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Predicting 3D Radiotherapy dose-Volume Based on Deep Learning

Intelligent Automation & Soft Computing 2024年第2期39卷 319-335页

作者： do nang Toan Lam Thanh Hien Ha Manh Toan nguyen Trong Vinh Pham Trung Hieu Institute of Information Technology Vietnam Academy of Science and TechnologyHanoi10072Vietnam Faculty of Information Technology Lac Hong UniversityBien HoaDong Nai76120Vietnam

Cancer is one of the most dangerous diseaseswith *** of the principal treatments is radiotherapy by using radiation beams to destroy cancer cells and this workflow requires a lot of experience and skill from doctors and *** our study,we focused on the 3D dose prediction problem in radiotherapy by applying the deeplearning approach to computed tomography(CT)images of cancer *** image data has more complex characteristics than normal image data,and this research aims to explore the effectiveness of data preprocessing and augmentation in the context of the 3D dose prediction *** proposed four strategies to clarify our hypothesis in different aspects of applying data preprocessing and *** strategies,we trained our custom convolutional neural network model which has a structure inspired by the U-net,and residual blocks were also applied to the *** output of the network is added with a rectified linear unit(re-Lu)function for each pixel to ensure there are no negative values,which are absurd with radiation *** experiments were conducted on the dataset of the Open Knowledge-Based Planning Challenge which was collected from head and neck cancer patients treatedwith radiation *** results of four strategies showthat our hypothesis is rational by evaluating metrics in terms of the dose-score and the dose-volume histogram score(DVH-score).In the best training cases,the dose-score is 3.08 and the DVH-score is *** addition,we also conducted a comparison with the results of another study in the same context of using the loss function.

关键词： CT image 3D dose prediction data preprocessing augmentation

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Turbine Passage Secondary Flow Dynamics and Endwall Heat Transfer Under Different Inflow Turbulence

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Journal of Harbin Institute of Technology(new Series) 2024年第3期31卷 51-62页

作者： Arjun K S Tide P S Biju n Division of Mechanical Engineering School of EngineeringCochin University of Science&TechnologyKalamassery 682022India

This study presents endwall hydrodynamics and heat transfer in a linear turbine cascade at re 5×105 at low and high intensities of *** are numerically predicted using the standard SST model and reθ-γtransition model as well as using the high-resolution LES *** major secondary flow components,comprising the horseshoe,corner,and passage vortices are recognized and the impact on heat or mass transfer is *** complicated behavior of turbine passage secondary flow generation and establishment are impacted by the perspective of boundary layer attributes and inflow *** passage vortex concerning the latest big leading-edge vane is generated by the enlargement of the circulation developed at the first instance adjacent to the pressure side becomes powerful and mixes with other vortex systems during its migration towards the suction *** study conclusions reveal that substantial enhancements are attained on the endwall surface,for the entire spanwise blade extension on the pressure surface,and in the highly 3-D region close to the endwall on the suction *** forecasted suction surface thermal exchange depicts great conformity with the measurement values and precisely reproduces the enhanced thermal exchange owing to the development and lateral distribution of the secondary flows along the midspan of the blade passage *** impacts of the different secondary flow structures on the endwall thermal exchange are described in depth.

关键词： turbine vane heat transfer endwall turbulence secondary flow

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Ca含量对时效态Mg-6.5Al-xCa-1Sn-0.3Sr镁合金显微组织和性能的影响

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铸造 2024年第4期73卷 503-508页

作者：热焱邱克强辽宁省交通高等专科学校辽宁沈阳110122 沈阳工业大学材料科学与工程学院辽宁沈阳110870

通过XRD、SEM和性能测试研究了Ca含量的变化对时效态Mg-6.5Al-xCa-1Sn-0.3Sr(x=1,1.5,2,2.5)镁合金的显微组织和性能的影响。结果表明,时效态合金主要由α-Mg和Al_(2)Ca相组成,Al_(2)Ca相成网状分布。合金的抗拉强度和伸长率随着Ca加入... 详细信息

通过XRD、SEM和性能测试研究了Ca含量的变化对时效态Mg-6.5Al-xCa-1Sn-0.3Sr(x=1,1.5,2,2.5)镁合金的显微组织和性能的影响。结果表明,时效态合金主要由α-Mg和Al_(2)Ca相组成,Al_(2)Ca相成网状分布。合金的抗拉强度和伸长率随着Ca加入量的增加而逐渐降低,当Ca含量为1%时合金的拉伸性能最佳,而合金的硬度随着Ca的加入而增加。在175℃、70 MPa下,Ca的添加使时效态合金的稳态蠕变速率降低。

关键词： Mg-Al-Ca-Sn-Sr镁合金显微组织力学性能蠕变性能

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Simplified seismic scenario analysis of existing masonry buildings accounting for local site effects

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Frontiers of Structural and Civil Engineering 2024年第2期18卷 309-318页

作者： Ayşe E.ÖZSOYÖZBAY Işıl SAnRI KARAPInAR Zehra n.KUTLU İsmail E.KILIÇ Department of Civil Engineering Maltepe UniversityIstanbul 34857Turkey School of Engineering and Construction Oryx Universal CollegeDoha 12253Qatar

This study discusses the effects of local sites and hazard amplification on the seismic vulnerability assessment of existing masonry *** this context,a rapid seismic evaluation procedure was implemented on an old masonry building stock in the historical center Galata,located inİstanbul,to determine the seismic risk priority of the built *** scenarios were generated for all soil classes,different moment magnitudes,and source-to-site distances to obtain more accurate results for the seismic vulnerability assessment of the studied building ***,damage distributions estimated under nine different scenarios with/without site effects were compared and illustrated in maps to discuss changes in vulnerability owing to amplification *** this study,by re-examining the rapid seismic evaluation procedure by including geo-hazard-based assessment,the importance of site effects on the vulnerability and risk assessment of built heritage was *** proposed framework integrating field data and local site effects is believed to advance the current applications for vulnerability assessment of masonry buildings and provide an improvement in the application of rapid seismic assessment procedures with more reliable results.

关键词： masonry buildings seismic vulnerability assessment cultural heritage local site effect

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The Evolutionary Profile of Patients Operated for Peptic Ulcer Perforation in Bujumbura

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Surgical Science 2024年第1期15卷 7-18页

作者： Jean Claude Mbonicura Prudence Bukuru Stanislas Harakandi Frank Ijeneza Révérien ndayirorere François nduwimana Astère Mbonicura Department of General and Gastro-Intestinal Surgery Centre Universitaire de Recherche en Santé Faculty of Medicine University of Burundi Bujumbura Burundi Department of Anesthesia-resuscitations Faculty of Health Sciences Hope Africa University Bujumbura Burundi Department of Anesthesia-resuscitation Centre Universitaire de Recherche en Santé Faculty of Medicine University of Burundi Bujumbura Burundi Department of Andro-Urology Centre Universitaire de Recherche en Santé Faculty of Medicine University of Burundi Bujumbura Burundi Department of Multi-Purpose Medicine Easter Grand Hospital Francilien Meaux France

Background: The evolutionary profile of patients operated for peptic ulcer perforation in Bujumbura. Perforated peptic ulcer is a serious complication of peptic ulcer with potential risk of grave complications. Aim: To study the early morbidity and mortality of surgery for peptic ulcer perforation in Bujumbura City Hall hospitals: Kamenge University Hospital Center (CHUK), Kamenge Military Hospital (HMK) and Prince Louis Rwagasore Clinic (CPLR). Patients and methods: This is a retrospective, descriptive and analytical study carried out in the three hospitals of Bujumbura over a period of three years from January 1, 2020 to December 31, 2022. It involved 57 cases (n = 57) of peptic ulcer perforation. results: The frequency of surgery for peptic ulcer perforation was 2.7% with a mean age of 43.6 years +/- 15.3 years and a male predominance with a sex ratio of 3.7. Eight percent of patients presented with shock, 24.5% were smokers, and 67.9% had taken non steroidal anti-inflammatory drugs. The mean hospital stay was 15.2 days with a standard deviation of 12.1. The morbidity rate was 30.2%, 32% were classified in grade IIIb of the Clavien-Dindo Surgical Complications Scale. There were 9 deaths (17%). Seven patients who underwent surgery and received late consultations died. Conclusion: Surgery for peptic ulcer perforation remains an intervention associated with a high rate of morbidity and mortality in Bujumbura. Surgery for peptic ulcer perforation remains a procedure associated with a high morbidity and mortality rate in Bujumbura. The time before consultation was the only factor associated with early morbidity and mortality of Surgery for peptic ulcer’s perforations.

关键词： Peritonitis Peptic Ulcer Perforation Complications

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小胶质细胞极化参与慢性疼痛的研究进展

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临床麻醉学杂志 2024年第2期40卷 200-203页

作者：钟毅单热爱赣南医科大学第一临床医学院赣州市341000 赣南医科大学第一附属医院麻醉手术中心赣州市麻醉学重点实验室赣南医科大学疼痛医学研究所

慢性疼痛是备受关注的公共健康问题之一,我国超过30%的人群受到慢性疼痛的影响,其发病机制是疼痛医学研究的热点与难点。中枢神经系统中固有的小胶质细胞在外界微环境改变时发生极化以及随之产生的神经炎症反应在慢性疼痛中至关重要。... 详细信息

慢性疼痛是备受关注的公共健康问题之一,我国超过30%的人群受到慢性疼痛的影响,其发病机制是疼痛医学研究的热点与难点。中枢神经系统中固有的小胶质细胞在外界微环境改变时发生极化以及随之产生的神经炎症反应在慢性疼痛中至关重要。小胶质细胞在神经炎症反应过程中可极化为促炎M1型或抗炎M2型,分别在神经系统中发挥神经毒性或神经保护作用。本文拟对小胶质细胞极化的主要机制及其参与慢性疼痛过程的机制进行综述。

关键词：小胶质细胞极化神经炎症反应慢性疼痛

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回归办公室的加速器 Plus公司园区及Cossette办公室

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室内设计与装修 2024年第11期 74-77页

作者： [加拿大]LAAB architectúre 沙漏(编译) LAAB architecture

2024年,加拿大领先的广告公司Cos'sette及其母公司Plus启动了一项雄心勃勃的项目,旨在将因疫情而分散的远程工作团队重新聚集到一个位于市中心的园区内。他们决定暂时租用WeWork的空间,吸引那些习惯于远程工作的员工回归办公室,促进团... 详细信息

2024年,加拿大领先的广告公司Cos'sette及其母公司Plus启动了一项雄心勃勃的项目,旨在将因疫情而分散的远程工作团队重新聚集到一个位于市中心的园区内。他们决定暂时租用WeWork的空间,吸引那些习惯于远程工作的员工回归办公室,促进团队之间的合作与交流。恰逢Shopify撤出了位于老蒙特利尔525Vig'erOuest的一层黄金办公楼,Cossette公司与母公司Plus抓住这一契机,并邀请LAAB建筑事务所对其进行重新设计,致力创造一处以员工需求为核心的人性化办公空间。

关键词：广告公司员工需求建筑事务所母公司办公空间 Plus 合作与交流回归

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nutraceutical Potentiality of Fruits of red Variety of Pseudospondias microcarpa (A. Rich) Engl.

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Food and nutrition Sciences 2024年第3期15卷 224-234页

作者： Babouongolo Sévère-Grébel niang Lahat nkounkou-Loumpangou Célestine Bonazaba Milandou Longin Justin Clair Ouamba Jean-Maurille Plant and Life Chemistry Unit (UC2V in French) Faculty of Science and Techniques University Marien Ngouabi Brazzaville Republic of the Congo Eau-Energie-Environnement and Industrial Processes Laboratory (LE3PI in French) University of Dakar Dakar Sénégal

The red fruits of Pseudospondias microcarpa (A. Rich) Engl. are widely consumed by the populations of northern Congo for their sweet and tangy flavor as well as for their characteristic smell. The objective of this study was to show the food potential of the fruits of this plant for their valorization. Organic solvent extracts were prepared and subjected to phytochemical screening to determine the nutrients and phytonutrients of this fruit. Raw juice was extracted by trituration without adding water and subjected to physicochemical and biochemical analyses in order to determine its quality and its antiradical activity. The raw juice obtained is moderately acidic (pH 3.28), very cloudy and colored (turbidity of 1019 nTU). It has a dry matter content of 3.771% ± 0.013% reflecting the 70% dominance of water in the weight of the fruit and the presence of dissolved organic matter in its juice. Energy nutrients (sugars, amino acids), carotenoids, coumarins, tannins, flavonoids, terpenes and sterols have been highlighted as nutrients with therapeutic potential commonly called phytonutrients of this fruit. The juice presented a dominance in polyphenols (134.8500 ± 0.0023 mg gallic acid/100 g) than in carotenoids (5.100 ± 0.010 mg carotene/100 g), high levels of mineral macroelements (calcium: 3570.00 ± 2.05 mg and potassium: 4576.00 ± 9.49 mg) and trace elements (copper: 11.13 ± 0.10 mg, iron: 3.02 ± 0.03 mg and zinc: 2.57 ± 0.08 mg). These compounds exhibited good antioxidant activity. The presence of these nutrients and phytonutrients in these fruits is interesting for the proper functioning of certain organs and the prevention of certain diseases. This fruit is therefore an energizing and functional food that can compete with conventional fruits whose juices are marketed.

关键词： Alicament Fruit Juice Pseudospondias microcarpa Phytochemistry

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Improving the nutritional values of yellow mealworm Tenebrio molitor(Coleoptera: Tenebrionidae) larvae as an animal feed ingredient: a review

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Journal of Animal Science and Biotechnology 2024年第1期15卷 35-52页

作者： Linggawastu Syahrulawal Magnhild Oust Torske Rumakanta Sapkota Geir næss Prabhat Khanal Animal Science Production and Welfare DivisionFaculty of Biosciences and AquacultureNord UniversitySkolegata 22Steinkjer 7713Norway Department of Environmental Science Faculty of Technical SciencesAarhus UniversityFrederiksborgvej 399Roskilde 4000Denmark

Yellow mealworm larvae(YML;Tenebrio molitor) are considered as a valuable insect species for animal feed due to their high nutritional values and ability to grow under different substrates and rearing conditions. Advances in the understanding of entomophagy and animal nutrition over the past decades have propelled research areas toward testing multiple aspects of YML to exploit them better as animal feed sources. This review aims to summarize various approaches that could be exploited to maximize the nutritional values of YML as an animal feed ingredient. In addition, YML has the potential to be used as an antimicrobial or bioactive agent to improve animal health and immune function in production animals. The dynamics of the nutritional profile of YML can be influenced by multiple factors and should be taken into account when attempting to optimize the nutrient contents of YML as an animal feed ingredient. Specifically, the use of novel land-based and aquatic feeding resources, probiotics, and the exploitation of larval gut microbiomes as novel strategies can assist to maximize the nutritional potential of YML. Selection of relevant feed supplies, optimization of ambient conditions, the introduction of novel genetic selection procedures, and implementation of effective post-harvest processing may be required in the future to commercialize mealworm production. Furthermore, the use of appropriate agricultural practices and technological improvements within the mealworm production sector should be aimed at achieving both economic and environmental sustainability. The issues highlighted in this review could pave the way for future approaches to improve the nutritional value of YML.

关键词： Alternative protein source Feed application nutritional value Yellow mealworm

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Multi‑omics integration identifies regulatory factors underlying bovine subclinical mastitis

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Journal of Animal Science and Biotechnology 2024年第3期15卷 987-1007页

作者： Mengqi Wang naisu Yang Mario Laterriere David Gagne Faith Omonijo Eveline M.Ibeagha‑Awemu Agriculture and Agri‑Food Canada Sherbrooke Research and Development CentreSherbrookeQCCanada Department of Animal Science Universite LavalQuebec CityQCCanada Quebec research and Development Centre Agriculture and Agri-Food CanadaQuebec CityQCCanada

Background Mastitis caused by multiple factors remains one of the most common and costly disease of the dairy ***-omics approaches enable the comprehensive investigation of the complex interactions between mul-tiple layers of information to provide a more holistic view of disease ***,this study investigated the genomic and epigenomic signatures and the possible regulatory mechanisms underlying subclinical mastitis by integrating RnA sequencing data(mRnA and lncRnA),small RnA sequencing data(miRnA)and DnA methylation sequencing data of milk somatic cells from 10 healthy cows and 20 cows with naturally occurring subclinical mastitis caused by Staphylococcus aureus or Staphylococcus *** Functional investigation of the data sets through gene set analysis uncovered 3458 biological process GO terms and 170 KEGG pathways with altered activities during subclinical mastitis,provided further insights into subclin-ical mastitis and revealed the involvement of multi-omics signatures in the altered immune responses and impaired mammary gland productivity during subclinical *** abundant genomic and epigenomic signatures with sig-nificant alterations related to subclinical mastitis were observed,including 30,846,2552,1276 and 57 differential methylation haplotype blocks(dMHBs),differentially expressed genes(DEGs),lncRnAs(DELs)and miRnAs(DEMs),***,5 factors presenting the principal variation of differential multi-omics signatures were *** important roles of Factor 1(DEG,DEM and DEL)and Factor 2(dMHB and DEM),in the regulation of immune defense and impaired mammary gland functions during subclinical mastitis were *** of the omics within Factors 1 and 2 explained about 20%of the source of variation in subclinical ***,networks of impor-tant functional gene sets with the involvement of multi-omics signatures were demonstrated,which contributed to a comprehensive view of the possible regu

关键词： Candidate discriminant multi-omics signature Gene Long non-coding RnA Methylation haplotype block MicroRnA Multi-omics integration natural killer cell mediated cytotoxicity pathway Staphylococcus aureus infection pathway

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