年第7期19卷 1427-1428页

作者： Ruth Hornedo-Ortega ana m.Espinosa-Oliva Departamento de Nutrición y Bromatología Toxicología y Medicina LegalFacultad de FarmaciaUniversidad de SevillaSevilleSpain Instituto de Biomedicina de Sevilla IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Departamento de Bioquímica y Biología molecular Facultad de FarmaciaUniversidad de SevillaSevillaSpain

Parkinson’s disease:Parkinson’s disease(PD) is the second most prevalent neurodegenerative disease,after Alzheimer’s disease,affecting 1%of the general population over the age of *** to data from the World Health Organization(WHO),its prevalence has doubled in the past 25 *** 2019,global estimates indicated over 8.5 million individuals with PD and it is suggested that PD caused 329000 deaths,an increase of over 100% since 2000(WHO,2022).

关键词： protective Alzheimer prevalence

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INTRINSIC FLUORESCENCE CHANGES IN NERVE TERmINALS,EVOKED BY ACTION POTENTIALS,ARE mODULATED BY KREBS CYCLE SUBSTRATES

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Journal of Innovative Optical Health Sciences 2011年第2期4卷 209-214页

作者： PAUL KOSTERIN ana LIA OBAID BRIAN m.SALZBERG Department of Neuroscience University of Pennsylvania School of medicine Philadelphia PA 19104USA Department of Physiology University of Pennsylvania School of medicine Philadelphia PA 19104USA

Electrical stimulation of the mammalian neurohypophysial infundibular stalk evokes the entry of Nat and Ca^(2+) into the neurosecretory terminals during the action *** events,in turn,increase intracellular Ca^(2+) and activate NaK-and Ca-ATPases,prompting the mitochondria to increase oxidative phosphorylation which can be monitored by recording the changes in FAD and *** paper reflects our efforts to determine whether or not modulating the capacity of mitochondria to produce ATP,by changing the concentrations of two important substrates of the Krebs cycle of the nerve terminal mitochondria,pyruvate and glucose,has an effect on the intrinsicfluorescence changes triggered by action potential stimulation.

关键词： Fluorescence FAD NADH action potential metabolism

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Effect of Zn binding to phytate and humic substances on its uptake by wheat(Triticum durum L.)as affected by carbonates and Fe oxides

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Pedosphere 2022年第6期32卷 823-832页

作者： ana m.GARCÍA-LÓPEZ Ramiro RECENA Antonio DELGADO Department of Agronomy ETSIAUniversity of SevilleSeville 41013(Spain)

Although complexation with soil organic matter may improve zinc(Zn)bioavailability to plants,the effect of Zn sorbent surface on the use of complexed Zn by plants remains *** objective of this research was to elucidate how Zn complexation with humic substances(HS)and phytate affects the uptake of Zn by wheat plants depending on the main sorbent surface in growth media,i.e.,carbonates and Fe *** this end,two pot experiments were performed,one using Fe oxide-coated siliceous as the siliceous growth medium sand and the other using a mixture of calcareous sand and siliceous sand as the calcareous growth *** experiment involved three Zn sources,Zn-HS complex,Zn phytate,and ZnSO_(4).All sources were applied with surface irrigation at two Zn rates(0.25 and 2 mg kg^(-1) growth medium).The Zn-HS complex significantly increased Zn uptake by plants in both media,relative to the other two Zn sources,but no significant difference was observed between Zn phytate and ZnSO_(4).In the calcareous medium,Zn-HS complex and Zn phytate resulted in significantly higher dry biomass yields of wheat than ZnSO_(4).In the siliceous medium,spike and shoot dry biomass yields with Zn-HS complex at the low rate and Zn phytate at both rates were not significantly different from those with ZnSO_(4) at the high *** harvest,approximately 50%of the Zn applied as Zn-HS complex remained extractable by diethylenetriaminepentaacetic acid(DTPA),while this proportion was less than 20%for the other Zn ***,Zn-HS complex and Zn phytate are sources of available Zn for plants,and they are more effective than ZnSO_(4) in increasing plant growth,particularly when carbonates are the main Zn sorbent surface.

关键词： calcareous growth medium micronutrient organic matter organic phosphorus Zn availability Zn deficiency Zn sorbent surface Zn source

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Evolutionary Genomics of Weedy Rice in the USA

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Journal of Integrative Plant Biology 2007年第6期49卷 811-816页

作者： Kenneth m. Olsen ana L. Caicedo Yulin Jia Department of Biology Washington University St Louis MO 63130 USA Department of Biology University of Massachusetts Amherst MA 01003 USA USDA-ARS Dale Bumpers National Rice Research Center Stuttgart AR 72160 USA

Red rice Is an Interfertlle, weedy form of cultivated rice （Oryza sativa L.） that competes aggressively with the crop In the southern US, reducing yields and contaminating harvests. No wild Oryza species occur In North America and the weed has been proposed to have evolved through multiple mechanisms, Including ＂de-domestication＂ of US crop cultlvars, accidental introduction of Asian weeds, and hybridization between US crops and Asian wild/weedy Oryza strains. The phenotype of US red rice ranges from ＂crop mimics＂, which share some domestication traits with the crop, to strains closely resembling Asian wild Oryza species. Assessments of genetic diversity have Indicated that many weed strains are closely related to Asian taxa （Including indica and aus rice varieties, which have never been cultivated In the US, and the Asian crop progenitor O. ruflpogon）, whereas others show genetic similarity to the tropical Japonica varieties cultivated In the southern US. Herein, we review what Is known about the evolutionary origins and genetic diversity of US red rice and describe an ongoing research project to further characterize the evolutionary genomlcs of this aggressive weed.

关键词： crop-weed introgression de-domestication Oryza sativa weed evolution weedy rice.

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Onto the sense of smell in macaws, amazons and toucans: can they use volatile cues of fruits to make foraging decisions?

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Integrative Zoology 2023年第4期18卷 762-771页

作者： m.Carmen HERNÁNDEZ ana maría VILLADA Isabel BARJA Unidad Zoología Departamento de BiologíaUniversidad Autónoma de MadridCampus Universitario de CantoblancoMadridSpain Toucan Rescue Ranch HerediaCosta Rica Centro de Investigación en Biodiversidad y Cambio Global(CIBC-UAm)Universidad Autónoma de madrid MadridSpain

Over the past decades,empirical evidence has been accumulated indicating that olfactory information plays a fundamental role in bird life ***,many aspects of avian olfaction remain poorly *** purpose was to broaden the knowledge about the importance of the sense of smell in some neglected bird groups:psittaciformes and ramphastids,and to compare how the response varied between the *** of the lack of information about the use of chemical cues for locating food in fruit-eating species,we also aimed to delve into this *** conducted a 3-choice(water/vinegar/papaya and banana juice)scent test in 5 Costa Rican native species:scarlet macaw(Ara macao),red-lored amazon(Amazona autumnalis),yellow-naped amazon(Amazona auropalliata),keel-billed toucan(Ramphastos sulfuratus),and yellow-throated toucan(Ramphastos ambiguus).Results revealed that macaws and toucans allocated signiﬁcantly more time to interacting with the fruit scent container,indicating that these species can perceive the volatile chemicals emitted by ripe fruits and that they can use this information to make foraging ***,amazons did not dedicate more time to interact with the fruit *** research provides theﬁrst evidence of the ability to exploit chemical volatile cues in macaws and toucans.

关键词： avian olfaction bird senses frugivorous birds psittaciformes ramphastids scent test

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