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Comprehensive semen examination in patients with pancreatic-sufficient and pancreatic-insufficient cystic fibrosis

Asian Journal of Andrology 2023年第5期25卷 591-597页

作者： an.a o sedova Maria I Shtaut Elizaveta E Bragina Tatyana M Sorokina Galina V Shmarina Marina V Andreeva Lyubov E Kurilo Stanislav A Krasovskiy Aleksander V Polyakov Vyacheslav B Chernykh Research Centre for Medical Genetics Russia Moscow 115522

We examined a cohort of 93 cystic fibrosis(CF)male patients who were pancreatic-sufficient(PS-CF;n=40)or pancreatic-insufficient(PI-CF;n=53).Complex semen examination was performed,including stan.ard semen analysis,quantitative karyological analysis(QKA)of immature germ cells(IGCs),transmission electronic microscopy(TEM),biochemical analysis,and sperm DNA fragmentation by terminal deoxynucleotidyl transferase-mediated dUTP nickend labeling(TUNEL)*** was diagnosed in 83(89.2%)*** other 10(10.8%)patients were found to be nonazoospermic and showed various spermatological diagnoses(asthenozoospermia,n=2;asthenoteratozoospermia,n=3;oligoasthenozoospermia,n=1;oligoasthenoteratozoospermia,n=3;and normozoospermia,n=1)with no specific morphological *** was detected in 89.2%azoospermic and 30.0%nonazoospermic *** seminal pH(ound in 74(89.2%)of 83 azoospermic *** leukocytospermia(2.0×10^(6)-2.2×10^(6)ml^(-1))was revealed in 2.4%azoospermic and 40.0%nonazoospermic semen *** signs of partial meiotic arrest at prophase I were found in 4 of 6 nonazoospermic patients examined by QKA of *** content of fructose and citrate was low in oligospermic and normal in nonoligospermic semen *** increased percentage(>30%)of spermatozoa with noncondensed(“immature”)chromatin was revealed in 2 of 6 nonazoospermic semen samples analyzed by TEM.

关键词： congenital bilateral agenesia/aplasia of vas deferens cystic fibrosis cystic fibrosis transmembrane conductance regulator gene semen spermatozoa

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Methodology of the Relationship between Bioethics, Philosophy, and Law

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Journal of Philosophy Study 2013年第7期3卷 669-675页

作者： Natalia sedova Volgograd State Medical University

one can distinguish three levels in the integrative unity of knowledge and norms (assessments), which is termed bioethics. The first level is theoretical. It is connected with the facts and truths. The second level deals with establishing of certain stan.ards and rules of conduct, with the monitoring of their implementation and the assessment of the results of implementation/violation of norms. The third level is associated with individual behavior, formed on the basis of relevant knowledge (or lack of it, as is evident from the table), and the rules governing its application. Theoretical Bioethics is an integral part of Philosophy?the practical Bioethics is directly related to Law and applied Bioethics deals with the personal stan.ards of specific behavior in concrete situations. Social need for regulatory control of any activity with living entities has led to rapid development of practical Bioethics, while its philosophical content developed more slowly. This creates a conflict of norms and values, hampering the adoption of individual decisions now in the field of applied Bioethics. Deontologization of Bioethics can lead to the fact that it will lose its philosophical content and become a specific area of Law. This, in turn, leads to the dehumanization of Bioethics. It is therefore necessary to conduct a methodological analysis of the relationship of Philosophy, Bioethics and Law, the results of which will focus the researchers on the synchronization of the axiological, praxeological and ethical components of scientific research in order to preserve the intellectual integrity of Bioethics.

关键词：生物伦理学分析哲学方法论生命伦理学法学个体行为组成部分社会需要

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双腔室分子束外延复合体在Ⅲ-Ⅴ族和Ⅱ-Ⅵ族半导体异质结生长中的应用(英文)

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电子工业专用设备 2010年第10期39卷 23-25页

作者： A.Alexeev D.Baranov S.Petrov I.sedova S.Sorokin SemiTEq JSC Ioffe Physical Technical Institute of RAS

半导体光电子学是当前科技发展最快的一个领域,光电子器件的增长需要加强新材料技术的研究与开发,Ⅲ -Ⅴ族和Ⅱ-Ⅳ族纳米结构生长的双腔室分子束外延复合体是目前工艺设备一个最好的例子,可以解决长期以来纳米光子学和纳米电子学的问题。

关键词：分子束外延 Ⅲ-Ⅴ族和Ⅱ-Ⅵ族半导体设备与技术

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