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Structural insight into acute intermittent porphyria

生物物理学报 2009年第S1期25卷 356-357页

作者： Ang Gao andrzej joachimiak Neil Shaw National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Structural Biology Center Advanced Photon Source Argonne National Laboratory

Acute intermittent porphyria (AIP), an inherited disease of heme biosynthesis, is one of the most common type of the porphyrias. Reduced activity of the enzyme

关键词： human porphobilinogen deaminase X-ray structure heme biosynthesis porphobilinogen hinge

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The Midwest Center for Structural Genomics in USA

The Midwest Center for Structural Genomics in USA

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第十次中国生物物理学术大会

作者： andrzej joachimiak Midwest Center for Structural Genomics and Structural Biology Center BiosciencesArgonne National Laboratory9700 South Cass Ave．ArgonneIL 60439

＜正＞Millions of predicted protein sequences have become available through genome sequencing efforts. Analyses of protein sequences allow for the extraction of only a portion of the proteome data since many aspects of protein function, including molecular recognition, assembly and catalysis, depend on the 3-D atomic structure. The analysis of 3-D protein

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Structural insight into acute intermittent porphyria

Structural insight into acute intermittent porphyria

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第十一次中国生物物理学术大会暨第九届全国会员代表大会

作者： andrzej joachimiak Neil Shaw Structural Biology Center Advanced Photon SourceArgonne National Laboratory National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of Sciences

＜正＞Acute intermittent porphyria（AIP）,an inherited disease of heme biosynthesis,is one of the most common type of the *** activity of the enzyme porphobilinogen

关键词： human porphobilinogen deaminase X-ray structure heme biosynthesis porphobilinogen hinge

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Discovery of a non-adenylating acyl-CoA ligase and restoring its adenylation activity

Discovery of a non-adenylating acyl-CoA ligase and restoring...

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中国化学会第十二届全国天然有机化学学术会议

作者： Nan Wang Jeffrey D.Rudolf Liao-Bin Dong Jerzy Osipiuk Catherine Hatzos-Skintges Michael Endres Chin-Yuan Chang Gyorgy Babnigg andrzej joachimiak George N.Phillips Jr Ben Shen Department of Chemistry The Scripps Research Institute Midwest Center for Structural Genomics and Structural Biology Center Biosciences DivisionArgonne National Laboratory Department of Biosciences Rice University Department of Molecular Medicine The Scripps Research Institute Natural Products Library Initiative at The Scripps Research Institute The Scripps Research Institute

Acyl-coenzyme A（CoA） ligases catalyze the activation of carboxylic acids via a two-step reaction of adenylation followed by ***,we report the discovery of a non-adenylating acyl-CoA ligase PtmA2 and the functional separation of an acyl-CoA ligase *** PtmA1 and PtmA2,two acyl-CoA ligases from the biosynthetic pathway of platensimycin and platencin,are necessary for the two steps of CoA *** inactivation of ptmA1 and ptmA2 resulted in the accumulation of free acid and adenylate intermediates,*** and structural characterization of PtmA2 confirmed its ability to only catalyze *** characterization of PtmA2 revealed it binds both free acid and adenylate substrates and undergoes the established mechanism of domain ***,site-directed mutagenesis restored both the adenylation and complete CoA activation *** study challenges the currently accepted paradigm of adenylating enzymes and inspires future investigations on functionally separated acyl-CoA ligases and their ramifications in biology.

关键词： acyl-CoA synthetase acyl-CoA ligase platensimycin platencin

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流感病毒聚合酶PA亚基与PB1多肽复合体的精细三维结构

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中国基础科学 2009年第2期11卷 24-26页

作者：贺晓静周杰 Mark Bartlam 张荣光马建源娄志勇李雪梅李晶晶 andrzej joachimiak 曾宗浩葛若雯饶子和刘迎芳中国科学院生物物理研究所生物大分子国家重点实验室南开大学生命科学院美国阿贡国家实验室结构基因组学和结构生物学中西部地区中心清华大学结构生物学实验室新加坡国立大学生物科学院

近年来禽流感病毒疫情的发生给全球带来了重大威胁。对流感病毒蛋白,特别是流感病毒RNA聚合酶复合体的结构生物学研究对揭示病毒复制机制以及开展相关药物设计都具有重大意义。流感病毒RNA聚合酶是由PB1、PB2以及PA亚基组成的负责流感... 详细信息

近年来禽流感病毒疫情的发生给全球带来了重大威胁。对流感病毒蛋白,特别是流感病毒RNA聚合酶复合体的结构生物学研究对揭示病毒复制机制以及开展相关药物设计都具有重大意义。流感病毒RNA聚合酶是由PB1、PB2以及PA亚基组成的负责流感病毒的RNA合成以及维持病毒生命周期至关重要的分子机器。其中,PB1是该聚合酶的RNA合成亚基,PB2负责获取宿主mRNA用于病毒mRNA合成,而PA亚基功能则不清楚。本研究报道了来源于禽流感病毒RNA聚合酶PA亚基羧基端与PB1氨基端短肽复合体的三维晶体结构。该结构揭示了PA与PB1亚基相互作用方式,并分析了PA分子在RNA结合等方面的功能,对进一步研究PA功能以及开展针对聚合酶PA分子的药物设计具有十分重大的意义。

关键词：禽流感 RNA聚合酶复合体 PA PB1晶体结构

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LCA in Environmental Management Systems—Results of Individual Interviews with Selected Enterprises from Poland and Sweden

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Journal of Environmental Protection 2013年第7期4卷 694-700页

作者： Katarzyna joachimiak-Lechman Department of Industrial Products Ecology and Quality Faculty of Commodity Science Poznan University of Economics Poznan Poland

Life Cycle Assessment (LCA) is an analytical tool used for the environmental optimization of products and services within the entirety of its life cycle. ISO 14040 recommends use of the technique in numerous areas of environmental management such as in designing for the environment, eco-labelling, environmental communications and the assessment of the effects of environmental activities. Despite being theoretically feasible, certain applications of the ecological assessment of a life cycle such as the possibility of identification and evaluation of environmental aspects with the use of LCA are, in practice, still new to many environmental managers. With its strong points, the technique seems to be a valuable tool, especially in the context of apparent concepts of Product-Oriented Environmental Management Systems (POEMS). In order to verify the hypothesis, the author decided to verify the level of use of LCA in the area of identification and assessment of environmental aspects in selected organizations. Therefore, questionnaire interviews were conducted with representatives of selected Polish and Swedish enterprises who, at the time of the interview, had certified environmental management systems. The organizations were analyzed with respect to applied methods and techniques used for identification and assessment of environmental aspects as well as the degree of use of LCA both in this respect and in other areas of environmental management. This paper will present the results of this research and conclusions.

关键词： Environmental Management System Life Cycle Assessment ISO 14001 Environmental Aspects Identification Assessment

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New steroid dimer derived from cholic acid as receptor for lanthanum(Ⅲ) and calcium(Ⅱ) nitrates

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Journal of Rare Earths 2010年第S1期28卷 56-60页

作者： Zdzisaw Paryzek Monika Piasecka Roman joachimiak Emilia Luks Wanda Radecka-Paryzek Faculty of Chemistry Adam Mickiewicz University

New steroid dimer,ethylene bridged bis-carbamate(3) was synthesized from cholic acid in few steps. Complexes of 3 with lanthanum(Ⅲ) and calcium(Ⅱ) nitrates were prepared in reaction of 3 and appropriate metal salts. They were characterized by spectral data(Infrared(IR) ,ultraviolet-visible(UV/Vis) ,nuclear magnetic resonance(NMR) spectroscopy and fast-atom bombardment(FAB) ,electrospray(ESI) and matrix-assisted laser desorption/ionization mass spectrometry(MALDI-MS)) and elemental analysis. The similarity in complexing behavior of steroidal dimer toward calcium and lanthanum ions was observed.

关键词： cholic acid steroid dimer carbamate lanthanum and calcium nitrate complexes rare earths

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