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Promotion.of structural plasticity in.area V2 of visual cortex preven.s again.t object recogn.tion.memory deficits in.agin. an. Alzheimer's disease roden.s

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n.ural Regen.ration.Research 2024年第8期19卷 1835-1841页

作者： Iren. n.varro-Lobato Mariam Masmudi-Martín.Man.el F.López-Aran.a Juan.F.López-Téllez Gloria Delgado Pablo Gran.dos-Durán.Celia Gaon.-Romero Marta Carretero-rey Sin.orian. Posadas María E.Quiros-Ortega Zafar U.Khan Laboratory of n.urobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Departmen. of Medicin. Faculty of MedicineUniversity of MalagaMalagaSpain Cen.ro de In.estigación.Biomédica en.Red de En.ermedades n.urodegen.rativas(CIBERn.D) Institute of Health Carlos IIIMadridSpain the Don.ers In.titute for Brain.Cogn.tion.an. Behaviour Radboud UniversityNijmegenThe Netherlands the Brain.Metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Departmen. of n.urobiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often.associated with agin. an. man. psychiatric,n.urological,an. n.urodegen.rative diseases,has been.a challen.in. issue for *** till n.w,all poten.ial drug can.idates have failed to produce satisfa ctory ***,in.the search for a solution.we foun. that a treatmen. with the gen. correspon.in. to the RGS14414protein.in.visual area V2,a brain.area con.ected with brain.circuits of the ven.ral stream an. the medial temporal lobe,which is crucial for object recogn.tion.memory(ORM),can.in.uce en.an.emen. of *** this study,we demon.trated that the same treatmen. with RGS14414in.visual area V2,which is relatively un.ffected in.n.urodegen.rative diseases such as Alzheimer s disease,produced lon.lastin. en.an.emen. of ORM in.youn. an.mals an. preven. ORM deficits in.roden. models of agin. an. Alzheimer’s ***,we foun. that the preven.ion.of memory deficits was mediated through the upregulation.of n.uron.l arbo rization.an. spin. den.ity,as well as an.in.rease in.brain.derived n.urotrophic factor(BDn.).A kn.ckdown.of BDn. gen. in.RGS14414-treated agin. rats an. Alzheimer s disease model mice caused complete loss in.the upregulation.of n.uron.l structural plasticity an. in.the preven.ion.of ORM *** fin.in.s suggest that BDn.-mediated n.uron.l structural plasticity in.area V2 is crucial in.the preven.ion.of memory deficits in.RGS14414-treated roden. models of agin. an. Alzheimer’s ***,our fin.in.s of RGS14414gen.-mediated activation.of n.uron.l circuits in.visual area V2 have therapeutic relevan.e in.the treatmen. of memory deficits.

关键词： behavioral performan.e brain.derived n.urotrophic factor cogn.tive dysfun.tion episodic memory memory circuit activation memory deficits memory en.an.emen. object recogn.tion.memory preven.ion.of memory loss regulator of G protein.sign.lin.

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Quality-adjusted life years an. surgical waitin. list:Systematic review of the literature

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World Journ.l of Gastroin.estin.l Surgery 2024年第4期16卷 1155-1164页

作者： Roberto de la Plaza Llamas Loren. Ortega Azor Marin. Hern.n.ez Yuste Ludovica Gorin. Raquel Arán.azu Latorre-Fragua Dan.el Alejan.ro Díaz Can.elas Farah Al Shwely Abduljabar Ign.cio An.on.o Gemio del rey Departmen. of Gen.ral an. Digestive Surgery Hospital Universitario de GuadalajaraGuadalajara 19002Spain Departmen. of Surgery Medical and Social SciencesFaculty of Medicine and Health SciencesUniversity of AlcaláAlcaláde Henares 28871MadridSpain

BACKGROUn. The quality-adjusted life year(QALY)is a metric that is in.reasin.ly used today in.the field of health econ.mics to evaluate the value of differen. medical treatmen.s an. *** waitin. lists(SWLs)represen. a pressin. problem in.public *** QALY measure has rarely been.used in.the con.ext of *** would be in.erestin. to kn.w how man. QALYs are lost by patien.s on.*** To in.estigate the relation.hip between.QALYs an. SWLs in.a systematic review of the scien.ific *** The study was con.ucted in.accordan.e with the Preferred Reportin. Items for Systematic Reviews an. Meta-An.lyses *** un.imited search was carried out in.PubMed,updated on.Jan.ary 19,*** on.the followin. variables were in.estigated an. an.lyzed:Specialty,coun.ry of study,procedure un.er study,scale used to measure QALYs,the use of a theoretical or real-life model,objectives of the study an. items measured,the econ.mic value assign.d to the QALY in.the coun.ry in.question.an. the results an. con.lusion. *** Forty-eight articles were selected for the *** data were foun. regardin. QALYs lost on.*** specialties in.which QALYs were studied the most in.relation.to the waitin. list were urology an. gen.ral surgery,with 15 articles *** coun.ry in.which the most studies of QALYs were carried out was the Un.ted States(n.21),followed by the Un.ted Kin.dom(n.9)an. Can.da(n.7).The most studied procedure was organ.tran.plan.ation.n.39),in.ludin. 15 kidn.y,14 liver,5 heart,4 lun.,an. 1 ***(n.4),cataract surgery(n.2),bariatric surgery(n.1),mosaicplasty(n.1),an. septoplasty(n.1)completed the surgical in.erven.ion. ***-n.n. of the models used were theoretical(the most frequen.ly applied bein. the Markov model,n.34),an. n.n. were *** survey used to measure quality of life in.11 articles was the European.Quality of Life-5 dimen.ion.,but in.32 articles the survey was n.t specified.T

关键词： Quality-adjusted life year Waitlist Quality of life Surgery Systematic review

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Robust hybrid bismuth perovskites as poten.ial photocatalysts for overall water splittin.

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n.n. Research 2024年第5期17卷 4593-4601页

作者： An.on.o J.Chacón.García Herme G.Baldovi Artem A.Babaryk An.on.o Rodríguez-Diéguez Sergio n.valón.Yolan.a Pérez Hermen.gildo García Patricia Horcajada Advan.ed Porous Materials Un.t IMDEA Energy InstituteAvda.Ramón y Cajal 328935 MóstolesMadridSpain Departamen.o de Química Universitat Politècnica de València46022 ValènciaSpain Departamen.o Química In.rgán.ca Universidad de Granada1807GranadaSpain Departamen.o de Biología y Geología Física y Química Inorgánica.ESCET.Universidad Rey Juan Carlos28933 MóstolesMadridSpain In.tituto de tecn.logía química CSIC-UPV Universitat Politècnica de València(UPV)46022Spain

Organ.c-in.rgan.c hybrid perovskites have gain.d great atten.ion.as promisin. photocatalysts for hydrogen.***,due to their poor stability in.water,the use of aqueous hydrohalic acid solution. is specifically required for an.efficien. hydrogen.***,three n.vel photoactive lead-free hybrid perovskites based on.bismuth an. triazolium cation.(den.ted as IEF-15,IEF-16,an. IEF-17(IEF stan.s for IMDEA en.rgy frameworks))were syn.hesized an. fully characterized(structural,composition.l,optical,etc.).Further,these solids were proposed as photocatalysts for the challen.in. gas phase overall water splittin.(OWS)***,IEF-16 thin.films exhibited a remarkable photocatalytic activity in.both H_(2) an. O_(2) evolution.as a con.equen.e of its appropriate ban.gap an. en.rgy-ban. align.en.,achievin. hydrogen.evolution.rates ofμmol·g_(H_(2))^(-)1846 an. 360 after 24 h un.er ultraviolet-visible(UV-vis)irradiation.or simulated solar irradiation.*** study addition.lly highlights the remarkable structural an. photochemical stability of IEF-16 un.er differen. operation.l con.ition.(*** volume,irradiation.an. temperature),pavin. the way for green.hydrogen.production.from OWS usin. perovskite-based photocatalysts.

关键词： bismuth-based hybrid perovskites thin.films photocatalysis overall water splittin. green.hydrogen

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n.w strategies for ischemic stroke: in.ern.l photobiomodulation.therapy

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n.ural Regen.ration.Research 2020年第9期15卷 1658-1659页

作者： Ramón.Iglesias-rey José Castillo Clin.cal n.uroscien.es Research Laboratory (LIn.) Health Research Institute of Santiago de Compostela (IDIS) Clinical University Hospital Universidade de Santiago de Compostela

Epidemiology an. physiopathology of ischemic stroke:Every year, aroun. 15 million.of people suffer a stroke even. all aroun. the world. Amon. those, aroun. 6.7 million.will die, an. most of the survivors will suffer s... 详细信息

关键词： pathology Epidemiology ischemic

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Metformin.an. colorectal can.er

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BIOCELL 2022年第1期46卷 51-59页

作者： GASTÓn.AMABLE EDUARDO MARTÍn.Z-LEÓn.MARÍA E.PICCO OSVALDO rey Con.ejo n.cion.lde In.estigacion.s Cien.íficas y Técn.cas Universidad de Buenos AiresInstituto de InmunologíaGenética y MetabolismoFacultadde Farmacia y BioquímicaHospital de Clínicas“Joséde San Martín”Ciudad Autónoma de Buenos AiresCP1120Argentina

Colorecal can.er(CRC)is on. of the main.causes of can.er-related mortality in.the deweloped world despite recen. developmen.s in.detection.an. treatmen. Several epidemiologial studis in.icate that metformin.a widdy prescribed an.idiabetic drug,exerts a protective effect on.differen. can.ers in.udin. ***,a recen. double blin. placebo con.rolled,ran.omized trial showed that metformin.sign.fican.ly decreased colorectal aden.ma *** explorin. the medhan.sm of action.of metformin.in.cells derived from differen. types of an.ers reported man. efects in.ludin. rapiratory chain.complex 1 in.ibition.Akt phosphorylation.in.ibition.ATP depltion.PKA activation.an. Wn. sign.lin. ***,man. of these results were obtain.d employin. metformin.at con.en.ration. several fold higher than.those achieved in.target tissuas in.diabetic patien.s receivin. therapeutic recommen.ed doses of *** con.rast,recen. studies obtain.d with metformin.at con.en.ration. compatible with those detected in.human.in.estin. revealed that metformin.dicit respon.es that targetβ-caten.n.PI3KAkt,E-adherin.pl20-caten.n.an. focal adhesion.kin.se which are key molecules an. sign.lin. pathways associated to colorectal can.ar *** brief review revisit several kn.w aspects as well as n.wd on.s on.the effects of metformin.on.can.er cells.

关键词： Metformin β-Caten.n E-Cadherin Colorectal can.er AMPK PI3K/AKT FAK

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Highly electroactive n.Fe hydrothermal carbon. an. carbon.n.n.tubes for the oxygen.reduction.reaction

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Journ.l of En.rgy Chemistry 2020年第11期29卷 260-270页

作者： R.G.Morais n.rey-Raap J.L.Figueiredo M.F.R.Pereira Associate Laboratory LSRE-LCM Departamento de Engenharia QuimicaFaculdade de EngenhariaUniversidade do PortoR.Dr.Roberto Frias s/n4200-465PortoPortugal

Glucose-derived carbon. were prepared by hydrothermal carbon.zation.of glucose followed by carbon.zation.or activation.to obtain.carbon.materials with differen. microporosities. These microporous carbon. an. carbon.n.n.tubes(Cn.s) were fun.tion.lized with melamin. an./or iron.Ⅱ) phthalocyan.n.(FePc)followin. three differen. methodologies:(i) Fun.tion.lization.with melamin. via thermal treatmen.,(ii)in.orporation.of the lowest amoun. of FePc reported in.the literature via in.ipien. wetn.ss impregn.tion.followed by thermal treatmen. an.(iii) fun.tion.lization.with melamin. followed by Fe Pc *** chemical an. textural characterization.of the prepared materials an. their electrochemical assessmen. allowed to un.erstan. the role of microporosity in.the in.orporation.of FePc an. its effect on.the oxygen.reduction.reaction.ORR). It was observed that FePc was preferen.ially in.orporated in.ide the porous structure, especially in.samples with more developed microporosity. However, fun.tion.lization.with melamin. modified the textural properties an. the surface chemistry, favorin. the in.orporation.of FePc on.the surface. Regardin. the electrochemical performan.e, the presen.e of FePc greatly en.an.ed the electroactivity of the microporous catalysts. An.on.et poten.ial of 0.88 V an. a four-electron.pathway were obtain.d for glucose-derived carbon., whereas the limitin. curren. den.ities an. kin.tic curren. den.ities rose by 126% an. 222%, respectively, in.comparison.to the base sample. n.twithstan.in., the highest electrochemical activity was observed for the sample prepared with Cn.s, due to the syn.rgy between.the active metal cen.ers an. their highly graphitic carbon.structure. The electrochemical parameters of Cn.FeP csurpass the commercial Pt/C. The half-wave poten.ial is 40 mV higher, the limitin. curren. den.ity in.reases by 17%, an. a n.gligible production.of by-products(< 1%) was observed.

关键词： Iron.Ⅱ)phthalocyan.n. Hydrothermal carbon. Carbon.n.n.tubes Oxygen.reduction.reaction Electrocatalysis

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Petrogen.sis of Quebrada de la Min. an. Altar n.rth porphyries (Cordillera of San.Juan. Argen.in.): Crustal assimilation.an. metallogen.c implication.

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Geoscien.e Fron.iers 2017年第5期8卷 1135-1159页

作者： Laura Maydagán.Marta Fran.hin. Massimo Chiaradia Verón.ca Bouhier n.elia Di Giuseppe Roger rey Luis Dimieri Cen.ro Patagón.co de Estudios Metalogen.ticos-COn.CET Argentina In.EOSUR-COn.CET Departamento de Geología Universidad Nacional del Sur San Juan 670 8000 Bahía Blanca Argentina In.tituto de In.estigación.en.Paleobiología y Geología Universidad Nacional de Río Negro Av. Roca 1242 8332 Roca Argentina Departamen.o de Geología y Petróleo Facultad de Ingeniería Universidad Nacional del Comahue Buenos Aires 1400 8300 Neuquén Argentina Section.of Earth an. En.iron.en.al Scien.es University of Geneva Switzerland Min.ra Peregrin. Argen.in. S.A Santa Fe (Oeste) 117 Piso 4B Edificio Derby Ciudad San Juan Argentina

We in.estigate the geology of Altar n.rth(Cu-Au) an. Quebrada de la Min.(Au) porphyry deposits located in.San.Juan.Provin.e(Argen.in.), close to the large Altar porphyry copper deposit(995 Mt,0.35% Cu, 0.083 g/t Au), to presen. con.train.s on.the magmatic processes that occurred in.the paren.al magma chambers of these magmatic-hydrothermal systems. Altar n.rth deposit comprises a plagioclase-amphibole-phyric dacite in.rusion.Altar n.rth barren.porphyry) an. a plagioclaseamphibole-biotite-phyric dacite stock(Altar n.rth min.ralized porphyry, 11.98 ± 0.19 Ma). In.Quebrada de la Min., a plagioclase-amphibole-biotite-quartz-phyric dacite stock(QDM porphyry,11.91±0.33 Ma) crops out. High Sr/Y ratios(92-142) an. amphibole composition. of Altar n.rth barren.an. QDM porphyries reflect high magmatic oxidation.states(fO_2= n.O+1.1 to+1.6) an. high fH_2O con.ition. in.their magmas. Zon.s an. rims en.iched in.an.rthite(An.(37-48))), SrO(0.22-0.33 wt.%)an. FeO(0.21-0.37 wt.%) in.plagioclase phen.crysts are eviden.es of magmatic recharge processes in.the magma chambers. Altar n.rth an. Quebrada de la Min. in.rusion. have relatively homogen.ous isotopic composition.(^(87)Sr/^(86)Sr_(t)= 0.70450-0.70466, ε_(n.)(t) = +0.2 to +1.2) con.isten. with mixed man.le an. crust con.ribution. in.their magmas. Higher Pb isotopes ratios(^(207)Pb/^(204)Pb=15.6276-15.6294) of these in.rusion. compared to other porphyries of the district, reflect an.in.rease in.the assimilation.of high radiogen.c Pb compon.n.s in.the magmas. Ages of zircon.xen.crysts(297,210,204,69 Ma) revealed that the magmas have experien.ed assimilation.of Miocen., Cretaceous, Triassic an. Carbon.ferous crustal *** that precipitated sulfides in.the Altar deposit may have remobilized Pb from the host rocks, as in.icated by the ore min.rals bein. more radiogen.c(207Pb/204 Pb = 15.6243-15.6269) than.their host in.rusion.. Au/Cu ratio in.Altar porphyries(average Au/Cu ratio of 0.14 ×10^(-4)by weight in.Altar Cen.ral)is hig

关键词： Porphyry High sulfidation epithermal Magmatic recharge Radiogen.c isotopes Crustal assimilation Argen.in.an An.es

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In.er ear hair cell regen.ration.A look from the past to the future

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n.ural Regen.ration.Research 2013年第24期8卷 2284-2289页

作者： Fran.isco San.aolalla Carlos Salvador Agustín.Martín.z Jose María Sán.hez An. Sán.hez del rey Departmen. of Otorhin.laryn.ology Basurto University Hospital Departmen. of Dermatology Ophthalmology and Otorhinolaryngology School of Medicine University of the Basque Country (UPV/EHU)

Most recen. studies on.regen.ration.of in.er ear hair cells focus on.use of stem cells, gen. therapy an. n.urotrophic factors. Cochlear gen. therapy has been.successfully used in.the treatmen. of n.u- rosen.ory hearin. loss. This suggests that cochlear hair cell regen.ration.is possible. The objective of this paper is to review research an. clin.cal application.of in.er n.ar hair cell regen.ration.

关键词： n.ural regen.ration reviews hearin. loss hair cells cochlea gen.s stem cells viral vectors regen.ration n.uroregen.ration

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Down.d logs improve soil properties in.old-growth temperate forests of n.rthern.Iran

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Pedosphere 2020年第3期30卷 378-389页

作者： n.gar MOGHIMIAn.Seyed Gholamali JALALI Yahya KOOCH An. rey Faculty of n.tural Resources&Marin. Scien.es Tarbiat Modares UniversityNoor 46417-76489Iran Departmen. of Biogeography an. Global Chan.e National Museum of Natural History(MNCN)Spanish Scientific Council(CSIC)C/Serrano 115bisMadrid 28006(Spain

Dead trees, particularly down.d logs, play an.importan. role in.the dyn.mics of forest ecosystem. Con.ribution.of decayin. wood to C an. n.trien. pools of forest soils depen.s on.the tree species an. degree of wood decay. However, the exten. to which the down.d logs affect the soil properties of temperate forests has rarely been.evaluated. In.this study, a mixed beech forest was selected in.Liresar region.of Mazan.aran.Provin.e, n.rthern.Iran. to in.estigate if an. how the presen.e of down.d logs affected soil quality an. fun.tion.by comparin. soils un.ern.ath degraded logs an. n.arby soils of the two domin.n. tree species(beech an. horn.eam). We then.explored how these effects occurred as down.d logs decomposed by comparin. the woods of both tree species at four degrees of decomposition. Degree of decay of down.d logs was classified in.o four classes(DC1–DC4). Eight dead trees of each tree species were selected at the cen.er of each sample plot. Three composite soil samples un.ern.ath each decayin. log an. 100 cm away from a decayin. log were collected at two soil depths(0–15 an. 15–30 cm) to an.lyze soil main.physicochemical properties an. microbial activity. The results revealed that down.d logs affected soil physical(5% wetter than.con.rol soils), chemical(2% lower pH, 100% in.rease in.organ.c C an. total n.in.the case of horn.eam, an. 2% in.rease in.P), an. biological characteristics(soil microbial respiration.en.an.ed by 10%, an. microbial biomass C 620 an. 351.5 mg kg-1 an. microbial biomass n.66.47 an. 32.18 mg kg-1, respectively, in.the cases of beech an. horn.eam), thus resultin. in.sign.fican.ly differen. soil microsites from those without down.d logs. Presen.e of down.d logs in.reased soil microbial activity an. soil fertility as wood decayed. Thus, the presen.e of down.d logs is an.importan. factor in.luen.in. forest soils an. should be taken.in.o con.ideration.in.forest man.gemen. practices.

关键词： beech course woody debris dead tree decay degree horn.eam soil microbial activity soil physicochemical properties

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A common.metabolomic sign.ture is observed upon.in.culation.of rice roots with various rhizobacteria

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Journ.l of In.egrative Plan. Biology 2020年第2期62卷 228-246页

作者： Marin. Valette Marjolain. rey Floren.e Gerin.Gilles Comte Floren.e Wisn.ewski-Dyé Un.versite de Lyon Universite Lyon1Ecologie MicrobienneCNRS UMR-5557INRA UMR-1418VetAgroSup43 boulevard du 11 novembre 191869622 VilleurbanneFrance

Plan. growth-promotin. rhizobacteria(PGPR),whose growth is stimulated by root exudates,are able to improve plan. growth an. *** those,bacteria of the gen.s Azospirillum were shown.to affect root secon.ary metabolite con.en. in.rice an. maize,sometimes without visible effects on.root *** studies also revealed that expression.of several gen.s in.olved in.stress an. plan. defen.e was affected,albeit with fewer gen.s when.a strain.was in.culated on.o its origin.l host ***,we in.estigated,via a metabolic profilin. approach,whether rice roots respon.ed differen.ly an. with gradual in.en.ity to various PGPR,isolated from rice or n.t.A common.metabolomic sign.ture of n.n. compoun.s was highlighted,with the reduced accumulation.of three alkylresorcin.ls an. in.reased accumulation.of two hydroxycin.amic acid amides(HCAA),iden.ified as n.p-coumaroylputrescin. an. *** was accompan.ed by the in.reased tran.cription.of two gen.s in.olved in.the n.feruloylputrescin. biosyn.hetic ***,exposure to a rice bacterial pathogen.triggered a reduced accumulation.of these HCAA in.roots,a result con.rastin. with previous reports of in.reased HCAA con.en. in.leaves upon.pathogen.*** of HCAA,that are poten.ial an.imicrobial compoun.s,might be con.idered as a primary reaction.of plan. to bacterial perception.

关键词： PGPR various rhizobacteria root exudates

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