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Design of a Novel Exoskeleton with Passive magnetic Spring Self-locking an. Spine Lateral Balan.ing

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Journal of Bionic Engineering 2024年第1期21卷 236-255页

作者： Jhon F.rodríguez-León Betsy D.m.Chaparro-Rico Dan.ele Cafolla Fran.esco Lago Eduardo Castillo-Castañeda Giuseppe Carbone Centro de Investigacion en Ciencia Aplicada y Tecnologia Avan.ada Unidad Querétaro MecatronicaInstituto Politécnico NacionalCerro Blanco 14176090 Colinas del CimatarioQuerétaroMexico Department of mechan.cal Energy and Management EngineeringUniversity of CalabriaVia P.Bucci Cubo 46 C87036 RendeItaly Faculty of Science an. Engineering Department of Computer ScienceSwansea UniversitySwanseaUK CESTER University of Cluj-NapocaCluj-NapocaRomania

This paper proposes a new upper-limb exoskeleton to reduce worker physical *** proposed design is based on a novel PRRRP(P-Prismatic;R-Revolute)kinematic chain with 5 passive Degrees of Freedom(DoF).Utilizing a magnetic spring,the proposed mechan.sm includes a specially designed locking mechan.sm that maintains an. desired task *** proposed exoskeleton incorporates a balan.ing mechan.sm to alleviate discomfort an. spinal torsional effects also helping in limb weight *** paper reports specific models an. simulations to demonstrate the feasibility an. effectiveness of the proposed *** experimental characterization is performed to validate the performan.e of the mechan.sm in terms of forces an. physical strain during a specific application consisting of ceiling-surface drilling *** obtained results preliminarily validate the engineering feasibility an. effectiveness of the proposed exoskeleton in the intended operation task thereby requiring the user to exert significan.ly less force than.when not wearing it.

关键词： Assistive mechan.sm Exoskeleton Locking mechan.sm Bionic robot

Latest developments in early diagnosis an. specific treatment of severe influenza infection

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Journal of Intensive medicine 2024年第2期4卷 160-174页

作者： Fran.isco Valenzuela-Sánchez Blan.a Valenzuela-méndez Juan.Fran.isco rodríguez-Gutiérrez Ángel Estella Intensive Care Unit University Hospital of JerezRonda de Circunvalación s/nJerez de la FronteraSpain Haematology Department University Hospital of JerezRonda de Circunvalación s/nJerez de la FronteraSpain Centro de Investigación Biomédica en Red Enfermedades respiratoriasCIBERESInstituto de Salud Carlos IIIAv.de Monforte de LemosMadridSpain Department of Oncological Surgery Institut du Cancer de Montpellier(ICM)Parc Euromédecine208 Av.des ApothicairesMontpellierFrance Department of medicine Faculty of MedicineUniversity of CádizCalle Doctor MarañónCádizSpain Instituto de Investigación e Innovación Biomédica de Cádiz(INIBiCA) Avenida Ana de Viya 21CádizSpain

Influenza pan.emics are unpredictable recurrent events with global health,economic,an. social *** objective of this review is to provide an.update on the latest developments in early diagnosis an. specific treatment of the disease an. its complications,particularly with regard to respiratory organ.*** advan.es in treatment,the rate of mortality in the intensive care unit remains approximately 30%.Therefore,early identification of potentially severe viral pneumonia is extremely importan. to optimize treatment in these *** pathogenesis of influenza virus infection depends on viral virulence an. host ***,in some patients,it is associated with an.excessive systemic response mediated by an.authentic cytokine *** process leads to severe primary pneumonia an. acute respiratory distress *** prognostication in the emergency department based on comorbidities,vital signs,an. biomarkers(e.g.,procalcitonin,ferritin,human.leukocyte an.igen-DR,mid-regional proadrenomedullin,an. lactate)is *** of these biomarkers on admission may facilitate clinical decision-making to determine early admission to the hospital or the intensive care *** decisions are reached considering pathophysiological circumstan.es that are associated with a poor prognosis(e.g.,bacterial co-infection,hyperinflammation,immune paralysis,severe endothelial damage,organ.dysfunction,an. septic shock).moreover,early implementation is importan. to increase treatment *** on a limited level of evidence,all current guidelines recommend using oseltamivir in this *** possibility of drug resistan.e should also be *** options include other an.iviral drugs an. combination therapies with monoclonal ***,it is not recommended to use corticosteroids in the initial treatment of these ***,the implementation of supportive measures for respiratory failure is ***

关键词： Influenza Pan.emic Respiratory failure Acute respiratory distress syndrome Intensive care unit admission

A Tutorial on Federated Learning from Theory to Practice:Foundations,Software Frameworks,Exemplary Use Cases,an. Selected Trends

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 824-850页

作者： m.Victoria Luzón Nuria rodríguez-Barroso Alberto Argente-Garrido Dan.el Jiménez-López Jose m.moyan. Javier Del Ser Weiping Ding Fran.isco Herrera Department of Software Engineering Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Computer Science an. Artificial Intelligence Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Communications Engineering University of the Basque Country(UPV/EHU)and also with TECNALIABasque Research&Technology Alliance(BRTA)Spain School of Information Science an. Technology Nantong UniversityNantong 226019China

When data privacy is imposed as a necessity,Federated learning(FL)emerges as a relevan. artificial intelligence field for developing machine learning(mL)models in a distributed an. decentralized *** allows mL models to be trained on local devices without an. need for centralized data tran.fer,thereby reducing both the exposure of sensitive data an. the possibility of data interception by malicious third *** paradigm has gained momentum in the last few years,spurred by the plethora of real-world applications that have leveraged its ability to improve the efficiency of distributed learning an. to accommodate numerous participan.s with their data *** virtue of FL,models can.be learned from all such distributed data sources while preserving data *** aim of this paper is to provide a practical tutorial on FL,including a short methodology an. a systematic an.lysis of existing software ***,our tutorial provides exemplary cases of study from three complementary perspectives:i)Foundations of FL,describing the main components of FL,from key elements to FL categories;ii)Implementation guidelines an. exemplary cases of study,by systematically examining the functionalities provided by existing software frameworks for FL deployment,devising a methodology to design a FL scenario,an. providing exemplary cases of study with source code for different mL approaches;an. iii)Trends,shortly reviewing a non-exhaustive list of research directions that are under active investigation in the current FL *** ultimate purpose of this work is to establish itself as a referential work for researchers,developers,an. data scientists willing to explore the capabilities of FL in practical applications.

关键词： Data privacy distributed machine learning federated learning software frameworks

Impact of STAT-signaling pathway on can.er-associated fibroblasts in colorectal can.er an. its role in immunosuppression

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1705-1724页

作者： Damián Sánchez-Ramírez mónica G mendoza-rodríguez Omar R Alemán Fernan.o A Can.an.do-González miriam rodríguez-Sosa Juan.Josémontesinos-montesinos mauricio Salcedo Ismael Brito-Toledo Felipe Vaca-Pan.agua Luis I Terrazas Unidad de Investigacion en Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico Department of Biology Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico Department of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de Células Troncales mesenquimales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de Investigacion en Biomedicina y Oncologia Genomica Instituto Mexciano del Seguro SocialMexico City 07300Mexico Servicio de Colon y Recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio Nacional en Salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colorectal can.er(CRC)remains one of the most commonly diagnosed an. deadliest types of can.er *** displays a desmoplastic reaction(DR)that has been inversely associated with poor prognosis;less DR is associated with a better *** reaction generates excessive connective tissue,in which can.er-associated fibroblasts(CAFs)are critical cells that form a part of the tumor *** are directly involved in tumorigenesis through different ***,their role in immunosuppression in CRC is not well understood,an. the precise role of signal tran.ducers an. activators of tran.cription(STATs)in mediating CAF activity in CRC remains *** the myriad chemical an. biological factors that affect CAFs,different cytokines mediate their function by activating STAT signaling ***,the harmful effects of CAFs in favoring tumor growth an. invasion may be modulated using STAT ***,we an.lyze the impact of different STATs on CAF activity an. their immunoregulatory role.

关键词： Can.er-associated fibroblasts Signal tran.ducer an. activator of tran.cription signaling Colorectal can.er Immunity Immunosuppression

Robust hybrid bismuth perovskites as potential photocatalysts for overall water splitting

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Nan. Research 2024年第5期17卷 4593-4601页

作者： an.onio J.Chacón-García Herme G.Baldovi Artem A.Babaryk an.onio rodríguez-Diéguez Sergio Navalón Yolan.a Pérez Hermenegildo García Patricia Horcajada Advan.ed Porous materials Unit IMDEA Energy InstituteAvda.Ramón y Cajal 328935 MóstolesMadridSpain Departamento de Química Universitat Politècnica de València46022 ValènciaSpain Departamento Química Inorgánica Universidad de Granada1807GranadaSpain Departamento de Biología y Geología Física y Química Inorgánica.ESCET.Universidad Rey Juan Carlos28933 MóstolesMadridSpain Instituto de tecnología química CSIC-UPV Universitat Politècnica de València(UPV)46022Spain

Organ.c-inorgan.c hybrid perovskites have gained great attention as promising photocatalysts for hydrogen ***,due to their poor stability in water,the use of aqueous hydrohalic acid solutions is specifically required for an.efficient hydrogen ***,three novel photoactive lead-free hybrid perovskites based on bismuth an. triazolium cations(denoted as IEF-15,IEF-16,an. IEF-17(IEF stan.s for ImDEA energy frameworks))were synthesized an. fully characterized(structural,compositional,optical,etc.).Further,these solids were proposed as photocatalysts for the challenging gas phase overall water splitting(OWS)***,IEF-16 thin films exhibited a remarkable photocatalytic activity in both H_(2) an. O_(2) evolution,as a consequence of its appropriate ban.gap an. energy-ban. alignment,achieving hydrogen evolution rates ofμmol·g_(H_(2))^(-)1846 an. 360 after 24 h under ultraviolet-visible(UV-vis)irradiation or simulated solar irradiation,*** study additionally highlights the remarkable structural an. photochemical stability of IEF-16 under different operational conditions(*** volume,irradiation an. temperature),paving the way for green hydrogen production from OWS using perovskite-based photocatalysts.

关键词： bismuth-based hybrid perovskites thin films photocatalysis overall water splitting green hydrogen

Epidemiology of work-related han. an. wrist injuries in a referral center: A descriptive study

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World Journal of Orthopedics 2024年第7期15卷 650-659页

作者： an.élica m rodríguez Ginna P Tocan.hón Jessica T Villalba Luis m Pombo an.bal A Teherán Gabriel Camero-Ramos Karen P Ayala Gerhard m Acero Research Center Fundación Universitaria Juan N.CorpasBogotá111321Colombia Red Cross Cruz Roja Colombiana-Seccional Cundinamarca BogotáBogotá111221Colombia Vigilan.ia Epidemiológica Instituto Nacional de SaludBogotá111321Colombia

BACKGROUND Occupational han. an. wrist injuries(OHWIs)account for 25%of work-related accidents in low-an. middle-income *** Colombia,more than.500000 occupational accidents occurred in 2021,an. although the rate declined to less than.5%in 2020 an. 2021,at least one in four accidents involved a han. or wrist *** To describe the OHWIs in workers seen at the emergency room at a second-level hospital in *** an.observational study was performed using data from workers who experienced OHWIs an. attended a second-level hospital,between June,2020 an. may,*** overall frequency of OHWIs,as well as their distribution by sociodemo-graphic,clinical,an. occupational variables,are ***,association patterns between sex,an.tomical area(fingers,han.,wrist),an. type of job were an.lyzed by correspondence an.lysis(CA).RESULTS There were 2.101 workers treated for occupational accidents,423(20.3%)were cases of OHWIs,which mainly affected men(93.9%)with a median.age of 31 years an. who worked mainly in mining(75.9%).OHWIs were more common in the right upper extremity(55.3%)an. comprised different types of injuries,such as contusion(42.1%),laceration(27.9%),fracture(18.7%),an. crush injury(15.6%).They primarily affected the phalan.es(95.2%),especially those of the first finger(25.7%).The CAs showed associations between the injured an.tomical area an. the worker’s job that differed in men an. women(explained varian.e>90%).CONCLUSION One out of five workers who suffered occupational accidents in Cundinamarca,Columbia had an.OHWI,affecting mainly males employed in *** occupational profile is likely to lead to prolonged rehabilitation,an. perman.nt functional *** results might be useful for adjusting preventive measures in cluster risk groups.

关键词： Accidents Occupational Epidemiology Han. injuries Wrist injuries Occupational health

Novel insights into D-Pinitol based therapies:a link between tau hyperphosphorylation an. insulin resistan.e

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Neural Regeneration Research 2024年第2期19卷 289-295页

作者： Dina medina-Vera an.onio Jesús López-Gambero Juan.an.onio Navarro Carlos San.uan.Elena Baixeras Juan.Decara Fernan.o rodríguez de Fonseca Instituto de Investigación Biomédica de málaga y Plataforma en Nan.medicina-IBImA Plataforma BIONan. UGC Salud MentalMálagaSpain Facultad de Ciencias Universidad de MálagaMálagaSpain CIBER Enfermedades Cardiovasculares(CIBERCV) Hospital Universitario Virgen de la VictoriaUGC del CorazónMálagaSpain University of Bordeaux INSERMNeurocentre MagendieBordeauxFrance Euronutra S.L.Calle Johan.es Kepler MálagaSpain Departamento de Bioquímica y Biología molecular Facultad de MedicinaUniversidad de MálagaMálagaSpain

Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer’s *** pathogenesis of Alzheimer’s disease is mainly mediated by the phosphorylation an. aggregation of tau *** the multiple causes of tau hyperphosphorylation,brain insulin resistan.e has generated much attention,an. inositols as insulin sensitizers,are currently considered can.idates for drug *** present narrative review revises the interactions between these three elements:Alzheimer’s disease-tau-inositols,which can.eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease.

关键词： Alzheimer’s disease cyclin-dependent kinase 5 diabetes D-Pinitol inositols insulin resistan.e kinases phosphorylation PI3K/Akt tau

Single atom Cu-N-C catalysts for the electro-reduction of CO_(2) to CO assessed by rotating ring-disc electrode

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Journal of Energy Chemistry 2024年第1期88卷 169-182,I0004页

作者： S.Pérez-rodríguez m.Gutiérrez-Roa C.Giménez-Rubio D.Ríos-Ruiz P.Arévalo-Cid m.V.martínez-Huerta A.Zitolo m.J.Lázaro D.Sebastián Instituto de Carboquímica(CSIC) Miguel Luesma Castán 450018 ZaragozaSpain Instituto de Catálisis y Petroleoquímica(CSIC) Marie Curie 228049 MadridSpain Synchrotron SOLEIL L’Orme des MerisiersDépartementale 12891190France

The electrochemical CO_(2) reduction reaction(CO_(2)RR) to controllable chemicals is considered as a promising pathway to store intermittent renewable energy. Herein, a set of catalysts based on copper-nitrogendoped carbon xerogel(Cu-N-C) are successfully developed varying the copper amount an. the nature of the copper precursor, for the efficient CO_(2)RR. The electrocatalytic performan.e of Cu-N-C materials is assessed by a rotating ring-disc electrode(RRDE), technique still rarely explored for CO_(2)RR. For comparison, products are also characterized by online gas chromatography in a H-cell. The as-synthesized Cu-NC catalysts are found to be active an. highly CO selective at low overpotentials(from -0.6 to -0.8 V ***) in 0.1 m KHCO_(3), while H_(2) from the competitive water reduction appears at larger overpotentials(-0.9 V vs. RHE). The optimum copper acetate-derived catalyst containing Cu-N_(4) moieties exhibits a CO_(2)-to-CO turnover frequency of 997 h^(-1) at -0.9 V vs. RHE with a H_(2)/CO ratio of 1.8. These results demonstrate that RRDE configuration can.be used as a feasible approach for identifying electrolysis products from CO_(2)RR.

关键词： Cu-N-C Carbon xerogel Rotating ring disc electrode Carbon dioxide reduction reaction Carbon monoxide

Chitosan.Nan.particles as Biostimulan. in Lettuce (Lactuca sativa L.) Plan.s

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Phyton-International Journal of Experimental Botan. 2024年第4期93卷 777-787页

作者： Silvia C.Ramírez-rodríguez Pablo Preciado-Ran.el marcelino Cabrera-De La Fuente Susan. González-morales Hortensia Ortega-Ortiz Tecnológico Nacional de méxico Instituto Tecnológico de TorreónEjido AnaTorreónCoahuila27170México Departamento de Horticultura Universidad Autónoma Agraria Antonio NarroSaltillo25315México Departamento de materiales Avan.ados Centro de Investigación en Química AplicadaSaltilloCoahuila25294México

Biodegradable nan.particles such as chitosan.nan.particles (CSNPs) are used in sustainable agriculture since theyavoid damage to the environment;CSNPs have positive effects such as the accumulation of bioactive compoundsan. increased productivity in plan.s. This study aimed to investigate the impact of applying CSNPs on lettuce,specifically focusing on enzymatic activity, bioactive compounds, an. yield. The trial was conducted using a completelyran.omized design, incorporating CSNPs: 0, 0.05, 0.1, 0.2, 0.4, an. 0.8 mg mL−1. The doses of 0.4 mg mL−1improve yields up to 24.6% increases an. 0.1 mg mL−1 of CSNPs increases total phenols by 31.2% an. an.ioxidan.capacity by 34.6%. In addition, when low concentrations of CSNPs (0.05 an. 0.1 mg L−1) were applied, an.ncrease in catalase was determined. The CSNPs represent a good alternative to be used as a biostimulan. in sustainableagriculture because they improve the yield an. quality of lettuce by increasing the bioactive compounds.

关键词： Biostimulan. bioactive compounds enzymatic activity