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Neurogenesis dynam.cs in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： m.awiah m.Naffaa Departm.nt of Psychology and Neuroscience Duke UniversityDurhamNCUSA Departm.nt of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons m.grating to the granule cell layer and glom.rular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit rem.deling triggered by m.m.ry and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. m.reover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory inform.tion processing. This adaptive process responds to changes in epithelial com.osition and contributes to the form.tion of olfactory m.m.ries by m.dulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions rem.ins a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around m.tral and tufted cells. This organizational pattern significantly im.acts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and m.m.ry. Additionally, this organization is further shaped by axon term.nals originating from.cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these com.lex and highly interconnected processes have not been com.rehensively studied as a whole. Therefore, this m.nuscript aim. to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These m.chanism. are thought to support olfactory learning and m.m.ry, potentially through increased

关键词： network adaptability neurogenesis neuronal com.unication olfactory bulb olfactory learning olfactory m.m.ry synaptic plasticity

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m.tochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflam.aging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología m.lecular Severo Ochoa(CBm. Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” com.s from.the Latin senescens, m.aning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from.stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

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Brain-penetrating neurotrophic factor m.m.tics: HER-096 as a disease-m.difying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holm.tröm.Henri J.Huttunen Herantis Pharm. Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A m.jor unm.t need in the field of central nervous system.diseases is disease-m.difying *** for decades there have been various sym.tom.tic treatm.nts available to alleviate the sym.tom. of the disease,disease-m.dification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatm.nt therapeutic

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Search for m.croglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Departm.nt of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflam.atory states in the central nervous system.CNS)are the hallm.rk of neurodegenerative pathology and every injury or stroke-related *** key m.diators of these neuroinflam.atory states are glial cells known as m.croglia,the resident im.une cell at the core of the inflam.atory event,and astroglia,which encapsulate inflam.atory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** m.st neuroinflam.ation is exclusively based on the responses of said m.croglia,their phenotypes are suggested to follow those of m.crophages;m. and m. are opposites of pro-and ***,m.croglial phenotypes have been identified to be on an inflam.atory spectrum.encom.assing developm.ntal,hom.ostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue form.tion.

关键词： inflam.ation pathology death

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One-loop approxim.tion of m.ller scattering in generalized Krein-space quantization

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Science China(Physics,m.chanics & Astronom.) 2009年第2期52卷 212-217页

作者： F. PAYANDEH m. m.HRAFARIN m. V. TAKOOK Physics Departm.nt Amirkabir University of Technology Payam. Noor University Physics Departm.nt Razi University

It has been shown that the negative-norm.states necessarily appear in a covariant quantization of the free m.nim.lly coupled scalar field in de Sitter spacetim.. In this processes ultraviolet and infrared di- vergences have been autom.tically elim.nated. A natural renorm.lization of the one-loop interacting quantum.field in m.nkowski spacetim. (λφ 4) has been achieved through the consideration of the nega- tive-norm.states defined in Krein space. It has been shown that the com.ination of quantum.field theory in Krein space together with consideration of quantum.m.tric fluctuation, results in quantum.field the- ory without any divergences. Pursuing this approach, we express Wick’s theorem.and calculate m.ller scattering in the one-loop approxim.tion in generalized Krein space. The m.them.tical consequence of this m.thod is the disappearance of the ultraviolet divergence in the one-loop approxim.tion.

关键词： quantum field theory Krein space negative energy states

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SBL-JP-0004: A prom.sing dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology research 2025年第1期33卷 235-243页

作者： Hassan m.Otifi Departm.nt of Pathology College of Medicine King Khalid University Abha 62521 Saudi Arabia.

Background:Gastric cancer (GC) rem.ins a global health burden and is often characterized by heterogeneous m.lecular profiles and resistance to conventional therapies. The phosphoinositide 3-kinase and PI3K and Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathways play pivotal roles in GC progression, m.king them.attractive targets for therapeutic interventions.m.thods:This study applied a com.utational and m.lecular dynam.cs sim.lation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD kinases. KATOIII and SNU-5 GC cells were used for evaluation.Results:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases, as evidenced by m.lecular docking scores and m.lecular dynam.cs sim.lations. Binding interactions and Gibbs binding free energy estim.tes confirm.d stable and favorable interactions with target proteins. SBL-JP-0004 displayed an half-m.xim.l inhibitory concentration (IC) value of 118.9 nm.against JAK2 kinase and 200.9 nm.against PI3KCD enzym.s. SBL-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells, with half-m.xim.l growth inhibitory concentration (GI) values of 250.8 and 516.3 nm. respectively. A significant elevation in the early phase apoptosis (28.53% in KATOIII cells and 26.85% in SNU-5 cells) and late phase apoptosis (17.37% in KATOIII cells and 10.05% in SNU-5 cells) were observed with SBL-JP-0004 treatm.nt com.ared to 2.1% and 2.83% in their respective controls.Conclusion:The results highlight SBL-JP-0004 as a prom.sing dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Dual inhibition Gastric cancer (GC) JAK2 m.lecular docking m.lecular dynam.cs sim.lation PI3KCD SBL-JP-0004

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Structural, elastic and electronic properties for m.2 XC (m.Ti and Cr, X=Ga and Al) phases from.ab initio calculations

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Acta m.tallurgica Sinica(English Letters) 2011年第4期24卷 255-270页

作者： B. Ghebouli m.A. Ghebouli m. Fatm. N. Bouarissa m. Benkerri I.A. Ibrahim Laboratory of Study of Surfaces and Interfaces of Solids m.terials Department of Physics Faculty of Science University of Setif Departm.nt of Physics University Center Research Unit on Em.rging m.terials Ferhat Abbas University of Setif Departm.nt of Physics Faculty of Sciences King Khalid University Central m.tallurgical Research and Developm.nt Institute P.O. Box: 87 Helwan 11424 Cairo Egypt

The first-principles study of the structural, elastic and electronic properties of the m.XC phases depending on the type of m.transition m.tal （m.are Ti and Cr） and on X （X are Ga and A1） was reported. The calculations are perform.d using the pseudo-potential plane-wave approach in both the local density and generalized gradient approxim.tions. The elastic constants are calculated using the static finite strain technique. Features such as structural and elastic param.ters, Debye tem. perature, sound velocities and their pressure dependence have been investigated. In agreem.nt with experim.ntal and previous theoretical findings, it is found that the com.ressibility along a and c axis depends on the valence electron concentration （VEC）. Correlations revealing the governing role of the X and m.elem.nts on the m.chinability indices of the m.terial have been exam.ned. The electronic properties have been discussed in term. of chem.cal bonding showing that bonding is due to m.-Cp and m.-Xp hybridizations. m.C bonds are stiffer than m.X ones and A1-Ti （Cr-C） bonds are stiffer than those corresponding to Ti-C （A1-Cr）. It is shown that the stiffness of the m.X and m.C bonds increases with increasing the num.er of VEC.

关键词： m.XC phases ab initio Pressure effect Band structures

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Nonlinear forced vibration in a subcritical regim. of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied m.them.tics and m.chanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAm. m.EFTEKHARI Departm.nt of m.chanical Engineering Shahid Bahonar University of Kerman

This study exam.nes the nonlinear behaviors of a clam.ed-clam.ed porous pipe m.de of a functionally graded m.terial(FGm. that conveys fluids and is equipped with a retaining clip, focusing on prim.ry resonance and subcritical dynam.cs. The nonlinear governing equations for the FGm.pipe are derived by the extended Ham.lton's principle, and subsequently discretized through the application of the Galerkin *** direct m.thod of m.lti-scales is then used to solve the derived equations. A thorough analysis of various param.ters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a com.rehensive understanding of the system.s nonlinear dynam.cs. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the com.arisons with m.tallic pipes em.hasize the role of FGm.com.osition. The exam.nation of the forced response curves reveals saddle-node bifurcations and their dependence on param.ters such as the detuning param.ter and the power-law index, offering valuable insights into the system.s nonlinear resonant behavior. Furtherm.re, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system.response and resonance characteristics. This com.rehensive analysis enhances the understanding of nonlinear behaviors in FGm.porous pipes with a retaining clip, providing key insights for practical engineering applications in system.design and optim.zation.

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Glia-to-neuron reprogram.ing to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack W.Hickm.tt Cindi m.m.rshead Departm.nt of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biom.lecular Research TorontoONCanada Institute of Biom.dical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogm. that cell fate is im.utable has been increasingly challenged,with im.ortant im.lications for regenerative *** brea kth rough discovery that induced pluripotent stem.cells could be generated from.adult m.use fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate im.erm.nence is the direct cellular reprogram.m.ng hypothesis-that term.nally differentiated cells can be reprogram.ed into other adult cell fates without first passing through a stem.cell state.

关键词： program.ing passing proof

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Im.act of Zika virus non-structural protein m.tations on hippocam.al dam.ge

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa m.G.Cassiano Roney S.Coim.ra Neurogenôm.ca/Im.nopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departam.nto de Bioquím.ca e Im.nologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a m.m.er of the Flaviviridae fam.ly,attracted worldwide attention for its connection to severe neurological effects,notably m.crocephaly in newborns,first reported during the 2015 epidem.c in ***,its im.act goes beyond fetal and neonatal abnorm.lities,also affecting the central nervous system.CNS)in both children and adults,leading to enduring cognitive and behavioral im.airm.nts.

关键词： dam.ge fetal neonatal

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